{"id":"https://openalex.org/W7203474520","doi":"https://doi.org/10.1016/j.virol.2026.111051","title":"Fluid shear stress delays viral gene expression in a human vascular model","display_name":"Fluid shear stress delays viral gene expression in a human vascular model","publication_year":2026,"publication_date":"2026-08-14","ids":{"openalex":"https://openalex.org/W7203474520","doi":"https://doi.org/10.1016/j.virol.2026.111051","pmid":"https://pubmed.ncbi.nlm.nih.gov/42628198"},"language":"en","primary_location":{"id":"doi:10.1016/j.virol.2026.111051","doi":"https://doi.org/10.1016/j.virol.2026.111051","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.virol.2026.111051","pdf_url":null,"source":{"id":"https://openalex.org/S6147291","display_name":"Virology","issn_l":"0042-6822","issn":["0042-6822","1089-862X","1096-0341"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047823360","display_name":"Michelle A. Nguyen","orcid":"https://orcid.org/0000-0001-8305-5303","observed_orcids":["https://orcid.org/0000-0001-8305-5303"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1343143571","display_name":"Draper Laboratory","ror":"https://ror.org/04378d909","country_code":"US","type":"funder","lineage":["https://openalex.org/I1343143571"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle A. Nguyen","raw_affiliation_strings":["Department of Pharmacology, Physiology, and Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA; Draper Scholar, The Charles Stark Draper Laboratory Inc., Cambridge, MA, USA; Bioengineering Division, The Charles Stark Draper Laboratory Inc., Cambridge, MA, USA; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA; Department of Virology, Immunology, & Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Physiology, and Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA; Draper Scholar, The Charles Stark Draper Laboratory Inc., Cambridge, MA, USA; Bioengineering Division, The Charles Stark Draper Laboratory Inc., Cambridge, MA, USA; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA; Department of Virology, Immunology, & Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1343143571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041114086","display_name":"Corin Williams","orcid":"https://orcid.org/0000-0002-5834-1727","observed_orcids":["https://orcid.org/0000-0002-5834-1727"]},"institutions":[{"id":"https://openalex.org/I1343143571","display_name":"Draper Laboratory","ror":"https://ror.org/04378d909","country_code":"US","type":"funder","lineage":["https://openalex.org/I1343143571"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corin Williams","raw_affiliation_strings":["Bioengineering Division, The Charles Stark Draper Laboratory Inc., Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioengineering Division, The Charles Stark Draper Laboratory Inc., Cambridge, MA, USA","institution_ids":["https://openalex.org/I1343143571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069200622","display_name":"Ashley L. Gard","orcid":"https://orcid.org/0000-0001-7436-469X","observed_orcids":["https://orcid.org/0000-0001-7436-469X"]},"institutions":[{"id":"https://openalex.org/I1343143571","display_name":"Draper Laboratory","ror":"https://ror.org/04378d909","country_code":"US","type":"funder","lineage":["https://openalex.org/I1343143571"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley L. Gard","raw_affiliation_strings":["Bioengineering Division, The Charles Stark Draper Laboratory Inc., Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioengineering Division, The Charles Stark Draper Laboratory Inc., Cambridge, MA, USA","institution_ids":["https://openalex.org/I1343143571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013526416","display_name":"John H. Connor","orcid":"https://orcid.org/0000-0002-8867-7256","observed_orcids":["https://orcid.org/0000-0002-8867-7256"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John H. Connor","raw_affiliation_strings":["Department of Pharmacology, Physiology, and Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA; Department of Virology, Immunology, & Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA. Electronic address: jhconnor@bu.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Physiology, and Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA, USA; Department of Virology, Immunology, & Microbiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA. Electronic address: jhconnor@bu.edu","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013526416"],"corresponding_institution_ids":["https://openalex.org/I111088046"],"apc_list":{"value":3160,"currency":"USD","value_usd":3160},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.58133253,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"624","issue":null,"first_page":"111051","last_page":"111051"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.28519999980926514,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.28519999980926514,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.14579999446868896,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.14249999821186066,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluid-shear-stress","display_name":"fluid