{"id":"https://openalex.org/W7203497166","doi":"https://doi.org/10.1016/j.bbadis.2026.168417","title":"Reduced Occludin expression in aortic endothelial cells mediates endothelial barrier dysfunction in aortic dissection","display_name":"Reduced Occludin expression in aortic endothelial cells mediates endothelial barrier dysfunction in aortic dissection","publication_year":2026,"publication_date":"2026-08-14","ids":{"openalex":"https://openalex.org/W7203497166","doi":"https://doi.org/10.1016/j.bbadis.2026.168417","pmid":"https://pubmed.ncbi.nlm.nih.gov/42600953"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbadis.2026.168417","doi":"https://doi.org/10.1016/j.bbadis.2026.168417","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbadis.2026.168417","pdf_url":null,"source":{"id":"https://openalex.org/S4210173099","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","issn_l":"0925-4439","issn":["0925-4439","1879-260X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101398204","display_name":"Shiqi Gao","orcid":"https://orcid.org/0000-0003-1572-7715","observed_orcids":["https://orcid.org/0000-0003-1572-7715"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiqi Gao","raw_affiliation_strings":["Department of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134556870","display_name":"Chenyu Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenyu Zhou","raw_affiliation_strings":["Department of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147195418","display_name":"Jiachen Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210119028","display_name":"Beijing Anzhen Hospital","ror":"https://ror.org/02h2j1586","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiachen Li","raw_affiliation_strings":["Department of Pediatric Cardiology, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Road, Chaoyang District, Beijing, 100029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Cardiology, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Road, Chaoyang District, Beijing, 100029, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210119028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089178230","display_name":"Xianchao Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianchao Jiang","raw_affiliation_strings":["Department of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079901012","display_name":"Yuanrui Gu","orcid":"https://orcid.org/0000-0002-8750-3078","observed_orcids":["https://orcid.org/0000-0002-8750-3078"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanrui Gu","raw_affiliation_strings":["Department of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147180164","display_name":"Yumengi Ji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yumengi Ji","raw_affiliation_strings":["Department of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102769831","display_name":"Kai Xu","orcid":"https://orcid.org/0009-0002-7339-0049","observed_orcids":["https://orcid.org/0009-0002-7339-0049","https://orcid.org/0000-0002-6761-1020"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Xu","raw_affiliation_strings":["Department of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100325221","display_name":"Jiang Liu","orcid":"https://orcid.org/0000-0002-0654-707X","observed_orcids":["https://orcid.org/0000-0002-0654-707X"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiang Liu","raw_affiliation_strings":["Department of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000783607","display_name":"Zhonghua Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhonghua Shen","raw_affiliation_strings":["Department of Cardiovascular Surgery, Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310001, China. Electronic address: shenzhonghua@zju.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310001, China. Electronic address: shenzhonghua@zju.edu.cn","institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008080361","display_name":"Enzehua Xie","orcid":"https://orcid.org/0000-0002-6092-1755","observed_orcids":["https://orcid.org/0000-0002-6092-1755"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Enzehua Xie","raw_affiliation_strings":["Department of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China. Electronic address: xieenzehua@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China. Electronic address: xieenzehua@126.com","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5147151238","display_name":"Juntao Qiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Juntao Qiu","raw_affiliation_strings":["Department of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China. Electronic address: qiujt0328@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China. Electronic address: qiujt0328@163.com","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5000783607","https://openalex.org/A5008080361","https://openalex.org/A5147151238"],"corresponding_institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210158318","https://openalex.org/I4210161896","https://openalex.org/I76130692"],"apc_list":{"value":4010,"currency":"USD","value_usd":4010},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.61493168,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1873","issue":"1","first_page":"168417","last_page":"168417"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aortic-dissection","display_name":"aortic dissection","score":0.9980000257492065},{"id":"https://openalex.org/keywords/occludin","display_name":"occludin","score":0.9409999847412109},{"id":"https://openalex.org/keywords/endothelial-barrier-dysfunction","display_name":"endothelial barrier dysfunction","score":0.9110000133514404},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.9359999895095825},{"id":"https://openalex.org/keywords/vascular-permeability","display_name":"vascular permeability","score":0.7910000085830688},{"id":"https://openalex.org/keywords/aortic-endothelial-cells","display_name":"aortic endothelial cells","score":0.8659999966621399},{"id":"https://openalex.org/keywords/macrophage-infiltration","display_name":"macrophage infiltration","score":0.8080000281333923},{"id":"https://openalex.org/keywords/elastic-fiber-degradation","display_name":"elastic fiber