{"id":"https://openalex.org/W7203470565","doi":"https://doi.org/10.3390/pharmaceutics18081008","title":"Bioequivalence, Food-Effect Assessment and Exploratory IVIVC of Two Extended-Release Tamsulosin 0.4 mg Formulations in Healthy Mexican Subjects","display_name":"Bioequivalence, Food-Effect Assessment and Exploratory IVIVC of Two Extended-Release Tamsulosin 0.4 mg Formulations in Healthy Mexican Subjects","publication_year":2026,"publication_date":"2026-08-14","ids":{"openalex":"https://openalex.org/W7203470565","doi":"https://doi.org/10.3390/pharmaceutics18081008","pmid":"https://pubmed.ncbi.nlm.nih.gov/42654125"},"language":"en","primary_location":{"id":"doi:10.3390/pharmaceutics18081008","doi":"https://doi.org/10.3390/pharmaceutics18081008","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics18081008","pdf_url":null,"source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/pharmaceutics18081008","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5137216996","display_name":"Omar Emmanuel Hern\u00e1ndez Pi\u00f1a","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Omar Emmanuel Hern\u00e1ndez Pi\u00f1a","raw_affiliation_strings":["Asofarma de M\u00e9xico S.A. de C.V., Av. Santa Fe 485, Lomas de Santa Fe, Contadero, Cuajimalpa de Morelos, Mexico City C.P. 05348, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asofarma de M\u00e9xico S.A. de C.V., Av. Santa Fe 485, Lomas de Santa Fe, Contadero, Cuajimalpa de Morelos, Mexico City C.P. 05348, Mexico","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041614257","display_name":"Alberto Mart\u00ednez Mu\u00f1oz","orcid":"https://orcid.org/0000-0002-7503-2328","observed_orcids":["https://orcid.org/0000-0002-7503-2328"]},"institutions":[{"id":"https://openalex.org/I59361560","display_name":"Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/059sp8j34","country_code":"MX","type":"education","lineage":["https://openalex.org/I59361560"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Alberto Mart\u00ednez Mu\u00f1oz","raw_affiliation_strings":["Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Salvador D\u00edaz Mir\u00f3n, Esq. Plan de San Luis S/N, Casco de Santo Tom\u00e1s, Miguel Hidalgo, Mexico City C.P. 11340, Mexico"],"raw_orcid":"https://orcid.org/0000-0002-7503-2328","affiliations":[{"raw_affiliation_string":"Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Salvador D\u00edaz Mir\u00f3n, Esq. Plan de San Luis S/N, Casco de Santo Tom\u00e1s, Miguel Hidalgo, Mexico City C.P. 11340, Mexico","institution_ids":["https://openalex.org/I59361560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137289295","display_name":"Erika Gabriela Guido \u00c1vila","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erika Gabriela Guido \u00c1vila","raw_affiliation_strings":["Asofarma de M\u00e9xico S.A. de C.V., Av. Santa Fe 485, Lomas de Santa Fe, Contadero, Cuajimalpa de Morelos, Mexico City C.P. 05348, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asofarma de M\u00e9xico S.A. de C.V., Av. Santa Fe 485, Lomas de Santa Fe, Contadero, Cuajimalpa de Morelos, Mexico City C.P. 05348, Mexico","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091474493","display_name":"Abraham Escobedo-Moratilla","orcid":"https://orcid.org/0000-0003-4676-1625","observed_orcids":["https://orcid.org/0000-0003-4676-1625"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abraham Escobedo-Moratilla","raw_affiliation_strings":["Asofarma de M\u00e9xico S.A. de C.V., Av. Santa Fe 485, Lomas de Santa Fe, Contadero, Cuajimalpa de Morelos, Mexico City C.P. 05348, Mexico"],"raw_orcid":"https://orcid.org/0000-0003-4676-1625","affiliations":[{"raw_affiliation_string":"Asofarma de M\u00e9xico S.A. de C.V., Av. Santa Fe 485, Lomas de Santa Fe, Contadero, Cuajimalpa de Morelos, Mexico City C.P. 05348, Mexico","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137228498","display_name":"Porfirio de la Cruz Cruz","orcid":"https://orcid.org/0000-0003-1105-5819","observed_orcids":["https://orcid.org/0000-0003-1105-5819"]},"institutions":[{"id":"https://openalex.org/I196664497","display_name":"Autonomous University of San Luis Potos\u00ed","ror":"https://ror.org/000917t60","country_code":"MX","type":"education","lineage":["https://openalex.org/I196664497"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Porfirio de la Cruz Cruz","raw_affiliation_strings":["Doctorado Institucional en Ingenier\u00eda y Ciencia de Materiales (DICIM), Universidad Aut\u00f3noma de San Luis Potos\u00ed (UASLP), Av. Sierra Leona No. 550, Col. Lomas 2da. Secci\u00f3n, San Luis Potos\u00ed C.P. 78210, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doctorado Institucional en Ingenier\u00eda y Ciencia de Materiales (DICIM), Universidad Aut\u00f3noma de San Luis Potos\u00ed (UASLP), Av. Sierra Leona No. 550, Col. Lomas 2da. Secci\u00f3n, San Luis Potos\u00ed C.P. 