{"id":"https://openalex.org/W72027354","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a123094","title":"Molecular Characterization of 1, 4-Dihydropyridine-Sensitive Calcium Channels of Chick Heart and Skeletal Muscle","display_name":"Molecular Characterization of 1, 4-Dihydropyridine-Sensitive Calcium Channels of Chick Heart and Skeletal Muscle","publication_year":1990,"publication_date":"1990-04-01","ids":{"openalex":"https://openalex.org/W72027354","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a123094","mag":"72027354","pmid":"https://pubmed.ncbi.nlm.nih.gov/2162821"},"language":"en","primary_location":{"id":"doi:10.1093/oxfordjournals.jbchem.a123094","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a123094","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.jbchem.a123094","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Akira Yoshida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Yoshida","raw_affiliation_strings":["Department of Biology, Faculty of Science, Osaka University","*Department of Biology, Faculty of Science, Osaka UniversityToyonaka, Osaka 150"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Science, Osaka University","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"*Department of Biology, Faculty of Science, Osaka UniversityToyonaka, Osaka 150","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103372892","display_name":"Masami Takahashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Masami Takahashi","raw_affiliation_strings":["**Mitsubishi Kasei Institute of Life\u2013SciencesMachida, Tokyo 194"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"**Mitsubishi Kasei Institute of Life\u2013SciencesMachida, Tokyo 194","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111672170","display_name":"Yoshiko Fujimoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshiko Fujimoto","raw_affiliation_strings":["Mitsubishi Kasei Institute of Life\u2013Sciences Machida, Tokyo 194"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mitsubishi Kasei Institute of Life\u2013Sciences Machida, Tokyo 194","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054590528","display_name":"Haruhiko Takisawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haruhiko Takisawa","raw_affiliation_strings":["Department of Biology, Faculty of Science, Osaka University Toyonaka, Osaka 150"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Science, Osaka University Toyonaka, Osaka 150","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110173310","display_name":"Takao Nakamura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takao Nakamura","raw_affiliation_strings":["Department of Biology, Faculty of Science, Osaka University Toyonaka, Osaka 150"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Science, Osaka University Toyonaka, Osaka 150","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103372892"],"corresponding_institution_ids":[],"apc_list":{"value":3276,"currency":"USD","value_usd":3276},"apc_paid":null,"fwci":1.3156,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.78209014,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"107","issue":"4","first_page":"608","last_page":"612"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dihydropyridine-sensitive-calcium-channels","display_name":"dihydropyridine-sensitive calcium channels","score":0.9169999957084656},{"id":"https://openalex.org/keywords/l-type-calcium-channels","display_name":"L-type calcium channels","score":0.824999988079071},{"id":"https://openalex.org/keywords/chick-heart","display_name":"chick heart","score":0.7870000004768372},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.9490000009536743},{"id":"https://openalex.org/keywords/wheat-germ-agglutinin-binding","display_name":"wheat germ agglutinin binding","score":0.9739999771118164}],"concepts":[{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.8383020162582397},{"id":"https://openalex.org/C2778996579","wikidata":"https://www.wikidata.org/wiki/Q10334846","display_name":"Cardiac