{"id":"https://openalex.org/W7203439864","doi":"https://doi.org/10.1093/ehjopen/oeag123","title":"Circulating anti-Ro/Sj\u00f6gren\u2019s syndrome-related antigen A antibodies and risk of heart rate-corrected QT interval prolongation: a meta-analysis","display_name":"Circulating anti-Ro/Sj\u00f6gren\u2019s syndrome-related antigen A antibodies and risk of heart rate-corrected QT interval prolongation: a meta-analysis","publication_year":2026,"publication_date":"2026-08-14","ids":{"openalex":"https://openalex.org/W7203439864","doi":"https://doi.org/10.1093/ehjopen/oeag123","pmid":"https://pubmed.ncbi.nlm.nih.gov/42877758","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13663800"},"language":"en","primary_location":{"id":"doi:10.1093/ehjopen/oeag123","doi":"https://doi.org/10.1093/ehjopen/oeag123","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ehjopen/oeag123","pdf_url":"https://academic.oup.com/ehjopen/advance-article-pdf/doi/10.1093/ehjopen/oeag123/70649695/oeag123.pdf","source":{"id":"https://openalex.org/S4210237792","display_name":"European Heart Journal Open","issn_l":"2752-4191","issn":["2752-4191"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal Open","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/ehjopen/advance-article-pdf/doi/10.1093/ehjopen/oeag123/70649695/oeag123.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046408327","display_name":"Pietro Enea Lazzerini","orcid":"https://orcid.org/0000-0001-6721-1214","observed_orcids":["https://orcid.org/0000-0001-6721-1214"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Pietro Enea Lazzerini","raw_affiliation_strings":["Department of Medical Sciences, Surgery and Neurosciences, University of Siena , Viale Bracci 14, Siena 53100 ,","Division of Internal Medicine and Geriatrics, Electroimmunology Unit, University of Siena , Viale Bracci 14, Siena 53100 ,"],"raw_orcid":"https://orcid.org/0000-0001-6721-1214","affiliations":[{"raw_affiliation_string":"Department of Medical Sciences, Surgery and Neurosciences, University of Siena , Viale Bracci 14, Siena 53100 ,","institution_ids":["https://openalex.org/I102064193"]},{"raw_affiliation_string":"Division of Internal Medicine and Geriatrics, Electroimmunology Unit, University of Siena , Viale Bracci 14, Siena 53100 ,","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026945619","display_name":"Mark M. Melamud","orcid":"https://orcid.org/0000-0003-4276-4597","observed_orcids":["https://orcid.org/0000-0003-4276-4597"]},"institutions":[{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Mark Markovich Melamud","raw_affiliation_strings":["Laboratory of Repair Enzymes, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences , 8 Lavrentyev Avenue, Novosibirsk 630090 ,"],"raw_orcid":"https://orcid.org/0000-0003-4276-4597","affiliations":[{"raw_affiliation_string":"Laboratory of Repair Enzymes, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences , 8 Lavrentyev Avenue, Novosibirsk 630090 ,","institution_ids":["https://openalex.org/I4210091979","https://openalex.org/I4210127387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024586103","display_name":"Evgeny A. Ermakov","orcid":"https://orcid.org/0000-0002-1084-6419","observed_orcids":["https://orcid.org/0000-0002-1084-6419"]},"institutions":[{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]},{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Evgeny Alexandrovich Ermakov","raw_affiliation_strings":["Department of Natural Sciences, Novosibirsk State University , 2 Pirogova Street, Novosibirsk 630090 ,","Laboratory of Repair Enzymes, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences , 8 Lavrentyev Avenue, Novosibirsk 630090 ,"],"raw_orcid":"https://orcid.org/0000-0002-1084-6419","affiliations":[{"raw_affiliation_string":"Department of Natural Sciences, Novosibirsk State University , 2 Pirogova Street, Novosibirsk 630090 ,","institution_ids":["https://openalex.org/I188973947"]},{"raw_affiliation_string":"Laboratory of Repair