{"id":"https://openalex.org/W7203484178","doi":"https://doi.org/10.3390/cancers18162633","title":"Pediatric B-Cell Acute Lymphoblastic Leukemia: Comprehensive Genomic Characterization Including SNP-Array and Analysis of Relapse Risk","display_name":"Pediatric B-Cell Acute Lymphoblastic Leukemia: Comprehensive Genomic Characterization Including SNP-Array and Analysis of Relapse Risk","publication_year":2026,"publication_date":"2026-08-14","ids":{"openalex":"https://openalex.org/W7203484178","doi":"https://doi.org/10.3390/cancers18162633","pmid":"https://pubmed.ncbi.nlm.nih.gov/42649943","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13511422"},"language":"en","primary_location":{"id":"doi:10.3390/cancers18162633","doi":"https://doi.org/10.3390/cancers18162633","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers18162633","pdf_url":null,"source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/cancers18162633","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011304567","display_name":"Concepci\u00f3n Prats\u2010Mart\u00edn","orcid":"https://orcid.org/0000-0003-3022-3427","observed_orcids":["https://orcid.org/0000-0003-3022-3427"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Concepci\u00f3n Prats-Mart\u00edn","raw_affiliation_strings":["Department of Hematology, Hospital Universitario Virgen del Roc\u00edo, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), Universidad de Sevilla, Avda. Manuel Siurot sn., CP 41013 Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hospital Universitario Virgen del Roc\u00edo, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), Universidad de Sevilla, Avda. Manuel Siurot sn., CP 41013 Sevilla, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I4210158561","https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015936856","display_name":"Laura P\u00e9rez-Ortega","orcid":"https://orcid.org/0000-0001-8049-1716","observed_orcids":["https://orcid.org/0000-0001-8049-1716"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Laura P\u00e9rez Ortega","raw_affiliation_strings":["Department of Hematology, Hospital Universitario Virgen del Roc\u00edo, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), Universidad de Sevilla, Avda. Manuel Siurot sn., CP 41013 Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hospital Universitario Virgen del Roc\u00edo, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), Universidad de Sevilla, Avda. Manuel Siurot sn., CP 41013 Sevilla, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I4210158561","https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069875702","display_name":"\u00c1gueda Molinos-Quintana","orcid":"https://orcid.org/0000-0003-4972-917X","observed_orcids":["https://orcid.org/0000-0003-4972-917X"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"\u00c1gueda Molinos Quintana","raw_affiliation_strings":["Department of Hematology, Hospital Universitario Virgen del Roc\u00edo, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), Universidad de Sevilla, Avda. Manuel Siurot sn., CP 41013 Sevilla, Spain"],"raw_orcid":"https://orcid.org/0000-0003-4972-917X","affiliations":[{"raw_affiliation_string":"Department of Hematology, Hospital Universitario Virgen del Roc\u00edo, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), Universidad de Sevilla, Avda. Manuel Siurot sn., CP 41013 Sevilla, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I4210158561","https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103119146","display_name":"Jordi Ribera","orcid":"https://orcid.org/0000-0003-4796-6470","observed_orcids":["https://orcid.org/0000-0003-4796-6470"]},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210089592","display_name":"Josep Carreras Leukaemia Research Institute","ror":"https://ror.org/00btzwk36","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089592","https://openalex.org/I4210144824","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jordi Ribera","raw_affiliation_strings":["Josep Carreras Leukaemia Research Institute (IJC), ICO-Hospital Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona, 08916 Badalona, Spain"],"raw_orcid":"https://orcid.org/0000-0003-4796-6470","affiliations":[{"raw_affiliation_string":"Josep Carreras Leukaemia Research Institute (IJC), ICO-Hospital Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona, 08916 Badalona, Spain","institution_ids":["https://openalex.org/I123044942","https://openalex.org/I4210089592"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112405472","display_name":"B Mora Rodr\u00edguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Beatriz Chiclana Rodr\u00edguez","raw_affiliation_strings":["Department