{"id":"https://openalex.org/W7203499059","doi":"https://doi.org/10.1677/jme.0.0300085","title":"G protein-coupled receptor signalling in neuroendocrine systems: A special section consisting of proceedings from a symposium at the 5th International Congress of Neuroendocrinology (ICN), Bristol, UK, 31 August\u20134 September 2002","display_name":"G protein-coupled receptor signalling in neuroendocrine systems: A special section consisting of proceedings from a symposium at the 5th International Congress of Neuroendocrinology (ICN), Bristol, UK, 31 August\u20134 September 2002","publication_year":2003,"publication_date":"2003-04-01","ids":{"openalex":"https://openalex.org/W7203499059","doi":"https://doi.org/10.1677/jme.0.0300085","mag":"1597173346"},"language":"en","primary_location":{"id":"doi:10.1677/jme.0.0300085","doi":"https://doi.org/10.1677/jme.0.0300085","is_oa":false,"landing_page_url":"https://doi.org/10.1677/jme.0.0300085","pdf_url":null,"source":{"id":"https://openalex.org/S15622159","display_name":"Journal of Molecular Endocrinology","issn_l":"0952-5041","issn":["0952-5041","1479-6813"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060733289","display_name":"Craig Alexander McArdle","orcid":"https://orcid.org/0000-0003-4836-5351","observed_orcids":["https://orcid.org/0000-0003-4836-5351"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Craig McArdle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5060733289"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1885,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.40118858,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"2","first_page":"85","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9869999885559082},{"id":"https://openalex.org/keywords/neuroendocrine-signalling","display_name":"neuroendocrine signalling","score":0.8489999771118164},{"id":"https://openalex.org/keywords/thyrotropin-releasing-hormone-receptor","display_name":"thyrotropin-releasing hormone receptor","score":0.8429999947547913},{"id":"https://openalex.org/keywords/receptor-trafficking","display_name":"receptor trafficking","score":0.7310000061988831},{"id":"https://openalex.org/keywords/oxytocin-receptor","display_name":"oxytocin receptor","score":0.8579999804496765},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/mapk-activation","display_name":"MAPK activation","score":0.906000018119812},{"id":"https://openalex.org/keywords/beta-arrestin","display_name":"beta-arrestin","score":0.9599999785423279},{"id":"https://openalex.org/keywords/erk","display_name":"ERK","score":0.3959999978542328},{"id":"https://openalex.org/keywords/receptor-desensitization","display_name":"receptor desensitization","score":0.5440000295639038},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.33000001311302185}],"concepts":[{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5649999976158142},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.5235000252723694},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.5188000202178955},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4657999873161316},{"id":"https://openalex.org/C139407321","wikidata":"https://www.wikidata.org/wiki/Q408561","display_name":"Heterotrimeric G protein","level":4,"score":0.46380001306533813},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.45570001006126404},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.439300000667572},{"id":"https://openalex.org/C104745856","wikidata":"https://www.wikidata.org/wiki/Q1335366","display_name":"Neuroendocrinology","level":3,"score":0.42800000309944153},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.3912999927997589},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3885999917984009},{"id":"https://openalex.org/C3018449070","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signalling