{"id":"https://openalex.org/W7203518038","doi":null,"title":"Development of a Sterilizable Hydrogel Platform for Biocontained Cell Therapy Delivery to the GI Tract","display_name":"Development of a Sterilizable Hydrogel Platform for Biocontained Cell Therapy Delivery to the GI Tract","publication_year":2022,"publication_date":"2022-04-22","ids":{"openalex":"https://openalex.org/W7203518038"},"language":"en","primary_location":{"id":"pmh:oai:repository.rice.edu:1911/113492","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1911/113492","pdf_url":null,"source":{"id":"https://openalex.org/S4306401268","display_name":"Rice Research Repository (Rice University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74775410","host_organization_name":"Rice University","host_organization_lineage":["https://openalex.org/I74775410"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041079358","display_name":"Michael Doerfert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Doerfert, Michael David","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5041079358"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genetically-modified-bacteria","display_name":"engineered bacteria","score":0.6389999985694885},{"id":"https://openalex.org/keywords/gastrointestinal-tract","display_name":"gastrointestinal tract","score":0.6740000247955322},{"id":"https://openalex.org/keywords/bacterial-encapsulation","display_name":"bacterial encapsulation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/biocontainment","display_name":"biocontainment","score":0.8799999952316284}],"concepts":[{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5878000259399414},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.3569999933242798},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3495999872684479},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3416999876499176},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.30230000615119934},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.29179999232292175},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.2782999873161316},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.27230000495910645},{"id":"https://openalex.org/C2992581678","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Digestive tract","level":2,"score":0.26089999079704285},{"id":"https://openalex.org/C2983812674","wikidata":"https://www.wikidata.org/wiki/Q134808","display_name":"Delivery system","level":2,"score":0.2563999891281128},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.25060001015663147},{"id":"https://openalex.org/C2994537864","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Human medicine","level":2,"score":0.25049999356269836}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:repository.rice.edu:1911/113492","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1911/113492","pdf_url":null,"source":{"id":"https://openalex.org/S4306401268","display_name":"Rice Research Repository (Rice University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74775410","host_organization_name":"Rice University","host_organization_lineage":["https://openalex.org/I74775410"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2073975127","https://openalex.org/W7165935136","https://openalex.org/W2614903907","https://openalex.org/W2730863042","https://openalex.org/W7213444629","https://openalex.org/W7220830974","https://openalex.org/W4415054049","https://openalex.org/W4400778887","https://openalex.org/W2167370663","https://openalex.org/W4384009036"],"abstract_inverted_index":{"Bacteria":[0],"are":[1],"a":[2,11,36,90,108,136],"ubiquitous":[3],"and":[4,19,41,77,83,96,110,125],"diverse":[5],"class":[6],"of":[7,14,26,35,39,56,63,73,85,113,127,144],"microorganism":[8],"that":[9,45,106,134],"play":[10],"wide":[12,37],"variety":[13,38],"roles":[15],"in":[16,23,67],"nature,":[17],"industry,":[18],"human":[20],"health.":[21],"Advances":[22],"genetic":[24],"engineering":[25],"bacteria":[27,43,100,116],"has":[28,69],"given":[29],"rise":[30],"to":[31,49,102,117,141],"the":[32,47,57,61,81,103,114,118,123,145],"rapid":[33],"development":[34,126],"diagnostic":[40],"therapeutic":[42,74],"strains":[44],"have":[46],"potential":[48],"greatly":[50],"improve":[51,142],"healthcare,":[52],"particularly":[53],"for":[54,99],"diseases":[55],"digestive":[58],"system.":[59],"However,":[60],"use":[62],"genetically":[64],"modified":[65],"organisms":[66],"medicine":[68],"raised":[70],"multiple":[71],"concerns":[72],"delivery,":[75],"control,":[76],"safety,":[78],"which":[79],"limits":[80],"translation":[82],"adoption":[84],"these":[86],"technologies.":[87],"There":[88],"exists":[89],"gap":[91],"between":[92],"current":[93],"biocontainment":[94,143],"technologies":[95],"platforms":[97],"made":[98],"delivery":[101,112],"GI":[104],"tract":[105],"ensures":[107],"safe":[109],"effective":[111],"engineered":[115],"patient.":[119],"This":[120],"report":[121],"details":[122],"design":[124],"an":[128],"externally":[129],"sterilizable":[130],"cell":[131],"therapy":[132],"platform":[133],"uses":[135],"UV-absorbent,":[137],"reinforced":[138],"hydrogel":[139],"formulation":[140],"encapsulated":[146],"bacteria.":[147]},"counts_by_year":[],"updated_date":"2026-09-05T08:02:43.246662","created_date":"2026-08-15T00:00:00"}
