{"id":"https://openalex.org/W7202390964","doi":"https://doi.org/10.1038/s41467-026-76652-8","title":"A glycolytic intermediate gatekeeps global mRNA decay in Escherichia coli","display_name":"A glycolytic intermediate gatekeeps global mRNA decay in Escherichia coli","publication_year":2026,"publication_date":"2026-08-13","ids":{"openalex":"https://openalex.org/W7202390964","doi":"https://doi.org/10.1038/s41467-026-76652-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/42733058"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-026-76652-8","doi":"https://doi.org/10.1038/s41467-026-76652-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-76652-8","pdf_url":null,"source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1038/s41467-026-76652-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061686203","display_name":"Ander Hern\u00e1ndez Pl\u00e1garo","orcid":"https://orcid.org/0000-0002-9239-5366","observed_orcids":["https://orcid.org/0000-0002-9239-5366"]},"institutions":[{"id":"https://openalex.org/I4210136969","display_name":"Institute of Molecular Biology, Academia Sinica","ror":"https://ror.org/047sbcx71","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210136969","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ander Hern\u00e1ndez Pl\u00e1garo","raw_affiliation_strings":["Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, ROC"],"raw_orcid":"https://orcid.org/0000-0002-9239-5366","affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, ROC","institution_ids":["https://openalex.org/I4210136969","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056335461","display_name":"Oleg N. Murashko","orcid":"https://orcid.org/0000-0003-0389-4284","observed_orcids":["https://orcid.org/0000-0003-0389-4284"]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]},{"id":"https://openalex.org/I4210136969","display_name":"Institute of Molecular Biology, Academia Sinica","ror":"https://ror.org/047sbcx71","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210136969","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Oleg N. Murashko","raw_affiliation_strings":["Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, ROC","Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, ROC","institution_ids":["https://openalex.org/I4210131804"]},{"raw_affiliation_string":"Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, ROC","institution_ids":["https://openalex.org/I4210136969","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147117438","display_name":"Chen-Hsin Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136969","display_name":"Institute of Molecular Biology, Academia Sinica","ror":"https://ror.org/047sbcx71","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210136969","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chen-Hsin Yu","raw_affiliation_strings":["Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, ROC","institution_ids":["https://openalex.org/I4210136969","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022265060","display_name":"Kun\u2010Hai Yeh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136969","display_name":"Institute of Molecular Biology, Academia Sinica","ror":"https://ror.org/047sbcx71","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210136969","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kun-Hai Yeh","raw_affiliation_strings":["Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, ROC","institution_ids":["https://openalex.org/I4210136969","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147082603","display_name":"Pankaj Leonard Tirkey","orcid":"https://orcid.org/0009-0006-9596-2502","observed_orcids":["https://orcid.org/0009-0006-9596-2502"]},"institutions":[{"id":"https://openalex.org/I4210136969","display_name":"Institute of Molecular Biology, Academia Sinica","ror":"https://ror.org/047sbcx71","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210136969","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Pankaj Leonard Tirkey","raw_affiliation_strings":["Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, ROC"],"raw_orcid":"https://orcid.org/0009-0006-9596-2502","affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, ROC","institution_ids":["https://openalex.org/I4210136969","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070469321","display_name":"Mikel