{"id":"https://openalex.org/W7203463400","doi":"https://doi.org/10.1590/1516-3180.2025.3467.13052026","title":"Effect of aminomix-1 solution as an in vitro scolicidal agent on the bile ducts and liver in rats: a controlled experimental animal study","display_name":"Effect of aminomix-1 solution as an in vitro scolicidal agent on the bile ducts and liver in rats: a controlled experimental animal study","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7203463400","doi":"https://doi.org/10.1590/1516-3180.2025.3467.13052026","pmid":"https://pubmed.ncbi.nlm.nih.gov/42659414","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13506168"},"language":"en","primary_location":{"id":"doi:10.1590/1516-3180.2025.3467.13052026","doi":"https://doi.org/10.1590/1516-3180.2025.3467.13052026","is_oa":true,"landing_page_url":"https://doi.org/10.1590/1516-3180.2025.3467.13052026","pdf_url":null,"source":{"id":"https://openalex.org/S158351634","display_name":"Sao Paulo Medical Journal","issn_l":"0035-0362","issn":["0035-0362","1516-3180","1806-9460"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","poland-40","russia-white-list-2","scielo","vabb-shw"],"host_organization":"https://openalex.org/P4310312490","host_organization_name":"Medical Association of S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/P4310312490"],"host_organization_lineage_names":["Medical Association of S\u00e3o Paulo"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sao Paulo Medical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1590/1516-3180.2025.3467.13052026","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035800682","display_name":"Recep \u00c7a\u011flar","orcid":"https://orcid.org/0000-0003-0987-9202","observed_orcids":["https://orcid.org/0000-0003-0987-9202"]},"institutions":[{"id":"https://openalex.org/I4405267937","display_name":"Mersin \u015eehir E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/053mrpy11","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4405267937"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Recep \u00c7a\u011flar","raw_affiliation_strings":["Mersin City Training and Research Hospital,  T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0003-0987-9202","affiliations":[{"raw_affiliation_string":"Mersin City Training and Research Hospital,  T\u00fcrkiye","institution_ids":["https://openalex.org/I4405267937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067399191","display_name":"H\u00fcseyin P\u00fclat","orcid":"https://orcid.org/0000-0003-0635-3387","observed_orcids":["https://orcid.org/0000-0003-0635-3387","https://orcid.org/0000-0001-6095-6002"]},"institutions":[{"id":"https://openalex.org/I4405267937","display_name":"Mersin \u015eehir E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/053mrpy11","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4405267937"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"P\u00fclat H\u00fcseyin","raw_affiliation_strings":["Mersin City Training and Research Hospital Mersin,  T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0003-0635-3387","affiliations":[{"raw_affiliation_string":"Mersin City Training and Research Hospital Mersin,  T\u00fcrkiye","institution_ids":["https://openalex.org/I4405267937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045001175","display_name":"Emine Teking\u00fcnd\u00fcz","orcid":"https://orcid.org/0000-0001-8341-1267","observed_orcids":["https://orcid.org/0000-0001-8341-1267"]},"institutions":[{"id":"https://openalex.org/I4405267937","display_name":"Mersin \u015eehir E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/053mrpy11","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4405267937"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Emine Teking\u00fcnd\u00fcz","raw_affiliation_strings":["Mersin City Training and Research Hospital Mersin,  T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0001-8341-1267","affiliations":[{"raw_affiliation_string":"Mersin City Training and Research Hospital Mersin,  T\u00fcrkiye","institution_ids":["https://openalex.org/I4405267937"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059333525","display_name":"Tiin\u00e7e Aksak","orcid":"https://orcid.org/0000-0001-7841-8456","observed_orcids":["https://orcid.org/0000-0001-7841-8456"]},"institutions":[{"id":"https://openalex.org/I12685407","display_name":"Toros University","ror":"https://ror.org/040zce739","country_code":"TR","type":"education","lineage":["https://openalex.org/I12685407"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Tiin\u00e7e Aksak","raw_affiliation_strings":["University of Toros Medical Services and Techniques Head of Department,  T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0001-7841-8456","affiliations":[{"raw_affiliation_string":"University of Toros Medical Services and Techniques Head of Department,  T\u00fcrkiye","institution_ids":["https://openalex.org/I12685407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"144","issue":"4","first_page":"e20253467","last_page":"e20253467"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11154","display_name":"Parasitic infections in humans and animals","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11154","display_name":"Parasitic infections in humans and animals","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10518","display_name":"Gallbladder and Bile Duct Disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scolicidal-agents","display_name":"scolicidal agents","score":0.9559999704360962},{"id":"https://openalex.org/keywords/echinococcosis","display_name":"echinococcosis","score":0.9200000166893005},{"id":"https://openalex.org/keywords/liver-histopathology","display_name":"liver