{"id":"https://openalex.org/W7202364152","doi":"https://doi.org/10.1016/j.lanafr.2026.100122","title":"Extending seasonal malaria chemoprevention to older children: a non-inferiority randomized controlled trial of Dihydroartemisinin\u2013piperaquine as a policy alternative in Mali","display_name":"Extending seasonal malaria chemoprevention to older children: a non-inferiority randomized controlled trial of Dihydroartemisinin\u2013piperaquine as a policy alternative in Mali","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7202364152","doi":"https://doi.org/10.1016/j.lanafr.2026.100122","pmid":"https://pubmed.ncbi.nlm.nih.gov/42808016","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13618436"},"language":"en","primary_location":{"id":"doi:10.1016/j.lanafr.2026.100122","doi":"https://doi.org/10.1016/j.lanafr.2026.100122","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.lanafr.2026.100122","pdf_url":null,"source":{"id":"https://openalex.org/S5407054332","display_name":"The Lancet Regional Health - Africa","issn_l":"3050-5011","issn":["3050-5011"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Regional Health - Africa","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1016/j.lanafr.2026.100122","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062690919","display_name":"Mahamoudou Tour\u00e9","orcid":"https://orcid.org/0000-0001-6238-5063","observed_orcids":["https://orcid.org/0000-0001-6238-5063"]},"institutions":[{"id":"https://openalex.org/I4210112095","display_name":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako","ror":"https://ror.org/023rbaw78","country_code":"ML","type":"education","lineage":["https://openalex.org/I4210112095"]}],"countries":["ML"],"is_corresponding":true,"raw_author_name":"Mahamoudou Toure","raw_affiliation_strings":["Infectious Diseases and Entomology Research and Training Center, Bamako, Mali","University Clinical Research Center, Bamako, Mali","Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali"],"raw_orcid":"https://orcid.org/0000-0001-6238-5063","affiliations":[{"raw_affiliation_string":"Infectious Diseases and Entomology Research and Training Center, Bamako, Mali","institution_ids":[]},{"raw_affiliation_string":"University Clinical Research Center, Bamako, Mali","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali","institution_ids":["https://openalex.org/I4210112095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044313408","display_name":"Soumba Keita","orcid":"https://orcid.org/0009-0006-3248-4961","observed_orcids":["https://orcid.org/0009-0006-3248-4961"]},"institutions":[{"id":"https://openalex.org/I4210112095","display_name":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako","ror":"https://ror.org/023rbaw78","country_code":"ML","type":"education","lineage":["https://openalex.org/I4210112095"]}],"countries":["ML"],"is_corresponding":false,"raw_author_name":"Soumba Keita","raw_affiliation_strings":["Infectious Diseases and Entomology Research and Training Center, Bamako, Mali","University Clinical Research Center, Bamako, Mali","Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases and Entomology Research and Training Center, Bamako, Mali","institution_ids":[]},{"raw_affiliation_string":"University Clinical Research Center, Bamako, Mali","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali","institution_ids":["https://openalex.org/I4210112095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006772191","display_name":"Fousseyni Kan\u00e9","orcid":"https://orcid.org/0000-0002-9967-7956","observed_orcids":["https://orcid.org/0000-0002-9967-7956"]},"institutions":[{"id":"https://openalex.org/I4210112095","display_name":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako","ror":"https://ror.org/023rbaw78","country_code":"ML","type":"education","lineage":["https://openalex.org/I4210112095"]}],"countries":["ML"],"is_corresponding":false,"raw_author_name":"Fousseyni Kane","raw_affiliation_strings":["Infectious Diseases and Entomology Research and Training Center, Bamako, Mali","University Clinical Research Center, Bamako, Mali","Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases and Entomology Research and Training Center, Bamako, Mali","institution_ids":[]},{"raw_affiliation_string":"University Clinical Research Center, Bamako, Mali","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali","institution_ids":["https://openalex.org/I4210112095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001651531","display_name":"Daouda Sanogo","orcid":"https://orcid.org/0009-0007-1152-5231","observed_orcids":["https://orcid.org/0009-0007-1152-5231"]},"institutions":[{"id":"https://openalex.org/I4210112095","display_name":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako","ror":"https://ror.org/023rbaw78","country_code":"ML","type":"education","lineage":["https://openalex.org/I4210112095"]}],"countries":["ML"],"is_corresponding":false,"raw_author_name":"Daouda