78210, Mexico","institution_ids":["https://openalex.org/I196664497"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067629585","display_name":"Jos\u00e9 P\u00e9rez\u2010Urizar","orcid":"https://orcid.org/0000-0003-0642-0033","observed_orcids":["https://orcid.org/0000-0003-0642-0033"]},"institutions":[{"id":"https://openalex.org/I196664497","display_name":"Autonomous University of San Luis Potos\u00ed","ror":"https://ror.org/000917t60","country_code":"MX","type":"education","lineage":["https://openalex.org/I196664497"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Jos\u00e9 Trinidad P\u00e9rez-Urizar","raw_affiliation_strings":["Facultad de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma de San Luis Potos\u00ed, Av. Dr. Manuel Nava No. 6, Zona Universitaria, San Luis Potos\u00ed C.P. 78210, Mexico"],"raw_orcid":"https://orcid.org/0000-0003-0642-0033","affiliations":[{"raw_affiliation_string":"Facultad de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma de San Luis Potos\u00ed, Av. Dr. Manuel Nava No. 6, Zona Universitaria, San Luis Potos\u00ed C.P. 78210, Mexico","institution_ids":["https://openalex.org/I196664497"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067629585"],"corresponding_institution_ids":["https://openalex.org/I196664497"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.65173154,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"8","first_page":"1008","last_page":"1008"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.43140000104904175,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.43140000104904175,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.16660000383853912,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.13529999554157257,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tamsulosin","display_name":"tamsulosin","score":0.9179999828338623},{"id":"https://openalex.org/keywords/extended-release-formulation","display_name":"sustained-release formulation","score":0.921999990940094},{"id":"https://openalex.org/keywords/bioequivalence","display_name":"bioequivalence","score":0.8489999771118164},{"id":"https://openalex.org/keywords/food-effect","display_name":"food effect","score":0.7889999747276306},{"id":"https://openalex.org/keywords/in-vitro-in-vivo-correlation","display_name":"in vitro-in vivo correlation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8389999866485596},{"id":"https://openalex.org/keywords/generic-drugs","display_name":"generic drugs","score":0.5400000214576721},{"id":"https://openalex.org/keywords/benign-prostatic-hyperplasia","display_name":"benign prostatic hyperplasia","score":0.9729999899864197},{"id":"https://openalex.org/keywords/dissolution","display_name":"dissolution","score":0.5400000214576721},{"id":"https://openalex.org/keywords/dose-dumping","display_name":"dose dumping","score":0.8270000219345093},{"id":"https://openalex.org/keywords/orthostatic-hypotension","display_name":"orthostatic hypotension","score":0.8989999890327454},{"id":"https://openalex.org/keywords/high-fat-meal","display_name":"high-fat meal","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C42404028","wikidata":"https://www.wikidata.org/wiki/Q864940","display_name":"Bioequivalence","level":3,"score":0.9251000285148621},{"id":"https://openalex.org/C2780542891","wikidata":"https://www.wikidata.org/wiki/Q418480","display_name":"Tamsulosin","level":3,"score":0.8185999989509583},{"id":"https://openalex.org/C2779484521","wikidata":"https://www.wikidata.org/wiki/Q5975478","display_name":"IVIVC","level":5,"score":0.7440000176429749},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7282999753952026},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7055000066757202},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5209000110626221},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.5134000182151794},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.508400022983551},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.4767000079154968},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4510999917984009},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.32510000467300415},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3222000002861023},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.3156999945640564},{"id":"https://openalex.org/C2778492647","wikidata":"https://www.wikidata.org/wiki/Q423401","display_name":"Isosorbide mononitrate","level":2,"score":0.2727000117301941}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/pharmaceutics18081008","doi":"https://doi.org/10.3390/pharmaceutics18081008","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics18081008","pdf_url":null,"source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},{"id":"pmid:42654125","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42654125","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0ac29a1e9fc948818d3c357c1d1d64c7","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/0ac29a1e9fc948818d3c357c1d1d64c7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, Vol 