histopathology","score":0.7549999952316284},{"id":"https://openalex.org/keywords/liver-function-tests","display_name":"liver function tests","score":0.7770000100135803},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.5249999761581421},{"id":"https://openalex.org/keywords/sclerosing-cholangitis","display_name":"sclerosing cholangitis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/focal-necrosis","display_name":"focal necrosis","score":0.7139999866485596},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8109999895095825},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.7081000208854675},{"id":"https://openalex.org/C2777513400","wikidata":"https://www.wikidata.org/wiki/Q104219","display_name":"Bilirubin","level":2,"score":0.7041000127792358},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.6888999938964844},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.5698000192642212},{"id":"https://openalex.org/C3020000481","wikidata":"https://www.wikidata.org/wiki/Q38344","display_name":"Experimental animal","level":2,"score":0.48910000920295715},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4729999899864197},{"id":"https://openalex.org/C2779777945","wikidata":"https://www.wikidata.org/wiki/Q851111","display_name":"Bile duct","level":2,"score":0.4431999921798706},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.41200000047683716},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4058000147342682},{"id":"https://openalex.org/C2778606649","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine transaminase","level":2,"score":0.40230000019073486},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4020000100135803},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39469999074935913},{"id":"https://openalex.org/C2776884468","wikidata":"https://www.wikidata.org/wiki/Q1263617","display_name":"Common bile duct","level":2,"score":0.38920000195503235},{"id":"https://openalex.org/C65409693","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Statistical significance","level":2,"score":0.3840999901294708},{"id":"https://openalex.org/C2992872382","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine aminotransferase","level":2,"score":0.3750999867916107},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.36390000581741333},{"id":"https://openalex.org/C512861765","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function tests","level":2,"score":0.3546999990940094},{"id":"https://openalex.org/C170835558","wikidata":"https://www.wikidata.org/wiki/Q17153","display_name":"Amylase","level":3,"score":0.3447999954223633},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3375999927520752},{"id":"https://openalex.org/C2992208098","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver function","level":2,"score":0.3345000147819519},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.322299987077713},{"id":"https://openalex.org/C2986587452","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical analysis","level":2,"score":0.31630000472068787},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3073999881744385},{"id":"https://openalex.org/C2993667909","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Hepatic fibrosis","level":3,"score":0.2919999957084656},{"id":"https://openalex.org/C2994203108","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Hepatic function","level":2,"score":0.2840000092983246},{"id":"https://openalex.org/C2775982439","wikidata":"https://www.wikidata.org/wiki/Q3562150","display_name":"Biliary tract","level":2,"score":0.2818000018596649},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.2741999924182892},{"id":"https://openalex.org/C2778593092","wikidata":"https://www.wikidata.org/wiki/Q1075923","display_name":"Cholestasis","level":2,"score":0.26899999380111694},{"id":"https://openalex.org/C3018233652","wikidata":"https://www.wikidata.org/wiki/Q101965","display_name":"Experimental research","level":2,"score":0.26660001277923584}],"mesh":[{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001219","descriptor_name":"Aspartate Aminotransferases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001652","descriptor_name":"Bile Ducts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001652","descriptor_name":"Bile Ducts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002756","descriptor_name":"Cholagogues and Choleretics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008111","descriptor_name":"Liver Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1590/1516-3180.2025.3467.13052026","doi":"https://doi.org/10.1590/1516-3180.2025.3467.13052026","is_oa":true,"landing_page_url":"https://doi.org/10.1590/1516-3180.2025.3467.13052026","pdf_url":null,"source":{"id":"https://openalex.org/S158351634","display_name":"Sao Paulo Medical Journal","issn_l":"0035-0362","issn":["0035-0362","1516-3180","1806-9460"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","poland-40","russia-white-list-2","scielo","vabb-shw"],"host_organization":"https://openalex.org/P4310312490","host_organization_name":"Medical Association of S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/P4310312490"],"host_organization_lineage_names":["Medical Association of S\u00e3o Paulo"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sao Paulo Medical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13506168","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13506168/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13506168/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sao Paulo Med J","raw_type":"Text"},{"id":"pmid:42659414","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42659414","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sao Paulo medical journal = Revista paulista