Sanogo","raw_affiliation_strings":["Infectious Diseases and Entomology Research and Training Center, Bamako, Mali","University Clinical Research Center, Bamako, Mali","Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases and Entomology Research and Training Center, Bamako, Mali","institution_ids":[]},{"raw_affiliation_string":"University Clinical Research Center, Bamako, Mali","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali","institution_ids":["https://openalex.org/I4210112095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025659746","display_name":"Ibrahim Sanogo","orcid":"https://orcid.org/0000-0001-9800-9369","observed_orcids":["https://orcid.org/0000-0001-9800-9369"]},"institutions":[{"id":"https://openalex.org/I4210112095","display_name":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako","ror":"https://ror.org/023rbaw78","country_code":"ML","type":"education","lineage":["https://openalex.org/I4210112095"]}],"countries":["ML"],"is_corresponding":false,"raw_author_name":"Ibrahim Sanogo","raw_affiliation_strings":["Deceased. Dr. Ibrahim Sanogo died on April 25th, 2026, before publication of this work","University Clinical Research Center, Bamako, Mali","Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deceased. Dr. Ibrahim Sanogo died on April 25th, 2026, before publication of this work","institution_ids":[]},{"raw_affiliation_string":"University Clinical Research Center, Bamako, Mali","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali","institution_ids":["https://openalex.org/I4210112095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125429052","display_name":"Moussa Keita","orcid":"https://orcid.org/0009-0009-6396-3801","observed_orcids":["https://orcid.org/0009-0009-6396-3801"]},"institutions":[{"id":"https://openalex.org/I4210112095","display_name":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako","ror":"https://ror.org/023rbaw78","country_code":"ML","type":"education","lineage":["https://openalex.org/I4210112095"]}],"countries":["ML"],"is_corresponding":false,"raw_author_name":"Moussa Keita","raw_affiliation_strings":["Infectious Diseases and Entomology Research and Training Center, Bamako, Mali","Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases and Entomology Research and Training Center, Bamako, Mali","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali","institution_ids":["https://openalex.org/I4210112095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111996987","display_name":"Ibrahim Moussa Sissoko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112095","display_name":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako","ror":"https://ror.org/023rbaw78","country_code":"ML","type":"education","lineage":["https://openalex.org/I4210112095"]}],"countries":["ML"],"is_corresponding":false,"raw_author_name":"Ibrahim M. Sissoko","raw_affiliation_strings":["Infectious Diseases and Entomology Research and Training Center, Bamako, Mali","Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases and Entomology Research and Training Center, Bamako, Mali","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali","institution_ids":["https://openalex.org/I4210112095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076174747","display_name":"Mountaga Diallo","orcid":"https://orcid.org/0009-0001-3543-7451","observed_orcids":["https://orcid.org/0009-0001-3543-7451"]},"institutions":[{"id":"https://openalex.org/I4210112095","display_name":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako","ror":"https://ror.org/023rbaw78","country_code":"ML","type":"education","lineage":["https://openalex.org/I4210112095"]}],"countries":["ML"],"is_corresponding":false,"raw_author_name":"Mountaga Diallo","raw_affiliation_strings":["University Clinical Research Center, Bamako, Mali","Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali"],"raw_orcid":"https://orcid.org/0009-0001-3543-7451","affiliations":[{"raw_affiliation_string":"University Clinical Research Center, Bamako, Mali","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali","institution_ids":["https://openalex.org/I4210112095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010781423","display_name":"Hamady Coulibaly","orcid":"https://orcid.org/0009-0005-6774-9192","observed_orcids":["https://orcid.org/0009-0005-6774-9192"]},"institutions":[{"id":"https://openalex.org/I4210112095","display_name":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako","ror":"https://ror.org/023rbaw78","country_code":"ML","type":"education","lineage":["https://openalex.org/I4210112095"]}],"countries":["ML"],"is_corresponding":false,"raw_author_name":"Hamady Coulibaly","raw_affiliation_strings":["University Clinical Research