of Hematology, Hospital Universitario Virgen del Roc\u00edo, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), Universidad de Sevilla, Avda. Manuel Siurot sn., CP 41013 Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hospital Universitario Virgen del Roc\u00edo, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), Universidad de Sevilla, Avda. Manuel Siurot sn., CP 41013 Sevilla, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I4210158561","https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090939618","display_name":"Teresa Caballero\u2010Vel\u00e1zquez","orcid":"https://orcid.org/0000-0001-7487-3793","observed_orcids":["https://orcid.org/0000-0001-7487-3793"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Teresa Caballero-Vel\u00e1zquez","raw_affiliation_strings":["Department of Hematology, Hospital Universitario Virgen del Roc\u00edo, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), Universidad de Sevilla, Avda. Manuel Siurot sn., CP 41013 Sevilla, Spain"],"raw_orcid":"https://orcid.org/0000-0001-7487-3793","affiliations":[{"raw_affiliation_string":"Department of Hematology, Hospital Universitario Virgen del Roc\u00edo, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), Universidad de Sevilla, Avda. Manuel Siurot sn., CP 41013 Sevilla, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I4210158561","https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058652833","display_name":"Estrella Carrillo\u2010Cruz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Estrella Carrillo Cruz","raw_affiliation_strings":["Department of Hematology, Hospital Universitario Virgen del Roc\u00edo, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), Universidad de Sevilla, Avda. Manuel Siurot sn., CP 41013 Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hospital Universitario Virgen del Roc\u00edo, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), Universidad de Sevilla, Avda. Manuel Siurot sn., CP 41013 Sevilla, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I4210158561","https://openalex.org/I79238269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099382814","display_name":"Henry Antonio Andrade-Ruiz","orcid":"https://orcid.org/0009-0008-5079-3420","observed_orcids":["https://orcid.org/0009-0008-5079-3420"]},"institutions":[{"id":"https://openalex.org/I4210102137","display_name":"Fundaci\u00f3n P\u00fablica Andaluza para la Gesti\u00f3n de la Investigaci\u00f3n en Salud de Sevilla","ror":"https://ror.org/01bp61317","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210102137"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Henry Antonio Andrade-Ruiz","raw_affiliation_strings":["Methodological and Statistical Support Unit, Fundaci\u00f3n para la Gesti\u00f3n de la Investigaci\u00f3n en Salud de Sevilla (FISEVI), 41013 Sevilla, Spain"],"raw_orcid":"https://orcid.org/0009-0008-5079-3420","affiliations":[{"raw_affiliation_string":"Methodological and Statistical Support Unit, Fundaci\u00f3n para la Gesti\u00f3n de la Investigaci\u00f3n en Salud de Sevilla (FISEVI), 41013 Sevilla, Spain","institution_ids":["https://openalex.org/I4210102137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000788897","display_name":"Maria Paz Garrastazul S\u00e1nchez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144722","display_name":"Hospital Universitario Puerta del Mar","ror":"https://ror.org/040xzg562","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210144722"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Paz Garrastazul S\u00e1nchez","raw_affiliation_strings":["Department of Hematology, Hospital Universitario Puerta del Mar, 11009 C\u00e1diz, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hospital Universitario Puerta del Mar, 11009 C\u00e1diz, Spain","institution_ids":["https://openalex.org/I4210144722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113060165","display_name":"Mar\u00eda Dolores Madrigal Toscano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090436","display_name":"Hospital Universitario Virgen Macarena","ror":"https://ror.org/016p83279","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210090436"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Dolores Madrigal Toscano","raw_affiliation_strings":["Department of Hematology, Hospital Universitario Virgen Macarena, 41009 Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hospital Universitario Virgen Macarena, 41009 Sevilla, Spain","institution_ids":["https://openalex.org/I4210090436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090772586","display_name":"Mar\u00eda Sol\u00e9 Rodriguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129320","display_name":"Hospital