{"id":"https://openalex.org/W7203543254","doi":"https://doi.org/10.1002/jmv.71104","title":"Dynamic Prognostic Value of IL\u20106/PLT Ratio for Mortality Discrimination in Patients With Crimean\u2010Congo Hemorrhagic Fever: Sequential ROC Analysis Throughout the Clinical Course","display_name":"Dynamic Prognostic Value of IL\u20106/PLT Ratio for Mortality Discrimination in Patients With Crimean\u2010Congo Hemorrhagic Fever: Sequential ROC Analysis Throughout the Clinical Course","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7203543254","doi":"https://doi.org/10.1002/jmv.71104","pmid":"https://pubmed.ncbi.nlm.nih.gov/42603104","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13476864"},"language":"en","primary_location":{"id":"doi:10.1002/jmv.71104","doi":"https://doi.org/10.1002/jmv.71104","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jmv.71104","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmv.71104","source":{"id":"https://openalex.org/S49828768","display_name":"Journal of Medical Virology","issn_l":"0146-6615","issn":["0146-6615","1096-9071"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmv.71104","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036494863","display_name":"Murtaza \u00d6z","orcid":"https://orcid.org/0000-0003-3415-5927","observed_orcids":["https://orcid.org/0000-0003-3415-5927"]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Murtaza \u00d6z","raw_affiliation_strings":["Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University Sivas T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0003-3415-5927","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University Sivas T\u00fcrkiye","institution_ids":["https://openalex.org/I12700597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050745953","display_name":"Caner \u00d6ks\u00fcz","orcid":"https://orcid.org/0000-0002-3944-4608","observed_orcids":["https://orcid.org/0000-0002-3944-4608"]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Caner \u00d6ks\u00fcz","raw_affiliation_strings":["Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University Sivas T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0002-3944-4608","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University Sivas T\u00fcrkiye","institution_ids":["https://openalex.org/I12700597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102837550","display_name":"Ertu\u011frul Keskin","orcid":"https://orcid.org/0000-0002-8447-7695","observed_orcids":["https://orcid.org/0000-0002-8447-7695"]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ertu\u011frul Keskin","raw_affiliation_strings":["Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University Sivas T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0002-8447-7695","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University Sivas T\u00fcrkiye","institution_ids":["https://openalex.org/I12700597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147250759","display_name":"R\u00fcveyda Parlak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"R\u00fcveyda Parlak","raw_affiliation_strings":["Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University Sivas T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University Sivas T\u00fcrkiye","institution_ids":["https://openalex.org/I12700597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137411092","display_name":"Esra \u0130rem Da\u011fc\u0131","orcid":"https://orcid.org/0009-0007-5429-607X","observed_orcids":["https://orcid.org/0009-0007-5429-607X"]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Esra \u0130rem Da\u011fci","raw_affiliation_strings":["Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University Sivas T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University Sivas T\u00fcrkiye","institution_ids":["https://openalex.org/I12700597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147247226","display_name":"\u00c7i\u011fdem Tutku Ba\u011f","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u00c7i\u011fdem Tutku Ba\u011f","raw_affiliation_strings":["Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University Sivas T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University Sivas T\u00fcrkiye","institution_ids":["https://openalex.org/I12700597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5131335798","display_name":"R\u0131dvan Karaarslan","orcid":"https://orcid.org/0009-0004-6358-248X","observed_orcids":["https://orcid.org/0009-0004-6358-248X"]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"R\u0131dvan Karaarslan","raw_affiliation_strings":["Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University Sivas T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0009-0004-6358-248X","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University Sivas T\u00fcrkiye","institution_ids":["https://openalex.org/I12700597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076958383","display_name":"Halef