Center, Bamako, Mali","Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Clinical Research Center, Bamako, Mali","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali","institution_ids":["https://openalex.org/I4210112095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126392519","display_name":"Bourema Cisse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112095","display_name":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako","ror":"https://ror.org/023rbaw78","country_code":"ML","type":"education","lineage":["https://openalex.org/I4210112095"]}],"countries":["ML"],"is_corresponding":false,"raw_author_name":"Bourema Cisse","raw_affiliation_strings":["University Clinical Research Center, Bamako, Mali","Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Clinical Research Center, Bamako, Mali","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali","institution_ids":["https://openalex.org/I4210112095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037434427","display_name":"Konat\u00e9 Drissa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112095","display_name":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako","ror":"https://ror.org/023rbaw78","country_code":"ML","type":"education","lineage":["https://openalex.org/I4210112095"]}],"countries":["ML"],"is_corresponding":false,"raw_author_name":"Drissa Konate","raw_affiliation_strings":["Infectious Diseases and Entomology Research and Training Center, Bamako, Mali","University Clinical Research Center, Bamako, Mali","Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases and Entomology Research and Training Center, Bamako, Mali","institution_ids":[]},{"raw_affiliation_string":"University Clinical Research Center, Bamako, Mali","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali","institution_ids":["https://openalex.org/I4210112095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126386109","display_name":"Issaka Guindo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112095","display_name":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako","ror":"https://ror.org/023rbaw78","country_code":"ML","type":"education","lineage":["https://openalex.org/I4210112095"]}],"countries":["ML"],"is_corresponding":false,"raw_author_name":"Issaka Guindo","raw_affiliation_strings":["University Clinical Research Center, Bamako, Mali","Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Clinical Research Center, Bamako, Mali","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali","institution_ids":["https://openalex.org/I4210112095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111109744","display_name":"Mamadou Mall\u00e9","orcid":"https://orcid.org/0009-0001-9847-3353","observed_orcids":["https://orcid.org/0009-0001-9847-3353"]},"institutions":[{"id":"https://openalex.org/I4210112095","display_name":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako","ror":"https://ror.org/023rbaw78","country_code":"ML","type":"education","lineage":["https://openalex.org/I4210112095"]}],"countries":["ML"],"is_corresponding":false,"raw_author_name":"Mossa Ag Malle","raw_affiliation_strings":["University Clinical Research Center, Bamako, Mali","Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali"],"raw_orcid":"https://orcid.org/0009-0001-9847-3353","affiliations":[{"raw_affiliation_string":"University Clinical Research Center, Bamako, Mali","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali","institution_ids":["https://openalex.org/I4210112095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077258873","display_name":"Cheick Oumar Tangara","orcid":"https://orcid.org/0000-0003-4686-0236","observed_orcids":["https://orcid.org/0000-0003-4686-0236"]},"institutions":[{"id":"https://openalex.org/I4210112095","display_name":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako","ror":"https://ror.org/023rbaw78","country_code":"ML","type":"education","lineage":["https://openalex.org/I4210112095"]}],"countries":["ML"],"is_corresponding":false,"raw_author_name":"Cheick Oumar Tangara","raw_affiliation_strings":["University Clinical Research Center, Bamako, Mali","Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Clinical Research Center, Bamako, Mali","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali","institution_ids":["https://openalex.org/I4210112095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066349786","display_name":"Sory Ibrahim Diawara","orcid":"https://orcid.org/0000-0001-5154-2940","observed_orcids":["https://orcid.org/0000-0001-5154-2940"]},"institutions":[{"id":"https://openalex.org/I4210112095","display_name":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako","ror":"https://ror.org/023rbaw78","country_code":"ML","type":"education","lineage":["https://openalex.org/I4210112095"]}],"countries":["ML"],"is_corresponding":false,"raw_author_name":"Sory