{"id":"https://openalex.org/W7202379463","doi":"https://doi.org/10.1186/s12885-026-16750-4","title":"Single-cell analysis reveals the potential immunoregulatory role of C3 + malignant cell subpopulations in dedifferentiated liposarcoma","display_name":"Single-cell analysis reveals the potential immunoregulatory role of C3 + malignant cell subpopulations in dedifferentiated liposarcoma","publication_year":2026,"publication_date":"2026-08-13","ids":{"openalex":"https://openalex.org/W7202379463","doi":"https://doi.org/10.1186/s12885-026-16750-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/42926214","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13695301"},"language":"en","primary_location":{"id":"doi:10.1186/s12885-026-16750-4","doi":"https://doi.org/10.1186/s12885-026-16750-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-026-16750-4","pdf_url":null,"source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12885-026-16750-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029726736","display_name":"Shengyun Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengyun Hu","raw_affiliation_strings":["Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China","Institute of Interconnected Intelligent Health Management, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Institute of Interconnected Intelligent Health Management, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147066619","display_name":"Yatong Dang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yatong Dang","raw_affiliation_strings":["Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China","Institute of Interconnected Intelligent Health Management, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Institute of Interconnected Intelligent Health Management, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029805200","display_name":"Baojing Tuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baojing Tuo","raw_affiliation_strings":["Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China","Institute of Interconnected Intelligent Health Management, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Institute of Interconnected Intelligent Health Management, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011042280","display_name":"Senbo Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Senbo Liu","raw_affiliation_strings":["Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China","Institute of Interconnected Intelligent Health Management, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Institute of Interconnected Intelligent Health Management, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100352583","display_name":"Zhiyong Zhang","orcid":"https://orcid.org/0000-0001-8576-1607","observed_orcids":["https://orcid.org/0000-0001-8576-1607"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiyong Zhang","raw_affiliation_strings":["Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019123797","display_name":"Lin Gan","orcid":"https://orcid.org/0009-0003-4771-7228","observed_orcids":["https://orcid.org/0009-0003-4771-7228"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Gan","raw_affiliation_strings":["Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China","Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147097378","display_name":"Xiaoqing Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoqing Gao","raw_affiliation_strings":["Day Surgery Operating Room, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Day Surgery Operating Room, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006261506","display_name":"Mengmeng Xiao","orcid":"https://orcid.org/0000-0003-2309-9480","observed_orcids":["https://orcid.org/0000-0003-2309-9480"]},"institutions":[{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mengmeng Xiao","raw_affiliation_strings":["Department of Retroperitoneal Tumor Surgery, Peking University People's Hospital, Beijing, 100044, China. xiaomengmeng@pku.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Retroperitoneal Tumor Surgery, Peking University People's Hospital, Beijing, 100044, China. xiaomengmeng@pku.edu.cn","institution_ids":["https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129604036","display_name":"\u80e1\u4fca\u5f18","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Junhong Hu","raw_affiliation_strings":["Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. hujunhong@zzu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. hujunhong@zzu.edu.cn","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047095388","display_name":"Zhenqiang Sun","orcid":"https://orcid.org/0000-0002-9098-7296","observed_orcids":["https://orcid.org/0000-0002-9098-7296","https://orcid.org/0000-0001-5926-2716"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhenqiang Sun","raw_affiliation_strings":["Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. fccsunzq@zzu.edu.cn","Institute of Interconnected Intelligent Health Management, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. fccsunzq@zzu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. fccsunzq@zzu.edu.cn","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Institute of Interconnected Intelligent Health