{"id":"https://openalex.org/W7203488288","doi":"https://doi.org/10.1158/0008-5472.33253055","title":"Supplementary Figure S3 from Mitophagy-Competent Cancer-Associated Fibroblasts Fuel Chemoresistance by Rewiring Pyrimidine Metabolism in Pancreatic Cancer","display_name":"Supplementary Figure S3 from Mitophagy-Competent Cancer-Associated Fibroblasts Fuel Chemoresistance by Rewiring Pyrimidine Metabolism in Pancreatic Cancer","publication_year":2026,"publication_date":"2026-08-14","ids":{"openalex":"https://openalex.org/W7203488288","doi":"https://doi.org/10.1158/0008-5472.33253055"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.33253055","doi":"https://doi.org/10.1158/0008-5472.33253055","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.33253055","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.33253055","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013511830","display_name":"Shaobo Zhang","orcid":"https://orcid.org/0000-0001-5413-5064","observed_orcids":["https://orcid.org/0000-0001-5413-5064"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shaobo Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5413-5064","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108579714","display_name":"Hao Yuan","orcid":"https://orcid.org/0009-0007-4848-3354","observed_orcids":["https://orcid.org/0009-0007-4848-3354"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hao Yuan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-4848-3354","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147198608","display_name":"Muzi Guo","orcid":"https://orcid.org/0009-0007-3750-0817","observed_orcids":["https://orcid.org/0009-0007-3750-0817"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Muzi Guo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-3750-0817","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051324146","display_name":"Zhijun Zhou","orcid":"https://orcid.org/0000-0003-2226-2223","observed_orcids":["https://orcid.org/0000-0003-2226-2223"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhijun Zhou","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2226-2223","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137095546","display_name":"Yumeng Hu","orcid":"https://orcid.org/0009-0000-8078-6127","observed_orcids":["https://orcid.org/0009-0000-8078-6127"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yumeng Hu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-8078-6127","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062922599","display_name":"Gaoyuan Lv","orcid":"https://orcid.org/0000-0002-4264-4803","observed_orcids":["https://orcid.org/0000-0002-4264-4803"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gaoyuan Lv","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4264-4803","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147176267","display_name":"Haoran Qi","orcid":"https://orcid.org/0009-0003-3273-6012","observed_orcids":["https://orcid.org/0009-0003-3273-6012"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haoran Qi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-3273-6012","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036177450","display_name":"Yuanyuan Guo","orcid":"https://orcid.org/0000-0002-2944-9595","observed_orcids":["https://orcid.org/0000-0002-2944-9595"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuanyuan Guo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2944-9595","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101102252","display_name":"Jing Han","orcid":"https://orcid.org/0009-0004-5023-1912","observed_orcids":["https://orcid.org/0009-0004-5023-1912"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Han","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-5023-1912","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102884707","display_name":"Michael S. Bronze","orcid":"https://orcid.org/0000-0002-8770-0872","observed_orcids":["https://orcid.org/0000-0002-8770-0872"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael S. Bronze","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8770-0872","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064340210","display_name":"Courtney W. Houchen","orcid":"https://orcid.org/0000-0003-2487-5242","observed_orcids":["https://orcid.org/0000-0003-2487-5242"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Courtney W. Houchen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2487-5242","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100400736","display_name":"Min Li","orcid":"https://orcid.org/0000-0002-3971-9130","observed_orcids":["https://orcid.org/0000-0002-3971-9130"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Min Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3971-9130","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5147209985","display_name":"Mingyang Liu","orcid":"https://orcid.org/0009-0005-8763-5192","observed_orcids":["https://orcid.org/0009-0005-8763-5192"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mingyang Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-8763-5192","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.8461999893188477,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.8461999893188477,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.1046999990940094,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.8360000252723694},{"id":"https://openalex.org/keywords/cancer-associated-fibroblasts","display_name":"cancer-associated fibroblasts","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9390000104904175},{"id":"https://openalex.org/keywords/pyrimidine-metabolism","display_name":"pyrimidine metabolism","score":0.8299999833106995},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9649999737739563},{"id":"https://openalex.org/keywords/zeb1","display_name":"ZEB1","score":0.9580000042915344},{"id":"https://openalex.org/keywords/bnip3","display_name":"BNIP3","score":0.9940000176429749},{"id":"https://openalex.org/keywords/gemcitabine-resistance","display_name":"gemcitabine resistance","score":0.9700000286102295}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6632000207901001},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6348000168800354},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.6299999952316284},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6144000291824341},{"id":"https://openalex.org/C2779321679","wikidata":"https://www.wikidata.org/wiki/Q207722","display_name":"Pyrimidine","level":2,"score":0.48420000076293945},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4284999966621399},{"id":"https://openalex.org/C2994294914","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired resistance","level":3,"score":0.38580000400543213},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3343999981880188},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.32260000705718994},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32179999351501465},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3158000111579895},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.29269999265670776},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2879999876022339},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.28459998965263367},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2809999883174896},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.27619999647140503},{"id":"https://openalex.org/C200159599","wikidata":"https://www.wikidata.org/wiki/Q4893563","display_name":"Pyrimidine metabolism","level":4,"score":0.2667999863624573},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2531000077724457}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.33253055","doi":"https://doi.org/10.1158/0008-5472.33253055","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.33253055","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.33253055","doi":"https://doi.org/10.1158/0008-5472.33253055","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.33253055","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7203468846","https://openalex.org/W7162509126","https://openalex.org/W6958751105","https://openalex.org/W6976981305","https://openalex.org/W6902105775","https://openalex.org/W4206438897","https://openalex.org/W6939788643","https://openalex.org/W4414241584","https://openalex.org/W6958164584","https://openalex.org/W2966064164"],"abstract_inverted_index":{"ZEB1":[0],"enhances":[1],"CAF":[2],"mitophagy":[3],"via":[4],"BNIP3":[5],"which":[6],"leads":[7],"to":[8],"GEM":[9],"resistance":[10],"in":[11],"PC":[12]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-08-15T00:00:00"}
