{"id":"https://openalex.org/W7202416451","doi":null,"title":"DoseBridge: Denoising Diffusion Bridge Model for Dose Prediction in Lung Intensity-Modulated Proton Therapy","display_name":"DoseBridge: Denoising Diffusion Bridge Model for Dose Prediction in Lung Intensity-Modulated Proton Therapy","publication_year":2026,"publication_date":"2026-08-10","ids":{"openalex":"https://openalex.org/W7202416451"},"language":"en","primary_location":{"id":"pmh:oai:arXiv.org:2608.10173","doi":null,"is_oa":true,"landing_page_url":"https://arxiv.org/abs/2608.10173","pdf_url":"https://arxiv.org/pdf/2608.10173","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"volume":null,"type":"preprint","indexed_in":["arxiv"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/2608.10173","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5147109941","display_name":"Zerun Zhang","orcid":"https://orcid.org/0009-0004-6335-5666","observed_orcids":["https://orcid.org/0009-0004-6335-5666"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhang, Zerun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100584219","display_name":"Xiaoda Cong","orcid":"https://orcid.org/0009-0003-5175-630X","observed_orcids":["https://orcid.org/0009-0003-5175-630X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cong, Xiaoda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147119490","display_name":"Xiangkun Xu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xu, Xiangkun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011309644","display_name":"Peter Y. Chen","orcid":"https://orcid.org/0009-0003-3615-3690","observed_orcids":["https://orcid.org/0009-0003-3615-3690"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chen, Peter Y.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068845250","display_name":"Xuanfeng Ding","orcid":"https://orcid.org/0000-0002-1733-6278","observed_orcids":["https://orcid.org/0000-0002-1733-6278"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ding, Xuanfeng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.8628000020980835,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.8628000020980835,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.11460000276565552,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiotherapy-dose-prediction","display_name":"radiotherapy dose prediction","score":0.7919999957084656},{"id":"https://openalex.org/keywords/intensity-modulated-proton-therapy","display_name":"intensity-modulated proton therapy","score":0.9860000014305115},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.8019999861717224},{"id":"https://openalex.org/keywords/denoising-diffusion-probabilistic-models","display_name":"denoising diffusion probabilistic models","score":0.8619999885559082},{"id":"https://openalex.org/keywords/beam-geometry","display_name":"beam geometry","score":0.5789999961853027},{"id":"https://openalex.org/keywords/organ-at-risk-dose","display_name":"organ at risk dose","score":0.8450000286102295},{"id":"https://openalex.org/keywords/normal-tissue-complication-probability","display_name":"normal tissue complication probability","score":0.8679999709129333},{"id":"https://openalex.org/keywords/radiation-pneumonitis","display_name":"radiation pneumonitis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/esophagitis","display_name":"esophagitis","score":0.9309999942779541},{"id":"https://openalex.org/keywords/treatment-planning","display_name":"treatment planning","score":0.4860000014305115}],"concepts":[{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.7049000263214111},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5705999732017517},{"id":"https://openalex.org/C168834538","wikidata":"https://www.wikidata.org/wiki/Q3705329","display_name":"Beam (structure)","level":2,"score":0.47360000014305115},{"id":"https://openalex.org/C2779244869","wikidata":"https://www.wikidata.org/wiki/Q507667","display_name":"Proton therapy","level":3,"score":0.45969998836517334},{"id":"https://openalex.org/C201645570","wikidata":"https://www.wikidata.org/wiki/Q830637","display_name":"Radiation treatment planning","level":3,"score":0.42649999260902405},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40230000019073486},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.39430001378059387},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.3882000148296356},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3808000087738037},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.3398999869823456},{"id":"https://openalex.org/C163294075","wikidata":"https://www.wikidata.org/wiki/Q581861","display_name":"Noise reduction","level":2,"score":0.3395000100135803},{"id":"https://openalex.org/C54516573","wikidata":"https://www.wikidata.org/wiki/Q2294","display_name":"Proton","level":2,"score":0.33059999346733093},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.30790001153945923},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.30550000071525574},{"id":"https://openalex.org/C2987700449","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Radiation