Enzymes, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences , 8 Lavrentyev Avenue, Novosibirsk 630090 ,","institution_ids":["https://openalex.org/I4210091979","https://openalex.org/I4210127387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104171361","display_name":"Vadim V. Kon\u2019kov","orcid":"https://orcid.org/0009-0001-1532-0985","observed_orcids":["https://orcid.org/0009-0001-1532-0985"]},"institutions":[{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Vadim Vyacheslavovich Konkov","raw_affiliation_strings":["Laboratory of Repair Enzymes, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences , 8 Lavrentyev Avenue, Novosibirsk 630090 ,"],"raw_orcid":"https://orcid.org/0009-0001-1532-0985","affiliations":[{"raw_affiliation_string":"Laboratory of Repair Enzymes, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences , 8 Lavrentyev Avenue, Novosibirsk 630090 ,","institution_ids":["https://openalex.org/I4210091979","https://openalex.org/I4210127387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087864126","display_name":"Valentina N. Buneva","orcid":"https://orcid.org/0000-0003-2556-979X","observed_orcids":["https://orcid.org/0000-0003-2556-979X"]},"institutions":[{"id":"https://openalex.org/I188973947","display_name":"Novosibirsk State University","ror":"https://ror.org/04t2ss102","country_code":"RU","type":"education","lineage":["https://openalex.org/I188973947"]},{"id":"https://openalex.org/I4210091979","display_name":"Institute of Chemical Biology and Fundamental Medicine","ror":"https://ror.org/00gmz2d02","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210091979","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Valentina Nikolaevna Buneva","raw_affiliation_strings":["Department of Natural Sciences, Novosibirsk State University , 2 Pirogova Street, Novosibirsk 630090 ,","Laboratory of Repair Enzymes, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences , 8 Lavrentyev Avenue, Novosibirsk 630090 ,"],"raw_orcid":"https://orcid.org/0000-0003-2556-979X","affiliations":[{"raw_affiliation_string":"Department of Natural Sciences, Novosibirsk State University , 2 Pirogova Street, Novosibirsk 630090 ,","institution_ids":["https://openalex.org/I188973947"]},{"raw_affiliation_string":"Laboratory of Repair Enzymes, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences , 8 Lavrentyev Avenue, Novosibirsk 630090 ,","institution_ids":["https://openalex.org/I4210091979","https://openalex.org/I4210127387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024390974","display_name":"Riccardo Accioli","orcid":"https://orcid.org/0000-0003-1983-4040","observed_orcids":["https://orcid.org/0000-0003-1983-4040"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Riccardo Accioli","raw_affiliation_strings":["Department of Medical Sciences, Surgery and Neurosciences, University of Siena , Viale Bracci 14, Siena 53100 ,","Division of Internal Medicine and Geriatrics, Electroimmunology Unit, University of Siena , Viale Bracci 14, Siena 53100 ,"],"raw_orcid":"https://orcid.org/0000-0003-1983-4040","affiliations":[{"raw_affiliation_string":"Department of Medical Sciences, Surgery and Neurosciences, University of Siena , Viale Bracci 14, Siena 53100 ,","institution_ids":["https://openalex.org/I102064193"]},{"raw_affiliation_string":"Division of Internal Medicine and Geriatrics, Electroimmunology Unit, University of Siena , Viale Bracci 14, Siena 53100 ,","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057041539","display_name":"Alessandra Cartocci","orcid":"https://orcid.org/0000-0002-1818-6275","observed_orcids":["https://orcid.org/0000-0002-1818-6275"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandra Cartocci","raw_affiliation_strings":["Division of Internal Medicine and Geriatrics, Electroimmunology Unit, University of Siena , Viale Bracci 14, Siena 53100 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Internal Medicine and Geriatrics, Electroimmunology Unit, University of Siena , Viale Bracci 14, Siena 53100 ,","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086483114","display_name":"Anna Cantore","orcid":"https://orcid.org/0009-0004-6890-3502","observed_orcids":["https://orcid.org/0009-0004-6890-3502"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Cantore","raw_affiliation_strings":["Division of Internal Medicine and Geriatrics, Electroimmunology Unit, University of Siena , Viale Bracci 14, Siena 53100 ,"],"raw_orcid":"https://orcid.org/0009-0004-6890-3502","affiliations":[{"raw_affiliation_string":"Division of Internal Medicine and Geriatrics, Electroimmunology Unit, University of Siena , Viale Bracci 14, Siena 53100 ,","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020346135","display_name":"Viola Salvini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Viola Salvini","raw_affiliation_strings":["Department of Medical Sciences, Surgery and Neurosciences, University of Siena , Viale Bracci 14, Siena 53100 ,","Division of Internal Medicine and Geriatrics, Electroimmunology Unit, University of Siena , Viale Bracci 14, Siena 53100 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Sciences, Surgery and Neurosciences, University of Siena , Viale Bracci 14, Siena 53100 ,","institution_ids":["https://openalex.org/I102064193"]},{"raw_affiliation_string":"Division of Internal Medicine and Geriatrics, Electroimmunology Unit, University of Siena , Viale Bracci 14, Siena 53100 ,","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004581451","display_name":"Decoroso Verrengia","orcid":"https://orcid.org/0000-0002-8227-6339","observed_orcids":["https://orcid.org/0000-0002-8227-6339"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Decoroso Verrengia","raw_affiliation_strings":["Department of Medical Sciences, Surgery and Neurosciences, University of Siena , Viale Bracci 14, Siena 53100 ,","Division of Internal Medicine and Geriatrics, Electroimmunology Unit, University of Siena , Viale Bracci 14, Siena 53100 ,"],"raw_orcid":"https://orcid.org/0000-0002-8227-6339","affiliations":[{"raw_affiliation_string":"Department of Medical Sciences, Surgery and Neurosciences, University of Siena , Viale Bracci 14, Siena 53100 ,","institution_ids":["https://openalex.org/I102064193"]},{"raw_affiliation_string":"Division of Internal Medicine and Geriatrics, Electroimmunology Unit, University of Siena , Viale Bracci 14, Siena 53100 ,","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091365787","display_name":"Maurizio Acampa","orcid":"https://orcid.org/0000-0003-4149-1785","observed_orcids":["https://orcid.org/0000-0003-4149-1785"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maurizio Acampa","raw_affiliation_strings":["Department of Medical Sciences, Surgery and Neurosciences, University of Siena , Viale Bracci 14, Siena 53100 ,","Division of Internal Medicine and Geriatrics, Electroimmunology Unit, University of Siena , Viale Bracci 14, Siena 53100 ,"],"raw_orcid":"https://orcid.org/0000-0003-4149-1785","affiliations":[{"raw_affiliation_string":"Department of Medical Sciences, Surgery and Neurosciences, University of Siena , Viale Bracci 14, Siena 53100 ,","institution_ids":["https://openalex.org/I102064193"]},{"raw_affiliation_string":"Division of Internal Medicine and Geriatrics, Electroimmunology Unit, University of Siena , Viale Bracci 14, Siena 53100 ,","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027061253","display_name":"Pier Leopoldo Capecchi","orcid":"https://orcid.org/0000-0001-7021-7764","observed_orcids":["https://orcid.org/0000-0001-7021-7764"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pier Leopoldo Capecchi","raw_affiliation_strings":["Department of Medical Sciences, Surgery and Neurosciences, University of Siena , Viale Bracci 14, Siena 53100 ,","Division of Internal Medicine and Geriatrics, Electroimmunology Unit, University of Siena , Viale Bracci 14, Siena 53100 ,"],"raw_orcid":"https://orcid.org/0000-0001-7021-7764","affiliations":[{"raw_affiliation_string":"Department of Medical Sciences, Surgery and Neurosciences, University of