{"id":"https://openalex.org/W7203473561","doi":"https://doi.org/10.1016/j.jagp.2026.03.179","title":"S11. THE SENESCENCE ASSOCIATED SECRETORY PHENOTYPE, A KEY MARKER OF CELLULAR SENESCENCE, IS ELEVATED IN DEPRESSION AND MODERATED BY SEX","display_name":"S11. THE SENESCENCE ASSOCIATED SECRETORY PHENOTYPE, A KEY MARKER OF CELLULAR SENESCENCE, IS ELEVATED IN DEPRESSION AND MODERATED BY SEX","publication_year":2026,"publication_date":"2026-08-14","ids":{"openalex":"https://openalex.org/W7203473561","doi":"https://doi.org/10.1016/j.jagp.2026.03.179"},"language":"en","primary_location":{"id":"doi:10.1016/j.jagp.2026.03.179","doi":"https://doi.org/10.1016/j.jagp.2026.03.179","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jagp.2026.03.179","pdf_url":null,"source":{"id":"https://openalex.org/S182891740","display_name":"American Journal of Geriatric Psychiatry","issn_l":"1064-7481","issn":["1064-7481","1545-7214"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Geriatric Psychiatry","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081603804","display_name":"Nishika Navrange","orcid":"https://orcid.org/0009-0002-9634-7422","observed_orcids":["https://orcid.org/0009-0002-9634-7422"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nishika Navrange","raw_affiliation_strings":["University of Connecticut, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Connecticut, School of Medicine","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037779014","display_name":"Breno Satler Diniz","orcid":"https://orcid.org/0000-0003-0653-1905","observed_orcids":["https://orcid.org/0000-0003-0653-1905"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Breno Satler Diniz","raw_affiliation_strings":["University of Connecticut, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Connecticut, School of Medicine","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059993280","display_name":"Ana Paula Mendes\u2010Silva","orcid":"https://orcid.org/0000-0002-0636-7239","observed_orcids":["https://orcid.org/0000-0002-0636-7239"]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ana Paula Mendes-Silva","raw_affiliation_strings":["University of Saskatchewan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Saskatchewan","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064264687","display_name":"Charles F. Reynolds","orcid":"https://orcid.org/0000-0002-2605-7887","observed_orcids":["https://orcid.org/0000-0002-2605-7887"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles F. Reynolds","raw_affiliation_strings":["University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003936892","display_name":"Julie Loebach Wetherell","orcid":"https://orcid.org/0000-0002-7402-3331","observed_orcids":["https://orcid.org/0000-0002-7402-3331"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie Wetherell","raw_affiliation_strings":["University of California San Diego"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Diego","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019562259","display_name":"Benoit H. Mulsant","orcid":"https://orcid.org/0000-0002-0303-6450","observed_orcids":["https://orcid.org/0000-0002-0303-6450"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Benoit Mulsant","raw_affiliation_strings":["University of Toronto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Toronto","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002977377","display_name":"Mary Kimmel","orcid":"https://orcid.org/0000-0002-6270-5394","observed_orcids":["https://orcid.org/0000-0002-6270-5394"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary C. Kimmel","raw_affiliation_strings":["Washington University in St. Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in St. Louis","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053095971","display_name":"Eric J. Lenze","orcid":"https://orcid.org/0000-0002-0471-9368","observed_orcids":["https://orcid.org/0000-0002-0471-9368"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric J. Lenze","raw_affiliation_strings":["Washington University in St. Louis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University in St. Louis","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"10","first_page":"S104","last_page":"S104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.7494999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.7494999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.07339999824762344,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.040300000458955765,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/senescence-associated-secretory-phenotype","display_name":"senescence-associated secretory phenotype","score":0.9319999814033508},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9980000257492065},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9850000143051147},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9810000061988831},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.767799973487854},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.6992999911308289},{"id":"https://openalex.org/C2779523775","wikidata":"https://www.wikidata.org/wiki/Q9075999","display_name":"Cellular senescence","level":4,"score":0.5608999729156494},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5564000010490417},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5235999822616577},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47269999980926514},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.44040000438690186},{"id":"https://openalex.org/C3017819807","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Healthy aging","level":2,"score":0.37700000405311584},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3199999928474426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3077000081539154},{"id":"https://openalex.org/C3019858935","wikidata":"https://www.wikidata.org/wiki/Q4340209","display_name":"Depressive symptoms","level":3,"score":0.29350000619888306}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jagp.2026.03.179","doi":"https://doi.org/10.1016/j.jagp.2026.03.179","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jagp.2026.03.179","pdf_url":null,"source":{"id":"https://openalex.org/S182891740","display_name":"American Journal of Geriatric Psychiatry","issn_l":"1064-7481","issn":["1064-7481","1545-7214"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Geriatric Psychiatry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4412424527","https://openalex.org/W4363678975","https://openalex.org/W2434328084","https://openalex.org/W2964960130","https://openalex.org/W4353055427","https://openalex.org/W2411714397","https://openalex.org/W7203493308","https://openalex.org/W4231036552","https://openalex.org/W2420479461","https://openalex.org/W4283714155"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-08-15T00:00:00"}