Management, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. fccsunzq@zzu.edu.cn","institution_ids":["https://openalex.org/I4210156804"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006261506","https://openalex.org/A5047095388","https://openalex.org/A5129604036"],"corresponding_institution_ids":["https://openalex.org/I4210124809","https://openalex.org/I4210156804"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.58721179,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dedifferentiated-liposarcoma","display_name":"dedifferentiated liposarcoma","score":1.0},{"id":"https://openalex.org/keywords/retroperitoneal-liposarcoma","display_name":"retroperitoneal liposarcoma","score":0.9229999780654907},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.7229999899864197},{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.7559999823570251},{"id":"https://openalex.org/keywords/c3ar1","display_name":"C3AR1","score":0.7350000143051147},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.5680000185966492},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.6930000185966492},{"id":"https://openalex.org/keywords/cd8-t-cell-exhaustion","display_name":"CD8+ T cell exhaustion","score":0.8870000243186951},{"id":"https://openalex.org/keywords/chromosome-6-deletion","display_name":"chromosome 6 deletion","score":0.7480000257492065},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.7670000195503235},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9369999766349792},{"id":"https://openalex.org/keywords/il2ra","display_name":"IL2RA","score":0.8240000009536743},{"id":"https://openalex.org/keywords/spp1-macrophages","display_name":"SPP1+ macrophages","score":0.8989999890327454},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.8080000281333923}],"concepts":[{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.6413999795913696},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6370000243186951},{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.5447999835014343},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.541700005531311},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5306000113487244},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4909000098705292},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46950000524520874},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.46630001068115234},{"id":"https://openalex.org/C2779568860","wikidata":"https://www.wikidata.org/wiki/Q1827425","display_name":"Liposarcoma","level":3,"score":0.46480000019073486},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4406999945640564},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.40849998593330383},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39959999918937683},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.3846000134944916},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.38280001282691956},{"id":"https://openalex.org/C3019684167","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignant cells","level":3,"score":0.3725000023841858},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34790000319480896},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.3377000093460083},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.33250001072883606},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3222000002861023},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.32010000944137573},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.29350000619888306},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.26489999890327454}],"mesh":[{"descriptor_ui":"D000094383","descriptor_name":"T-Cell Exhaustion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008080","descriptor_name":"Liposarcoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008080","descriptor_name":"Liposarcoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008080","descriptor_name":"Liposarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012186","descriptor_name":"Retroperitoneal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012186","descriptor_name":"Retroperitoneal Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012186","descriptor_name":"Retroperitoneal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12885-026-16750-4","doi":"https://doi.org/10.1186/s12885-026-16750-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-026-16750-4","pdf_url":null,"source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13695301","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13695301/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13695301/pdf/12885_2026_Article_16750.