muscle","level":2,"score":0.558834433555603},{"id":"https://openalex.org/C71829478","wikidata":"https://www.wikidata.org/wiki/Q901305","display_name":"Immunoprecipitation","level":3,"score":0.5469645261764526},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5084132552146912},{"id":"https://openalex.org/C2778920010","wikidata":"https://www.wikidata.org/wiki/Q410968","display_name":"Digitonin","level":3,"score":0.48422694206237793},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4604343771934509},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.4553121328353882},{"id":"https://openalex.org/C2781212610","wikidata":"https://www.wikidata.org/wiki/Q39094","display_name":"Dihydropyridine","level":3,"score":0.4515378773212433},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4491427540779114},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4016236364841461},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4016059935092926},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3870580196380615},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.18808427453041077},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.18690863251686096},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06632465124130249},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004095","descriptor_name":"Dihydropyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011233","descriptor_name":"Precipitin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/oxfordjournals.jbchem.a123094","doi":"https://doi.org/10.1093/oxfordjournals.jbchem.a123094","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.jbchem.a123094","pdf_url":null,"source":{"id":"https://openalex.org/S184547178","display_name":"The Journal of Biochemistry","issn_l":"0021-924X","issn":["0021-924X","1756-2651"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Biochemistry","raw_type":"journal-article"},{"id":"pmid:2162821","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2162821","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2053389631","https://openalex.org/W1559171641","https://openalex.org/W1514747567","https://openalex.org/W2159380998","https://openalex.org/W2048197063","https://openalex.org/W1570544530","https://openalex.org/W2072401575","https://openalex.org/W1978680594","https://openalex.org/W1978264691","https://openalex.org/W2114276844"],"abstract_inverted_index":{"A":[0],"monoclonal":[1],"antibody":[2],"designated":[3],"as":[4,43,57],"MAC-L1":[5],"immunoprecipitated":[6],"[3H]PN200-110-labeled":[7],"calcium":[8,186,207],"channels":[9],"of":[10,19,47,80,97,104,112,126,131,148,171,203],"chick":[11],"cardiac":[12,81,185],"and":[13,27,31,33,76,82,99,114,191],"skeletal":[14,36,83,105,149,205],"muscle.":[15],"On":[16],"specific":[17],"immunoprecipitation":[18],"125I-labeled":[20],"proteins,":[21],"two":[22],"large":[23],"polypeptides":[24,51,139],"(Mr":[25],"197,000":[26],"139,000":[28],"for":[29,35],"heart,":[30],"172,000":[32],"135,000":[34],"muscle,":[37],"under":[38],"reducing":[39],"conditions)":[40],"were":[41,52,86],"identified":[42],"the":[44,93,100,122,127,138,166,172,183,204],"major":[45,167],"components":[46],"these":[48],"channels.":[49],"Both":[50],"found":[53],"to":[54,64,133,201],"exist":[55],"together":[56],"a":[58,144,159],"complex":[59],"in":[60,70],"1%":[61,71],"digitonin,":[62],"but":[63,120,164,198],"become":[65],"separated":[66],"from":[67],"each":[68],"other":[69],"Triton":[72],"X-100.":[73],"The":[74,117],"197":[75,123,168],"172":[77],"kDa":[78,95,102,119,124,146,162,169],"peptides":[79],"muscles,":[84],"respectively,":[85],"photolabeled":[87],"with":[88],"[3H]azidopine.":[89],"Under":[90],"nonreducing":[91],"conditions,":[92],"139":[94,118],"polypeptide":[96,103],"heart":[98,128,173],"135":[101],"muscle":[106,150,206],"took":[107],"on":[108],"larger":[109],"molecular":[110],"weights":[111],"192,000":[113],"190,000,":[115],"respectively.":[116],"not":[121,165,199],"component":[125],"was":[129,151,174],"capable":[130],"binding":[132],"wheat":[134],"germ":[135],"agglutinin-Sepharose.":[136],"Among":[137],"specifically":[140],"precipitated":[141],"by":[142,153,176],"MAC-L1,":[143],"165":[145],"peptide":[147],"phosphorylated":[152,175],"cAMP-dependent":[154],"protein":[155],"kinase.":[156,178],"In":[157],"contrast,":[158],"minor":[160],"99":[161],"polypeptide,":[163,170],"this":[177],"These":[179],"results":[180],"suggest":[181],"that":[182,195],"dihydropyridine-sensitive":[184],"channel":[187],"has":[188],"alpha":[189,192],"1":[190],"2":[193],"subunits":[194],"are":[196],"homologous":[197],"identical":[200],"those":[202],"channel.":[208]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}