Okan Do\u011fan","orcid":"https://orcid.org/0000-0001-8738-0760","observed_orcids":["https://orcid.org/0000-0001-8738-0760"]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Halef Okan Do\u011fan","raw_affiliation_strings":["Department of Biochemistry Sivas Cumhuriyet University School of Medicine Sivas T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0001-8738-0760","affiliations":[{"raw_affiliation_string":"Department of Biochemistry Sivas Cumhuriyet University School of Medicine Sivas T\u00fcrkiye","institution_ids":["https://openalex.org/I12700597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050501573","display_name":"Seyit Ali B\u00fcy\u00fcktuna","orcid":"https://orcid.org/0000-0001-6518-7361","observed_orcids":["https://orcid.org/0000-0001-6518-7361"]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Seyit Ali B\u00fcy\u00fcktuna","raw_affiliation_strings":["Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University Sivas T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0001-6518-7361","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University Sivas T\u00fcrkiye","institution_ids":["https://openalex.org/I12700597"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081830159","display_name":"Nazif Elald\u0131","orcid":"https://orcid.org/0000-0002-9515-770X","observed_orcids":["https://orcid.org/0000-0002-9515-770X"]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Nazif Elaldi","raw_affiliation_strings":["Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University Sivas T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0002-9515-770X","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Clinical Microbiology Sivas Cumhuriyet University Sivas T\u00fcrkiye","institution_ids":["https://openalex.org/I12700597"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5036494863"],"corresponding_institution_ids":["https://openalex.org/I12700597"],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":{"value":4730,"currency":"USD","value_usd":4730},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.60888301,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"98","issue":"8","first_page":"e71104","last_page":"e71104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crimean-congo-hemorrhagic-fever","display_name":"Crimean-Congo hemorrhagic fever","score":0.9980000257492065},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.906000018119812},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.7179999947547913},{"id":"https://openalex.org/keywords/ferritin","display_name":"ferritin","score":0.8960000276565552},{"id":"https://openalex.org/keywords/mortality-prediction","display_name":"mortality prediction","score":0.7049999833106995},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9919999837875366},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6840000152587891},{"id":"https://openalex.org/keywords/hemostatic-dysfunction","display_name":"hemostatic dysfunction","score":0.925000011920929},{"id":"https://openalex.org/keywords/time-course-of-biomarkers","display_name":"time course of biomarkers","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6998000144958496},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6036999821662903},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5364999771118164},{"id":"https://openalex.org/C102803821","wikidata":"https://www.wikidata.org/wiki/Q7598403","display_name":"Standardized mortality ratio","level":3,"score":0.5320000052452087},{"id":"https://openalex.org/C97931131","wikidata":"https://www.wikidata.org/wiki/Q5282087","display_name":"Discriminative model","level":2,"score":0.5048999786376953},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.5040000081062317},{"id":"https://openalex.org/C2776291640","wikidata":"https://www.wikidata.org/wiki/Q2912517","display_name":"Value (mathematics)","level":2,"score":0.424699991941452},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.329800009727478},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.3181999921798706},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.31209999322891235},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.2849999964237213},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.28189998865127563},{"id":"https://openalex.org/C167704817","wikidata":"https://www.wikidata.org/wiki/Q7295548","display_name":"Rate ratio","level":3,"score":0.2700999975204468},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.26589998602867126},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.25270000100135803}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005293","descriptor_name":"Ferritins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006479","descriptor_name":"Hemorrhagic Fever, Crimean","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006479","descriptor_name":"Hemorrhagic Fever, Crimean","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006479","descriptor_name":"Hemorrhagic