{"id":"https://openalex.org/W7202363224","doi":"https://doi.org/10.64898/2026.10.09.757098","title":"Developmental rewiring of EHMT1 function during human cortical neurogenesis","display_name":"Developmental rewiring of EHMT1 function during human cortical neurogenesis","publication_year":2026,"publication_date":"2026-10-12","ids":{"openalex":"https://openalex.org/W7202363224","doi":"https://doi.org/10.64898/2026.10.09.757098"},"language":"en","primary_location":{"id":"doi:10.64898/2026.10.09.757098","doi":"https://doi.org/10.64898/2026.10.09.757098","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.09.757098","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/12/2026.10.09.757098.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/12/2026.10.09.757098.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115575515","display_name":"Kritika Kasliwal","orcid":"https://orcid.org/0000-0003-0004-1593","observed_orcids":["https://orcid.org/0000-0003-0004-1593"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kritika Kasliwal","raw_affiliation_strings":["Molecular Biology Program, Graduate School of Medical Sciences, Weill Cornell Medicine, New York, 10065, USA","Sanford I Weill Department of Medicine, Division of Regenerative Medicine, Weill Cornell Medicine, New York, NY 10021, USA"],"raw_orcid":"https://orcid.org/0000-0003-0004-1593","affiliations":[{"raw_affiliation_string":"Molecular Biology Program, Graduate School of Medical Sciences, Weill Cornell Medicine, New York, 10065, USA","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Sanford I Weill Department of Medicine, Division of Regenerative Medicine, Weill Cornell Medicine, New York, NY 10021, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063537620","display_name":"Kaushiki Chatterjee","orcid":"https://orcid.org/0000-0003-1663-8810","observed_orcids":["https://orcid.org/0000-0003-1663-8810"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaushiki Chatterjee","raw_affiliation_strings":["Sanford I Weill Department of Medicine, Division of Regenerative Medicine, Weill Cornell Medicine, New York, NY 10021, USA"],"raw_orcid":"https://orcid.org/0000-0003-1663-8810","affiliations":[{"raw_affiliation_string":"Sanford I Weill Department of Medicine, Division of Regenerative Medicine, Weill Cornell Medicine, New York, NY 10021, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071777853","display_name":"Vittoria Dickinson Bocchi","orcid":"https://orcid.org/0000-0002-0541-0151","observed_orcids":["https://orcid.org/0000-0002-0541-0151"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vittoria Dickinson Bocchi","raw_affiliation_strings":["The Center for Stem Cell Biology, Sloan Kettering Institute for Cancer Research, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-0541-0151","affiliations":[{"raw_affiliation_string":"The Center for Stem Cell Biology, Sloan Kettering Institute for Cancer Research, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043999162","display_name":"Syed Raza Mahmood","orcid":"https://orcid.org/0000-0003-3418-1383","observed_orcids":["https://orcid.org/0000-0003-3418-1383"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Syed R. Mahmood","raw_affiliation_strings":["Sanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA"],"raw_orcid":"https://orcid.org/0000-0003-3418-1383","affiliations":[{"raw_affiliation_string":"Sanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016682238","display_name":"Christopher M. Uyehara","orcid":"https://orcid.org/0000-0002-3210-9428","observed_orcids":["https://orcid.org/0000-0002-3210-9428"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher M Uyehara","raw_affiliation_strings":["Sanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA"],"raw_orcid":"https://orcid.org/0000-0002-3210-9428","affiliations":[{"raw_affiliation_string":"Sanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158471582","display_name":"William Marchese","orcid":"https://orcid.org/0009-0007-9143-2851","observed_orcids":["https://orcid.org/0009-0007-9143-2851"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Marchese","raw_affiliation_strings":["Molecular Biology Program, Graduate School of Medical Sciences, Weill Cornell Medicine, New York, 10065, USA"],"raw_orcid":"https://orcid.org/0009-0007-9143-2851","affiliations":[{"raw_affiliation_string":"Molecular Biology Program, Graduate School of Medical Sciences, Weill Cornell Medicine, New York, 10065, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074531097","display_name":"Alejandra Laguillo-Diego","orcid":"https://orcid.org/0000-0003-2724-7890","observed_orcids":["https://orcid.org/0000-0003-2724-7890"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alejandra Laguillo-Diego","raw_affiliation_strings":["Sanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA"],"raw_orcid":"https://orcid.org/0000-0003-2724-7890","affiliations":[{"raw_affiliation_string":"Sanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065427627","display_name":"Emily