pathways","level":3,"score":0.3456000089645386},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.2897000014781952},{"id":"https://openalex.org/C127955056","wikidata":"https://www.wikidata.org/wiki/Q83133937","display_name":"Netrin","level":4,"score":0.2833000123500824},{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.2775000035762787},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.2734000086784363},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.2700999975204468},{"id":"https://openalex.org/C2993458768","wikidata":"https://www.wikidata.org/wiki/Q3477549","display_name":"Special section","level":2,"score":0.2696000039577484},{"id":"https://openalex.org/C85771745","wikidata":"https://www.wikidata.org/wiki/Q5514732","display_name":"GTP-binding protein regulators","level":4,"score":0.26159998774528503},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.259799987077713},{"id":"https://openalex.org/C75184817","wikidata":"https://www.wikidata.org/wiki/Q5381540","display_name":"Enzyme-linked receptor","level":3,"score":0.25200000405311584}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1677/jme.0.0300085","doi":"https://doi.org/10.1677/jme.0.0300085","is_oa":false,"landing_page_url":"https://doi.org/10.1677/jme.0.0300085","pdf_url":null,"source":{"id":"https://openalex.org/S15622159","display_name":"Journal of Molecular Endocrinology","issn_l":"0952-5041","issn":["0952-5041","1479-6813"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire_cris_publications/7d7cf92f-1450-4f1c-967d-8e0e729be0cb","doi":null,"is_oa":false,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/7d7cf92f-1450-4f1c-967d-8e0e729be0cb","pdf_url":null,"source":{"id":"https://openalex.org/S7407055359","display_name":"Explore Bristol Research","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"McArdle, CA 2003, 'G-protein coupled receptor signalling in neuroendocrine systems', Journal of Molecular Endocrinology, vol. 30, pp. 85 - 86.","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:1597173346","doi":null,"is_oa":false,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/g-protein-coupled-receptor-signalling-in-neuroendocrine-systems","pdf_url":null,"source":{"id":"https://openalex.org/S15622159","display_name":"Journal of Molecular Endocrinology","issn_l":"0952-5041","issn":["0952-5041","1479-6813"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Molecular Endocrinology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W2001725885","https://openalex.org/W2020377181","https://openalex.org/W2027002868","https://openalex.org/W2050161311","https://openalex.org/W2064025098","https://openalex.org/W2083555314","https://openalex.org/W2085380563","https://openalex.org/W2119008435","https://openalex.org/W2164097764"],"related_works":["https://openalex.org/W2914872022","https://openalex.org/W1597173346","https://openalex.org/W4388318169","https://openalex.org/W3967456","https://openalex.org/W2184735842","https://openalex.org/W2500256412","https://openalex.org/W3036061132","https://openalex.org/W2896524040","https://openalex.org/W4294119580","https://openalex.org/W7010168042"],"abstract_inverted_index":{"Abstract":[0],"G":[1,57],"protein-coupled":[2,212],"receptors":[3,71],"(GPCRs)":[4],"are":[5,13,65,82,99],"the":[6,19,37,85,112,182,223,266,274,284,294,317,395,416],"largest":[7],"class":[8],"of":[9,21,31,36,76,144,150,154,158,179,188,225,238,268,277,302,313,319,354,378,386,398,402,412],"signalling":[10,81,172,190,214,388,407],"proteins.":[11],"They":[12],"targeted":[14],"(directly":[15],"or":[16,343,352],"indirectly)":[17],"by":[18,27,122,201,206,209,230,241,261],"majority":[20],"current":[22],"medicines":[23],"as":[24,26,48],"well":[25],"a":[28,207],"vast":[29],"array":[30],"physiological":[32,177,419],"regulators,":[33],"including":[34],"all":[35,153],"classic":[38],"neuroendocrine":[39,216,376,413],"releasing":[40],"and":[41,73,80,92,129,148,233,247,324,346,384,406,418],"inhibitory":[42],"factors.":[43],