{"id":"https://openalex.org/W7203444399","doi":"https://doi.org/10.1158/1078-0432.c.8653773","title":"Data from Dose Escalation with Intensity-Modulated Proton Therapy for Patients with High-Risk Meningiomas \u2013 Results from a Phase I Trial","display_name":"Data from Dose Escalation with Intensity-Modulated Proton Therapy for Patients with High-Risk Meningiomas \u2013 Results from a Phase I Trial","publication_year":2026,"publication_date":"2026-08-14","ids":{"openalex":"https://openalex.org/W7203444399","doi":"https://doi.org/10.1158/1078-0432.c.8653773"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.8653773","doi":"https://doi.org/10.1158/1078-0432.c.8653773","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.8653773","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.c.8653773","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073563490","display_name":"Felix Ehret","orcid":"https://orcid.org/0000-0001-6177-1755","observed_orcids":["https://orcid.org/0000-0001-6177-1755"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Felix Ehret","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6177-1755","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073757407","display_name":"Nora Horick","orcid":"https://orcid.org/0000-0002-4355-5853","observed_orcids":["https://orcid.org/0000-0002-4355-5853"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nora K. Horick","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4355-5853","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114045816","display_name":"Beow Yong Yeap","orcid":"https://orcid.org/0009-0004-6157-5489","observed_orcids":["https://orcid.org/0009-0004-6157-5489"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beow Y. Yeap","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-6157-5489","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056980089","display_name":"William T. Curry","orcid":"https://orcid.org/0000-0002-8036-1847","observed_orcids":["https://orcid.org/0000-0002-8036-1847"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William T. Curry","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8036-1847","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080480694","display_name":"Brian Vala Nahed","orcid":"https://orcid.org/0000-0001-8537-106X","observed_orcids":["https://orcid.org/0000-0001-8537-106X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian Nahed","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8537-106X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006359971","display_name":"Juliane Daartz","orcid":"https://orcid.org/0009-0006-7576-4576","observed_orcids":["https://orcid.org/0009-0006-7576-4576"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juliane Daartz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-7576-4576","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078349984","display_name":"Jason Michael Johnson","orcid":"https://orcid.org/0000-0001-7724-5784","observed_orcids":["https://orcid.org/0000-0001-7724-5784"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason M. Johnson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7724-5784","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062383673","display_name":"Samir A. Dagher","orcid":"https://orcid.org/0000-0003-0155-7444","observed_orcids":["https://orcid.org/0000-0003-0155-7444"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samir A. Dagher","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0155-7444","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072907410","display_name":"Shaan Mohammed Raza","orcid":"https://orcid.org/0000-0003-2722-2781","observed_orcids":["https://orcid.org/0000-0003-2722-2781"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shaan M. Raza","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2722-2781","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081212023","display_name":"Franco DeMonte","orcid":"https://orcid.org/0000-0002-6488-3645","observed_orcids":["https://orcid.org/0000-0002-6488-3645"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Franco DeMonte","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6488-3645","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088198448","display_name":"Debra Nana Yeboa","orcid":"https://orcid.org/0000-0002-2901-7477","observed_orcids":["https://orcid.org/0000-0002-2901-7477"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Debra N. Yeboa","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2901-7477","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111844637","display_name":"Todd Allen Swanson","orcid":"https://orcid.org/0000-0003-3966-3680","observed_orcids":["https://orcid.org/0000-0003-3966-3680"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Todd A. Swanson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3966-3680","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090115592","display_name":"Mary Frances McAleer","orcid":"https://orcid.org/0000-0003-0585-1712","observed_orcids":["https://orcid.org/0000-0003-0585-1712"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary Frances McAleer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0585-1712","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136363747","display_name":"Peggy Leland","orcid":"https://orcid.org/0009-0001-7169-5941","observed_orcids":["https://orcid.org/0009-0001-7169-5941"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peggy Leland","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-7169-5941","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017360357","display_name":"Susan Lynne McGovern","orcid":"https://orcid.org/0000-0002-5286-0649","observed_orcids":["https://orcid.org/0000-0002-5286-0649"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan L. McGovern","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5286-0649","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5045425111","display_name":"Helen Alice Shih","orcid":"https://orcid.org/0000-0003-1550-9726","observed_orcids":["https://orcid.org/0000-0003-1550-9726"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helen A. Shih","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1550-9726","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11251","display_name":"Meningioma