Goetzler","orcid":"https://orcid.org/0009-0004-1254-8513","observed_orcids":["https://orcid.org/0009-0004-1254-8513"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Goetzler","raw_affiliation_strings":["Molecular Biology Program, Graduate School of Medical Sciences, Weill Cornell Medicine, New York, 10065, USA"],"raw_orcid":"https://orcid.org/0009-0004-1254-8513","affiliations":[{"raw_affiliation_string":"Molecular Biology Program, Graduate School of Medical Sciences, Weill Cornell Medicine, New York, 10065, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158437005","display_name":"Gabriel Theis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriel Theis","raw_affiliation_strings":["Sanford I Weill Department of Medicine, Division of Regenerative Medicine, Weill Cornell Medicine, New York, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanford I Weill Department of Medicine, Division of Regenerative Medicine, Weill Cornell Medicine, New York, NY 10021, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011430458","display_name":"Andrew P. Minotti","orcid":"https://orcid.org/0009-0002-3785-6390","observed_orcids":["https://orcid.org/0009-0002-3785-6390"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Minotti","raw_affiliation_strings":["The Center for Stem Cell Biology, Sloan Kettering Institute for Cancer Research, New York, NY, USA"],"raw_orcid":"https://orcid.org/0009-0002-3785-6390","affiliations":[{"raw_affiliation_string":"The Center for Stem Cell Biology, Sloan Kettering Institute for Cancer Research, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158425640","display_name":"Ryan M Walsh","orcid":"https://orcid.org/0000-0002-5636-5549","observed_orcids":["https://orcid.org/0000-0002-5636-5549"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Walsh","raw_affiliation_strings":["The Center for Stem Cell Biology, Sloan Kettering Institute for Cancer Research, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-5636-5549","affiliations":[{"raw_affiliation_string":"The Center for Stem Cell Biology, Sloan Kettering Institute for Cancer Research, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009377586","display_name":"Alexander Polyzos","orcid":"https://orcid.org/0000-0002-2509-9698","observed_orcids":["https://orcid.org/0000-0002-2509-9698"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Polyzos","raw_affiliation_strings":["Sanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA"],"raw_orcid":"https://orcid.org/0000-0002-2509-9698","affiliations":[{"raw_affiliation_string":"Sanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017913027","display_name":"Effie Apostolou","orcid":"https://orcid.org/0000-0002-8111-0863","observed_orcids":["https://orcid.org/0000-0002-8111-0863"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eftychia Apostolou","raw_affiliation_strings":["Sanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA"],"raw_orcid":"https://orcid.org/0000-0002-8111-0863","affiliations":[{"raw_affiliation_string":"Sanford I. Weill Department of Medicine, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060898511","display_name":"Simone Sidoli","orcid":"https://orcid.org/0000-0001-9073-6641","observed_orcids":["https://orcid.org/0000-0001-9073-6641"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simone Sidoli","raw_affiliation_strings":["Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA"],"raw_orcid":"https://orcid.org/0000-0001-9073-6641","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065135570","display_name":"Lorenz Studer","orcid":"https://orcid.org/0000-0003-0741-7987","observed_orcids":["https://orcid.org/0000-0003-0741-7987","https://orcid.org/0000-0002-5417-5995"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lorenz Studer","raw_affiliation_strings":["The Center for Stem Cell Biology, Sloan Kettering Institute for Cancer Research, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0003-0741-7987","affiliations":[{"raw_affiliation_string":"The Center for Stem Cell Biology, Sloan Kettering Institute for Cancer Research, New York, NY, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046792632","display_name":"Matthias Stadtfeld","orcid":"https://orcid.org/0000-0002-5852-9906","observed_orcids":["https://orcid.org/0000-0002-5852-9906"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthias Stadtfeld","raw_affiliation_strings":["Sanford I Weill Department of Medicine, Division of Regenerative Medicine, Weill Cornell Medicine, New York, NY 10021, USA"],"raw_orcid":"https://orcid.org/0000-0002-5852-9906","affiliations":[{"raw_affiliation_string":"Sanford I Weill Department of Medicine, Division of Regenerative Medicine, Weill Cornell Medicine, New York, NY 10021, USA","institution_ids":["https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5046792632"],"corresponding_institution_ids":["https://openalex.org/I4387153466"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9009000062942505,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9009000062942505,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.07029999792575836,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ehmt1","display_name":"EHMT1","score":1.0},{"id":"https://openalex.org/keywords/histone-methyltransferase","display_name":"histone