18, Iss 8, p 1008 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13517056","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13517056/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/pharmaceutics18081008","doi":"https://doi.org/10.3390/pharmaceutics18081008","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics18081008","pdf_url":null,"source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.539557695388794}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1617275881","https://openalex.org/W1853527412","https://openalex.org/W1975660031","https://openalex.org/W2010598851","https://openalex.org/W2011596886","https://openalex.org/W2016493905","https://openalex.org/W2017988838","https://openalex.org/W2021569546","https://openalex.org/W2027507514","https://openalex.org/W2030529857","https://openalex.org/W2032446049","https://openalex.org/W2045489526","https://openalex.org/W2064690405","https://openalex.org/W2064921242","https://openalex.org/W2073859834","https://openalex.org/W2074042159","https://openalex.org/W2091611410","https://openalex.org/W2094711407","https://openalex.org/W2132438186","https://openalex.org/W2258710565","https://openalex.org/W2379628571","https://openalex.org/W2483800985","https://openalex.org/W2766700443","https://openalex.org/W2889371301","https://openalex.org/W2891242773","https://openalex.org/W2937963363","https://openalex.org/W3016726787","https://openalex.org/W3122256891","https://openalex.org/W3205427784","https://openalex.org/W3213425375","https://openalex.org/W4361285509","https://openalex.org/W4390405587","https://openalex.org/W4408283400","https://openalex.org/W4410785546","https://openalex.org/W4411638622","https://openalex.org/W4414082856","https://openalex.org/W4415384062","https://openalex.org/W7128507724"],"related_works":[],"abstract_inverted_index":{"Background/Objectives:":[0],"Tamsulosin":[1],"extended-release":[2],"(ER)":[3],"formulations":[4,120,165],"minimize":[5],"peak-related":[6],"vasodilatory":[7],"adverse":[8,169],"events":[9,170],"in":[10,49,80,133,194,221],"benign":[11],"prostatic":[12],"hyperplasia":[13],"(BPH)":[14],"treatment.":[15],"This":[16],"study":[17],"assessed":[18],"the":[19,32,115,137,141,191],"pharmacokinetics":[20],"and":[21,36,94,107,155,197,214,224,230],"bioequivalence":[22,117],"of":[23,140,160],"a":[24,57,62,66,207],"generic":[25,182],"tamsulosin":[26,70,183],"0.4":[27,184],"mg":[28,185],"ER":[29,186],"formulation":[30,143,187],"against":[31],"innovator":[33],"under":[34,151],"fasting":[35,196],"fed":[37,198],"conditions.":[38],"Methods:":[39],"Two":[40],"randomized,":[41],"open-label,":[42],"four-period":[43],"crossover,":[44],"single-dose":[45],"trials":[46],"were":[47,166,171],"conducted":[48],"healthy":[50],"Mexican":[51],"males.":[52],"Subjects":[53],"received":[54],"treatment":[55],"following":[56],"10":[58],"h":[59,75],"fast":[60],"or":[61],"high-fat":[63],"meal,":[64],"with":[65,127,146,173],"7-day":[67],"washout.":[68],"Plasma":[69],"was":[71,86,144],"quantified":[72],"over":[73],"72":[74],"via":[76],"LC-MS/MS.":[77],"An":[78],"exploratory":[79,134],"vitro\u2013in":[81],"vivo":[82,222],"correlation":[83],"(IVIVC)":[84],"analysis":[85],"also":[87],"performed.":[88],"Results:":[89],"Analyses":[90],"included":[91],"32":[92],"(fasting)":[93],"58":[95],"(fed)":[96],"subjects.":[97],"In":[98],"both":[99,152,195],"states,":[100],"90%":[101],"confidence":[102],"intervals":[103],"for":[104],"Cmax,":[105],"AUC0-t,":[106],"AUC0-\u221e":[108],"geometric":[109],"mean":[110],"ratios":[111],"fell":[112],"entirely":[113],"within":[114],"80.00\u2013125.00%":[116],"limits.":[118],"The":[119,181],"showed":[121,156],"comparable":[122],"dissolution":[123,213],"(f2":[124],"=":[125],"92.47),":[126],"numerical":[128],"deconvolution":[129],"proving":[130],"most":[131],"predictive":[132],"IVIVC.":[135],"Notably,":[136],"pharmacokinetic":[138,158],"profile":[139],"test":[142],"consistent":[145],"maintained":[147],"controlled":[148],"drug":[149],"release":[150],"dietary":[153],"conditions":[154],"no":[157,174],"evidence":[159],"food-induced":[161],"dose":[162,204],"dumping.":[163],"Both":[164],"well-tolerated;":[167],"all":[168],"mild,":[172],"clinically":[175],"significant":[176],"orthostatic":[177],"hypotension":[178],"observed.":[179],"Conclusions:":[180],"is":[188],"bioequivalent":[189],"to":[190],"reference":[192],"product":[193],"states.":[199],"Its":[200],"structural":[201],"robustness":[202],"prevents":[203],"dumping,":[205],"ensuring":[206],"favorable":[208],"hemodynamic":[209],"safety":[210],"profile.":[211],"Comparable":[212],"IVIVC":[215],"findings":[216],"further":[217],"support":[218],"their":[219],"reliability":[220],"performance":[223],"therapeutic":[225],"interchangeability.":[226],"ClinicalTrials.gov":[227],"identifiers:":[228],"NCT07698288":[229],"NCT07698275.":[231]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-08-15T00:00:00"}