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"Text"},{"id":"pmid:42926214","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42926214","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cancer","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:929e3caa8af247cbb49be3b3e469be5f","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/929e3caa8af247cbb49be3b3e469be5f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cancer, Vol 26, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12885-026-16750-4","doi":"https://doi.org/10.1186/s12885-026-16750-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12885-026-16750-4","pdf_url":null,"source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7280488531","display_name":null,"funder_award_id":"LHGJ20240223","funder_id":"https://openalex.org/F4320318564","funder_display_name":"Health Commission of Henan Province"},{"id":"https://openalex.org/G7364615126","display_name":null,"funder_award_id":"SBGJ202502064","funder_id":"https://openalex.org/F4320318564","funder_display_name":"Health Commission of Henan Province"},{"id":"https://openalex.org/G7755912295","display_name":null,"funder_award_id":"2023QNRC001","funder_id":"https://openalex.org/F4320311778","funder_display_name":"China Association for Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320311778","display_name":"China Association for Science and Technology","ror":"https://ror.org/035vmht26"},{"id":"https://openalex.org/F4320318564","display_name":"Health Commission of Henan Province","ror":"https://ror.org/04nne1357"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7202379463.pdf","grobid_xml":"https://content.openalex.org/works/W7202379463.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W2035561282","https://openalex.org/W2035618305","https://openalex.org/W2082081720","https://openalex.org/W2127192086","https://openalex.org/W2148226248","https://openalex.org/W2151941382","https://openalex.org/W2159707944","https://openalex.org/W2162527129","https://openalex.org/W2323526189","https://openalex.org/W2472063172","https://openalex.org/W2546514099","https://openalex.org/W2561926137","https://openalex.org/W2582033455","https://openalex.org/W2591978212","https://openalex.org/W2595030035","https://openalex.org/W2762797139","https://openalex.org/W2765468373","https://openalex.org/W2766710286","https://openalex.org/W2794480084","https://openalex.org/W2800392236","https://openalex.org/W2891415253","https://openalex.org/W2898311608","https://openalex.org/W2917547201","https://openalex.org/W2920631851","https://openalex.org/W2965171334","https://openalex.org/W3006526394","https://openalex.org/W3019970601","https://openalex.org/W3036206386","https://openalex.org/W3039227338","https://openalex.org/W3047375046","https://openalex.org/W3086258129","https://openalex.org/W3092007298","https://openalex.org/W3097361322","https://openalex.org/W3097370403","https://openalex.org/W3109486609","https://openalex.org/W3132661792","https://openalex.org/W3135656011","https://openalex.org/W3182110147","https://openalex.org/W3188755614","https://openalex.org/W3193609746","https://openalex.org/W4221085385","https://openalex.org/W4223507222","https://openalex.org/W4283263276","https://openalex.org/W4285097283","https://openalex.org/W4290989555","https://openalex.org/W4296991903","https://openalex.org/W4298008730","https://openalex.org/W4319597836","https://openalex.org/W4319755519","https://openalex.org/W4320913159","https://openalex.org/W4366490430","https://openalex.org/W4381952962","https://openalex.org/W4389266107","https://openalex.org/W4400682531","https://openalex.org/W4401234258","https://openalex.org/W4401274889","https://openalex.org/W4402533797","https://openalex.org/W4415947926"],"related_works":["https://openalex.org/W7169666853","https://openalex.org/W4281630880","https://openalex.org/W7140275465","https://openalex.org/W4404064380","https://openalex.org/W6939678331","https://openalex.org/W3196563977","https://openalex.org/W2037386047","https://openalex.org/W4396978279","https://openalex.org/W2966728053","https://openalex.org/W4404064333"],"abstract_inverted_index":{"BACKGROUND:":[0],"Dedifferentiated":[1],"liposarcoma":[2,26],"(DDLPS),":[3],"a":[4,87,95],"rare":[5],"disease":[6],"with":[7,55,101],"limited":[8],"research,":[9],"exhibits":[10],"resistance":[11],"to":[12,68],"radiotherapy":[13],"and":[14,41,65,84,105,123],"chemotherapy.":[15],"Few":[16],"reports":[17],"have":[18],"analyzed":[19],"the":[20,39,76,128,138],"tumor":[21],"microenvironment":[22],"of":[23,33,78,89,140],"retroperitoneal":[24,35],"undifferentiated":[25],"using":[27],"single-cell":[28],"sequencing.":[29],"METHODS:":[30],"Single-cell":[31],"analysis":[32],"three":[34],"DDLPS":[36],"cases":[37],"characterized":[38],"cellular":[40],"immune":[42],"microenvironment.":[43],"RESULTS:":[44],"Our":[45,132],"findings":[46,133],"reveal":[47],"significant":[48],"heterogeneity":[49],"among":[50],"malignant":[51,62,98,115],"cells":[52,116,122],"in":[53,142],"DDLPS,":[54],"chromosome":[56],"6":[57],"deletions":[58],"being":[59],"prevalent":[60],"across":[61],"cell":[63,82,99],"subpopulations":[64],"potentially":[66],"linked":[67],"reduced":[69],"immunogenicity":[70],"based":[71],"on":[72],"pathway":[73],"analyses.":[74],"Notably,":[75],"coexistence":[77],"CD8":[79],"+":[80,97,114,125],"T":[81,121],"exhaustion":[83,90],"cytotoxicity":[85],"reflects":[86],"continuum":[88],"transition.":[91],"Moreover,":[92],"we":[93],"identify":[94],"C3":[96,113],"subpopulation":[100],"ECM":[102],"remodeling,":[103],"angiogenesis,":[104],"activated":[106],"complement":[107],"pathway.":[108],"Further":[109],"exploration":[110],"suggested":[111],"that":[112],"may":[117],"recruit":[118],"IL2RA+":[119],"regulatory":[120],"SPP1":[124],"macrophages":[126],"through":[127],"C3-C3aR1":[129],"axis.":[130],"CONCLUSION:":[131],"provide":[134],"new":[135],"insights":[136],"into":[137],"application":[139],"immunotherapy":[141],"sarcoma.":[143]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-14T00:00:00"}
