{"id":"https://openalex.org/W7203444294","doi":"https://doi.org/10.32604/cju.2026.081481","title":"A multi-omics analysis and clinical relevance of regulated cell death in bladder cancer","display_name":"A multi-omics analysis and clinical relevance of regulated cell death in bladder cancer","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7203444294","doi":"https://doi.org/10.32604/cju.2026.081481"},"language":"en","primary_location":{"id":"doi:10.32604/cju.2026.081481","doi":"https://doi.org/10.32604/cju.2026.081481","is_oa":true,"landing_page_url":"https://doi.org/10.32604/cju.2026.081481","pdf_url":null,"source":{"id":"https://openalex.org/S5406954669","display_name":"Canadian Journal of Urology","issn_l":"1195-9479","issn":["1195-9479","1488-5581"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["anvur-scientific","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4324000061","host_organization_name":"Tech Science Press","host_organization_lineage":["https://openalex.org/P4324000061"],"host_organization_lineage_names":["Tech Science Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.32604/cju.2026.081481","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5147201381","display_name":"Haiwen Zhou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haiwen Zhou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141104454","display_name":"Yan Zhao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147152731","display_name":"Jingxian Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jingxian Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108835093","display_name":"Yuanjiong Qi","orcid":"https://orcid.org/0000-0002-2331-2205","observed_orcids":["https://orcid.org/0000-0002-2331-2205"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuanjiong Qi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147206559","display_name":"Yang Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yang Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147185958","display_name":"Changwen Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Changwen Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147194755","display_name":"Yue Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yue Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014414134","display_name":"Shiyong Qi","orcid":"https://orcid.org/0009-0004-5967-8075","observed_orcids":["https://orcid.org/0009-0004-5967-8075"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shiyong Qi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5147157374","display_name":"Zhihong Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhihong Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"5","first_page":"1227","last_page":"1250"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.5557000041007996,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.5557000041007996,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.3386000096797943,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.07750000059604645,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regulated-cell-death","display_name":"regulated cell death","score":0.8399999737739563},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9359999895095825},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":1.0},{"id":"https://openalex.org/keywords/pyroptosis","display_name":"pyroptosis","score":1.0},{"id":"https://openalex.org/keywords/necroptosis","display_name":"necroptosis","score":1.0},{"id":"https://openalex.org/keywords/autophagic-cell-death","display_name":"autophagic cell death","score":0.9629999995231628},{"id":"https://openalex.org/keywords/multi-omics-integration","display_name":"multi-omics integration","score":0.8240000009536743},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.75},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.6970000267028809},{"id":"https://openalex.org/keywords/timp-1","display_name":"TIMP-1","score":0.7799999713897705},{"id":"https://openalex.org/keywords/immunotherapy-response","display_name":"immunotherapy response","score":0.7870000004768372},{"id":"https://openalex.org/keywords/chemosensitivity","display_name":"chemosensitivity","score":0.9750000238418579},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.7559999823570251},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.7739999890327454},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.36000001430511475}],"concepts":[{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.8585000038146973},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7630000114440918},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5450000166893005},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.5449000000953674},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5113999843597412},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.49880000948905945},{"id":"https://openalex.org/C2780692422","wikidata":"https://www.wikidata.org/wiki/Q18031995","display_name":"TIMP1","level":4,"score":0.482699990272522},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4794999957084656},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.46070000529289246},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.44859999418258667},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4302000105381012},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.4250999987125397},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3610999882221222},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.35510000586509705},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3424000144004822},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33799999952316284},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.334199994802475},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3319999873638153},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.3190999925136566},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.31139999628067017},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.31049999594688416},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.30730000138282776},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3052000105381012},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.30329999327659607},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.27900001406669617},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.27810001373291016},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.274399995803833},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.26829999685287476},{"id":"https://openalex.org/C29374701","wikidata":"https://www.wikidata.org/wiki/Q1931388","display_name":"Cause