de medicina","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a204c5feb8dd42e7beb792b417dd288f","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a204c5feb8dd42e7beb792b417dd288f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"S\u00e3o Paulo Medical Journal, Vol 144, Iss 4 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1590/1516-3180.2025.3467.13052026","doi":"https://doi.org/10.1590/1516-3180.2025.3467.13052026","is_oa":true,"landing_page_url":"https://doi.org/10.1590/1516-3180.2025.3467.13052026","pdf_url":null,"source":{"id":"https://openalex.org/S158351634","display_name":"Sao Paulo Medical Journal","issn_l":"0035-0362","issn":["0035-0362","1516-3180","1806-9460"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","poland-40","russia-white-list-2","scielo","vabb-shw"],"host_organization":"https://openalex.org/P4310312490","host_organization_name":"Medical Association of S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/P4310312490"],"host_organization_lineage_names":["Medical Association of S\u00e3o Paulo"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sao Paulo Medical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203463400.pdf","grobid_xml":"https://content.openalex.org/works/W7203463400.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W52073128","https://openalex.org/W107871566","https://openalex.org/W1455331800","https://openalex.org/W1938678831","https://openalex.org/W1964235232","https://openalex.org/W1976293270","https://openalex.org/W1995946621","https://openalex.org/W2007784374","https://openalex.org/W2013287347","https://openalex.org/W2018066083","https://openalex.org/W2018908351","https://openalex.org/W2020387899","https://openalex.org/W2059871015","https://openalex.org/W2070369077","https://openalex.org/W2083053447","https://openalex.org/W2086993052","https://openalex.org/W2087883210","https://openalex.org/W2090313808","https://openalex.org/W2114127682","https://openalex.org/W2167177480","https://openalex.org/W2270199558","https://openalex.org/W2409540387","https://openalex.org/W2594953454","https://openalex.org/W2754833831","https://openalex.org/W2889342959","https://openalex.org/W2935091996","https://openalex.org/W2935934933","https://openalex.org/W2963263230","https://openalex.org/W3008500384","https://openalex.org/W4200068209","https://openalex.org/W4239794555"],"related_works":["https://openalex.org/W1980358395","https://openalex.org/W2059871015","https://openalex.org/W3103801677","https://openalex.org/W7100575401","https://openalex.org/W2296161924","https://openalex.org/W2075183928","https://openalex.org/W2413847781","https://openalex.org/W2785434402","https://openalex.org/W1993709830","https://openalex.org/W3201130544"],"abstract_inverted_index":{"BACKGROUND:":[0],"Many":[1],"scolicidal":[2,26],"agents":[3,40],"are":[4,28,50],"used":[5],"to":[6],"treat":[7],"hydatid":[8,34],"cysts.":[9],"However,":[10],"most":[11],"of":[12,18,33,59,68,86],"these":[13],"have":[14],"been":[15],"discontinued":[16],"because":[17],"complications.":[19],"Currently,":[20],"no":[21],"safe,":[22],"effective,":[23],"and":[24,47,65,105,120,122,164,181,185,188,232],"useful":[25],"agent":[27],"available":[29],"for":[30,116,143],"the":[31,57,63,91,102,111,132,169,178,194,214],"treatment":[32],"cysts":[35],"in":[36,101,110,177,204,213],"humans.":[37],"Therefore,":[38],"novel":[39],"with":[41,95],"greater":[42],"efficacy,":[43],"fewer":[44],"side":[45],"effects,":[46],"lower":[48],"costs":[49],"required.":[51],"In":[52],"this":[53],"study,":[54],"we":[55],"evaluated":[56],"effects":[58],"aminomix-1":[60,87,157,208,228],"solution":[61,85],"on":[62],"liver":[64,121,242],"bile":[66,93,123],"ducts":[67],"rats.":[69],"MATERIALS":[70],"AND":[71],"METHODS:":[72],"Twenty-two":[73],"male":[74],"Wistar-Albino":[75],"rats":[76],"were":[77,126,137,175,192],"divided":[78],"into":[79,90],"two":[80],"groups.":[81],"A":[82],"0.5":[83],"mL":[84],"was":[88,149,202,220],"injected":[89],"common":[92],"duct":[94,124],"a":[96],"27-gauge":[97],"syringe":[98],"without":[99],"pressure":[100],"experimental":[103],"group":[104,158,209],"normal":[106],"saline":[107],"(0.9%":[108],"isotonic)":[109],"control":[112,170],"group.":[113,171,206],"Blood":[114],"samples":[115],"hepatic":[117],"function":[118],"tests":[119],"tissues":[125],"examined":[127],"histopathologically":[128],"4":[129],"weeks":[130],"after":[131],"procedure.":[133],"All":[134],"statistical":[135],"analyses":[136],"performed":[138],"using":[139],"IBM":[140],"SPSS":[141],"Statistics":[142],"Windows,":[144],"version":[145],"21.0.":[146],"Statistical":[147],"significance":[148],"set":[150],"at":[151],"p":[152],"<":[153],"0.05.":[154],"RESULTS:":[155],"The":[156,207],"showed":[159,210],"significantly":[160],"higher":[161],"aspartate":[162],"aminotransferase":[163,180],"alkaline":[165],"phosphatase":[166],"levels":[167,191],"than":[168],"No":[172,197],"significant":[173,222],"differences":[174],"observed":[176,203],"alanine":[179],"amylase":[182],"levels.":[183],"Total":[184],"direct":[186],"bilirubin":[187],"gamma-glutamyl":[189],"transferase":[190],"below":[193],"detection":[195],"limits.":[196],"fibrosis":[198],"or":[199,240,244],"confluent":[200],"necrosis":[201,212,217],"either":[205],"moderate":[211],"spotty":[215],"(focal)":[216],"analysis,":[218],"which":[219],"borderline":[221],"(p":[223],"\u2248":[224],"0.08).":[225],"CONCLUSION:":[226],"Although":[227],"caused":[229],"mild":[230],"biochemical":[231],"histopathological":[233],"changes,":[234],"it":[235],"did":[236],"not":[237],"cause":[238],"advanced":[239],"irreversible":[241],"damage":[243],"sclerosing":[245],"cholangitis.":[246]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-08-15T00:00:00"}