methyltransferase","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cortical-neurogenesis","display_name":"cortical neurogenesis","score":0.925000011920929},{"id":"https://openalex.org/keywords/human-brain-development","display_name":"human brain development","score":0.6549999713897705},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.6200000047683716},{"id":"https://openalex.org/keywords/neural-stem-cells","display_name":"neural stem cells","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6104999780654907},{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.58160001039505},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5522000193595886},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43389999866485596},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3456000089645386},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.29589998722076416},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.25760000944137573},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.250900000333786},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.24940000474452972},{"id":"https://openalex.org/C3018390542","wikidata":"https://www.wikidata.org/wiki/Q1073","display_name":"Brain function","level":2,"score":0.21940000355243683}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.64898/2026.10.09.757098","doi":"https://doi.org/10.64898/2026.10.09.757098","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.09.757098","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/12/2026.10.09.757098.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"doi:10.5281/zenodo.21925203","doi":"https://doi.org/10.5281/zenodo.21925203","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.21925203","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.5281/zenodo.21925204","doi":"https://doi.org/10.5281/zenodo.21925204","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.21925204","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.5281/zenodo.22822865","doi":"https://doi.org/10.5281/zenodo.22822865","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22822865","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.64898/2026.10.09.757098","doi":"https://doi.org/10.64898/2026.10.09.757098","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.10.09.757098","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/10/12/2026.10.09.757098.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2533196969","display_name":null,"funder_award_id":"S10-OD030286","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332513","display_name":"Weill Cornell Medical College","ror":"https://ror.org/02r109517"},{"id":"https://openalex.org/F4320332582","display_name":"Center for AIDS Research, University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320337349","display_name":"NIH Office of the Director","ror":"https://ror.org/00fj8a872"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7202363224.pdf","grobid_xml":"https://content.openalex.org/works/W7202363224.grobid-xml"},"referenced_works_count":107,"referenced_works":["https://openalex.org/W1531821806","https://openalex.org/W1598350571","https://openalex.org/W1753997046","https://openalex.org/W1968916422","https://openalex.org/W1973303388","https://openalex.org/W1978905882","https://openalex.org/W1979245454","https://openalex.org/W1980730318","https://openalex.org/W1986586739","https://openalex.org/W1999775510","https://openalex.org/W2022851859","https://openalex.org/W2031627559","https://openalex.org/W2034391603","https://openalex.org/W2054429098","https://openalex.org/W2055739897","https://openalex.org/W2060355887","https://openalex.org/W2063786220","https://openalex.org/W2065364505","https://openalex.org/W2079816742","https://openalex.org/W2080018207","https://openalex.org/W2089187573","https://openalex.org/W2091884937","https://openalex.org/W2095452027","https://openalex.org/W2095626300","https://openalex.org/W2099143842","https://openalex.org/W2101022368","https://openalex.org/W2102552859","https://openalex.org/W2102619694","https://openalex.org/W2108234281","https://openalex.org/W2110417468","https://openalex.org/W2131478115","https://openalex.org/W2138207763","https://openalex.org/W2162467606","https://openalex.org/W2163771097","https://openalex.org/W2169456326","https://openalex.org/W2170551349","https://openalex.org/W2170830174","https://openalex.org/W2171808845","https://openalex.org/W2184563578","https://openalex.org/W2319992520","https://openalex.org/W2406278632","https://openalex.org/W2418343927","https://openalex.org/W2472342174","https://openalex.org/W2509351424","https://openalex.org/W2512322712","https://openalex.org/W2556513628","https://openalex.org/W2557087167","https://openalex.org/W2560558522","https://openalex.org/W2562443