{"id":"https://openalex.org/W7202380052","doi":"https://doi.org/10.1099/acmi.0.001306.v1","title":"In Vitro Assessment of Ceftaroline Against Methicillin-Resistant Staphylococcus aureus (MRSA) Isolates in a Tertiary Care Hospital in Pakistan","display_name":"In Vitro Assessment of Ceftaroline Against Methicillin-Resistant Staphylococcus aureus (MRSA) Isolates in a Tertiary Care Hospital in Pakistan","publication_year":2026,"publication_date":"2026-08-13","ids":{"openalex":"https://openalex.org/W7202380052","doi":"https://doi.org/10.1099/acmi.0.001306.v1"},"language":"en","primary_location":{"id":"doi:10.1099/acmi.0.001306.v1","doi":"https://doi.org/10.1099/acmi.0.001306.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1099/acmi.0.001306.v1","pdf_url":"https://www.microbiologyresearch.org/deliver/fulltext/acmi/10.1099/acmi.0.001306.v1/acmi.0.001306.v1.1.pdf?itemId=/content/reviewreports/10.1099/acmi.0.001306.v1.1&mimeType=pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.microbiologyresearch.org/deliver/fulltext/acmi/10.1099/acmi.0.001306.v1/acmi.0.001306.v1.1.pdf?itemId=/content/reviewreports/10.1099/acmi.0.001306.v1.1&mimeType=pdf","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024893755","display_name":"Fareeha Adnan","orcid":"https://orcid.org/0000-0001-6150-1798","observed_orcids":["https://orcid.org/0000-0001-6150-1798"]},"institutions":[{"id":"https://openalex.org/I2800984189","display_name":"Indus Hospital","ror":"https://ror.org/04amwz106","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I2800984189"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Fareeha Adnan","raw_affiliation_strings":["The Indus Hospital Korangi Campus, Plot C-76, Sector 31/5, Opposite Darussalam Society, Korangi Crossing, Karachi, Karachi"],"raw_orcid":"https://orcid.org/0000-0001-6150-1798","affiliations":[{"raw_affiliation_string":"The Indus Hospital Korangi Campus, Plot C-76, Sector 31/5, Opposite Darussalam Society, Korangi Crossing, Karachi, Karachi","institution_ids":["https://openalex.org/I2800984189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052489247","display_name":"Nazia Khursheed","orcid":"https://orcid.org/0009-0006-8227-3396","observed_orcids":["https://orcid.org/0009-0006-8227-3396"]},"institutions":[{"id":"https://openalex.org/I2800984189","display_name":"Indus Hospital","ror":"https://ror.org/04amwz106","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I2800984189"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Nazia Khursheed","raw_affiliation_strings":["Department of Microbiology, The Indus Hospital and Health Network, Karachi, Pakistan"],"raw_orcid":"https://orcid.org/0009-0006-8227-3396","affiliations":[{"raw_affiliation_string":"Department of Microbiology, The Indus Hospital and Health Network, Karachi, Pakistan","institution_ids":["https://openalex.org/I2800984189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112880326","display_name":"Qurat Ul Ain Zahid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800984189","display_name":"Indus Hospital","ror":"https://ror.org/04amwz106","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I2800984189"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Qurat ul Ain Zahid","raw_affiliation_strings":["Department of Microbiology, The Indus Hospital and Health Network, Karachi, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, The Indus Hospital and Health Network, Karachi, Pakistan","institution_ids":["https://openalex.org/I2800984189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108111364","display_name":"Nida Ghouri","orcid":"https://orcid.org/0000-0003-4475-697X","observed_orcids":["https://orcid.org/0000-0003-4475-697X"]},"institutions":[{"id":"https://openalex.org/I2800984189","display_name":"Indus Hospital","ror":"https://ror.org/04amwz106","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I2800984189"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Nida