shear stress","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vesicular-stomatitis-virus","display_name":"vesicular stomatitis virus","score":0.8899999856948853},{"id":"https://openalex.org/keywords/viral-gene-expression","display_name":"viral gene expression","score":0.8080000281333923},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8130000233650208},{"id":"https://openalex.org/keywords/microphysiological-systems","display_name":"microphysiological systems","score":0.7519999742507935},{"id":"https://openalex.org/keywords/virus-attenuation","display_name":"viral attenuation","score":0.6489999890327454},{"id":"https://openalex.org/keywords/viral-dissemination","display_name":"viral dissemination","score":0.5260000228881836},{"id":"https://openalex.org/keywords/hemodynamics","display_name":"hemodynamics","score":0.7419999837875366},{"id":"https://openalex.org/keywords/vero-e6-cells","display_name":"Vero E6 cells","score":0.7160000205039978},{"id":"https://openalex.org/keywords/primary-endothelial-cells","display_name":"primary endothelial cells","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7527999877929688},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6262999773025513},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6256999969482422},{"id":"https://openalex.org/C21141959","wikidata":"https://www.wikidata.org/wiki/Q657936","display_name":"Shear stress","level":2,"score":0.5756000280380249},{"id":"https://openalex.org/C96035792","wikidata":"https://www.wikidata.org/wiki/Q43606218","display_name":"Shear (geology)","level":2,"score":0.4982999861240387},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.3874000012874603},{"id":"https://openalex.org/C21036866","wikidata":"https://www.wikidata.org/wiki/Q181767","display_name":"Stress (linguistics)","level":2,"score":0.38260000944137573},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3517000079154968},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3465999960899353},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3059999942779541},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2930000126361847},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.2924000024795532},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.28299999237060547},{"id":"https://openalex.org/C166397571","wikidata":"https://www.wikidata.org/wiki/Q968604","display_name":"Vascular tissue","level":2,"score":0.26409998536109924}],"mesh":[{"descriptor_ui":"D000094182","descriptor_name":"Microphysiological Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014709","descriptor_name":"Vero Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014721","descriptor_name":"Vesicular stomatitis Indiana virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014721","descriptor_name":"Vesicular stomatitis Indiana virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018116","descriptor_name":"Vesiculovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018116","descriptor_name":"Vesiculovirus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.virol.2026.111051","doi":"https://doi.org/10.1016/j.virol.2026.111051","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.virol.2026.111051","pdf_url":null,"source":{"id":"https://openalex.org/S6147291","display_name":"Virology","issn_l":"0042-6822","issn":["0042-6822","1089-862X","1096-0341"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology","raw_type":"journal-article"},{"id":"pmid:42628198","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42628198","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Virology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9074000120162964}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309015","display_name":"Charles Stark Draper Laboratory","ror":"https://ror.org/04378d909"},{"id":"https://openalex.org/F4320337504","display_name":"Research and Development","ror":"https://ror.org/027s68j25"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1965094062","https://openalex.org/W2023755326","https://openalex.org/W2035774172","https://openalex.org/W2059658426","https://openalex.org/W2062891727","https://openalex.org/W2073246940","https://openalex.org/W2075748936","https://openalex.org/W2080798849","https://openalex.org/W2081610560","https://openalex.org/W2083214415","https://openalex.org/W2083682299","https://openalex.org/W2119680107","https://openalex.org/W2130901375","https://openalex.org/W2146986766","https://openalex.org/W2945832107","https://openalex.org/W3039409489","https://openalex.org/W3044388005","https://openalex.org/W3110272192","https://openalex.org/W3140499432","https://openalex.org/W3167823751"],"related_works":["https://openalex.org/W2026239217","https://openalex.org/W4396915369","https://openalex.org/W2154557661","https://openalex.org/W2896329096","https://openalex.org/W4406456631","https://openalex.org/W4281630004","https://openalex.org/W4300689615","https://openalex.org/W2113539618","https://openalex.org/W18020296","https://openalex.org/W7165742646"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-08-15T00:00:00"}