Juan Ram\u00f3n Jim\u00e9nez","ror":"https://ror.org/03fpqn433","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210129320"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Sol\u00e9 Rodr\u00edguez","raw_affiliation_strings":["Department of Hematology, Hospital Universitario Juan Ram\u00f3n Jim\u00e9nez, 21005 Huelva, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hospital Universitario Juan Ram\u00f3n Jim\u00e9nez, 21005 Huelva, Spain","institution_ids":["https://openalex.org/I4210129320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102586355","display_name":"Marina Gomez Rosa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148397","display_name":"Hospital Universitario de Valme","ror":"https://ror.org/04cxs7048","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210148397"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marina G\u00f3mez Rosa","raw_affiliation_strings":["UGC Hematolog\u00eda y Hemoterapia, Hospital Universitario Virgen de Valme, 41014 Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UGC Hematolog\u00eda y Hemoterapia, Hospital Universitario Virgen de Valme, 41014 Sevilla, Spain","institution_ids":["https://openalex.org/I4210148397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089418637","display_name":"Jos\u00e9 Antonio P\u00e9rez\u2010Sim\u00f3n","orcid":"https://orcid.org/0000-0003-3616-6101","observed_orcids":["https://orcid.org/0000-0003-3616-6101"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Antonio P\u00e9rez-Sim\u00f3n","raw_affiliation_strings":["Department of Hematology, Hospital Universitario Virgen del Roc\u00edo, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), Universidad de Sevilla, Avda. Manuel Siurot sn., CP 41013 Sevilla, Spain"],"raw_orcid":"https://orcid.org/0000-0003-3616-6101","affiliations":[{"raw_affiliation_string":"Department of Hematology, Hospital Universitario Virgen del Roc\u00edo, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), Universidad de Sevilla, Avda. Manuel Siurot sn., CP 41013 Sevilla, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I4210158561","https://openalex.org/I79238269"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066370151","display_name":"Rosario M. Morales\u2010Camacho","orcid":"https://orcid.org/0000-0001-7179-0693","observed_orcids":["https://orcid.org/0000-0001-7179-0693"]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]},{"id":"https://openalex.org/I79238269","display_name":"Universidad de Sevilla","ror":"https://ror.org/03yxnpp24","country_code":"ES","type":"education","lineage":["https://openalex.org/I79238269"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rosario M. Morales-Camacho","raw_affiliation_strings":["Department of Hematology, Hospital Universitario Virgen del Roc\u00edo, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), Universidad de Sevilla, Avda. Manuel Siurot sn., CP 41013 Sevilla, Spain"],"raw_orcid":"https://orcid.org/0000-0001-7179-0693","affiliations":[{"raw_affiliation_string":"Department of Hematology, Hospital Universitario Virgen del Roc\u00edo, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), Universidad de Sevilla, Avda. Manuel Siurot sn., CP 41013 Sevilla, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I4210158561","https://openalex.org/I79238269"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5011304567"],"corresponding_institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139","https://openalex.org/I4210158561","https://openalex.org/I79238269"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"16","first_page":"2633","last_page":"2633"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-b-cell-acute-lymphoblastic-leukemia","display_name":"pediatric B-cell acute lymphoblastic leukemia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/risk-of-relapse","display_name":"relapse risk","score":0.8429999947547913},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.8299999833106995},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.781000018119812},{"id":"https://openalex.org/keywords/ikzf1","display_name":"IKZF1","score":0.7300000190734863},{"id":"https://openalex.org/keywords/hyperdiploidy","display_name":"hyperdiploidy","score":0.7829999923706055},{"id":"https://openalex.org/keywords/cytogenetic-risk","display_name":"cytogenetic risk","score":0.921999990940094},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.5860000252723694},{"id":"https://openalex.org/keywords/snp-array","display_name":"SNP