Fever, Crimean","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010976","descriptor_name":"Platelet Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/jmv.71104","doi":"https://doi.org/10.1002/jmv.71104","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jmv.71104","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmv.71104","source":{"id":"https://openalex.org/S49828768","display_name":"Journal of Medical Virology","issn_l":"0146-6615","issn":["0146-6615","1096-9071"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Virology","raw_type":"journal-article"},{"id":"pmid:42603104","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42603104","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medical virology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13476864","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13476864/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Med Virol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/jmv.71104","doi":"https://doi.org/10.1002/jmv.71104","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jmv.71104","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmv.71104","source":{"id":"https://openalex.org/S49828768","display_name":"Journal of Medical Virology","issn_l":"0146-6615","issn":["0146-6615","1096-9071"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Virology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321621","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203543254.pdf","grobid_xml":"https://content.openalex.org/works/W7203543254.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W1974415901","https://openalex.org/W2000645789","https://openalex.org/W2021540990","https://openalex.org/W2127414127","https://openalex.org/W2227516281","https://openalex.org/W2514004244","https://openalex.org/W4293276053","https://openalex.org/W4293461588","https://openalex.org/W4395448975","https://openalex.org/W4406981149","https://openalex.org/W4415008437","https://openalex.org/W4415438635","https://openalex.org/W4416397911","https://openalex.org/W7124890450"],"related_works":["https://openalex.org/W7204966086","https://openalex.org/W4293461588","https://openalex.org/W3033259420","https://openalex.org/W4409326207","https://openalex.org/W3007047786","https://openalex.org/W4415008437","https://openalex.org/W7131300735","https://openalex.org/W4311161601","https://openalex.org/W2098574828","https://openalex.org/W4316371259"],"abstract_inverted_index":{"This":[0],"study":[1],"aimed":[2],"to":[3,27],"compare":[4],"the":[5,29,33,54,61,97,102,111,114,118,139,167,175,197],"prognostic":[6,172],"performances":[7,64],"of":[8,32,38,65,126,159,177,185,202],"individual":[9,66,98],"laboratory":[10],"parameters":[11],"and":[12,26,48,60,67,79,188,199],"biomarker":[13,194],"ratios":[14],"derived":[15,68,112],"from":[16],"them":[17],"formortality":[18],"in":[19,53,94,153,205],"patients":[20,41,91,155],"with":[21,42,122,156],"Crimean-Congo":[22],"Hemorrhagic":[23],"Fever":[24],"(CCHF),":[25],"examine":[28],"temporal":[30],"stability":[31,173],"strongest":[34],"index.":[35],"A":[36],"total":[37],"1171":[39],"adult":[40],"laboratory-confirmed":[43],"CCHF":[44],"followed":[45],"between":[46],"2014":[47],"2024":[49],"were":[50,58,85],"retrospectively":[51],"included":[52],"study.":[55],"Admission":[56],"data":[57],"recorded,":[59],"mortality":[62,84,107,203],"discriminative":[63,104],"biomarkers":[69],"(interleukin-6-to-platelet":[70],"ratio":[71,74,77,81,116,141,158,169],"[IL-6/PLT],":[72],"interleukin-6-to-calcium":[73],"[IL-6/Ca],":[75],"ferritin-to-platelet":[76],"[Ferritin/PLT],":[78],"ferritin-to-calcium":[80],"[Ferritin/Ca])":[82],"for":[83,106,138,196],"compared":[86],"using":[87],"ROC":[88,163],"analysis.":[89],"Ninety-seven":[90],"(8.3%)":[92],"resulted":[93],"mortality.":[95],"Among":[96,110],"parameters,":[99],"IL-6":[100],"demonstrated":[101,117,165],"highest":[103,119],"ability":[105],"(AUC:":[108],"0.887).":[109],"indices,":[113],"IL-6/PLT":[115,140,168,180],"overall":[120],"performance":[121],"an":[123],"AUC":[124],"value":[125,137],"0.920":[127],"(95%":[128],"CI:":[129],"0.871-0.969;":[130],"p":[131],"<":[132],"0.001).":[133],"The":[134,179],"optimal":[135],"cut-off":[136],"was":[142],"determined":[143],"as":[144],"0.78":[145],"(88%":[146],"sensitivity,":[147],"81%":[148],"specificity).":[149],"Mortality":[150],"reached":[151],"100%":[152],"all":[154],"a":[157,182,192],"\u2265":[160],"16.":[161],"Sequential":[162],"analyzes":[164],"that":[166],"maintained":[170],"high":[171],"throughout":[174],"course":[176],"infection.":[178],"ratio,":[181],"combined":[183],"indicator":[184],"inflammatory":[186],"response":[187],"hemostatic":[189],"dysfunction,":[190],"is":[191],"powerful":[193],"candidate":[195],"early":[198],"dynamic":[200],"monitoring":[201],"risk":[204],"CCHF.":[206]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-08-16T00:00:00"}