I Diawara","raw_affiliation_strings":["Infectious Diseases and Entomology Research and Training Center, Bamako, Mali","University Clinical Research Center, Bamako, Mali","Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases and Entomology Research and Training Center, Bamako, Mali","institution_ids":[]},{"raw_affiliation_string":"University Clinical Research Center, Bamako, Mali","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali","institution_ids":["https://openalex.org/I4210112095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070932590","display_name":"Mady Cissoko","orcid":"https://orcid.org/0000-0002-0200-8191","observed_orcids":["https://orcid.org/0000-0002-0200-8191"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mady Cissoko","raw_affiliation_strings":["Programme National de Lutte Contre le Paludisme, Bamako, Mali"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programme National de Lutte Contre le Paludisme, Bamako, Mali","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042886705","display_name":"Vincent Sanogo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vincent Sanogo","raw_affiliation_strings":["Programme National de Lutte Contre le Paludisme, Bamako, Mali"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programme National de Lutte Contre le Paludisme, Bamako, Mali","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111076629","display_name":"Aissata Kon\u00e9","orcid":"https://orcid.org/0009-0007-6192-8266","observed_orcids":["https://orcid.org/0009-0007-6192-8266"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aissata Kone","raw_affiliation_strings":["Programme National de Lutte Contre le Paludisme, Bamako, Mali"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programme National de Lutte Contre le Paludisme, Bamako, Mali","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147117230","display_name":"Sidi Niare","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sidi Niare","raw_affiliation_strings":["Koulikoro District Health Center, Koulikoro, Mali"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Koulikoro District Health Center, Koulikoro, Mali","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147100941","display_name":"Aissatou Maiga","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aissatou Maiga","raw_affiliation_strings":["Koulikoro District Health Center, Koulikoro, Mali"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Koulikoro District Health Center, Koulikoro, Mali","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016564666","display_name":"Nafomon Sogoba","orcid":"https://orcid.org/0000-0003-2926-220X","observed_orcids":["https://orcid.org/0000-0003-2926-220X"]},"institutions":[{"id":"https://openalex.org/I4210112095","display_name":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako","ror":"https://ror.org/023rbaw78","country_code":"ML","type":"education","lineage":["https://openalex.org/I4210112095"]}],"countries":["ML"],"is_corresponding":false,"raw_author_name":"Nafomon Sogoba","raw_affiliation_strings":["Infectious Diseases and Entomology Research and Training Center, Bamako, Mali","Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases and Entomology Research and Training Center, Bamako, Mali","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali","institution_ids":["https://openalex.org/I4210112095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147123060","display_name":"Helle Holm Hansonn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Helle Holm Hansonn","raw_affiliation_strings":["Department of Immunology and Microbiology - Centre for Translational Medicine and Parasitology, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbiology - Centre for Translational Medicine and Parasitology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085522877","display_name":"Michael Alifrangis","orcid":"https://orcid.org/0000-0002-3835-3333","observed_orcids":["https://orcid.org/0000-0002-3835-3333"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Michael Alifrangis","raw_affiliation_strings":["Department of Immunology and Microbiology - Centre for Translational Medicine and Parasitology, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbiology - Centre for Translational Medicine and Parasitology, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101948226","display_name":"Mahamadou Diakit\u00e9","orcid":"https://orcid.org/0000-0002-4268-8857","observed_orcids":["https://orcid.org/0000-0002-4268-8857"]},"institutions":[{"id":"https://openalex.org/I4210112095","display_name":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako","ror":"https://ror.org/023rbaw78","country_code":"ML","type":"education","lineage":["https://openalex.org/I4210112095"]}],"countries":["ML"],"is_corresponding":false,"raw_author_name":"Mahamadou