degradation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.890999972820282},{"id":"https://openalex.org/keywords/endothelial-specific-knockout","display_name":"endothelial-specific knockout","score":0.6389999985694885},{"id":"https://openalex.org/keywords/aortic-rupture","display_name":"aortic rupture","score":0.5820000171661377},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C2775962179","wikidata":"https://www.wikidata.org/wiki/Q2013337","display_name":"Occludin","level":3,"score":0.9584000110626221},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6622999906539917},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.5789999961853027},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.534500002861023},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47909998893737793},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.4788999855518341},{"id":"https://openalex.org/C2779993142","wikidata":"https://www.wikidata.org/wiki/Q594660","display_name":"Aortic dissection","level":3,"score":0.4359999895095825},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.4327999949455261},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.41679999232292175},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.41029998660087585},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4050999879837036},{"id":"https://openalex.org/C15215337","wikidata":"https://www.wikidata.org/wiki/Q18032325","display_name":"Vascular endothelial growth factor B","level":5,"score":0.39570000767707825},{"id":"https://openalex.org/C35866371","wikidata":"https://www.wikidata.org/wiki/Q6005502","display_name":"Immunocytochemistry","level":2,"score":0.3864000141620636},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.375},{"id":"https://openalex.org/C2777649898","wikidata":"https://www.wikidata.org/wiki/Q5415983","display_name":"Evans Blue","level":2,"score":0.37310001254081726},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3691999912261963},{"id":"https://openalex.org/C2776246508","wikidata":"https://www.wikidata.org/wiki/Q5376428","display_name":"Endothelial activation","level":3,"score":0.35589998960494995},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.32710000872612},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32499998807907104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3070000112056732},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.3027999997138977},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.29919999837875366},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.29899999499320984},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.27619999647140503},{"id":"https://openalex.org/C2781380885","wikidata":"https://www.wikidata.org/wiki/Q17859848","display_name":"VE-cadherin","level":4,"score":0.266400009393692},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2547999918460846}],"mesh":[{"descriptor_ui":"D000629","descriptor_name":"Aminopropionitrile","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000784","descriptor_name":"Aortic Dissection","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D000784","descriptor_name":"Aortic Dissection","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000784","descriptor_name":"Aortic Dissection","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000784","descriptor_name":"Aortic Dissection","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062793","descriptor_name":"Occludin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D062793","descriptor_name":"Occludin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbadis.2026.168417","doi":"https://doi.org/10.1016/j.bbadis.2026.168417","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbadis.2026.168417","pdf_url":null,"source":{"id":"https://openalex.org/S4210173099","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","issn_l":"0925-4439","issn":["0925-4439","1879-260X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","raw_type":"journal-article"},{"id":"pmid:42600953","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42600953","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta. Molecular basis of disease","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8360846638679504,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1705787095","display_name":null,"funder_award_id":"3332024026","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G228419045","display_name":null,"funder_award_id":"3332024035","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G7847569969","display_name":null,"funder_award_id":"82400565","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8275222745","display_name":null,"funder_award_id":"3332025129","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W2018778283","https://openalex.org/W2059369568","https://openalex.org/W2066660579","https://openalex.org/W2068793465","https://openalex.org/W2126378968","https://openalex.org/W2167857017","https://openalex.org/W2169186082","https://openalex.org/W2173261479","https://openalex.org/W2554066586","https://openalex.org/W2785455409","https://openalex.org/W2967076383","https://openalex.org/W2982830994","https://openalex.org/W3036762817","https://openalex.org/W3127987724","https://openalex.org/W4223910793","https://openalex.org/W4290770789","https://openalex.org/W4294127807","https://openalex.org/W4315977638","https://openalex.org/W4317107758","https://openalex.org/W4360600738","https://openalex.org/W4381187103","https://openalex.org/W4388900694","https://openalex.org/W4389565342","https://openalex.org/W4390955731","https://openalex.org/W4400595043","https://openalex.org/W4404412433","https://openalex.org/W4404929408","https://openalex.org/W4405830357","https://openalex.org/W4407924754","https://openalex.org/W4410374493"],"related_works":["https://openalex.org/W4415792571","https://openalex.org/W4304989710","https://openalex.org/W4200628498","https://openalex.org/W4315977638","https://openalex.org/W4389956836","https://openalex.org/W7165637159","https://openalex.org/W4407930735","https://openalex.org/W2028000765","https://openalex.org/W2177456672","https://openalex.org/W4242330551"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2026-08-15T00:00:00"}