"Although":[44,133],"conventionally":[45],"viewed":[46],"simply":[47],"guanine":[49],"nucleotide":[50],"exchange":[51],"factors":[52],"for":[53,161,176,283,329],"their":[54,95],"cognate":[55],"heterotrimeric":[56],"proteins,":[58],"it":[59],"is":[60,197,298,380,408],"now":[61],"clear":[62,138],"that":[63,74,87,169,185,192,273,296],"there":[64,297],"multiple":[66,327],"\u2018\u2018platforms\u2019\u2019":[67],"through":[68],"which":[69,155,219],"these":[70,162,387,391],"signal":[72],"control":[75,377],"GPCR":[77,403],"expression,":[78,304],"location":[79],"central":[83],"to":[84,254,335,373],"ways":[86],"cells":[88],"integrate":[89],"information":[90],"from,":[91],"adapt":[93],"to,":[94],"environments.":[96],"These":[97],"issues":[98],"explored":[100],"in":[101,104,142,181,195,215,218,251,287,291,337,400],"five":[102],"articles":[103,392],"this":[105,369],"journal,":[106],"based":[107],"on":[108,116,210,382],"talks":[109],"presented":[110],"at":[111,415],"5th":[113],"International":[114],"Congress":[115],"Neuroendocrinology.":[117],"The":[118,164],"first":[119],"lecture":[120],"was":[121,136,166,204,258],"Marvin":[123],"Gershengorn,":[124],"who":[125,264],"compared":[126],"type":[127],"I":[128],"II":[130],"TRH":[131],"receptors.":[132,163],"ligand":[134],"specificity":[135],"indistinguishable,":[137],"differences":[139],"were":[140,156],"seen":[141,290],"terms":[143],"basal":[145,170,189],"signalling,":[146,367],"trafficking":[147],"influence":[149,364],"receptor":[151,213,228,270,366],"mutations,":[152],"indicative":[157],"distinct":[159],"conformations":[160],"idea":[165],"then":[167,310],"developed":[168,259],"(ligand-independent)":[171],"might":[173],"be":[174],"important":[175,299],"effects":[178],"TRH-2":[180],"CNS":[183],"but":[184],"molecular":[186],"constraints":[187],"ensure":[191],"TRH-R1":[193],"activity":[194],"thyrotrophs":[196],"more":[198],"tightly":[199],"controlled":[200],"ligands.":[202],"This":[203,256],"followed":[205],"symposium":[208],"_G":[211],"systems_":[217],"Greti":[220],"Aguilera":[221],"described":[222,265],"regulation":[224,267,301,414],"V1b":[226],"vasopressin":[227],"expression":[229,289],"both":[231],"transcriptional":[232],"translational":[234],"mechanisms,":[235],"emphasising":[236],"activation":[237,332,336,351],"V1bR":[239],"translation":[240],"an":[242],"internal":[243],"ribosome":[244],"entry":[245],"site":[246],"its":[248],"possible":[249],"role":[250],"adaptive":[252],"responses":[253],"stress.":[255],"theme":[257],"further":[260],"Tadashi":[262],"Kimura":[263],"oxytocin":[269],"levels,":[271],"showing":[272,325],"known":[275],"regulators":[276],"OTR":[278,288,303],"transcription":[279],"do":[280],"not":[281],"account":[282],"dramatic":[285],"changes":[286],"vivo":[292],"with":[293,347,370],"implication":[295],"post-transcriptional":[300],"function":[305,405],"and/or":[306],"stability.":[307],"Louis":[308],"Luttrell":[309],"discussed":[311],"mechanisms":[312,328],"MAPK":[314,331],"activation,":[315],"stressing":[316],"importance":[318],"scaffolding":[320],"(e.g.":[321,341,350],"via":[322],"_-arrestins)":[323],"how":[326,360,375,394],"GPCR-mediated":[330],"can":[333,363],"lead":[334],"different":[338,348],"cellular":[339,417],"compartments":[340],"nuclear":[342],"cytoplasmic":[344],"ERK)":[345],"consequences":[349],"inhibition":[353],"transcription).":[355],"Finally,":[356],"Shaila":[357],"Mani":[358],"showed":[359],"GPCR-activated":[361],"phosphorylation":[362],"progesterone":[365],"extending":[368],"behavioural":[371],"models":[372],"show":[374],"reproduction":[379],"dependent":[381],"convergence":[383],"integration":[385],"pathways.":[389],"Together,":[390],"illustrate":[393],"breathtaking":[396],"rate":[397],"advance":[399],"knowledge":[401],"structure,":[404],"driving":[409],"our":[410],"understanding":[411],"levels.":[420]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-08-15T00:00:00"}