{"id":"https://openalex.org/W7203439846","doi":"https://doi.org/10.1177/10732748261480330","title":"Prognostic Impact of Combined Oral Contraceptive Use Among Ovarian Cancer Patients in Addis Ababa, Ethiopia: A Cohort Study","display_name":"Prognostic Impact of Combined Oral Contraceptive Use Among Ovarian Cancer Patients in Addis Ababa, Ethiopia: A Cohort Study","publication_year":2026,"publication_date":"2026-06-01","ids":{"openalex":"https://openalex.org/W7203439846","doi":"https://doi.org/10.1177/10732748261480330","pmid":"https://pubmed.ncbi.nlm.nih.gov/42600139","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13477535"},"language":"en","primary_location":{"id":"doi:10.1177/10732748261480330","doi":"https://doi.org/10.1177/10732748261480330","is_oa":true,"landing_page_url":"https://doi.org/10.1177/10732748261480330","pdf_url":null,"source":{"id":"https://openalex.org/S2491417253","display_name":"Cancer Control","issn_l":"1073-2748","issn":["1073-2748","1526-2359"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Control","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1177/10732748261480330","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5096644648","display_name":"Abrham Tesfaye Habteyes","orcid":"https://orcid.org/0009-0007-2911-748X","observed_orcids":["https://orcid.org/0009-0007-2911-748X"]},"institutions":[{"id":"https://openalex.org/I4210147662","display_name":"Ethiopian Defence University","ror":"https://ror.org/04v3p2s41","country_code":"ET","type":"education","lineage":["https://openalex.org/I4210147662"]}],"countries":["ET"],"is_corresponding":true,"raw_author_name":"Abrham Tesfaye Habteyes","raw_affiliation_strings":["Ethiopian Defence University"],"raw_orcid":"https://orcid.org/0009-0007-2911-748X","affiliations":[{"raw_affiliation_string":"Ethiopian Defence University","institution_ids":["https://openalex.org/I4210147662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125529679","display_name":"Fekadeselassie Teferi Mekonen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4537092","display_name":"Addis Ababa University","ror":"https://ror.org/038b8e254","country_code":"ET","type":"education","lineage":["https://openalex.org/I4537092"]}],"countries":["ET"],"is_corresponding":false,"raw_author_name":"Fekadeselassie Teferi Mekonen","raw_affiliation_strings":["Addis Ababa University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Addis Ababa University","institution_ids":["https://openalex.org/I4537092"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084905438","display_name":"Temesgen Ashagrie Haile","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141281","display_name":"Addis Ababa City Administration Health Bureau","ror":"https://ror.org/04zt8qr11","country_code":"ET","type":"government","lineage":["https://openalex.org/I4210141281"]}],"countries":["ET"],"is_corresponding":false,"raw_author_name":"Temesgen Ashagrie Haile","raw_affiliation_strings":["City Administration of Addis Ababa Health Bureau"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City Administration of Addis Ababa Health Bureau","institution_ids":["https://openalex.org/I4210141281"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5096644648"],"corresponding_institution_ids":["https://openalex.org/I4210147662"],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":{"value":2650,"currency":"USD","value_usd":2650},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":null,"first_page":"10732748261480330","last_page":"10732748261480330"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9210000038146973},{"id":"https://openalex.org/keywords/combined-oral-contraceptives","display_name":"combined oral contraceptives","score":0.9440000057220459},{"id":"https://openalex.org/keywords/ovarian-cancer-survival","display_name":"ovarian cancer survival","score":0.652999997138977},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.699999988079071},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7739999890327454},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.6129999756813049},{"id":"https://openalex.org/keywords/addis-ababa","display_name":"Addis Ababa","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9699000120162964},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.7350999712944031},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5885999798774719},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.5830000042915344},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5702999830245972},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5685999989509583},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.5529999732971191},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5019000172615051},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.48410001397132874},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4602999985218048},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4348999857902527},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.40459999442100525},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.40059998631477356},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.397599995136261},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.38769999146461487},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37929999828338623},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.34599998593330383},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.3086000084877014},{"id":"https://openalex.org/C2778515176","wikidata":"https://www.wikidata.org/wiki/Q1209744","display_name":"Uterine cancer","level":3,"score":0.2799000144004822},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.27469998598098755},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.25999999046325684}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003277","descriptor_name":"Contraceptives, Oral, Combined","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005002","descriptor_name":"Ethiopia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1177/10732748261480330","doi":"https://doi.org/10.1177/10732748261480330","is_oa":true,"landing_page_url":"https://doi.org/10.1177/10732748261480330","pdf_url":null,"source":{"id":"https://openalex.org/S2491417253","display_name":"Cancer