{"id":"https://openalex.org/W7202399269","doi":"https://doi.org/10.1038/s41597-026-08064-8","title":"An integrated single-cell transcriptomic and microbiome dataset of orbital adipose tissue in thyroid eye disease","display_name":"An integrated single-cell transcriptomic and microbiome dataset of orbital adipose tissue in thyroid eye disease","publication_year":2026,"publication_date":"2026-08-13","ids":{"openalex":"https://openalex.org/W7202399269","doi":"https://doi.org/10.1038/s41597-026-08064-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/42897260","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13680605"},"language":"en","primary_location":{"id":"doi:10.1038/s41597-026-08064-8","doi":"https://doi.org/10.1038/s41597-026-08064-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41597-026-08064-8","pdf_url":"https://www.nature.com/articles/s41597-026-08064-8_reference.pdf","source":{"id":"https://openalex.org/S2607323502","display_name":"Scientific Data","issn_l":"2052-4463","issn":["2052-4463"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Data","raw_type":"journal-article"},"volume":null,"type":"data-paper","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41597-026-08064-8_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100547688","display_name":"Xiang Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang Xu","raw_affiliation_strings":["Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China","International Center of Microvascular Medicine, Chinese Academy of Medical Sciences, Beijing, 100005, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"International Center of Microvascular Medicine, Chinese Academy of Medical Sciences, Beijing, 100005, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115695181","display_name":"Fei Wang","orcid":"https://orcid.org/0000-0001-9459-9461","observed_orcids":["https://orcid.org/0000-0001-9459-9461","https://orcid.org/0009-0004-0539-0973"]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Wang","raw_affiliation_strings":["Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China","Department of Ophthalmology, Air Force Medical Center, Beijing, 100142, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]},{"raw_affiliation_string":"Department of Ophthalmology, Air Force Medical Center, Beijing, 100142, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100675203","display_name":"Weiqi Liu","orcid":"https://orcid.org/0000-0001-6262-9312","observed_orcids":["https://orcid.org/0000-0001-6262-9312","https://orcid.org/0009-0004-1913-9501","https://orcid.org/0009-0004-8852-987X"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiqi Liu","raw_affiliation_strings":["Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China","International Center of Microvascular Medicine, Chinese Academy of Medical Sciences, Beijing, 100005, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"International Center of Microvascular Medicine, Chinese Academy of Medical Sciences, Beijing, 100005, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147090312","display_name":"Haowen Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haowen Li","raw_affiliation_strings":["Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143195394","display_name":"Yingyu Wang","orcid":"https://orcid.org/0009-0008-0206-7264","observed_orcids":["https://orcid.org/0009-0008-0206-7264"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingyu Wang","raw_affiliation_strings":["Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China","International Center of Microvascular Medicine, Chinese Academy of Medical Sciences, Beijing, 100005, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"International Center of Microvascular Medicine, Chinese Academy of Medical Sciences, Beijing, 100005, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147065007","display_name":"Yuan Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuan Li","raw_affiliation_strings":["Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Lab, Capital Medical University, Beijing, 100730, China. liyangtongren@163.com","Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China. liyangtongren@163.com","Diabetes Research Center, Chinese Academy of Medical Sciences, Beijing, 100005, China","Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China","International Center of Microvascular Medicine, Chinese Academy of Medical Sciences, Beijing, 100005, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Lab, Capital Medical University, Beijing, 100730, China. liyangtongren@163.com","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]},{"raw_affiliation_string":"Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China. liyangtongren@163.com","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]},{"raw_affiliation_string":"Diabetes Research Center, Chinese Academy of Medical Sciences, Beijing, 100005, China","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"International Center of Microvascular Medicine, Chinese Academy of Medical Sciences, Beijing, 100005, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159663941","display_name":"Bing Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bing Wang","raw_affiliation_strings":["Diabetes Research Center, Chinese Academy of Medical Sciences, Beijing, 100005, China","Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China","International Center of Microvascular Medicine, Chinese Academy of Medical Sciences, Beijing, 100005, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes Research Center, Chinese Academy of Medical Sciences, Beijing, 100005, China","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"International Center of Microvascular Medicine, Chinese Academy of Medical Sciences, Beijing, 100005, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125372524","display_name":"Mingming Liu","orcid":"https://orcid.org/0000-0002-6750-5068","observed_orcids":["https://orcid.org/0000-0002-6750-5068"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mingming Liu","raw_affiliation_strings":["Diabetes Research Center, Chinese Academy of Medical Sciences, Beijing, 100005, China. mingmingliu@imc.pumc.edu.cn","Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China. mingmingliu@imc.pumc.edu.cn","International Center of Microvascular Medicine, Chinese Academy of Medical Sciences, Beijing, 100005, China. mingmingliu@imc.pumc.