array","score":0.4180000126361847},{"id":"https://openalex.org/keywords/etv6","display_name":"ETV6","score":0.5130000114440918},{"id":"https://openalex.org/keywords/pax5","display_name":"PAX5","score":0.6679999828338623},{"id":"https://openalex.org/keywords/ebf1","display_name":"EBF1","score":0.6710000038146973},{"id":"https://openalex.org/keywords/rb1","display_name":"RB1","score":0.5429999828338623},{"id":"https://openalex.org/keywords/eto1","display_name":"ETO1","score":0.3569999933242798}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8657000064849854},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6972000002861023},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6410999894142151},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.559499979019165},{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.5148000121116638},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4779999852180481},{"id":"https://openalex.org/C2778488018","wikidata":"https://www.wikidata.org/wiki/Q42395","display_name":"White blood cell","level":2,"score":0.42820000648498535},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4278999865055084},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3206000030040741},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.3172000050544739},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.3041999936103821},{"id":"https://openalex.org/C2779668873","wikidata":"https://www.wikidata.org/wiki/Q6693756","display_name":"Lower risk","level":3,"score":0.2919999957084656},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2847000062465668},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.2818000018596649},{"id":"https://openalex.org/C2781107101","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Acute lymphocytic leukemia","level":4,"score":0.2743000090122223},{"id":"https://openalex.org/C196166836","wikidata":"https://www.wikidata.org/wiki/Q902926","display_name":"Immunophenotyping","level":3,"score":0.2721000015735626},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2632000148296356},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.2533999979496002},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.2531000077724457},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.2502000033855438},{"id":"https://openalex.org/C174475383","wikidata":"https://www.wikidata.org/wiki/Q246128","display_name":"Cytogenetics","level":4,"score":0.25}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/cancers18162633","doi":"https://doi.org/10.3390/cancers18162633","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers18162633","pdf_url":null,"source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13511422","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13511422/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13511422/pdf/cancers-18-02633.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmid:42649943","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42649943","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:digital.csic.es:10261/444353","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/444353","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/cancers18162633","doi":"https://doi.org/10.3390/cancers18162633","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers18162633","pdf_url":null,"source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203484178.pdf","grobid_xml":"https://content.openalex.org/works/W7203484178.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1770669347","https://openalex.org/W1919084303","https://openalex.org/W1964025558","https://openalex.org/W1984684983","https://openalex.org/W2022941976","https://openalex.org/W2033383345","https://openalex.org/W2048654561","https://openalex.org/W2080611686","https://openalex.org/W2113594413","https://openalex.org/W2118890264","https://openalex.org/W2294256298","https://openalex.org/W2339658711","https://openalex.org/W2405220018","https://openalex.org/W2557296082","https://openalex.org/W2558502346","https://openalex.org/W2566723262","https://openalex.org/W2596667846","https://openalex.org/W2605654758","https://openalex.org/W2794056739","https://openalex.org/W2808297040","https://openalex.org/W2909111441","https://openalex.org/W2909547032","https://openalex.org/W2910434299","https://openalex.org/W2918708984","https://openalex.org/W2947314900","https://openalex.org/W2957551926","https://openalex.org/W3004666691","https://openalex.org/W3012175741","https://openalex.org/W3040163109","https://openalex.org/W3095392273","https://openalex.org/W3201388387","https://openalex.org/W3210124852","https://openalex.org/W4200436225","https://openalex.org/W4200490862","https://openalex.org/W4214925550","https://openalex.org/W4220861148","https://openalex.org/W4221080345","https://openalex.org/W