Irastortza\u2010Olaziregi","orcid":"https://orcid.org/0000-0003-4553-288X","observed_orcids":["https://orcid.org/0000-0003-4553-288X"]},"institutions":[{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]},{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["ES","IL"],"is_corresponding":false,"raw_author_name":"Mikel Irastortza-Olaziregi","raw_affiliation_strings":["Department of Immunology, Microbiology and Parasitology, University of the Basque Country UPV/EHU, Leioa, Spain","Department of Microbiology and Molecular Genetics, IMRIC - Faculty of Medicine, The Hebrew, University of Jerusalem, Jerusalem, Israel"],"raw_orcid":"https://orcid.org/0000-0003-4553-288X","affiliations":[{"raw_affiliation_string":"Department of Immunology, Microbiology and Parasitology, University of the Basque Country UPV/EHU, Leioa, Spain","institution_ids":["https://openalex.org/I169108374"]},{"raw_affiliation_string":"Department of Microbiology and Molecular Genetics, IMRIC - Faculty of Medicine, The Hebrew, University of Jerusalem, Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046323184","display_name":"Vladimir R. Kaberdin","orcid":"https://orcid.org/0000-0002-7166-5136","observed_orcids":["https://orcid.org/0000-0002-7166-5136"]},"institutions":[{"id":"https://openalex.org/I110594554","display_name":"Ikerbasque","ror":"https://ror.org/01cc3fy72","country_code":"ES","type":"other","lineage":["https://openalex.org/I110594554"]},{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Vladimir R. Kaberdin","raw_affiliation_strings":["Basque Foundation for Science, IKERBASQUE, Bilbao, Spain","Department of Immunology, Microbiology and Parasitology, University of the Basque Country UPV/EHU, Leioa, Spain","Research Centre for Experimental Marine Biology and Biotechnology (PIE-UPV/EHU), Plentzia, Spain"],"raw_orcid":"https://orcid.org/0000-0002-7166-5136","affiliations":[{"raw_affiliation_string":"Basque Foundation for Science, IKERBASQUE, Bilbao, Spain","institution_ids":["https://openalex.org/I110594554"]},{"raw_affiliation_string":"Department of Immunology, Microbiology and Parasitology, University of the Basque Country UPV/EHU, Leioa, Spain","institution_ids":["https://openalex.org/I169108374"]},{"raw_affiliation_string":"Research Centre for Experimental Marine Biology and Biotechnology (PIE-UPV/EHU), Plentzia, Spain","institution_ids":["https://openalex.org/I169108374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000420275","display_name":"Yelina Ortiz","orcid":"https://orcid.org/0000-0002-3528-1733","observed_orcids":["https://orcid.org/0000-0002-3528-1733"]},"institutions":[{"id":"https://openalex.org/I13134134","display_name":"Universidad de Cantabria","ror":"https://ror.org/046ffzj20","country_code":"ES","type":"education","lineage":["https://openalex.org/I13134134"]},{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210102893","display_name":"Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria","ror":"https://ror.org/01d963745","country_code":"ES","type":"facility","lineage":["https://openalex.org/I13134134","https://openalex.org/I134820265","https://openalex.org/I4210102893"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Yelina Ortiz P\u00e9rez","raw_affiliation_strings":["Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria (IBBTEC), CSIC - Universidad de Cantabria, Santander, Spain"],"raw_orcid":"https://orcid.org/0000-0002-3528-1733","affiliations":[{"raw_affiliation_string":"Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria (IBBTEC), CSIC - Universidad de Cantabria, Santander, Spain","institution_ids":["https://openalex.org/I13134134","https://openalex.org/I134820265","https://openalex.org/I4210102893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020679547","display_name":"F\u00e9lix Javier Sangari","orcid":"https://orcid.org/0000-0002-3298-6076","observed_orcids":["https://orcid.org/0000-0002-3298-6076"]},"institutions":[{"id":"https://openalex.org/I13134134","display_name":"Universidad de Cantabria","ror":"https://ror.org/046ffzj20","country_code":"ES","type":"education","lineage":["https://openalex.org/I13134134"]},{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210102893","display_name":"Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria","ror":"https://ror.org/01d963745","country_code":"ES","type":"facility","lineage":["https://openalex.org/I13134134","https://openalex.org/I134820265","https://openalex.org/I4210102893"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"F\u00e9lix Javier Sangari","raw_affiliation_strings":["Departamento de Biolog\u00eda Molecular, Universidad de