Siena , Viale Bracci 14, Siena 53100 ,","institution_ids":["https://openalex.org/I102064193"]},{"raw_affiliation_string":"Division of Internal Medicine and Geriatrics, Electroimmunology Unit, University of Siena , Viale Bracci 14, Siena 53100 ,","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020010287","display_name":"Mohamed Boutjdir","orcid":"https://orcid.org/0000-0002-6068-223X","observed_orcids":["https://orcid.org/0000-0002-6068-223X"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]},{"id":"https://openalex.org/I2800015068","display_name":"VA NY Harbor Healthcare System","ror":"https://ror.org/03s5r4e84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2800015068","https://openalex.org/I4210094901"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamed Boutjdir","raw_affiliation_strings":["Department of Medicine, Cell Biology and Pharmacology, Cardiovascular Research Program, VA New York Harbor Healthcare System, SUNY Downstate Health Sciences University , 445 Lenox Rd, Brooklyn, New York, NY 11203 ,","Department of Medicine, New York University Grossman School of Medicine , 550 First Avenue, New York, NY 10016 ,"],"raw_orcid":"https://orcid.org/0000-0002-6068-223X","affiliations":[{"raw_affiliation_string":"Department of Medicine, Cell Biology and Pharmacology, Cardiovascular Research Program, VA New York Harbor Healthcare System, SUNY Downstate Health Sciences University , 445 Lenox Rd, Brooklyn, New York, NY 11203 ,","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535","https://openalex.org/I2800015068"]},{"raw_affiliation_string":"Department of Medicine, New York University Grossman School of Medicine , 550 First Avenue, New York, NY 10016 ,","institution_ids":["https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5046408327","https://openalex.org/A5087864126"],"corresponding_institution_ids":["https://openalex.org/I102064193","https://openalex.org/I188973947","https://openalex.org/I4210091979","https://openalex.org/I4210127387"],"apc_list":{"value":2365,"currency":"EUR","value_usd":2673},"apc_paid":{"value":2365,"currency":"EUR","value_usd":2673},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"5","first_page":"oeag123","last_page":"oeag123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.7465999722480774,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.7465999722480774,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.22529999911785126,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-ssa-antibodies","display_name":"anti-SSA antibodies","score":0.9750000238418579},{"id":"https://openalex.org/keywords/qtc-prolongation","display_name":"QTc prolongation","score":0.7839999794960022},{"id":"https://openalex.org/keywords/herg-channel","display_name":"hERG","score":0.7509999871253967},{"id":"https://openalex.org/keywords/connective-tissue-diseases","display_name":"connective tissue diseases","score":0.7910000085830688},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.6629999876022339},{"id":"https://openalex.org/keywords/arrhythmia-risk","display_name":"arrhythmia risk","score":0.6809999942779541},{"id":"https://openalex.org/keywords/sjogren-s-syndrome","display_name":"Sj\u00f6gren's syndrome","score":0.6809999942779541},{"id":"https://openalex.org/keywords/risk-of-bias-assessment","display_name":"risk of bias assessment","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.8482999801635742},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8228999972343445},{"id":"https://openalex.org/C70437156","wikidata":"https://www.wikidata.org/wiki/Q7228652","display_name":"Pooling","level":2,"score":0.6007000207901001},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5828999876976013},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5065000057220459},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.439300000667572},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.39480000734329224},{"id":"https://openalex.org/C143095724","wikidata":"https://www.wikidata.org/wiki/Q515895","display_name":"Odds","level":3,"score":0.3287999927997589},{"id":"https://openalex.org/C2780040984","wikidata":"https://www.wikidata.org/wiki/Q79785","display_name":"Electrocardiography","level":2,"score":0.3125},{"id":"https://openalex.org/C2779703243","wikidata":"https://www.wikidata.org/wiki/Q653924","display_name":"Long