of death","level":3,"score":0.26750001311302185},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.26579999923706055},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25780001282691956},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2535000145435333},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.2508000135421753}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.32604/cju.2026.081481","doi":"https://doi.org/10.32604/cju.2026.081481","is_oa":true,"landing_page_url":"https://doi.org/10.32604/cju.2026.081481","pdf_url":null,"source":{"id":"https://openalex.org/S5406954669","display_name":"Canadian Journal of Urology","issn_l":"1195-9479","issn":["1195-9479","1488-5581"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["anvur-scientific","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4324000061","host_organization_name":"Tech Science Press","host_organization_lineage":["https://openalex.org/P4324000061"],"host_organization_lineage_names":["Tech Science Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Urology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.32604/cju.2026.081481","doi":"https://doi.org/10.32604/cju.2026.081481","is_oa":true,"landing_page_url":"https://doi.org/10.32604/cju.2026.081481","pdf_url":null,"source":{"id":"https://openalex.org/S5406954669","display_name":"Canadian Journal of Urology","issn_l":"1195-9479","issn":["1195-9479","1488-5581"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["anvur-scientific","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4324000061","host_organization_name":"Tech Science Press","host_organization_lineage":["https://openalex.org/P4324000061"],"host_organization_lineage_names":["Tech Science Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Urology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4308843647","https://openalex.org/W4308896221","https://openalex.org/W4285010811","https://openalex.org/W4389476633","https://openalex.org/W7148354989","https://openalex.org/W4399721573","https://openalex.org/W4409688908","https://openalex.org/W4293717122","https://openalex.org/W4309699536","https://openalex.org/W4399057056"],"abstract_inverted_index":{"Background:":[0],"Regulated":[1],"cell":[2,61,87,123,289],"death":[3,62,290],"(RCD)":[4,63],"is":[5],"critical":[6],"for":[7,162,277],"tumor":[8,101,249],"progression":[9],"and":[10,32,55,77,85,97,104,136,152,187,226,235,269,281],"treatment":[11,279],"response,":[12],"but":[13],"its":[14,245],"integrated":[15,56],"role":[16],"in":[17,39,120,292],"bladder":[18,40,45,121,238,263,293],"cancer":[19,46,122,156,239,264],"remains":[20],"unclear.":[21],"This":[22],"study":[23],"aimed":[24],"to":[25,50,93,206],"systematically":[26,108],"characterize":[27,51],"the":[28,52,218,227,233,253,283],"cross-talk,":[29],"multi-omics":[30],"alterations,":[31],"clinical":[33],"relevance":[34],"of":[35,58,68,229,237,286],"major":[36,59],"RCD":[37,139,170,191,202],"pathways":[38,291],"cancer.":[41,294],"Methods:":[42],"Publicly":[43],"available":[44],"cohorts":[47],"were":[48,90,107,165,215],"analyzed":[49],"expression":[53,141],"patterns":[54],"regulation":[57],"regulated":[60,288],"programs.":[64],"A":[65],"curated":[66],"set":[67],"862":[69],"RCD-related":[70,94,129,254],"genes":[71,130],"was":[72,114,131,142,194,223],"compiled":[73],"from":[74,252],"public":[75],"databases":[76],"published":[78],"literature,":[79],"encompassing":[80],"apoptosis,":[81],"ferroptosis,":[82],"pyroptosis,":[83],"necroptosis,":[84],"autophagy-dependent":[86],"death.":[88],"Patients":[89],"stratified":[91,166],"according":[92],"transcriptional":[95,137],"profiles,":[96],"associations":[98],"with":[99,197,247,267],"prognosis,":[100],"immune":[102,181],"features,":[103],"therapeutic":[105,270],"sensitivity":[106,189],"evaluated.":[109],"Selected":[110],"RCD-associated":[111],"hub":[112,220],"gene":[113,140,210],"further":[115],"examined":[116],"through":[117],"functional":[118],"experiments":[119],"lines.":[124],"Results:":[125],"Extensive":[126],"cross-talk":[127],"among":[128],"observed":[132],"across":[133],"genomic,":[134],"epigenetic,":[135],"levels.":[138],"influenced":[143],"by":[144],"somatic":[145],"mutation,":[146],"copy":[147],"number":[148],"alteration,":[149],"DNA":[150],"methylation,":[151],"RNA":[153],"modification.":[154],"Bladder":[155],"patients":[157],"(TCGA-BLCA,":[158],"n":[159],"=":[160],"402":[161],"survival":[163,175],"analysis)":[164],"into":[167],"two":[168],"distinct":[169,262],"clusters":[171],"demonstrating":[172],"significantly":[173,231],"different":[174],"outcomes":[176],"(log-rank":[177],"p":[178],"<":[179,242],"0.05),":[180,243],"pathway":[182],"enrichment,":[183],"predicted":[184],"immunotherapy":[185],"responsiveness,":[186],"chemotherapy":[188],"profiles.":[190],"cluster":[192,203,213],"1":[193],"predominantly":[195],"associated":[196,266],"basal/squamous":[198],"molecular":[199,258],"subtypes,":[200],"whereas":[201],"2":[204],"corresponded":[205],"luminal":[207],"subtypes.":[208],"Prognostic":[209],"modules":[211],"underlying":[212],"heterogeneity":[214],"identified.":[216],"Among":[217],"identified":[219,251],"genes,":[221],"TIMP1":[222,230],"functionally":[224],"validated,":[225],"silencing":[228],"inhibited":[232],"proliferation":[234],"migration":[236],"cells":[240],"(p":[241],"supporting":[244],"association":[246],"aggressive":[248],"phenotypes":[250],"network.":[255],"Conclusions:":[256],"RCD-based":[257],"stratification":[259],"defines":[260],"clinically":[261],"subtypes":[265],"prognosis":[268],"response.":[271],"These":[272],"findings":[273],"provide":[274],"a":[275],"framework":[276],"personalized":[278],"strategies":[280],"support":[282],"translational":[284],"potential":[285],"targeting":[287]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-08-15T00:00:00"}
