{"id":"https://openalex.org/W7203470608","doi":"https://doi.org/10.4103/jopp.jopp_14_26","title":"Exploring the Role of Bilastine Alone and in Combination with Montelukast in Pediatric Populations with Allergic Rhinitis","display_name":"Exploring the Role of Bilastine Alone and in Combination with Montelukast in Pediatric Populations with Allergic Rhinitis","publication_year":2026,"publication_date":"2026-05-01","ids":{"openalex":"https://openalex.org/W7203470608","doi":"https://doi.org/10.4103/jopp.jopp_14_26"},"language":"en","primary_location":{"id":"doi:10.4103/jopp.jopp_14_26","doi":"https://doi.org/10.4103/jopp.jopp_14_26","is_oa":true,"landing_page_url":"https://doi.org/10.4103/jopp.jopp_14_26","pdf_url":null,"source":{"id":"https://openalex.org/S4387283377","display_name":"Journal of Pediatric Pulmonology","issn_l":"2949-8074","issn":["2949-8074","2949-8082"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Pulmonology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.4103/jopp.jopp_14_26","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036322594","display_name":"Vijay Warad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vijay Warad","raw_affiliation_strings":["Sai Allergy Asthma Eye Children\u2019s Hospital, Pune, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sai Allergy Asthma Eye Children\u2019s Hospital, Pune, Maharashtra, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147158165","display_name":"Prasenjit Ghosh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I288496929","display_name":"Narayana Health","ror":"https://ror.org/05kx1ke03","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I288496929"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prasenjit Ghosh","raw_affiliation_strings":["Narayana Multispecialty Hospital, Howrah, West Bengal, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Narayana Multispecialty Hospital, Howrah, West Bengal, India","institution_ids":["https://openalex.org/I288496929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052720594","display_name":"Mohnish Grover","orcid":"https://orcid.org/0000-0002-8895-2254","observed_orcids":["https://orcid.org/0000-0002-8895-2254"]},"institutions":[{"id":"https://openalex.org/I164135366","display_name":"SMS Medical College","ror":"https://ror.org/02x3hmg72","country_code":"IN","type":"education","lineage":["https://openalex.org/I164135366"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mohnish Grover","raw_affiliation_strings":["Department of ENT, SMS Medical College, Jaipur, Rajasthan, India","Dr. Mohnish\u2019s Clinic, Jaipur, Rajasthan, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of ENT, SMS Medical College, Jaipur, Rajasthan, India","institution_ids":["https://openalex.org/I164135366"]},{"raw_affiliation_string":"Dr. Mohnish\u2019s Clinic, Jaipur, Rajasthan, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147226332","display_name":"Pawan K. Bhutani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pawan K. Bhutani","raw_affiliation_strings":["Madhukar Rainbow Children\u2019s Hospital, New Delhi, Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Madhukar Rainbow Children\u2019s Hospital, New Delhi, Delhi, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147172868","display_name":"Koolla Pavan Kumar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Koolla Pavan Kumar","raw_affiliation_strings":["Lotus Children Hospital, Hyderabad, Telangana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lotus Children Hospital, Hyderabad, Telangana, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034236689","display_name":"Vaishali Gupte","orcid":"https://orcid.org/0000-0003-4439-2416","observed_orcids":["https://orcid.org/0000-0003-4439-2416","https://orcid.org/0009-0008-3459-2629"]},"institutions":[{"id":"https://openalex.org/I4210133301","display_name":"Cipla (India)","ror":"https://ror.org/02w6dqa48","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210133301"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vaishali Gupte","raw_affiliation_strings":["Department of Medical Affairs, Cipla Ltd., Mumbai, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Affairs, Cipla Ltd., Mumbai, Maharashtra, India","institution_ids":["https://openalex.org/I4210133301"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114130638","display_name":"Gurmeet Kaur Thakur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133301","display_name":"Cipla (India)","ror":"https://ror.org/02w6dqa48","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210133301"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Gurmeet Kaur Thakur","raw_affiliation_strings":["Department of Medical Affairs, Cipla Ltd., Mumbai, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Affairs, Cipla Ltd., Mumbai, Maharashtra, India","institution_ids":["https://openalex.org/I4210133301"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5123716846","display_name":"Manjushree Naik Patil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133301","display_name":"Cipla (India)","ror":"https://ror.org/02w6dqa48","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210133301"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Manjushree Naik Patil","raw_affiliation_strings":["Department of Medical Affairs, Cipla Ltd., Mumbai, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Affairs, Cipla Ltd., Mumbai, Maharashtra, India","institution_ids":["https://openalex.org/I4210133301"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"2","first_page":"57","last_page":"66"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-allergic-rhinitis","display_name":"pediatric allergic rhinitis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/bilastine","display_name":"bilastine","score":1.0},{"id":"https://openalex.org/keywords/montelukast","display_name":"montelukast","score":1.0},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8240000009536743},{"id":"https://openalex.org/keywords/second-generation-antihistamines","display_name":"second-generation antihistamines","score":0.8650000095367432},{"id":"https://openalex.org/keywords/leukotriene-receptor-antagonists","display_name":"leukotriene receptor antagonists","score":0.9940000176429749},{"id":"https://openalex.org/keywords/rhinitis-management","display_name":"rhinitis management","score":0.5299999713897705},{"id":"https://openalex.org/keywords/pediatric-drug-safety","display_name":"drug safety in children","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C2776322731","wikidata":"https://www.wikidata.org/wiki/Q417767","display_name":"Montelukast","level":3,"score":0.9797999858856201},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8996000289916992},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.5368000268936157},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4553000032901764},{"id":"https://openalex.org/C2780212800","wikidata":"https://www.wikidata.org/wiki/Q20708039","display_name":"Leukotriene receptor","level":4,"score":0.4471000134944916},{"id":"https://openalex.org/C2776452501","wikidata":"https://www.wikidata.org/wiki/Q424190","display_name":"Leukotriene","level":3,"score":0.40230000019073486},{"id":"https://openalex.org/C2780842079","wikidata":"https://www.wikidata.org/wiki/Q1324592","display_name":"Laryngospasm","level":3,"score":0.3741999864578247},{"id":"https://openalex.org/C2992053201","wikidata":"https://www.wikidata.org/wiki/Q2585693","display_name":"Clinical efficacy","level":2,"score":0.36320000886917114},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.35580000281333923},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3490000069141388},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.33059999346733093},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.31540000438690186},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.2930000126361847},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.2754000127315521},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.2515000104904175}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4103/jopp.jopp_14_26","doi":"https://doi.org/10.4103/jopp.jopp_14_26","is_oa":true,"landing_page_url":"https://doi.org/10.4103/jopp.jopp_14_26","pdf_url":null,"source":{"id":"https://openalex.org/S4387283377","display_name":"Journal of Pediatric Pulmonology","issn_l":"2949-8074","issn":["2949-8074","2949-8082"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Pulmonology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4103/jopp.jopp_14_26","doi":"https://doi.org/10.4103/jopp.jopp_14_26","is_oa":true,"landing_page_url":"https://doi.org/10.4103/jopp.jopp_14_26","pdf_url":null,"source":{"id":"https://openalex.org/S4387283377","display_name":"Journal of Pediatric