{"id":"https://openalex.org/W7203471171","doi":"https://doi.org/10.1016/j.lungcan.2026.109582","title":"The impact of EGFR subtype combined with TP53 co-mutation status on survival outcomes with front-line osimertinib in non-small cell lung cancer (NSCLC)","display_name":"The impact of EGFR subtype combined with TP53 co-mutation status on survival outcomes with front-line osimertinib in non-small cell lung cancer (NSCLC)","publication_year":2026,"publication_date":"2026-08-14","ids":{"openalex":"https://openalex.org/W7203471171","doi":"https://doi.org/10.1016/j.lungcan.2026.109582","pmid":"https://pubmed.ncbi.nlm.nih.gov/42660014"},"language":"en","primary_location":{"id":"doi:10.1016/j.lungcan.2026.109582","doi":"https://doi.org/10.1016/j.lungcan.2026.109582","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.lungcan.2026.109582","pdf_url":null,"source":{"id":"https://openalex.org/S100767427","display_name":"Lung Cancer","issn_l":"0169-5002","issn":["0169-5002","1872-8332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022378324","display_name":"Hye Sung Kim","orcid":"https://orcid.org/0000-0002-7256-7597","observed_orcids":["https://orcid.org/0000-0002-7256-7597"]},"institutions":[{"id":"https://openalex.org/I4210117083","display_name":"Temple University Hospital","ror":"https://ror.org/028rvnd71","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117083","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hye Sung Kim","raw_affiliation_strings":["Department of Medicine, Temple University Hospital, United States"],"raw_orcid":"https://orcid.org/0000-0002-7256-7597","affiliations":[{"raw_affiliation_string":"Department of Medicine, Temple University Hospital, United States","institution_ids":["https://openalex.org/I4210117083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147223951","display_name":"Li Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Zhang","raw_affiliation_strings":["Biostatistics and Bioinformatics Facility, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics and Bioinformatics Facility, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030983210","display_name":"Joseph Nicholas Bodor","orcid":"https://orcid.org/0000-0001-5209-4502","observed_orcids":["https://orcid.org/0000-0001-5209-4502"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Nicholas Bodor","raw_affiliation_strings":["Department of Medical Oncology, United States"],"raw_orcid":"https://orcid.org/0000-0001-5209-4502","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022569332","display_name":"Margie L. Clapper","orcid":"https://orcid.org/0000-0001-7712-5109","observed_orcids":["https://orcid.org/0000-0001-7712-5109"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margie L. Clapper","raw_affiliation_strings":["Cancer Prevention and Control Program, Fox Chase Cancer Center, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Prevention and Control Program, Fox Chase Cancer Center, United States","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012061864","display_name":"Hossein Borghaei","orcid":"https://orcid.org/0000-0002-2577-4454","observed_orcids":["https://orcid.org/0000-0002-2577-4454"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hossein Borghaei","raw_affiliation_strings":["Department of Medical Oncology, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063441489","display_name":"Martin Joseph Edelman","orcid":"https://orcid.org/0000-0002-3752-0726","observed_orcids":["https://orcid.org/0000-0002-3752-0726"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin J. Edelman","raw_affiliation_strings":["Department of Medical Oncology, United States"],"raw_orcid":"https://orcid.org/0000-0002-3752-0726","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100620673","display_name":"Yunyun Zhou","orcid":"https://orcid.org/0000-0003-1689-8575","observed_orcids":["https://orcid.org/0000-0003-1689-8575"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yunyun Zhou","raw_affiliation_strings":["Biostatistics and Bioinformatics Facility, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics and Bioinformatics Facility, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075190711","display_name":"Mitchell Cheung","orcid":"https://orcid.org/0009-0005-3140-6032","observed_orcids":["https://orcid.org/0009-0005-3140-6032"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchell Cheung","raw_affiliation_strings":["Cancer Prevention and Control Program, Fox Chase Cancer Center, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Prevention and Control Program, Fox Chase Cancer Center, United States","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"last","author":{"id":null,"display_name":"Joseph Treat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Joseph Treat","raw_affiliation_strings":["Department of Medical Oncology, United States. Electronic address: Joseph.Treat2@fccc.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, United States. Electronic address: Joseph.Treat2@fccc.edu","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.60771349,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"220","issue":null,"first_page":"109582","last_page":"109582"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osimertinib","display_name":"osimertinib","score":0.9110000133514404},{"id":"https://openalex.org/keywords/egfr-mutant-non-small-cell-lung-cancer","display_name":"EGFR-mutant non-small cell lung cancer","score":0.9300000071525574},{"id":"https://openalex.org/keywords/egfr-l858r-mutation","display_name":"L858R mutation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/exon-19-deletion","display_name":"exon 19 deletion","score":0.8209999799728394},{"id":"https://openalex.org/keywords/tp53-co-mutation","display_name":"TP53 co-mutation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.6869999766349792},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":1.0},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7609999775886536},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.8489999771118164}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9556000232696533},{"id":"https://openalex.org/C2777626846","wikidata":"https://www.wikidata.org/wiki/Q21506464","display_name":"Osimertinib","level":5,"score":0.9248999953269958},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7484999895095825},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6636999845504761},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5996000170707703},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.31709998846054077},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3116999864578247},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.2574999928474426},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.2535000145435333},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.24879999458789825}],"mesh":[{"descriptor_ui":"D000178","descriptor_name":"Acrylamides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.lungcan.2026.109582","doi":"https://doi.org/10.1016/j.lungcan.2026.109582","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.lungcan.2026.109582","pdf_url":null,"source":{"id":"https://openalex.org/S100767427","display_name":"Lung Cancer","issn_l":"0169-5002","issn":["0169-5002","1872-8332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung Cancer","raw_type":"journal-article"},{"id":"pmid:42660014","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42660014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung cancer (Amsterdam, Netherlands)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G8669705299","display_name":null,"funder_award_id":"P30 CA006927","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G9000285491","display_name":"Comprehensive Cancer Center Program at Fox Chase","funder_award_id":"P30CA006927","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320319356","display_name":"Flatiron Health","ror":"https://ror.org/0508h6p74"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332523","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W2965486449","https://openalex.org/W2967365762","https://openalex.org/W2990041408","https://openalex.org/W3015975085","https://openalex.org/W4220879423","https://openalex.org/W4319967395","https://openalex.org/W4389780842","https://openalex.org/W4400029468"],"related_works":["https://openalex.org/W4411873504","https://openalex.org/W4399527119","https://openalex.org/W4207054516","https://openalex.org/W7162655456","https://openalex.org/W4414042429","https://openalex.org/W4409324332","https://openalex.org/W4388045429","https://openalex.org/W4410809197","https://openalex.org/W7212293498","https://openalex.org/W7117566518"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-08-15T00:00:00"}
