{"id":"https://openalex.org/W7203446859","doi":"https://doi.org/10.1007/s12032-026-03358-8","title":"Doxorubicin-loaded chitosan\u2013silver nanocarrier elicits chemoresistance in liver cancer cells","display_name":"Doxorubicin-loaded chitosan\u2013silver nanocarrier elicits chemoresistance in liver cancer cells","publication_year":2026,"publication_date":"2026-08-14","ids":{"openalex":"https://openalex.org/W7203446859","doi":"https://doi.org/10.1007/s12032-026-03358-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/42599562"},"language":"en","primary_location":{"id":"doi:10.1007/s12032-026-03358-8","doi":"https://doi.org/10.1007/s12032-026-03358-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12032-026-03358-8","pdf_url":null,"source":{"id":"https://openalex.org/S204953464","display_name":"Medical Oncology","issn_l":"1357-0560","issn":["1357-0560","1559-131X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5147150865","display_name":"Ebru Ba\u015fak Ba\u015fb\u00fcy\u00fck","orcid":"https://orcid.org/0009-0004-6551-4851","observed_orcids":["https://orcid.org/0009-0004-6551-4851"]},"institutions":[{"id":"https://openalex.org/I265519392","display_name":"Erzurum Technical University","ror":"https://ror.org/038pb1155","country_code":"TR","type":"education","lineage":["https://openalex.org/I265519392"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ebru Ba\u015fak Ba\u015fb\u00fcy\u00fck","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Faculty of Science, Erzurum Technical University, Erzurum, T\u00fcrkiye","High Technology Application and Research Center (Y\u00dcTAM), Erzurum Technical University, Erzurum, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0009-0004-6551-4851","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Faculty of Science, Erzurum Technical University, Erzurum, T\u00fcrkiye","institution_ids":["https://openalex.org/I265519392"]},{"raw_affiliation_string":"High Technology Application and Research Center (Y\u00dcTAM), Erzurum Technical University, Erzurum, T\u00fcrkiye","institution_ids":["https://openalex.org/I265519392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067073278","display_name":"Mesut Aky\u00fcz","orcid":"https://orcid.org/0000-0001-8161-2479","observed_orcids":["https://orcid.org/0000-0001-8161-2479"]},"institutions":[{"id":"https://openalex.org/I265519392","display_name":"Erzurum Technical University","ror":"https://ror.org/038pb1155","country_code":"TR","type":"education","lineage":["https://openalex.org/I265519392"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Mesut Aky\u00fcz","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Faculty of Science, Erzurum Technical University, Erzurum, T\u00fcrkiye. mesut.akyuz@erzurum.edu.tr","High Technology Application and Research Center (Y\u00dcTAM), Erzurum Technical University, Erzurum, T\u00fcrkiye. mesut.akyuz@erzurum.edu.tr"],"raw_orcid":"https://orcid.org/0000-0001-8161-2479","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Faculty of Science, Erzurum Technical University, Erzurum, T\u00fcrkiye. mesut.akyuz@erzurum.edu.tr","institution_ids":["https://openalex.org/I265519392"]},{"raw_affiliation_string":"High Technology Application and Research Center (Y\u00dcTAM), Erzurum Technical University, Erzurum, T\u00fcrkiye. mesut.akyuz@erzurum.edu.tr","institution_ids":["https://openalex.org/I265519392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067461511","display_name":"K\u00fcbra Solak","orcid":"https://orcid.org/0000-0001-6643-3368","observed_orcids":["https://orcid.org/0000-0001-6643-3368"]},"institutions":[{"id":"https://openalex.org/I64134780","display_name":"Atat\u00fcrk University","ror":"https://ror.org/03je5c526","country_code":"TR","type":"education","lineage":["https://openalex.org/I64134780"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"K\u00fcbra Solak","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Faculty of Science, Atat\u00fcrk University, Erzurum, T\u00fcrkiye","East Anatolia High Technology Application and Research Center (DAYTAM), Atat\u00fcrk University, Erzurum, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0001-6643-3368","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Faculty of Science, Atat\u00fcrk University, Erzurum, T\u00fcrkiye","institution_ids":["https://openalex.org/I64134780"]},{"raw_affiliation_string":"East Anatolia High Technology Application and Research Center (DAYTAM), Atat\u00fcrk University, Erzurum, T\u00fcrkiye","institution_ids":["https://openalex.org/I64134780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062556330","display_name":"Adem Kara","orcid":"https://orcid.org/0000-0002-5766-6116","observed_orcids":["https://orcid.org/0000-0002-5766-6116"]},"institutions":[{"id":"https://openalex.org/I265519392","display_name":"Erzurum Technical University","ror":"https://ror.org/038pb1155","country_code":"TR","type":"education","lineage":["https://openalex.org/I265519392"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Adem Kara","raw_affiliation_strings":["Department of Molecular Biology and Genetics, Faculty of Science, Erzurum Technical University, Erzurum, T\u00fcrkiye","High Technology Application and Research Center (Y\u00dcTAM), Erzurum Technical University, Erzurum, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0002-5766-6116","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Faculty of Science, Erzurum Technical University, Erzurum, T\u00fcrkiye","institution_ids":["https://openalex.org/I265519392"]},{"raw_affiliation_string":"High Technology Application and Research Center (Y\u00dcTAM), Erzurum Technical