Cantabria, Santander, Spain","Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria (IBBTEC), CSIC - Universidad de Cantabria, Santander, Spain"],"raw_orcid":"https://orcid.org/0000-0002-3298-6076","affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda Molecular, Universidad de Cantabria, Santander, Spain","institution_ids":["https://openalex.org/I13134134"]},{"raw_affiliation_string":"Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria (IBBTEC), CSIC - Universidad de Cantabria, Santander, Spain","institution_ids":["https://openalex.org/I13134134","https://openalex.org/I134820265","https://openalex.org/I4210102893"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091326298","display_name":"Sue Lin\u2010Chao","orcid":"https://orcid.org/0000-0002-8415-9304","observed_orcids":["https://orcid.org/0000-0002-8415-9304"]},"institutions":[{"id":"https://openalex.org/I4210136969","display_name":"Institute of Molecular Biology, Academia Sinica","ror":"https://ror.org/047sbcx71","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210136969","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Sue Lin-Chao","raw_affiliation_strings":["Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, ROC. mbsue@gate.sinica.edu.tw"],"raw_orcid":"https://orcid.org/0000-0002-8415-9304","affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, ROC. mbsue@gate.sinica.edu.tw","institution_ids":["https://openalex.org/I4210136969","https://openalex.org/I84653119"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5091326298"],"corresponding_institution_ids":["https://openalex.org/I4210136969","https://openalex.org/I84653119"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.65975029,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9160000085830688,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.03689999878406525,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.03269999846816063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polynucleotide-phosphorylase","display_name":"polynucleotide phosphorylase","score":0.9750000238418579},{"id":"https://openalex.org/keywords/rna-degradation","display_name":"RNA degradation","score":0.7350000143051147},{"id":"https://openalex.org/keywords/rna-stability","display_name":"RNA stability","score":0.515999972820282},{"id":"https://openalex.org/keywords/fructose-1-6-bisphosphate","display_name":"fructose-1,6-bisphosphate","score":0.9430000185966492},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/metabolite-sensing","display_name":"metabolite sensing","score":0.5400000214576721},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/metabolon","display_name":"metabolon","score":0.5950000286102295},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8339999914169312},{"id":"https://openalex.org/keywords/exoribonuclease","display_name":"exoribonuclease","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.7742000222206116},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.579200029373169},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.5435000061988831},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4602000117301941},{"id":"https://openalex.org/C2908821069","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli Proteins","level":4,"score":0.4562000036239624},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4124000072479248},{"id":"https://openalex.org/C2778910516","wikidata":"https://www.wikidata.org/wiki/Q380136","display_name":"Enterobacteriaceae","level":4,"score":0.3677000105381012},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3508000075817108},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.34630000591278076},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.31310001015663147},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29580000042915344},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2922999858856201},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2896000146865845},{"id":"https://openalex.org/C2993175405","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Bacterial protein","level":3,"score":0.273499995470047},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.26829999685287476},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26589998602867126}],"mesh":[{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005095","descriptor_name":"Exoribonucleases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005095","descriptor_name":"Exoribonucleases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005635","descriptor_name":"Fructosediphosphates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005635","descriptor_name":"Fructosediphosphates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011117","descriptor_name":"Polyribonucleotide Nucleotidyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011117","descriptor_name":"Polyribonucleotide Nucleotidyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011117","descriptor_name":"Polyribonucleotide Nucleotidyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011117","descriptor_name":"Polyribonucleotide Nucleotidyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012329","descriptor_name":"RNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012329","descriptor_name":"RNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012329","descriptor_name":"RNA, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012329","descriptor_name":"RNA, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020871","descriptor_name":"RNA Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020871","descriptor_name":"RNA Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41467-026-76652-8","doi":"https://doi.org/10.1038/s41467-026-76652-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-76652-8","pdf_url":null,"source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmid:42733058","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42733058","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3c93175c963542c2837661da7f595604","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/3c93175c963542c2837661da7f595604","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 17, Iss 1 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13572404","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13572404/pdf/41467_2026_Article_76652.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nat Commun","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41467-026-76652-8","doi":"https://doi.org/10.1038/s41467-026-76652-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-026-76652-8","pdf_url":null,"source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.6495589017868042}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4476389314","display_name":null,"funder_award_id":"AS-IA-110-L03","funder_id":"https://openalex.org/F4320321041","funder_display_name":"Academia Sinica"},{"id":"https://openalex.org/G946896677","display_name":null,"funder_award_id":"AS-2323","funder_id":"https://openalex.org/F4320321041","funder_display_name":"Academia Sinica"}],"funders":[{"id":"https://openalex.org/F4320321041","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":97,"referenced_works":["https://openalex.org/W43134475","https://openalex.org/W159687900","https://openalex.org/W289916777","https://openalex.org/W1121458180","https://openalex.org/W1498391596","https://openalex.org/W1501390529","https://openalex.org/W1570147840","https://openalex.org/W1736567173","https://openalex.org/W1832598496","https://openalex.org/W1926303070","https://openalex.org/W1964706228","https://openalex.org/W1967162537","https://openalex.org/W1974127479","https://openalex.org/W1976380282","https://openalex.org/W1980782563","https://openalex.org/W1981021420","https://openalex.org/W1986742454","https://openalex.org/W1988098435","https://openalex.org/W1989504029","https://openalex.org/W1990227323","https://openalex.org/W1997670436","https://openalex.org/W1999574084","https://openalex.org/W2000106654","https://openalex.org/W2003550222","https://openalex.org/W2004235182","https://openalex.org/W2010577059","https://openalex.org/W2013003830","https://openalex.org/W2013732906","https://openalex.org/W2015474832","https://openalex.org/W2020442384","https://openalex.org/W2023251152","https://openalex.org/W2026866184","https://openalex.org/W2037846176","https://openalex.org/W2041570078","https://openalex.org/W2045683699","https://openalex.org/W2045878447","https://openalex.org/W2047153828","https://openalex.org/W2047670590","https://openalex.org/W2053680822","https://openalex.org/W2054962153","https://openalex.org/W2060904524","https://openalex.org/W2061429937","https://openalex.org/W2061659241","https://openalex.org/W2062423576","https://openalex.org/W2066712272","https://openalex.org/W2066886643","https://openalex.org/W2069790213","https://openalex.org/W2070622238","https://openalex.org/W2077592317","https://openalex.org/W2085776880","https://openalex.org/W2098152091","https://openalex.org/W2105422109","https://openalex