{"id":"https://openalex.org/W7203467684","doi":"https://doi.org/10.1016/j.bej.2026.110368","title":"Rational metabolic engineering of Bacillus subtilis for the efficient production of L-valine","display_name":"Rational metabolic engineering of Bacillus subtilis for the efficient production of L-valine","publication_year":2026,"publication_date":"2026-08-14","ids":{"openalex":"https://openalex.org/W7203467684","doi":"https://doi.org/10.1016/j.bej.2026.110368"},"language":"en","primary_location":{"id":"doi:10.1016/j.bej.2026.110368","doi":"https://doi.org/10.1016/j.bej.2026.110368","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bej.2026.110368","pdf_url":null,"source":{"id":"https://openalex.org/S168210271","display_name":"Biochemical Engineering Journal","issn_l":"1369-703X","issn":["1369-703X","1873-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Engineering Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5144310438","display_name":"Kai Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Wang","raw_affiliation_strings":["The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, WuXi 214122, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, WuXi 214122, People's Republic of China","institution_ids":["https://openalex.org/I111599522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122332647","display_name":"Qing-Yuan Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qing-Yuan Liu","raw_affiliation_strings":["The Center of Research Translation in Bayannur, Bayannur 015000, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Center of Research Translation in Bayannur, Bayannur 015000, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ting Lu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ting Lu","raw_affiliation_strings":["Wulateqianqi Rongsheng Dadi Biotechnology Feed Co., LTD, Bayannur 015000, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wulateqianqi Rongsheng Dadi Biotechnology Feed Co., LTD, Bayannur 015000, People's Republic of China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122346438","display_name":"Rong-Sheng Zhai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rong-Sheng Zhai","raw_affiliation_strings":["Wulateqianqi Rongsheng Dadi Biotechnology Feed Co., LTD, Bayannur 015000, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wulateqianqi Rongsheng Dadi Biotechnology Feed Co., LTD, Bayannur 015000, People's Republic of China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015292967","display_name":"Jian-Zhong Xu","orcid":"https://orcid.org/0000-0003-0750-6875","observed_orcids":["https://orcid.org/0000-0003-0750-6875","https://orcid.org/0000-0001-6555-6059"]},"institutions":[{"id":"https://openalex.org/I111599522","display_name":"Jiangnan University","ror":"https://ror.org/04mkzax54","country_code":"CN","type":"education","lineage":["https://openalex.org/I111599522"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian-Zhong Xu","raw_affiliation_strings":["The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, WuXi 214122, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0003-0750-6875","affiliations":[{"raw_affiliation_string":"The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, WuXi 214122, People's Republic of China","institution_ids":["https://openalex.org/I111599522"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015292967"],"corresponding_institution_ids":["https://openalex.org/I111599522"],"apc_list":{"value":3820,"currency":"USD","value_usd":3820},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.52842946,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"236","issue":null,"first_page":"110368","last_page":"110368"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-valine-production","display_name":"L-valine production","score":0.9919999837875366},{"id":"https://openalex.org/keywords/bacillus-subtilis","display_name":"Bacillus subtilis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/metabolic-engineering","display_name":"metabolic engineering","score":0.7950000166893005},{"id":"https://openalex.org/keywords/branched-chain-amino-acid-biosynthesis","display_name":"branched-chain amino acid biosynthesis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/promoter-replacement","display_name":"promoter replacement","score":0.5849999785423279},{"id":"https://openalex.org/keywords/pyruvate-kinase","display_name":"pyruvate kinase","score":0.7900000214576721},{"id":"https://openalex.org/keywords/malic-enzyme","display_name":"malic enzyme","score":0.9599999785423279},{"id":"https://openalex.org/keywords/branched-chain-alpha-keto-acid-dehydrogenase","display_name":"branched-chain ketoacid dehydrogenase","score":0.9210000038146973},{"id":"https://openalex.org/keywords/pyruvate-dehydrogenase","display_name":"pyruvate dehydrogenase","score":0.8309999704360962},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.6669999957084656},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.8989999890327454},{"id":"https://openalex.org/keywords/digestive-enzymes","display_name":"digestive enzymes","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.8364999890327454},{"id":"https://openalex.org/C2777272437","wikidata":"https://www.wikidata.org/wiki/Q131238","display_name":"Bacillus subtilis","level":3,"score":0.8342999815940857},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.566100001335144},{"id":"https://openalex.org/C2778348673","wikidata":"https://www.wikidata.org/wiki/Q739302","display_name":"Production (economics)","level":2,"score":0.5611000061035156},{"id":"https://openalex.org/C2777932965","wikidata":"https://www.wikidata.org/wiki/Q149098","display_name":"Bacillaceae","level":4,"score":0.4902999997138977},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.4846000075340271},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4636000096797943},{"id":"https://openalex.org/C2778039104","wikidata":"https://www.wikidata.org/wiki/Q149088","display_name":"Bacillales","level":4,"score":0.40540000796318054},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.39570000767707825},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.3702000081539154},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.33899998664855957},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3260999917984009},{"id":"https://openalex.org/C168170006","wikidata":"https://www.wikidata.org/wiki/Q864699","display_name":"Bioreactor","level":2,"score":0.32499998807907104},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3228999972343445},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.32260000705718994},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.3188000023365021},{"id":"https://openalex.org/C2779039970","wikidata":"https://www.wikidata.org/wiki/Q3610387","display_name":"Industrial microbiology","level":3,"score":0.2957000136375427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2840999960899353},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.2802000045776367},{"id":"https://openalex.org/C2779150676","wikidata":"https://www.wikidata.org/wiki/Q2091405","display_name":"Bacillus (shape)","level":2,"score":0.26829999685287476},{"id":"https://openalex.org/C70818257","wikidata":"https://www.wikidata.org/wiki/Q502671","display_name":"Metabolic control analysis","level":3,"score":0.25859999656677246},{"id":"https://openalex.org/C2993927895","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolic activity","level":2,"score":0.2572000026702881},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2538999915122986}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.bej.2026.110368","doi":"https://doi.org/10.1016/j.bej.2026.110368","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bej.2026.110368","pdf_url":null,"source":{"id":"https://openalex.org/S168210271","display_name":"Biochemical Engineering Journal","issn_l":"1369-703X","issn":["1369-703X","1873-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Engineering Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.40450000762939453,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"sustainable_development_goals_aurora":[{"score":0.4912291467189789,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5982612560","display_name":null,"funder_award_id":"CX (22) 1012","funder_id":"https://openalex.org/F4320334925","funder_display_name":"Science and Technology Support Program of Jiangsu Province"},{"id":"https://openalex.org/G614534118","display_name":null,"funder_award_id":"32271534","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320309870","display_name":"Jiangsu Agricultural Science and Technology Innovation Fund","ror":"https://ror.org/0335n2618"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320334925","display_name":"Science and Technology Support Program of Jiangsu Province","ror":"https://ror.org/02mkqta53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W15282186","https://openalex.org/W1485360994","https://openalex.org/W1546932446","https://openalex.org/W1559169404","https://openalex.org/W1569217615","https://openalex.org/W1781805691","https://openalex.org/W1997573130","https://openalex.org/W2017140888","https://openalex.org/W2024940488","https://openalex.org/W2041426527","https://openalex.org/W2054506883","https://openalex.org/W2059849803","https://openalex.org/W2060553364","https://openalex.org/W2074044440","https://openalex.org/W2086689771","https://openalex.org/W2094934497","https://openalex.org/W2100882223","https://openalex.org/W2103076834","https://openalex.org/W2117012700","https://openalex.org/W2129364846","https://openalex.org/W2130775386","https://openalex.org/W2166334190","https://openalex.org/W2216454044","https://openalex.org/W2770643712","https://openalex.org/W2801885456","https://openalex.org/W2819386545","https://openalex.org/W2848794158","https://openalex.org/W2889500241","https://openalex.org/W2963976604","https://openalex.org/W3009512333","https://openalex.org/W3083459141","https://openalex.org/W3087326082","https://openalex.org/W3176918291","https://openalex.org/W3195973127","https://openalex.org/W3196531446","https://openalex.org/W3198897191","https://openalex.org/W3200123842","https://openalex.org/W4206840732","https://openalex.org/W4282968425","https://openalex.org/W4306867884","https://openalex.org/W4376868509","https://openalex.org/W4377092927","https://openalex.org/W4382196826","https://openalex.org/W4387213308","https://openalex.org/W4399074131","https://openalex.org/W4400212936","https://openalex.org/W4404234480","https://openalex.org/W4405135456","https://openalex.org/W4407626286","https://openalex.org/W4410535604","https://openalex.org/W4410959529","https://openalex.org/W4411475405","https://openalex.org/W4414274540","https://openalex.org/W7119536875"],"related_works":["https://openalex.org/W2819386545","https://openalex.org/W3087326082","https://openalex.org/W2061652808","https://openalex.org/W3145925446","https://openalex.org/W4313500488","https://openalex.org/W2064567525","https://openalex.org/W2113916940","https://openalex.org/W3024553405","https://openalex.org/W2767595336","https://openalex.org/W2038821752"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-09T09:14:12.587421","created_date":"2026-08-15T00:00:00"}