QT syndrome","level":3,"score":0.30820000171661377},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.27649998664855957},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.2720000147819519},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.26159998774528503}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/ehjopen/oeag123","doi":"https://doi.org/10.1093/ehjopen/oeag123","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ehjopen/oeag123","pdf_url":"https://academic.oup.com/ehjopen/advance-article-pdf/doi/10.1093/ehjopen/oeag123/70649695/oeag123.pdf","source":{"id":"https://openalex.org/S4210237792","display_name":"European Heart Journal Open","issn_l":"2752-4191","issn":["2752-4191"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal Open","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13663800","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13663800/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13663800/pdf/oeag123.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eur Heart J Open","raw_type":"Text"},{"id":"pmid:42877758","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42877758","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European heart journal open","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/ehjopen/oeag123","doi":"https://doi.org/10.1093/ehjopen/oeag123","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ehjopen/oeag123","pdf_url":"https://academic.oup.com/ehjopen/advance-article-pdf/doi/10.1093/ehjopen/oeag123/70649695/oeag123.pdf","source":{"id":"https://openalex.org/S4210237792","display_name":"European Heart Journal Open","issn_l":"2752-4191","issn":["2752-4191"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal Open","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[{"id":"https://openalex.org/G1414145070","display_name":null,"funder_award_id":"23-15-00357","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203439864.pdf","grobid_xml":"https://content.openalex.org/works/W7203439864.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W187712674","https://openalex.org/W1551914071","https://openalex.org/W1689549856","https://openalex.org/W1900818882","https://openalex.org/W1967812114","https://openalex.org/W1969000674","https://openalex.org/W1990672635","https://openalex.org/W1991374767","https://openalex.org/W1993300848","https://openalex.org/W2000802347","https://openalex.org/W2012552020","https://openalex.org/W2014425110","https://openalex.org/W2017358970","https://openalex.org/W2018083990","https://openalex.org/W2021970728","https://openalex.org/W2031857913","https://openalex.org/W2039727359","https://openalex.org/W2047427653","https://openalex.org/W2070188059","https://openalex.org/W2082072065","https://openalex.org/W2146342800","https://openalex.org/W2147412391","https://openalex.org/W2155848427","https://openalex.org/W2158477733","https://openalex.org/W2167148868","https://openalex.org/W2168718800","https://openalex.org/W2170075216","https://openalex.org/W2323222227","https://openalex.org/W2399988715","https://openalex.org/W2416854062","https://openalex.org/W2582004300","https://openalex.org/W2610341885","https://openalex.org/W2810227481","https://openalex.org/W2991270061","https://openalex.org/W3001584416","https://openalex.org/W3119518127","https://openalex.org/W3127449994","https://openalex.org/W3176638948","https://openalex.org/W4296795920","https://openalex.org/W4307229368","https://openalex.org/W4383550757","https://openalex.org/W4396928127","https://openalex.org/W4399167831","https://openalex.org/W4399741167","https://openalex.org/W4408224444","https://openalex.org/W4410220451","https://openalex.org/W4413768807"],"related_works":["https://