dose","level":2,"score":0.3028999865055084},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.29120001196861267},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2874999940395355},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2856000065803528},{"id":"https://openalex.org/C187954543","wikidata":"https://www.wikidata.org/wiki/Q1501273","display_name":"Hounsfield scale","level":3,"score":0.2759999930858612},{"id":"https://openalex.org/C27101514","wikidata":"https://www.wikidata.org/wiki/Q206120","display_name":"Lung volumes","level":3,"score":0.27570000290870667},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.27300000190734863},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2678000032901764}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:arXiv.org:2608.10173","doi":null,"is_oa":true,"landing_page_url":"https://arxiv.org/abs/2608.10173","pdf_url":"https://arxiv.org/pdf/2608.10173","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:2608.10173","doi":null,"is_oa":true,"landing_page_url":"https://arxiv.org/abs/2608.10173","pdf_url":"https://arxiv.org/pdf/2608.10173","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7130399237","https://openalex.org/W3208552028","https://openalex.org/W6891988332","https://openalex.org/W7214402128","https://openalex.org/W4401415175","https://openalex.org/W7140173891","https://openalex.org/W4393405390","https://openalex.org/W4387225552","https://openalex.org/W7220841244","https://openalex.org/W7172425645"],"abstract_inverted_index":{"Most":[0],"radiotherapy":[1,230],"dose-prediction":[2],"models":[3,154],"use":[4],"only":[5,203],"CT":[6,42,78],"images":[7,79],"and":[8,23,48,65,80,103,113,120,145,182,189,198],"anatomical":[9],"structures,":[10],"although":[11],"intensity-modulated":[12],"proton":[13],"therapy":[14],"(IMPT)":[15],"dose":[16,166,231],"also":[17],"depends":[18],"strongly":[19],"on":[20,76,155],"beam":[21,51,57,205],"geometry":[22,52],"available":[24],"clinical":[25],"datasets":[26],"are":[27],"often":[28],"small.":[29],"We":[30],"present":[31],"DoseBridge,":[32],"a":[33,44,54,132,239],"denoising":[34,225],"diffusion":[35,226],"bridge":[36,46,227],"model":[37,228],"that":[38],"uses":[39],"the":[40,127,164,204,214,223],"patient":[41],"as":[43,238],"structured":[45],"endpoint":[47],"encodes":[49],"plan-specific":[50],"in":[53,94,248],"spatially":[55],"aligned":[56],"mask.":[58],"Multiscale":[59],"fusion":[60],"combines":[61],"CT,":[62],"target,":[63],"organ-at-risk,":[64],"beam-mask":[66],"representations":[67],"with":[68,86,91,122],"1.95%":[69],"additional":[70],"parameters.":[71],"DoseBridge":[72,130,221],"was":[73,108],"retrospectively":[74],"evaluated":[75],"single-institution":[77],"treatment":[81],"plans":[82],"from":[83,163,177],"52":[84],"patients":[85],"advanced-stage":[87],"lung":[88,244],"cancer":[89],"treated":[90],"60":[92],"Gy":[93],"30":[95],"fractions;":[96],"42":[97],"cases":[98],"were":[99,185],"used":[100],"for":[101,105,195,229,243],"training":[102],"10":[104],"testing.":[106],"Performance":[107],"assessed":[109],"using":[110],"image-similarity,":[111],"dose-volume,":[112],"Lyman-Kutcher-Burman":[114],"normal-tissue":[115],"complication":[116],"probability":[117],"(NTCP)":[118],"metrics":[119],"compared":[121],"two":[123],"deep-learning":[124],"models.":[125],"On":[126],"test":[128],"cohort,":[129],"achieved":[131],"mean":[133],"absolute":[134],"error":[135],"of":[136,142,149],"4.170":[137],"Gy,":[138,181],"peak":[139],"signal-to-noise":[140],"ratio":[141],"23.06":[143],"dB,":[144],"structural":[146],"similarity":[147],"index":[148],"0.798,":[150],"outperforming":[151],"both":[152],"comparison":[153],"these":[156],"metrics.":[157],"Clinical":[158],"target":[159,216],"volume":[160],"D95":[161],"differed":[162],"reference":[165],"by":[167],"0.62":[168],"+/-":[169,187,191],"1.6":[170],"Gy;":[171],"signed":[172],"organ-at-risk":[173],"mean-dose":[174],"differences":[175,184],"ranged":[176],"-0.32":[178],"to":[179],"0.24":[180],"NTCP":[183],"-0.40":[186],"2.2":[188],"0.52":[190],"3.4":[192],"percentage":[193],"points":[194],"acute":[196],"esophagitis":[197],"radiation":[199],"pneumonitis,":[200],"respectively.":[201],"Changing":[202],"mask":[206],"redirected":[207],"predicted":[208],"low-dose":[209],"entrance":[210],"regions":[211],"while":[212],"preserving":[213],"high-dose":[215],"region.":[217],"To":[218],"our":[219],"knowledge,":[220],"is":[222],"first":[224],"prediction.":[232],"These":[233],"results":[234],"support":[235],"its":[236],"feasibility":[237],"beam-aware":[240],"planning":[241],"prior":[242],"IMPT,":[245],"pending":[246],"evaluation":[247],"larger":[249],"external":[250],"cohorts.":[251]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-08-14T00:00:00"}