Diakite","raw_affiliation_strings":["Infectious Diseases and Entomology Research and Training Center, Bamako, Mali","University Clinical Research Center, Bamako, Mali","Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali"],"raw_orcid":"https://orcid.org/0000-0002-4268-8857","affiliations":[{"raw_affiliation_string":"Infectious Diseases and Entomology Research and Training Center, Bamako, Mali","institution_ids":[]},{"raw_affiliation_string":"University Clinical Research Center, Bamako, Mali","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali","institution_ids":["https://openalex.org/I4210112095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049957635","display_name":"Jeffrey G. Shaffer","orcid":"https://orcid.org/0000-0002-3941-3772","observed_orcids":["https://orcid.org/0000-0002-3941-3772"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey G. Shaffer","raw_affiliation_strings":["Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054654748","display_name":"Seydou Doumbia","orcid":"https://orcid.org/0000-0003-1637-5600","observed_orcids":["https://orcid.org/0000-0003-1637-5600"]},"institutions":[{"id":"https://openalex.org/I4210112095","display_name":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako","ror":"https://ror.org/023rbaw78","country_code":"ML","type":"education","lineage":["https://openalex.org/I4210112095"]}],"countries":["ML"],"is_corresponding":false,"raw_author_name":"Seydou Doumbia","raw_affiliation_strings":["Infectious Diseases and Entomology Research and Training Center, Bamako, Mali","University Clinical Research Center, Bamako, Mali","Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases and Entomology Research and Training Center, Bamako, Mali","institution_ids":[]},{"raw_affiliation_string":"University Clinical Research Center, Bamako, Mali","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali","institution_ids":["https://openalex.org/I4210112095"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5062690919"],"corresponding_institution_ids":["https://openalex.org/I4210112095"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.57414371,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"100122","last_page":"100122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12402","display_name":"Travel-related health issues","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/seasonal-malaria-chemoprevention","display_name":"seasonal malaria chemoprevention","score":1.0},{"id":"https://openalex.org/keywords/dihydroartemisinin-piperaquine","display_name":"dihydroartemisinin-piperaquine","score":0.996999979019165},{"id":"https://openalex.org/keywords/malaria-incidence","display_name":"malaria incidence","score":0.5049999952316284},{"id":"https://openalex.org/keywords/children-aged-5-9-years","display_name":"children aged 5-9 years","score":0.878000020980835},{"id":"https://openalex.org/keywords/non-inferiority","display_name":"non-inferiority","score":0.8669999837875366},{"id":"https://openalex.org/keywords/antimalarial-drug-resistance","display_name":"antimalarial drug resistance","score":0.8349999785423279},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8371000289916992},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.739799976348877},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.5023999810218811},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.34369999170303345},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.24789999425411224},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.24420000612735748},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.24210000038146973},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.2410999983549118},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2328999936580658},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.2222999930381775}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.lanafr.2026.100122","doi":"https://doi.org/10.1016/j.lanafr.2026.100122","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.lanafr.2026.100122","pdf_url":null,"source":{"id":"https://openalex.org/S5407054332","display_name":"The Lancet Regional Health - Africa","issn_l":"3050-5011","issn":["3050-5011"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Regional Health - Africa","raw_type":"journal-article"},{"id":"pmid:42808016","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42808016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet regional health. Africa","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.lanafr.2026.100122","doi":"https://doi.org/10.1016/j.lanafr.2026.100122","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.lanafr.2026.100122","pdf_url":null,"source":{"id":"https://openalex.org/S5407054332","display_name":"The Lancet Regional Health - Africa","issn_l":"3050-5011","issn":["3050-5011"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Regional