openalex.org/W3127449994","https://openalex.org/W2017358970","https://openalex.org/W1967812114","https://openalex.org/W2158477733","https://openalex.org/W2043455330","https://openalex.org/W1990672635","https://openalex.org/W2215849455","https://openalex.org/W2156539947","https://openalex.org/W2324623567","https://openalex.org/W4297317389"],"abstract_inverted_index":{"Abstract":[0],"Aims":[1],"Accumulating":[2],"evidence":[3],"indicates":[4],"that":[5,246,267],"anti-Ro/Sj\u00f6gren\u2019s":[6],"syndrome-related":[7],"antigen":[8],"A":[9,62],"(SSA)":[10],"antibodies,":[11],"specifically":[12],"the":[13,26,30,36,48,224,230,244,260,277,291],"anti-Ro/SSA-52kD":[14],"subtype,":[15],"can":[16],"promote":[17],"heart":[18],"rate-corrected":[19],"QT":[20],"interval":[21],"(QTc)":[22],"prolongation":[23,141,179,196],"by":[24],"inhibiting":[25],"hERG-K+":[27],"channel.":[28],"However,":[29,259],"numerous":[31],"clinical":[32,68,297],"studies":[33,69,106,265],"published":[34],"over":[35],"past":[37],"two":[38,135],"decades":[39],"yielded":[40],"conflicting":[41,264],"results.":[42],"This":[43,241],"meta-analysis":[44,242],"aims":[45],"at":[46],"pooling":[47,109],"available":[49],"data":[50],"to":[51,229,288],"provide":[52],"clarity":[53],"on":[54],"this":[55],"clinically":[56],"relevant":[57],"issue.":[58],"Methods":[59],"and":[60,81,101,112,131,152,177,293],"results":[61],"systematic":[63],"review":[64],"was":[65,95],"performed":[66],"for":[67,256],"comparing":[70],"QTc":[71,123,140,165,178,195,225,257],"in":[72,157,191,201,210,221,296],"anti-Ro/SSA-positive":[73,111,158],"vs.":[74],"-negative":[75],"subjects.":[76,115],"Standardized":[77],"mean":[78],"differences":[79],"(SMDs)":[80],"odds":[82],"ratios":[83],"(ORs)":[84],"were":[85,107],"compared":[86,228],"using":[87,97],"random":[88],"effects":[89],"models.":[90],"The":[91],"risk":[92,138,254],"of":[93,139,262,272,279],"bias":[94],"assessed":[96],"RoBANS2,":[98],"Egger's":[99],"test":[100],"contour-enhanced":[102],"funnel":[103],"plots.":[104],"Twenty-five":[105],"included,":[108],"2122":[110],"8865":[113],"anti-Ro/SSA-negative":[114],"Overall,":[116],"anti-Ro/SSA-positivity":[117],"is":[118,197,226],"associated":[119],"with":[120,160,206],"a":[121,132,252,268],"longer":[122,227],"[SMD":[124,170,233],"=":[125,143,171,175,184,214,218,234,238],"0.36":[126],"(0.18\u20130.53),":[127],"P":[128,146,174,187,217,237],"<":[129,147,188],"0.001],":[130],"more":[133,181,199,269],"than":[134,190,209],"times":[136],"higher":[137,169],"[OR":[142,183,213],"2.24":[144],"(1.54\u20133.27),":[145],"0.001].":[148],"Several":[149],"sub-analyses":[150],"supported":[151],"refined":[153],"these":[154],"findings.":[155],"Specifically,":[156],"patients":[159,205],"unselected":[161],"connective":[162],"tissue":[163],"disease,":[164],"absolute":[166],"values":[167],"are":[168],"0.56":[172],"(0.20\u20130.93),":[173],"0.0026]":[176],"occurs":[180],"frequently":[182],"6.99":[185],"(2.35\u201320.75),":[186],"0.001]":[189],"negative":[192,231],"patients;":[193],"furthermore,":[194],"also":[198],"common":[200],"systemic":[202],"lupus":[203],"erythematosus":[204],"circulating":[207,247],"anti-Ro/SSA-antibodies":[208,248],"those":[211],"without":[212],"1.86":[215],"(1.19\u20132.90),":[216],"0.006].":[219],"Finally,":[220],"anti-Ro/SSA-52kD-positive":[222],"subjects,":[223],"ones":[232],"0.43":[235],"(0.15\u20130.71),":[236],"0.002].":[239],"Conclusion":[240],"supports":[243],"conclusion":[245],"per":[249],"se":[250],"represents":[251],"significant":[253],"factor":[255],"prolongation.":[258],"presence":[261],"several":[263],"suggests":[266],"accurate":[270],"investigation":[271],"specific":[273],"factors,":[274],"such":[275],"as":[276],"impact":[278],"individual":[280],"antibody":[281],"subtype":[282],"levels":[283],"(anti-52kD/anti-60kD),":[284],"will":[285],"be":[286],"critical":[287],"fully":[289],"clarify":[290],"topic":[292],"its":[294],"implications":[295],"practice.":[298]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-08-15T00:00:00"}