Pulmonology","issn_l":"2949-8074","issn":["2949-8074","2949-8082"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Pulmonology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W86738069","https://openalex.org/W1586538457","https://openalex.org/W1979643076","https://openalex.org/W1987575117","https://openalex.org/W1998724525","https://openalex.org/W2007422312","https://openalex.org/W2016186233","https://openalex.org/W2028161518","https://openalex.org/W2032148343","https://openalex.org/W2033918050","https://openalex.org/W2043013505","https://openalex.org/W2053282598","https://openalex.org/W2086757670","https://openalex.org/W2097152044","https://openalex.org/W2107915037","https://openalex.org/W2109951782","https://openalex.org/W2117675193","https://openalex.org/W2123622482","https://openalex.org/W2128180999","https://openalex.org/W2128942515","https://openalex.org/W2134261811","https://openalex.org/W2160918196","https://openalex.org/W2161225813","https://openalex.org/W2274239973","https://openalex.org/W2425134285","https://openalex.org/W2427587131","https://openalex.org/W2464096655","https://openalex.org/W2491524160","https://openalex.org/W2619239534","https://openalex.org/W2729931428","https://openalex.org/W2764189638","https://openalex.org/W2783906681","https://openalex.org/W2977161965","https://openalex.org/W2980595867","https://openalex.org/W2980927365","https://openalex.org/W2981319023","https://openalex.org/W2999263142","https://openalex.org/W3009962339","https://openalex.org/W3092042124","https://openalex.org/W3181598262","https://openalex.org/W3187160740","https://openalex.org/W3201976720","https://openalex.org/W4211003574","https://openalex.org/W4225607483","https://openalex.org/W4253311735","https://openalex.org/W4282922866","https://openalex.org/W4292589777","https://openalex.org/W4310295536","https://openalex.org/W4313590648","https://openalex.org/W4322719773","https://openalex.org/W4377990902","https://openalex.org/W4385336843","https://openalex.org/W4392201706","https://openalex.org/W4396221448","https://openalex.org/W4396772352","https://openalex.org/W4396779402","https://openalex.org/W4400620066","https://openalex.org/W4402404320","https://openalex.org/W4404865930"],"related_works":["https://openalex.org/W4367019545","https://openalex.org/W2051838400","https://openalex.org/W7171695892","https://openalex.org/W3216303800","https://openalex.org/W4368356302","https://openalex.org/W1982396715","https://openalex.org/W3208563416","https://openalex.org/W2385657121","https://openalex.org/W2142042925","https://openalex.org/W2374950471"],"abstract_inverted_index":{"Abstract":[0],"Pediatric":[1],"allergic":[2],"rhinitis":[3],"(AR),":[4],"characterized":[5],"by":[6,73,91],"inflammatory":[7],"responses,":[8],"poses":[9],"significant":[10],"challenges":[11],"in":[12,34,97,116,128,145,188,192],"management":[13,101,194],"due":[14],"to":[15],"its":[16],"impact":[17],"on":[18,137,156],"the":[19,46,74,92,100,122,173,182,193],"quality":[20],"of":[21,59,78,85,95,102,152,159,184,195],"life":[22],"and":[23,44,63,178,187],"potential":[24],"long-term":[25],"consequences.":[26],"Bilastine,":[27],"a":[28,52,106,150],"second-generation":[29],"H1-antihistamine,":[30],"has":[31,38,112,133],"shown":[32],"efficacy":[33],"alleviating":[35],"AR":[36,118,144,176],"symptoms,":[37],"high":[39],"specificity,":[40],"shows":[41],"rapid":[42],"action,":[43],"reduces":[45],"need":[47],"for":[48,80,99,126,143,163],"frequent":[49],"dosing":[50],"with":[51,67,190],"favorable":[53],"safety":[54],"profile.":[55],"The":[56],"pediatric":[57,157,175,196],"formulation":[58],"bilastine":[60,64,185],"10":[61,65],"mg":[62,66,70],"montelukast":[68,191],"4":[69],"is":[71,88,105,121],"approved":[72],"Drugs":[75],"Controller":[76],"General":[77],"India":[79],"children":[81,129],"above":[82],"6":[83],"years":[84],"age.":[86],"Bilastine":[87],"also":[89],"recommended":[90],"Indian":[93],"Academy":[94],"Pediatrics":[96],"2022":[98],"AR.":[103,197],"Montelukast":[104,120],"leukotriene":[107],"receptor":[108],"antagonist":[109],"(LTRA),":[110],"which":[111],"demonstrated":[113],"synergistic":[114],"effects":[115],"controlling":[117],"symptoms.":[119],"only":[123],"LTRA":[124],"licensed":[125],"administration":[127],"<12.":[130],"While":[131],"there":[132,147],"been":[134],"considerable":[135],"research":[136],"combination":[138,161,189],"therapy":[139,162],"(LTRA":[140],"+":[141],"antihistamines)":[142],"adults,":[146],"is,":[148],"indeed,":[149],"scarcity":[151],"clinical":[153,168,179],"trial":[154],"data":[155],"usage":[158],"this":[160],"AR,":[164],"thus":[165],"necessitating":[166],"more":[167],"trials.":[169],"This":[170],"review":[171],"summarizes":[172],"existing":[174],"diagnosis":[177],"evidence":[180],"supporting":[181],"use":[183],"alone":[186]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-15T00:00:00"}