and schwannoma management","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11251","display_name":"Meningioma and schwannoma management","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/meningioma","display_name":"meningioma","score":0.8640000224113464},{"id":"https://openalex.org/keywords/intensity-modulated-proton-therapy","display_name":"intensity-modulated proton therapy","score":0.9380000233650208},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.878000020980835},{"id":"https://openalex.org/keywords/high-grade-meningioma","display_name":"high-grade meningioma","score":0.9129999876022339},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.7730000019073486},{"id":"https://openalex.org/keywords/late-toxicity","display_name":"late toxicity","score":0.8349999785423279},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.972000002861023},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9169999957084656},{"id":"https://openalex.org/keywords/residual-disease","display_name":"residual disease","score":0.4869999885559082},{"id":"https://openalex.org/keywords/recurrent-meningioma","display_name":"recurrent meningioma","score":0.8840000033378601}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.907800018787384},{"id":"https://openalex.org/C2779160599","wikidata":"https://www.wikidata.org/wiki/Q369157","display_name":"Meningioma","level":2,"score":0.6830000281333923},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.6269000172615051},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.5388000011444092},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5049999952316284},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5034000277519226},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.48339998722076416},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4578999876976013},{"id":"https://openalex.org/C2780045450","wikidata":"https://www.wikidata.org/wiki/Q16948563","display_name":"Malignant meningioma","level":3,"score":0.38100001215934753},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3734000027179718},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.37119999527931213},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36899998784065247},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.367000013589859},{"id":"https://openalex.org/C2779244869","wikidata":"https://www.wikidata.org/wiki/Q507667","display_name":"Proton therapy","level":3,"score":0.35269999504089355},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.34689998626708984},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.29260000586509705},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.2904999852180481},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.28139999508857727},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.25780001282691956},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.25110000371932983}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.8653773","doi":"https://doi.org/10.1158/1078-0432.c.8653773","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.8653773","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.8653773","doi":"https://doi.org/10.1158/1078-0432.c.8653773","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.8653773","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7161557454","https://openalex.org/W1969266436","https://openalex.org/W2014077233","https://openalex.org/W2066729944","https://openalex.org/W4387206622","https://openalex.org/W4387245362","https://openalex.org/W2043750760","https://openalex.org/W4388588466","https://openalex.org/W2560332746","https://openalex.org/W2163840343"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"Outcomes":[2],"for":[3,36,83,91,217,243],"grade":[4,37,54,65,84,92,121,125,156,170,174,183],"2":[5,38,55,85,122,171,184],"and":[6,26,39,43,88,113,123,130,134,139,145,172,189,196,206,226,231],"3":[7,40,66,93,126,157,175],"meningiomas":[8,127,219],"are":[9,234],"poor.":[10],"A":[11],"few":[12],"studies":[13,233],"suggest":[14],"a":[15,221],"benefit":[16],"from":[17],"radiotherapy":[18],"dose":[19,29,241],"escalation.":[20],"This":[21,45,210],"trial":[22,50,213],"evaluates":[23],"the":[24,238],"safety":[25,224],"efficacy":[27],"of":[28,240],"escalation":[30,242],"with":[31,53,57,64,119,182],"intensity-modulated":[32],"proton":[33],"therapy":[34],"(IMPT)":[35],"meningiomas.":[41,185,245],"Patients":[42,72],"Methods:":[44],"prospective":[46,212],"single-arm":[47],"phase":[48],"I":[49],"enrolled":[51,129],"patients":[52,63,118,181],"meningioma":[56,67],"residual":[58],"disease":[59,87],"or":[60,62],"recurrence":[61],"after":[68],"gross":[69,86],"total":[70],"resection.":[71],"underwent":[73],"dose-escalated":[74,215],"IMPT":[75,216],"to":[76,236],"66":[77],"Gy":[78],"relative":[79],"biological":[80],"effectiveness":[81],"[Gy(RBE)]":[82],"63":[89],"Gy(RBE)":[90],"tumor":[94],"beds.":[95],"The":[96,136,186,199],"primary":[97],"endpoint":[98],"was":[99,151],"acute":[100],"dose-limiting":[101],"toxicity":[102],"(DLT).":[103],"Secondary":[104],"endpoints":[105],"included":[106],"progression-free":[107],"survival":[108,111],"(PFS),":[109],"overall":[110],"(OS),":[112],"late":[114,155],"toxicity.":[115],"Results:":[116],"Twenty-one":[117],"16":[120],"5":[124],"were":[128,143,166,193,203],"treated":[131],"between":[132],"2016":[133],"2023.":[135],"median":[137],"clinical":[138,227],"radiographic":[140],"follow-up":[141],"periods":[142],"3.4":[144],"3.2":[146],"years,":[147],"respectively.":[148,198,208],"No":[149],"DLT":[150],"observed.":[152],"Five":[153],"new":[154],"toxicities":[158],"occurred":[159,179],"in":[160,168,180],"four":[161],"patients.":[162],"Three":[163],"treatment":[164],"failures":[165],"observed":[167],"two":[169],"one":[173],"tumors.":[176],"Two":[177],"deaths":[178],"1-,":[187],"2-,":[188],"3-year":[190],"PFS":[191],"rates":[192,202],"100%,":[194,204],"95%,":[195,205,207],"88.2%,":[197],"corresponding":[200],"OS":[201],"Conclusions:":[209],"first":[211],"investigating":[214],"high-grade":[218,244],"demonstrated":[220],"favorable":[222],"early":[223],"profile":[225],"outcomes.":[228],"Phase":[229],"II":[230],"III":[232],"warranted":[235],"confirm":[237],"superiority":[239]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-08-15T00:00:00"}