Ghouri","raw_affiliation_strings":["Department of Microbiology, The Indus Hospital and Health Network, Karachi, Pakistan"],"raw_orcid":"https://orcid.org/0000-0003-4475-697X","affiliations":[{"raw_affiliation_string":"Department of Microbiology, The Indus Hospital and Health Network, Karachi, Pakistan","institution_ids":["https://openalex.org/I2800984189"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5147132376","display_name":"Arsalan Abid","orcid":"https://orcid.org/0009-0001-1220-7602","observed_orcids":["https://orcid.org/0009-0001-1220-7602"]},"institutions":[{"id":"https://openalex.org/I2800984189","display_name":"Indus Hospital","ror":"https://ror.org/04amwz106","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I2800984189"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Arsalan Abid","raw_affiliation_strings":["Department of Microbiology, The Indus Hospital and Health Network, Karachi, Pakistan"],"raw_orcid":"https://orcid.org/0009-0001-1220-7602","affiliations":[{"raw_affiliation_string":"Department of Microbiology, The Indus Hospital and Health Network, Karachi, Pakistan","institution_ids":["https://openalex.org/I2800984189"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2800984189"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ceftaroline","display_name":"ceftaroline","score":0.9919999837875366},{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":1.0},{"id":"https://openalex.org/keywords/antimicrobial-susceptibility","display_name":"antimicrobial susceptibility","score":0.9210000038146973},{"id":"https://openalex.org/keywords/penicillin-binding-protein-2a","display_name":"penicillin-binding protein 2a","score":0.7919999957084656},{"id":"https://openalex.org/keywords/vancomycin","display_name":"vancomycin","score":0.6940000057220459},{"id":"https://openalex.org/keywords/teicoplanin","display_name":"teicoplanin","score":0.9800000190734863},{"id":"https://openalex.org/keywords/linezolid","display_name":"linezolid","score":1.0},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.46700000762939453},{"id":"https://openalex.org/keywords/antibiotic-prescribing-patterns","display_name":"antibiotic prescribing patterns","score":0.6570000052452087},{"id":"https://openalex.org/keywords/beta-lactam-resistance","display_name":"beta-lactam resistance","score":0.699999988079071},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.5899999737739563},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.6899999976158142},{"id":"https://openalex.org/keywords/pakistan","display_name":"Pakistan","score":0.6899999976158142},{"id":"https://openalex.org/keywords/hospital-isolates","display_name":"hospital isolates","score":0.5},{"id":"https://openalex.org/keywords/doxycycline","display_name":"doxycycline","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7807000279426575},{"id":"https://openalex.org/C2781414143","wikidata":"https://www.wikidata.org/wiki/Q411377","display_name":"Linezolid","level":5,"score":0.7631000280380249},{"id":"https://openalex.org/C2776703206","wikidata":"https://www.wikidata.org/wiki/Q2731762","display_name":"Teicoplanin","level":5,"score":0.7620000243186951},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.70169997215271},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.5949000120162964},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5659000277519226},{"id":"https://openalex.org/C64778159","wikidata":"https://www.wikidata.org/wiki/Q271021","display_name":"Cephalosporin","level":3,"score":0.5307999849319458},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5241000056266785},{"id":"https://openalex.org/C2777052132","wikidata":"https://www.wikidata.org/wiki/Q595158","display_name":"Methicillin-resistant Staphylococcus