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes Research Center, Chinese Academy of Medical Sciences, Beijing, 100005, China. mingmingliu@imc.pumc.edu.cn","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China. mingmingliu@imc.pumc.edu.cn","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"International Center of Microvascular Medicine, Chinese Academy of Medical Sciences, Beijing, 100005, China. mingmingliu@imc.pumc.edu.cn","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5147097859","display_name":"Yang Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294606314","display_name":"Beijing Tongren Hospital","ror":"https://ror.org/013e4n276","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294606314"]},{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yang Li","raw_affiliation_strings":["Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Lab, Capital Medical University, Beijing, 100730, China. liyangtongren@163.com","Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China. liyangtongren@163.com","Diabetes Research Center, Chinese Academy of Medical Sciences, Beijing, 100005, China","Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China","International Center of Microvascular Medicine, Chinese Academy of Medical Sciences, Beijing, 100005, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Lab, Capital Medical University, Beijing, 100730, China. liyangtongren@163.com","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]},{"raw_affiliation_string":"Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China. liyangtongren@163.com","institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381"]},{"raw_affiliation_string":"Diabetes Research Center, Chinese Academy of Medical Sciences, Beijing, 100005, China","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"International Center of Microvascular Medicine, Chinese Academy of Medical Sciences, Beijing, 100005, China","institution_ids":["https://openalex.org/I200296433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5125372524","https://openalex.org/A5147065007","https://openalex.org/A5147097859"],"corresponding_institution_ids":["https://openalex.org/I1294606314","https://openalex.org/I183519381","https://openalex.org/I200296433"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11538","display_name":"Ophthalmology and Eye Disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11538","display_name":"Ophthalmology and Eye Disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12989","display_name":"Ocular Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/graves-ophthalmopathy","display_name":"Graves' ophthalmopathy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/orbital-adipose-tissue","display_name":"orbital adipose tissue","score":0.9760000109672546},{"id":"https://openalex.org/keywords/orbital-fibroblasts","display_name":"orbital fibroblasts","score":0.8610000014305115},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.9610000252723694},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.7179999947547913},{"id":"https://openalex.org/keywords/subcutaneous-adipose-tissue","display_name":"subcutaneous adipose tissue","score":0.8080000281333923},{"id":"https://openalex.org/keywords/dysbiosis","display_name":"dysbiosis","score":0.6480000019073486},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.5979999899864197},{"id":"https://openalex.org/keywords/16s-rrna-gene-sequencing","display_name":"16S rRNA gene sequencing","score":0.9369999766349792}],"concepts":[{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.6626999974250793},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6245999932289124},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.6101999878883362},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5685999989509583},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.49630001187324524},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.4609000086784363},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4271000027656555},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4237000048160553},{"id":"https://openalex.org/C122927707","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Adipogenesis","level":3,"score":0.3752000033855438},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.329800009727478},{"id":"https://openalex.org/C2776685619","wikidata":"https://www.wikidata.org/wiki/Q1340722","display_name":"Graves' ophthalmopathy","level":4,"score":0.3255000114440918},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.31949999928474426},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.2939000129699707},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.29280000925064087},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.28780001401901245},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27889999747276306},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2782000005245209},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2770000100135803},{"id":"https://openalex.org/C107397762","wikidata":"https://www.wikidata.org/wiki/Q2542347","display_name":"RNA-Seq","level":5,"score":0.2741999924182892},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.257099986076355},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2563000023365021},{"id":"https://openalex.org/C2909668393","wikidata":"https://www.wikidata.org/wiki/Q156075","display_name":"Orbital