513","https://openalex.org/W2607585298","https://openalex.org/W2614267207","https://openalex.org/W2616922646","https://openalex.org/W2748881498","https://openalex.org/W2767078245","https://openalex.org/W2790395649","https://openalex.org/W2792453707","https://openalex.org/W2804302228","https://openalex.org/W2910451516","https://openalex.org/W2914387173","https://openalex.org/W2935613324","https://openalex.org/W2945865759","https://openalex.org/W2946618087","https://openalex.org/W2952053464","https://openalex.org/W2980364999","https://openalex.org/W2982393021","https://openalex.org/W2998336860","https://openalex.org/W3008179347","https://openalex.org/W3036206386","https://openalex.org/W3042896257","https://openalex.org/W3048399165","https://openalex.org/W3080237557","https://openalex.org/W3087526660","https://openalex.org/W3088618023","https://openalex.org/W3089296243","https://openalex.org/W3102913447","https://openalex.org/W3122109253","https://openalex.org/W3139489512","https://openalex.org/W3157630266","https://openalex.org/W3175752499","https://openalex.org/W3176869552","https://openalex.org/W3197855566","https://openalex.org/W3209131722","https://openalex.org/W4210458810","https://openalex.org/W4213156779","https://openalex.org/W4289527519","https://openalex.org/W4291708389","https://openalex.org/W4296046336","https://openalex.org/W4297092788","https://openalex.org/W4310911230","https://openalex.org/W4313561500","https://openalex.org/W4317811480","https://openalex.org/W4320913079","https://openalex.org/W4378212544","https://openalex.org/W4385332596","https://openalex.org/W4385879204","https://openalex.org/W4393246315","https://openalex.org/W4396873648","https://openalex.org/W4405612126","https://openalex.org/W4408946055","https://openalex.org/W4410387818","https://openalex.org/W4412723759","https://openalex.org/W4413103898","https://openalex.org/W4413324384","https://openalex.org/W4415076219","https://openalex.org/W4417164530","https://openalex.org/W7117872459","https://openalex.org/W7126018283"],"related_works":["https://openalex.org/W6991002193","https://openalex.org/W2129649737","https://openalex.org/W2947259649","https://openalex.org/W2739665045","https://openalex.org/W3168687323","https://openalex.org/W7135344778","https://openalex.org/W3150265319","https://openalex.org/W2610695108","https://openalex.org/W7125793877","https://openalex.org/W3214369066"],"abstract_inverted_index":{"Summary":[0],"Ubiquitously":[1],"expressed":[2,54],"chromatin":[3,66],"regulators":[4],"orchestrate":[5],"cell-type-specific":[6],"gene":[7,100,185],"expression":[8,101],"programs,":[9,108],"yet":[10],"how":[11,172],"they":[12],"acquire":[13],"distinct":[14,61,110],"regulatory":[15,186],"functions":[16],"during":[17,29,81,142],"development":[18],"remains":[19],"fundamentally":[20],"unresolved":[21],"1,2":[22],".":[23],"Using":[24],"temporally":[25],"controlled":[26],"protein":[27],"depletion":[28,126],"human":[30],"cortical":[31,51],"neurogenesis":[32],"in":[33,102],"vitro":[34],",":[35],"we":[36],"show":[37],"that":[38],"the":[39,131,136,181],"autism-associated":[40],"histone":[41],"methyltransferase":[42],"EHMT1":[43,59,78,114,144,152],"3,4":[44],"is":[45,90,145],"developmentally":[46],"repurposed":[47],"from":[48,96],"epiblast":[49],"to":[50,60,105,188],"neurons.":[52],"Broadly":[53],"zinc":[55],"finger":[56],"proteins":[57],"recruit":[58],"cis-regulatory":[62],"elements":[63],"within":[64],"changing":[65],"landscapes":[67],"associated":[68],"with":[69,74,109,164,191],"lineage-specific":[70],"transcription":[71],"factor":[72],"activity,":[73],"extensive":[75,161],"remodeling":[76],"of":[77,113,138,183],"enhancer":[79],"occupancy":[80],"neural":[82,117,132],"induction":[83],"dependent":[84],"on":[85],"ZNF462.":[86],"This":[87],"genomic":[88],"rewiring":[89],"accompanied":[91],"by":[92],"a":[93,139],"fundamental":[94],"shift":[95],"restraining":[97],"premature":[98],"developmental":[99,140,177,184],"pluripotent":[103],"cells":[104],"supporting":[106],"neuronal":[107,123,149],"transcriptional":[111,162],"consequences":[112],"loss":[115],"across":[116],"progenitors":[118],"and":[119,121,127],"excitatory":[120],"inhibitory":[122],"subtypes.":[124],"Timed":[125],"recovery":[128,163],"experiments":[129],"identify":[130],"progenitor":[133],"stage":[134],"as":[135],"onset":[137],"period":[141],"which":[143],"required":[146],"for":[147,193],"faithful":[148],"maturation.":[150],"Remarkably,":[151],"can":[153],"re-engage":[154],"stage-specific":[155],"targets":[156],"after":[157],"prolonged":[158,189],"deficiency,":[159],"allowing":[160],"only":[165],"limited":[166],"molecular":[167],"scarring.":[168],"These":[169],"findings":[170],"reveal":[171],"ubiquitous":[173],"epigenetic":[174],"machinery":[175],"acquires":[176],"specificity":[178],"while":[179],"demonstrating":[180],"resilience":[182],"programs":[187],"disruption,":[190],"implications":[192],"neurodevelopmental":[194],"disorders.":[195]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-08-14T00:00:00"}