.org/W2107277218","https://openalex.org/W2111967267","https://openalex.org/W2115780677","https://openalex.org/W2116137883","https://openalex.org/W2116242363","https://openalex.org/W2134153749","https://openalex.org/W2134440848","https://openalex.org/W2139915240","https://openalex.org/W2142433339","https://openalex.org/W2146750282","https://openalex.org/W2148277388","https://openalex.org/W2148699435","https://openalex.org/W2167279371","https://openalex.org/W2169456326","https://openalex.org/W2171389223","https://openalex.org/W2181098546","https://openalex.org/W2239702807","https://openalex.org/W2313292657","https://openalex.org/W2424716884","https://openalex.org/W2516278741","https://openalex.org/W2544360569","https://openalex.org/W2565659580","https://openalex.org/W2569383255","https://openalex.org/W2591817974","https://openalex.org/W2751125917","https://openalex.org/W2768421721","https://openalex.org/W2768848446","https://openalex.org/W2884606236","https://openalex.org/W2942481300","https://openalex.org/W2964834357","https://openalex.org/W3005766797","https://openalex.org/W4200250548","https://openalex.org/W4242123597","https://openalex.org/W4246178785","https://openalex.org/W4247892234","https://openalex.org/W4360600105","https://openalex.org/W4384557591","https://openalex.org/W4387164156","https://openalex.org/W4396721167","https://openalex.org/W4399640724","https://openalex.org/W4399640777","https://openalex.org/W4400942530","https://openalex.org/W4404225840","https://openalex.org/W4404511389","https://openalex.org/W4410405913"],"related_works":[],"abstract_inverted_index":{"Polynucleotide":[0],"phosphorylase":[1],"(PNPase)":[2],"is":[3,20,93,118,155,185,211],"a":[4,33,60,143,159],"highly":[5],"conserved":[6],"exoribonuclease":[7],"crucial":[8],"for":[9,120],"RNA":[10,36,70,109,146,152,209,241],"degradation":[11,37,153,210],"across":[12],"all":[13],"domains":[14],"of":[15,46,77,101,173,179],"life.":[16],"In":[17],"bacteria,":[18],"PNPase":[19,47,58,87,117,135,204,235],"found":[21],"in":[22,40,89,95,111,125,247],"multi-protein":[23],"ribonucleolytic":[24],"complexes":[25],"that":[26,63,74,201,228],"include":[27],"glycolytic":[28,138,160,230],"enzymes.":[29,139],"While":[30],"evidence":[31],"supports":[32],"link":[34],"between":[35,134],"and":[38,48,65,83,106,124,136,162,197,243],"glycolysis":[39,68],"Escherichia":[41],"coli,":[42],"the":[43,49,75,99,170,174,206,217,225,229],"precise":[44],"contribution":[45],"underlying":[50,218],"regulatory":[51,183],"mechanism":[52,144,168],"remain":[53],"unknown.":[54],"Here":[55],"we":[56],"establish":[57],"as":[59,205],"metabolic":[61,171,238],"sensor":[62],"physically":[64],"functionally":[66],"links":[67,169],"to":[69,82,176,193,213,240],"stability.":[71],"We":[72],"find":[73],"intermediate":[76],"glycolysis,":[78],"fructose":[79,232],"1,6-diphosphate,":[80],"binds":[81],"inhibits":[84,234],"E.":[85,113],"coli":[86,114],"activity":[88],"vitro.":[90],"This":[91,167,182],"inhibition":[92],"confirmed":[94],"vivo,":[96],"where":[97,116,145],"increasing":[98],"levels":[100],"this":[102],"metabolite":[103,161,231],"compromises":[104],"growth":[105],"globally":[107],"prolongs":[108],"half-lives":[110],"an":[112,150],"strain":[115],"essential":[119],"growth.":[121],"Bacterial":[122],"two-hybrid":[123],"vivo":[126],"crosslinking":[127],"followed":[128],"by":[129,148,158,164,188],"immunoprecipitation":[130],"suggest":[131],"potential":[132],"interaction":[133],"multiple":[137],"Our":[140],"results":[141],"propose":[142],"phosphorolysis":[147],"PNPase,":[149],"energy-saving":[151],"pathway,":[154],"directly":[156],"modulated":[157],"facilitated":[163],"metabolon":[165],"association.":[166],"state":[172,239],"cell":[175],"post-transcriptional":[177],"control":[178],"gene":[180,245],"expression.":[181],"system":[184],"likely":[186],"exploited":[187],"other":[189],"bacterial":[190],"species":[191],"relevant":[192],"human":[194],"health,":[195],"environment":[196],"industry,":[198],"particularly":[199],"those":[200],"rely":[202],"on":[203],"sole":[207],"exoribonuclease.":[208],"linked":[212],"cellular":[214],"metabolism,":[215],"but":[216],"mechanisms":[219],"are":[220],"not":[221],"fully":[222],"understood.":[223],"Here,":[224],"authors":[226],"show":[227],"1,6\u2011bisphosphate":[233],"activity,":[236],"connecting":[237],"stability":[242],"post\u2011transcriptional":[244],"regulation":[246],"bacteria.":[248]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2026-08-14T00:00:00"}
