{"id":"https://openalex.org/W7203471680","doi":"https://doi.org/10.1016/j.ejphar.2026.179255","title":"Astragalus polysaccharide relieves chronic intermittent hypoxia-induced vascular endothelial dysfunction by inhibiting ferroptosis through activation of the Nrf2/SLC7A11/GPX4 axis","display_name":"Astragalus polysaccharide relieves chronic intermittent hypoxia-induced vascular endothelial dysfunction by inhibiting ferroptosis through activation of the Nrf2/SLC7A11/GPX4 axis","publication_year":2026,"publication_date":"2026-08-14","ids":{"openalex":"https://openalex.org/W7203471680","doi":"https://doi.org/10.1016/j.ejphar.2026.179255","pmid":"https://pubmed.ncbi.nlm.nih.gov/42601008"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejphar.2026.179255","doi":"https://doi.org/10.1016/j.ejphar.2026.179255","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejphar.2026.179255","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5147227081","display_name":"Susu Wu","orcid":"https://orcid.org/0009-0008-5805-5959","observed_orcids":["https://orcid.org/0009-0008-5805-5959"]},"institutions":[{"id":"https://openalex.org/I85430964","display_name":"Jinzhou Medical University","ror":"https://ror.org/02yd1yr68","country_code":"CN","type":"education","lineage":["https://openalex.org/I85430964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Susu Wu","raw_affiliation_strings":["Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Jinzhou Medical University, Jinzhou, 121000, China"],"raw_orcid":"https://orcid.org/0009-0008-5805-5959","affiliations":[{"raw_affiliation_string":"Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Jinzhou Medical University, Jinzhou, 121000, China","institution_ids":["https://openalex.org/I85430964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134946703","display_name":"Xiangfeng Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I85430964","display_name":"Jinzhou Medical University","ror":"https://ror.org/02yd1yr68","country_code":"CN","type":"education","lineage":["https://openalex.org/I85430964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangfeng Zhang","raw_affiliation_strings":["Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Jinzhou Medical University, Jinzhou, 121000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Jinzhou Medical University, Jinzhou, 121000, China","institution_ids":["https://openalex.org/I85430964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147168674","display_name":"Silin Wei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I85430964","display_name":"Jinzhou Medical University","ror":"https://ror.org/02yd1yr68","country_code":"CN","type":"education","lineage":["https://openalex.org/I85430964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Silin Wei","raw_affiliation_strings":["Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Jinzhou Medical University, Jinzhou, 121000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Jinzhou Medical University, Jinzhou, 121000, China","institution_ids":["https://openalex.org/I85430964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033499895","display_name":"Meili Lu","orcid":"https://orcid.org/0000-0002-1646-6839","observed_orcids":["https://orcid.org/0000-0002-1646-6839"]},"institutions":[{"id":"https://openalex.org/I85430964","display_name":"Jinzhou Medical University","ror":"https://ror.org/02yd1yr68","country_code":"CN","type":"education","lineage":["https://openalex.org/I85430964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meili Lu","raw_affiliation_strings":["Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Jinzhou Medical University, Jinzhou, 121000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Jinzhou Medical University, Jinzhou, 121000, China","institution_ids":["https://openalex.org/I85430964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147209423","display_name":"Lili Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I85430964","display_name":"Jinzhou Medical University","ror":"https://ror.org/02yd1yr68","country_code":"CN","type":"education","lineage":["https://openalex.org/I85430964"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lili Sun","raw_affiliation_strings":["The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121000, China. Electronic address: sunll@jzmu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121000, China. Electronic address: sunll@jzmu.edu.cn","institution_ids":["https://openalex.org/I85430964"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081449674","display_name":"Hongxin Wang","orcid":"https://orcid.org/0000-0002-3256-3137","observed_orcids":["https://orcid.org/0000-0002-3256-3137"]},"institutions":[{"id":"https://openalex.org/I85430964","display_name":"Jinzhou Medical University","ror":"https://ror.org/02yd1yr68","country_code":"CN","type":"education","lineage":["https://openalex.org/I85430964"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongxin Wang","raw_affiliation_strings":["Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Jinzhou Medical University, Jinzhou, 121000, China. Electronic address: hongxinwang@jzmu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0002-3256-3137","affiliations":[{"raw_affiliation_string":"Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Jinzhou Medical University, Jinzhou, 121000, China. Electronic address: hongxinwang@jzmu.edu.cn","institution_ids":["https://openalex.org/I85430964"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081449674","https://openalex.org/A5147209423"],"corresponding_institution_ids":["https://openalex.org/I85430964"],"apc_list":{"value":3230,"currency":"USD","value_usd":3230},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1032","issue":null,"first_page":"179255","last_page":"179255"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/astragalus-polysaccharide","display_name":"Astragalus polysaccharide","score":0.9169999957084656},{"id":"https://openalex.org/keywords/chronic-intermittent-hypoxia","display_name":"chronic intermittent hypoxia","score":0.8730000257492065},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9810000061988831},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":1.0},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8289999961853027},{"id":"https://openalex.org/keywords/antioxidant-capacity","display_name":"antioxidant capacity","score":0.7020000219345093},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.9150000214576721},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.7480000257492065},{"id":"https://openalex.org/keywords/ferrostatin-1","display_name":"ferrostatin-1","score":0.8700000047683716},{"id":"https://openalex.org/keywords/erastin","display_name":"erastin","score":0.7950000166893005},{"id":"https://openalex.org/keywords/ml385","display_name":"ML385","score":0.796999990940094},{"id":"https://openalex.org/keywords/pulmonary-artery-endothelial-cells","display_name":"pulmonary artery endothelial cells","score":0.8519999980926514},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.4259999990463257}],"concepts":[{"id":"https://openalex.org/C2780798337","wikidata":"https://www.wikidata.org/wiki/Q157184","display_name":"Astragalus","level":4,"score":0.669700026512146},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.6032999753952026},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5239999890327454},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.5113000273704529},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46459999680519104},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.43059998750686646},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4047999978065491},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35420000553131104},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3183000087738037},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.29249998927116394},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.2533999979496002}],"mesh":[{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000080662","descriptor_name":"Phospholipid Hydroperoxide Glutathione Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027883","descriptor_name":"Astragalus Plant","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ejphar.2026.179255","doi":"https://doi.org/10.1016/j.ejphar.2026.179255","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejphar.2026.179255","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:42601008","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42601008","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3058768285","display_name":null,"funder_award_id":"82474170","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7511041988","display_name":null,"funder_award_id":"2023-MSLH-049","funder_id":"https://openalex.org/F4320323086","funder_display_name":"Natural Science Foundation of Liaoning Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323086","display_name":"Natural Science Foundation of Liaoning Province","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1420152522","https://openalex.org/W1911261086","https://openalex.org/W1997023449","https://openalex.org/W1997183854","https://openalex.org/W2002005268","https://openalex.org/W2035898183","https://openalex.org/W2067501865","https://openalex.org/W2109115943","https://openalex.org/W2113934014","https://openalex.org/W2114138419","https://openalex.org/W2124149023","https://openalex.org/W2151514508","https://openalex.org/W2155162140","https://openalex.org/W2163294546","https://openalex.org/W2165753570","https://openalex.org/W2187950219","https://openalex.org/W2265062179","https://openalex.org/W2474199515","https://openalex.org/W2621371007","https://openalex.org/W2762087180","https://openalex.org/W2795028304","https://openalex.org/W2799290037","https://openalex.org/W2807334922","https://openalex.org/W2884428355","https://openalex.org/W2909817598","https://openalex.org/W2948576639","https://openalex.org/W2962098235","https://openalex.org/W3005253578","https://openalex.org/W3012264214","https://openalex.org/W3016878892","https://openalex.org/W3038361184","https://openalex.org/W3136661179","https://openalex.org/W3153822510","https://openalex.org/W3165793489","https://openalex.org/W3177042347","https://openalex.org/W4225874003","https://openalex.org/W4281263419","https://openalex.org/W4288926708","https://openalex.org/W4311145601","https://openalex.org/W4313250647","https://openalex.org/W4315607640","https://openalex.org/W4321768735","https://openalex.org/W4323925085","https://openalex.org/W4324010199","https://openalex.org/W4361291094","https://openalex.org/W4387359380","https://openalex.org/W4388766877","https://openalex.org/W4388979416","https://openalex.org/W4389766220","https://openalex.org/W4391888549","https://openalex.org/W4396978970","https://openalex.org/W4398184520","https://openalex.org/W4403728293","https://openalex.org/W4411768996"],"related_works":["https://openalex.org/W4395052037","https://openalex.org/W2609619443","https://openalex.org/W4319441968","https://openalex.org/W4289521305","https://openalex.org/W7202254796","https://openalex.org/W4292335444","https://openalex.org/W2474199515","https://openalex.org/W3202595754","https://openalex.org/W7204087445","https://openalex.org/W3047356675"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-08-15T00:00:00"}