aureus","level":4,"score":0.5080000162124634},{"id":"https://openalex.org/C2778512257","wikidata":"https://www.wikidata.org/wiki/Q256602","display_name":"Ciprofloxacin","level":3,"score":0.4731000065803528},{"id":"https://openalex.org/C2780206985","wikidata":"https://www.wikidata.org/wiki/Q213511","display_name":"Erythromycin","level":3,"score":0.4578999876976013},{"id":"https://openalex.org/C174802600","wikidata":"https://www.wikidata.org/wiki/Q12190","display_name":"Penicillin","level":3,"score":0.42820000648498535},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.41749998927116394},{"id":"https://openalex.org/C2781336494","wikidata":"https://www.wikidata.org/wiki/Q5210237","display_name":"Dalbavancin","level":5,"score":0.36329999566078186},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.357699990272522},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.336899995803833},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.296099990606308},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.2815999984741211},{"id":"https://openalex.org/C2780950330","wikidata":"https://www.wikidata.org/wiki/Q19903614","display_name":"Broth microdilution","level":4,"score":0.273499995470047},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.2603999972343445}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1099/acmi.0.001306.v1","doi":"https://doi.org/10.1099/acmi.0.001306.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1099/acmi.0.001306.v1","pdf_url":"https://www.microbiologyresearch.org/deliver/fulltext/acmi/10.1099/acmi.0.001306.v1/acmi.0.001306.v1.1.pdf?itemId=/content/reviewreports/10.1099/acmi.0.001306.v1.1&mimeType=pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1099/acmi.0.001306.v1","doi":"https://doi.org/10.1099/acmi.0.001306.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1099/acmi.0.001306.v1","pdf_url":"https://www.microbiologyresearch.org/deliver/fulltext/acmi/10.1099/acmi.0.001306.v1/acmi.0.001306.v1.1.pdf?itemId=/content/reviewreports/10.1099/acmi.0.001306.v1.1&mimeType=pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9912999868392944,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7202380052.pdf","grobid_xml":"https://content.openalex.org/works/W7202380052.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W2089915191","https://openalex.org/W2562293596","https://openalex.org/W2585535976","https://openalex.org/W2728618198","https://openalex.org/W2893352320","https://openalex.org/W2898224513","https://openalex.org/W2973957938","https://openalex.org/W3014361683","https://openalex.org/W3016423865","https://openalex.org/W3049129644","https://openalex.org/W3200304787","https://openalex.org/W3208991311","https://openalex.org/W4200395880","https://openalex.org/W4288051775","https://openalex.org/W4295904319","https://openalex.org/W4317611897","https://openalex.org/W4322487582","https://openalex.org/W4386782785","https://openalex.org/W4392764176","https://openalex.org/W4393434995","https://openalex.org/W4400083802","https://openalex.org/W4401993214","https://openalex.org/W4410502720","https://openalex.org/W4414072759"],"related_works":["https://openalex.org/W7117565029","https://openalex.org/W7164171797","https://openalex.org/W7215759310","https://openalex.org/W4389286450","https://openalex.org/W3110294128","https://openalex.org/W2973189762","https://openalex.org/W7169000330","https://openalex.org/W2530412655","https://openalex.org/W4285556990","https://openalex.org/W7118132030"],"abstract_inverted_index":{"In":[0,284],"Vitro":[1],"assessment":[2],"of":[3,37,80,200,228,258,264,331,343],"Ceftaroline":[4,64,81,223,270,292],"against":[5,69,276],"Methicillin-Resistant":[6],"Staphylococcus":[7,13],"aureus":[8,14],"(MRSA)":[9,15],"isolates":[10,84,124,203],"Background":[11],"Methicillin-resistant":[12],"continues":[16],"to":[17,26,29,76,86,116,280,286,300,319],"be":[18],"a":[19,41,45,56,108,226,252,295],"significant":[20,253,328],"global":[21],"public":[22],"health":[23],"concern":[24],"due":[25],"its":[27,88,287],"resistance":[28,329],"conventional":[30],"\u03b2-lactam":[31],"antibiotics":[32,175,334],"and":[33,85,97,130,140,156,190,220,243,266,282,309,338,347],"the":[34,149,171,207,247,256,262,341],"rising":[35],"prevalence":[36],"multidrug-resistant":[38],"strains.":[39],"Ceftaroline,":[40,178],"fifth-generation":[42],"cephalosporin":[43],"with":[44,90,170,213,230,307,324],"strong":[46,272],"affinity":[47],"for":[48,240],"Penicillin-Binding":[49],"Protein":[50],"2a":[51],"(PBP2a),":[52],"has":[53,316],"emerged":[54],"as":[55,336],"promising":[57,288],"therapeutic":[58,311],"option.":[59],"However,":[60],"regional":[61,349],"data":[62],"on":[63,82,127,164],"susceptibility":[65,144,209,227],"are":[66],"still":[67],"limited":[68],"MRSA.":[70],"Therefore,":[71],"this":[72],"study":[73,103],"was":[74,104,146,251],"conducted":[75,105],"evaluate":[77],"in-vitro":[78],"activity":[79],"MRSA":[83,123,202,277],"compare":[87],"efficacy":[89],"commonly":[91],"used":[92,333],"anti-MRSA":[93,302],"agents":[94],"like":[95],"vancomycin":[96,218,281],"linezolid.":[98,283],"Methods":[99],"A":[100,198],"retrospective":[101],"cross-sectional":[102],"at":[106,107],"tertiary-care":[109],"hospital":[110],"in":[111,168,255,273,289],"Pakistan,":[112],"from":[113],"January":[114],"2023":[115],"December":[117],"2024.":[118],"Clinical":[119],"specimens":[120],"that":[121],"yielded":[122],"were":[125,162,195,204,211,237],"cultured":[126],"standard":[128,133],"media":[129],"identified":[131],"using":[132,148],"phenotypic":[134],"methods":[135],"(Gram":[136],"stain,":[137],"catalase,":[138],"coagulase,":[139],"DNase":[141],"tests).":[142],"Antimicrobial":[143],"testing":[145,161],"performed":[147,163],"Kirby\u2013Bauer":[150],"disc":[151],"diffusion":[152],"method.":[153],"For":[154],"Vancomycin":[155,304],"Teicoplanin,":[157,180],"Minimal-inhibitory":[158],"concentrations":[159],"(MIC)":[160],"VITEK\u00ae":[165],"2":[166],"Compact,":[167],"accordance":[169],"CLSI":[172],"standards.":[173],"The":[174,327],"tested":[176],"included":[177],"Vancomycin,":[179],"Linezolid,":[181],"Doxycycline,":[182],"Ciprofloxacin,":[183],"Erythromycin,":[184],"Clindamycin,":[185],"And":[186],"Cotrimoxazole.":[187],"Additionally,":[188],"pre-":[189],"post-culture":[191],"antibiotic":[192],"prescribing":[193],"patterns":[194],"analyzed.":[196,205],"Results":[197],"total":[199],"363":[201],"Overall,":[206],"highest":[208],"rates":[210,236],"observed":[212],"linezolid":[214,315],"(100%),":[215,217,219],"doxycycline":[216],"teicoplanin":[221],"(97.2%).":[222],"also":[224],"showed":[225,271],"100%,":[229],"none":[231],"displaying":[232],"complete":[233],"resistance.":[234],"Resistance":[235],"notably":[238],"high":[239],"erythromycin":[241,337],"(71.1%)":[242],"ciprofloxacin":[244,339],"(60.4%).":[245],"After":[246],"culture":[248],"results,":[249],"there":[250],"decrease":[254],"use":[257,263],"broad-spectrum":[259],"\u03b2-lactams,":[260],"while":[261,314],"aminoglycosides":[265],"tetracyclines":[267],"increased.":[268],"Conclusions":[269],"vitro":[274,290],"effectiveness":[275],"isolates,":[278],"similar":[279],"addition":[285],"activity,":[291],"could":[293],"offer":[294],"favorable":[296],"safety":[297],"profile":[298,330],"compared":[299],"traditional":[301],"agents.":[303],"is":[305],"associated":[306],"nephrotoxicity":[308],"requires":[310],"drug":[312],"monitoring,":[313],"been":[317],"linked":[318],"hematological":[320],"toxicity,":[321],"particularly":[322],"thrombocytopenia":[323],"prolonged":[325],"use.":[326],"frequently":[332],"such":[335],"highlight":[340],"importance":[342],"ongoing":[344],"antimicrobial":[345],"stewardship":[346],"continuous":[348],"monitoring.":[350]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-08-14T00:00:00"}