Control","issn_l":"1073-2748","issn":["1073-2748","1526-2359"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Control","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13477535","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13477535/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13477535/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Control","raw_type":"Text"},{"id":"pmid:42600139","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42600139","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer control : journal of the Moffitt Cancer Center","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:94e87ac3afd74fffb6dc8c5136a4cfb2","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/94e87ac3afd74fffb6dc8c5136a4cfb2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Control, Vol 33 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1177/10732748261480330","doi":"https://doi.org/10.1177/10732748261480330","is_oa":true,"landing_page_url":"https://doi.org/10.1177/10732748261480330","pdf_url":null,"source":{"id":"https://openalex.org/S2491417253","display_name":"Cancer Control","issn_l":"1073-2748","issn":["1073-2748","1526-2359"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Control","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203439846.pdf","grobid_xml":"https://content.openalex.org/works/W7203439846.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W89513426","https://openalex.org/W1493538532","https://openalex.org/W1521030336","https://openalex.org/W1970131324","https://openalex.org/W1981989535","https://openalex.org/W1993578102","https://openalex.org/W1999754181","https://openalex.org/W2010948558","https://openalex.org/W2029678906","https://openalex.org/W2039223647","https://openalex.org/W2047119337","https://openalex.org/W2051069212","https://openalex.org/W2070137667","https://openalex.org/W2077843062","https://openalex.org/W2085734263","https://openalex.org/W2126560499","https://openalex.org/W2137678033","https://openalex.org/W2137849078","https://openalex.org/W2138154261","https://openalex.org/W2138979636","https://openalex.org/W2148084356","https://openalex.org/W2148976855","https://openalex.org/W2154466955","https://openalex.org/W2171385762","https://openalex.org/W2275737843","https://openalex.org/W2333245858","https://openalex.org/W2341999292","https://openalex.org/W2346630997","https://openalex.org/W2382112263","https://openalex.org/W2421251813","https://openalex.org/W2438866487","https://openalex.org/W2489402803","https://openalex.org/W2593625946","https://openalex.org/W2594404528","https://openalex.org/W2886210251","https://openalex.org/W2889646458","https://openalex.org/W2937531659","https://openalex.org/W2996665999","https://openalex.org/W3012747399","https://openalex.org/W3089775333","https://openalex.org/W3128646645","https://openalex.org/W3128847906","https://openalex.org/W4211177900","https://openalex.org/W4307178999","https://openalex.org/W4311611319","https://openalex.org/W4312066566","https://openalex.org/W4319294355","https://openalex.org/W4381046780","https://openalex.org/W4386645647","https://openalex.org/W4390699842","https://openalex.org/W4412528048"],"related_works":["https://openalex.org/W2148084356","https://openalex.org/W2421251813","https://openalex.org/W2023008991","https://openalex.org/W2034114064","https://openalex.org/W2955445824","https://openalex.org/W2043200608","https://openalex.org/W7095977182","https://openalex.org/W7097889939","https://openalex.org/W2110370996","https://openalex.org/W1493538532"],"abstract_inverted_index":{"IntroductionGlobally,":[0],"ovarian":[1,29,50,64,85,132,153,255],"cancer":[2,30,65,86,133,154],"is":[3,31,35],"the":[4,25,38,58,99,206,239,278],"third":[5],"most":[6],"common":[7],"gynecological":[8],"malignancy,":[9],"following":[10,130],"cervical":[11],"and":[12,92,98,276],"uterine":[13],"cancers.":[14],"The":[15,110,121,179,200],"protective":[16],"effect":[17,122],"of":[18,27,42,60,83,114,123,146,225,262],"combined":[19],"oral":[20],"contraceptive":[21],"(COC)":[22],"use":[23,44,62,125,159,218,244],"against":[24],"development":[26],"primary":[28],"well-established.":[32],"However,":[33],"little":[34],"known":[36],"about":[37],"potential":[39,214],"prognostic":[40,265],"benefit":[41],"COC":[43,61,90,124,158,187,217,243],"among":[45,80,152,177,186,194,251],"patients":[46,155],"already":[47],"diagnosed":[48,253],"with":[49,142,156,169,221,228,247,254],"cancer.":[51,256],"Therefore,":[52],"this":[53],"study":[54,77],"aimed":[55],"to":[56,104,128,272],"evaluate":[57],"association":[59],"on":[63,126],"survival":[66,96,182,203,250],"in":[67,70,107],"oncology":[68],"centers":[69],"Addis":[71],"Ababa,":[72],"Ethiopia.MethodsA":[73],"hospital-based,":[74],"retrospective":[75],"cohort":[76,207],"was":[78,116,135,160,184,208,219,245],"conducted":[79],"a":[81,143,222,263],"total":[82],"436":[84],"patients,":[87],"comprising":[88],"109":[89],"users":[91,188],"327":[93],"non-users.":[94,178],"Kaplan-Meier":[95],"curves":[97],"log-rank":[100],"test":[101],"were":[102],"used":[103],"assess":[105],"differences":[106],"overall":[108,181,202,249],"survival.":[109],"incidence":[111,149],"density":[112,150],"rate":[113,151,183],"mortality":[115,148,226],"calculated":[117],"for":[118,205,213],"each":[119],"group.":[120],"time":[127,204],"death":[129],"an":[131],"diagnosis":[134],"estimated":[136],"using":[137],"Cox":[138],"proportional":[139],"hazards":[140],"regression,":[141],"significance":[144],"level":[145],"5%.ResultsThe":[147],"prior":[157,216,242],"5.55":[161],"per":[162,171],"1,000":[163,172],"person-years":[164,173],"(95%":[165,174],"CI:":[166,175,191,198,237],"3.69-8.35),":[167],"compared":[168,227],"13.95":[170],"11.89-16.35)":[176],"5-year":[180],"higher":[185],"(66.18%;":[189],"95%":[190,197,236],"53.07-76.41)":[192],"than":[193],"non-users":[195],"(37.65%;":[196],"31.26-44.01).":[199],"median":[201],"49.80":[209],"months.":[210],"After":[211],"adjustment":[212],"confounders,":[215],"associated":[220,246],"lower":[223],"hazard":[224,231],"non-use":[229],"(adjusted":[230],"ratio":[232],"[AHR]":[233],"=":[234],"0.37;":[235],"0.24-0.59).ConclusionsIn":[238],"present":[240],"study,":[241],"improved":[248],"women":[252],"These":[257],"findings":[258,275],"provide":[259],"preliminary":[260],"evidence":[261],"possible":[264],"association;":[266],"however,":[267],"further":[268],"studies":[269],"are":[270],"needed":[271],"confirm":[273],"these":[274],"clarify":[277],"underlying":[279],"mechanisms.":[280]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-08-15T00:00:00"}