4283381496","https://openalex.org/W4291396348","https://openalex.org/W4298111089","https://openalex.org/W4309924734","https://openalex.org/W4322489444","https://openalex.org/W4385258738","https://openalex.org/W4396556457","https://openalex.org/W4401759222","https://openalex.org/W4405471749","https://openalex.org/W4406199857","https://openalex.org/W4406714046","https://openalex.org/W4410267890","https://openalex.org/W4411825185","https://openalex.org/W4414162495","https://openalex.org/W4415257712"],"related_works":["https://openalex.org/W3040163109","https://openalex.org/W7213580351","https://openalex.org/W4401450637","https://openalex.org/W2809598427","https://openalex.org/W7220370678","https://openalex.org/W2405220018","https://openalex.org/W2517605669","https://openalex.org/W2994186634","https://openalex.org/W2994272035","https://openalex.org/W4386021508"],"abstract_inverted_index":{"Background:":[0],"Accurate":[1],"identification":[2],"of":[3,14,26,50,68,148,164,168,236,246,261,267,306],"pediatric":[4,53,57,309],"B-cell":[5],"acute":[6],"lymphoblastic":[7],"leukemia":[8],"(B-ALL)":[9],"patients":[10,29,58,169,189],"at":[11,139,145,222,233,314],"increased":[12],"risk":[13,198,245,253,321],"relapse":[15,22,51,78,307],"remains":[16],"a":[17,66,204,242,292],"major":[18],"clinical":[19],"challenge,":[20],"as":[21,32],"occurs":[23],"in":[24,52,308],"10\u201320%":[25],"cases,":[27],"including":[28,96,126,289],"initially":[30],"classified":[31,171],"low-":[33],"or":[34],"intermediate-risk.":[35],"This":[36],"study":[37],"aimed":[38],"to":[39,77,99,120,160,173],"identify":[40,100,161],"clinical,":[41],"genomic,":[42],"and":[43,63,93,117,119,133,144,153,202,228,254,275,299,316,323],"measurable":[44],"residual":[45],"disease":[46],"(MRD)":[47],"related":[48],"predictors":[49,163,260,305],"B-ALL.":[54,310],"Methods:":[55],"51":[56],"with":[59,178,195,208,217,230,263],"B-ALL":[60,107],"were":[61,74,150,158,170],"included":[62],"followed":[64],"for":[65],"median":[67],"30.5":[69],"months":[70],"(IQR,":[71],"16\u201345.5).":[72],"Patients":[73,216],"stratified":[75],"according":[76,172],"status.":[79,123],"At":[80],"diagnosis,":[81],"all":[82],"cases":[83],"underwent":[84],"comprehensive":[85],"genomic":[86],"characterization":[87],"based":[88],"on":[89],"the":[90,146,174,182,234],"2022":[91,175],"WHO":[92],"ICC":[94],"classifications,":[95,177],"SNP-array":[97,290],"analysis":[98],"copy":[101],"number":[102],"alterations":[103],"(CNA)":[104],"involving":[105],"recurrent":[106],"genes":[108],"(IKZF1,":[109],"CDKN2A/B,":[110],"PAX5,":[111],"ETV6,":[112],"BTG1,":[113],"EBF1,":[114],"ERG,":[115],"RB1,":[116],"PAR1)":[118],"determine":[121],"IKZF1plus":[122],"Clinical":[124],"variables,":[125],"white":[127],"blood":[128],"cell":[129],"count,":[130],"cytogenetic":[131,197,297],"risk,":[132],"MRD":[134,232,257,302],"assessed":[135],"by":[136],"flow":[137],"cytometry":[138],"day":[140,142,223],"15,":[141],"33,":[143],"end":[147,235],"induction,":[149],"analyzed.":[151],"Kaplan\u2013Meier":[152],"Firth-penalized":[154],"Cox":[155],"regression":[156],"analyses":[157],"performed":[159],"independent":[162,259,304],"relapse.":[165,247],"Results:":[166],"86.3%":[167],"WHO/ICC":[176],"high":[179,196,251,293],"hyperdiploidy":[180],"being":[181],"most":[183],"frequent":[184],"subtype.":[185],"During":[186],"follow-up,":[187],"11":[188],"relapsed.":[190],"Relapse":[191],"was":[192],"significantly":[193,243],"associated":[194],"(p":[199,213,225,238],"=":[200,214,239,273,281],"0.007)":[201],"showed":[203],"trend":[205],"toward":[206],"association":[207],"an":[209],"adverse":[210],"CNA":[211],"profile":[212],"0.075).":[215],">25%":[218],"bone":[219],"marrow":[220],"blasts":[221],"15":[224],"<":[226],"0.001)":[227],"those":[229],"positive":[231,255,300],"induction":[237],"0.017)":[240],"had":[241],"higher":[244],"In":[248],"multivariable":[249],"analysis,":[250],"genetic":[252],"end-of-induction":[256,301],"remained":[258],"relapse,":[262],"hazard":[264],"ratios":[265],"(HRs)":[266],"9.31":[268],"(95%":[269,277],"CI,":[270,278],"1.55\u201356.1),":[271],"p":[272,280],"0.010,":[274],"10.9":[276],"2.39\u201349.9),":[279],"0.002,":[282],"respectively.":[283],"Conclusions:":[284],"An":[285],"integrated":[286],"diagnostic":[287,294],"strategy":[288],"provides":[291],"yield.":[295],"High-risk":[296],"abnormalities":[298],"are":[303],"Their":[311],"combined":[312],"assessment":[313],"diagnosis":[315],"early":[317],"treatment":[318],"may":[319,324],"improve":[320],"stratification":[322],"support":[325],"personalized":[326],"therapeutic":[327],"approaches.":[328]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-08-15T00:00:00"}