Health - Africa","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G3717332771","display_name":"Population-based Approach to Malaria Research and Control","funder_award_id":"U19AI089696","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8265816615","display_name":null,"funder_award_id":"U19AI089696","funder_id":"https://openalex.org/F4320309123","funder_display_name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000897441","display_name":"Multidisciplinary Implementation Research for malaria control and elimination in West Africa","funder_award_id":"U19AI129387","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320309123","display_name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1972457996","https://openalex.org/W1973192869","https://openalex.org/W1988262403","https://openalex.org/W1990136727","https://openalex.org/W2070197127","https://openalex.org/W2116219018","https://openalex.org/W2125634589","https://openalex.org/W2151407894","https://openalex.org/W2168226801","https://openalex.org/W2294130235","https://openalex.org/W2338878209","https://openalex.org/W2606536577","https://openalex.org/W2744600822","https://openalex.org/W2757629837","https://openalex.org/W2780525796","https://openalex.org/W3134912823","https://openalex.org/W3137173841","https://openalex.org/W3190114291","https://openalex.org/W4246026898","https://openalex.org/W4387960105","https://openalex.org/W4406389162","https://openalex.org/W4409344568","https://openalex.org/W4413286152"],"related_works":["https://openalex.org/W7096670512","https://openalex.org/W4387960105","https://openalex.org/W13105838","https://openalex.org/W4386561931","https://openalex.org/W4401212958","https://openalex.org/W4406389162","https://openalex.org/W4389918502","https://openalex.org/W7117151663","https://openalex.org/W7162667139","https://openalex.org/W4283269084"],"abstract_inverted_index":{"Background:":[0],"Seasonal":[1],"malaria":[2,11,190,213],"chemoprevention":[3],"(SMC)":[4],"with":[5,64,174],"Sulfadoxine-pyrimethamine":[6],"plus":[7],"amodiaquine":[8],"(SPAQ)":[9],"reduces":[10],"in":[12,48,87,91,116],"children":[13,21,71,192,207],"under":[14],"five,":[15],"but":[16],"substantial":[17],"burden":[18],"remains":[19],"among":[20],"5-9":[22,182,209],"years.":[23,77],"Emerging":[24],"SP/AQ":[25],"resistance":[26,233],"and":[27,59,140,169,219],"adherence":[28,231],"challenges":[29],"underscore":[30],"the":[31,49,57,123],"need":[32],"for":[33,136],"alternative":[34,227],"regimens.":[35],"Dihydroartemisinin-piperaquine":[36],"(DHAPQ)":[37],"is":[38,51],"a":[39,81,113,185],"promising":[40],"option,":[41],"although":[42],"evidence":[43],"from":[44],"multi-season":[45],"programmatic":[46],"settings":[47],"Sahel":[50],"limited.":[52],"We":[53,79],"aimed":[54],"to":[55,70,75,112,160,206,228],"evaluate":[56],"effectiveness":[58],"safety":[60],"of":[61,125,188],"DHAPQ":[62,107,157,215],"compared":[63],"SPAQ":[65,96,101,162,229],"when":[66],"SMC":[67,97,205,235],"was":[68,122,144,158,216],"extended":[69],"aged":[72,181,208],"3":[73],"months":[74],"9":[76],"Methods:":[78],"conducted":[80],"two-year,":[82],"three-arm,":[83],"cluster-randomized":[84],"crossover":[85],"trial":[86],"nine":[88],"health-catchment":[89],"clusters":[90],"Mali.":[92],"Clusters":[93],"received":[94],"standard":[95],"(<5":[98],"years),":[99,103,109],"extended-age":[100,106,161],"(<10":[102,108],"or":[104,232],"(3)":[105],"crossing":[110],"over":[111],"different":[114],"regimen":[115],"year":[117],"two.":[118],"The":[119],"primary":[120],"outcome":[121],"incidence":[124],"clinical":[126,189],"malaria,":[127],"analyzed":[128],"using":[129],"mixed-effects":[130],"negative":[131],"binomial":[132],"models":[133],"that":[134],"accounted":[135],"clustering,":[137],"period":[138],"effects,":[139],"recurrent":[141],"events.":[142],"Non-inferiority":[143],"predefined":[145],"as":[146,225],"an":[147,226],"upper":[148],"95%":[149,166,200],"CI":[150,167,201],"<":[151],"1.25.":[152],"Findings:":[153],"Among":[154],"12,854":[155],"children,":[156],"non-inferior":[159],"(HR":[163,197],"=":[164,198],"0.7,":[165],"0.6-0.9)":[168],"achieved":[170],"higher":[171],"intervention":[172],"coverage,":[173],"no":[175],"serious":[176],"adverse":[177],"events":[178],"reported.":[179],"Children":[180],"years":[183,196,210],"had":[184],"lower":[186],"hazard":[187],"than":[191,194],"younger":[193],"5":[195],"0.9,":[199],"0.8-0.9).":[202],"Interpretation:":[203],"Extending":[204],"substantially":[211],"reduced":[212],"burden.":[214],"safe,":[217],"effective,":[218],"operationally":[220],"feasible,":[221],"supporting":[222],"its":[223],"consideration":[224],"where":[230],"threatens":[234],"effectiveness.":[236],"Funding:":[237],"NIH/NIAID-ICEMR-WAF.":[238]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-14T00:00:00"}