Diseases","level":4,"score":0.2554999887943268},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.2547999918460846}],"mesh":[{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009915","descriptor_name":"Orbit","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049970","descriptor_name":"Graves Ophthalmopathy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D049970","descriptor_name":"Graves Ophthalmopathy","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D049970","descriptor_name":"Graves Ophthalmopathy","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41597-026-08064-8","doi":"https://doi.org/10.1038/s41597-026-08064-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41597-026-08064-8","pdf_url":"https://www.nature.com/articles/s41597-026-08064-8_reference.pdf","source":{"id":"https://openalex.org/S2607323502","display_name":"Scientific Data","issn_l":"2052-4463","issn":["2052-4463"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Data","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13680605","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13680605/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13680605/pdf/41597_2026_Article_8064.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Data","raw_type":"Text"},{"id":"pmid:42897260","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42897260","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific data","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:18c24425a64b480998e1a33e0522c1b5","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/18c24425a64b480998e1a33e0522c1b5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Data, Vol 13, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41597-026-08064-8","doi":"https://doi.org/10.1038/s41597-026-08064-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41597-026-08064-8","pdf_url":"https://www.nature.com/articles/s41597-026-08064-8_reference.pdf","source":{"id":"https://openalex.org/S2607323502","display_name":"Scientific Data","issn_l":"2052-4463","issn":["2052-4463"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Data","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G4415605811","display_name":null,"funder_award_id":"7252093","funder_id":"https://openalex.org/F4320322919","funder_display_name":"Natural Science Foundation of Beijing Municipality"},{"id":"https://openalex.org/G8656737306","display_name":null,"funder_award_id":"82571806","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322919","display_name":"Natural Science Foundation of Beijing Municipality","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7202399269.pdf","grobid_xml":"https://content.openalex.org/works/W7202399269.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W7125825954","https://openalex.org/W7135054605"],"related_works":["https://openalex.org/W4285601966","https://openalex.org/W4288045523","https://openalex.org/W4417183840","https://openalex.org/W4387807882","https://openalex.org/W7213871153","https://openalex.org/W7171535497","https://openalex.org/W2800447315","https://openalex.org/W7211885927","https://openalex.org/W7117474661","https://openalex.org/W4389917009"],"abstract_inverted_index":{"Thyroid":[0],"eye":[1],"disease":[2],"(TED),":[3],"also":[4],"historically":[5],"referred":[6],"to":[7,154,180],"as":[8],"thyroid-associated":[9],"ophthalmopathy":[10,19],"(TAO)":[11],"or":[12],"Graves'":[13],"orbitopathy":[14],"(GO),":[15],"is":[16,40],"an":[17,178],"autoimmune":[18],"characterized":[20],"by":[21],"inflammation":[22],"and":[23,37,45,73,95,102,126,168,188,199],"adipogenesis":[24],"within":[25],"orbital":[26,55,92,122,138,158],"adipose":[27,93,139],"(OA)":[28],"tissue.":[29],"While":[30],"the":[31,42,46,54,118,144,156,182,200],"contribution":[32],"of":[33,49,69,107,121,202],"immune":[34,124],"cell":[35],"infiltration":[36],"fibroblast":[38],"activation":[39],"recognized,":[41],"cellular":[43,186],"heterogeneity":[44],"potential":[47,189],"role":[48],"local":[50,190],"microbial":[51,170],"dysbiosis":[52],"in":[53],"microenvironment":[56],"remain":[57],"poorly":[58],"defined.":[59],"Here,":[60],"we":[61],"present":[62],"a":[63,105],"multi-omics":[64],"dataset":[65,82,176],"derived":[66],"from":[67,90,143],"OA":[68],"patients":[70],"with":[71],"TED":[72],"healthy":[74],"controls":[75],"collected":[76,142],"at":[77],"Beijing":[78],"Tongren":[79],"Hospital.":[80],"The":[81],"comprises":[83],"single-cell":[84],"RNA":[85],"sequencing":[86,134,163],"(scRNA-seq)":[87],"data":[88],"generated":[89],"human":[91],"tissue":[94,140],"subcutaneous":[96],"fat.":[97],"Following":[98],"quality":[99],"control":[100],"filtering":[101],"doublet":[103],"removal,":[104],"total":[106],"61,302":[108],"high-quality":[109],"singlet":[110],"cells":[111],"were":[112],"retained":[113],"for":[114,151,206],"downstream":[115],"analyses,":[116],"capturing":[117],"transcriptomic":[119],"landscape":[120],"fibroblasts,":[123],"subsets,":[125],"vascular":[127],"cells.":[128],"In":[129],"parallel,":[130],"16S":[131],"rRNA":[132],"gene":[133],"was":[135],"performed":[136],"on":[137],"samples":[141,150],"integrated":[145],"study":[146],"cohort,":[147],"alongside":[148],"environmental":[149],"contamination":[152],"assessment,":[153],"characterize":[155],"low-biomass":[157],"microbiome":[159,191],"DNA":[160],"signatures.":[161],"Raw":[162],"reads,":[164],"quality-controlled":[165],"gene-expression":[166],"matrices,":[167],"contamination-corrected":[169],"feature":[171],"tables":[172],"are":[173],"provided.":[174],"Our":[175],"provides":[177],"opportunity":[179],"investigate":[181],"crosstalk":[183,198],"between":[184],"host":[185],"immunity":[187],"signatures,":[192],"facilitating":[193],"hypothesis":[194],"generation":[195],"regarding":[196],"host-microbiome":[197],"exploration":[201],"novel":[203],"therapeutic":[204],"targets":[205],"TED.":[207]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-14T00:00:00"}