University, Erzurum, T\u00fcrkiye","institution_ids":["https://openalex.org/I265519392"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067073278"],"corresponding_institution_ids":["https://openalex.org/I265519392"],"apc_list":{"value":4290,"currency":"USD","value_usd":4290},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.45625959,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"43","issue":"9","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/nanocarriers","display_name":"nanocarriers","score":0.6610000133514404},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.8859999775886536},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.972000002861023},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9950000047683716},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.8569999933242798},{"id":"https://openalex.org/keywords/nanoparticle-cytotoxicity","display_name":"nanoparticle cytotoxicity","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.9099000096321106},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.7926999926567078},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.6995999813079834},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.6277999877929688},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.6079000234603882},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5712000131607056},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5454000234603882},{"id":"https://openalex.org/C19106626","wikidata":"https://www.wikidata.org/wiki/Q230749","display_name":"Bystander effect","level":2,"score":0.5202000141143799},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4986000061035156},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47760000824928284},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.45899999141693115},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43070000410079956},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.412200003862381},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.4002000093460083},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.35010001063346863},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3443000018596649},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3294000029563904},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.328000009059906},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3228999972343445},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.31470000743865967},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.31360000371932983},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3095000088214874},{"id":"https://openalex.org/C204399865","wikidata":"https://www.wikidata.org/wiki/Q17157402","display_name":"Nanocapsules","level":3,"score":0.3034000098705292},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2897000014781952},{"id":"https://openalex.org/C127445965","wikidata":"https://www.wikidata.org/wiki/Q2518429","display_name":"Nanotoxicology","level":3,"score":0.28700000047683716},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.2840000092983246},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.28369998931884766},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.27469998598098755},{"id":"https://openalex.org/C2993709057","wikidata":"https://www.wikidata.org/wiki/Q1349821","display_name":"Liver toxicity","level":3,"score":0.27250000834465027},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.27079999446868896},{"id":"https://openalex.org/C2776964913","wikidata":"https://www.wikidata.org/wiki/Q1671502","display_name":"Liver tumor","level":3,"score":0.2596000134944916}],"mesh":[{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012834","descriptor_name":"Silver","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012834","descriptor_name":"Silver","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D053768","descriptor_name":"Metal Nanoparticles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D053768","descriptor_name":"Metal Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s12032-026-03358-8","doi":"https://doi.org/10.1007/s12032-026-03358-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12032-026-03358-8","pdf_url":null,"source":{"id":"https://openalex.org/S204953464","display_name":"Medical Oncology","issn_l":"1357-0560","issn":["1357-0560","1559-131X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Oncology","raw_type":"journal-article"},{"id":"pmid:42599562","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42599562","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical oncology (Northwood, London, England)","raw_type":"Journal Article"},{"id":"pmh:00b070fd-4100-4a5d-abcb-f52217929758","doi":null,"is_oa":false,"landing_page_url":"https://avesis.atauni.edu.tr/publication/details/00b070fd-4100-4a5d-abcb-f52217929758/oai","pdf_url":null,"source":{"id":"https://openalex.org/S7407055159","display_name":"Ataturk University - AVESIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W2050910224","https://openalex.org/W2079351077","https://openalex.org/W2102897174","https://openalex.org/W2143463421","https://openalex.org/W2217342753","https://openalex.org/W2317055602","https://openalex.org/W2582200580","https://openalex.org/W2592137976","https://openalex.org/W2811244359","https://openalex.org/W2899871244","https://openalex.org/W3011289764","https://openalex.org/W3016093487","https://openalex.org/W3044674855","https://openalex.org/W3088838661","https://openalex.org/W3107733841","https://openalex.org/W3133992342","https://openalex.org/W3194843554","https://openalex.org/W3213378938","https://openalex.org/W4321378115","https://openalex.org/W4399142763","https://openalex.org/W4410953885","https://openalex.org/W4412763143","https://openalex.org/W4412785201","https://openalex.org/W4414851981"],"related_works":["https://openalex.org/W7164149274","https://openalex.org/W4405334080","https://openalex.org/W4413849048","https://openalex.org/W7220553990","https://openalex.org/W7130516277","https://openalex.org/W3173672258","https://openalex.org/W2740403319","https://openalex.org/W2584917591","https://openalex.org/W1981745506","https://openalex.org/W4280505726"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-08-15T00:00:00"}