{"id":"https://openalex.org/W7202363081","doi":"https://doi.org/10.1093/jnci/djag267","title":"Somatic alterations in TP53 , PIK3CA , and CCND1 reveal exposure-driven patterns in oral and oropharyngeal tumors","display_name":"Somatic alterations in TP53 , PIK3CA , and CCND1 reveal exposure-driven patterns in oral and oropharyngeal tumors","publication_year":2026,"publication_date":"2026-08-10","ids":{"openalex":"https://openalex.org/W7202363081","doi":"https://doi.org/10.1093/jnci/djag267","pmid":"https://pubmed.ncbi.nlm.nih.gov/42593222"},"language":"en","primary_location":{"id":"doi:10.1093/jnci/djag267","doi":"https://doi.org/10.1093/jnci/djag267","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jnci/djag267","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI: Journal of the National Cancer Institute","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1093/jnci/djag267","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065773168","display_name":"Ricardo Cortez Cardoso Penha","orcid":"https://orcid.org/0000-0002-2847-1993","observed_orcids":["https://orcid.org/0000-0002-2847-1993"]},"institutions":[{"id":"https://openalex.org/I42237331","display_name":"Centre international de recherche sur le cancer","ror":"https://ror.org/00v452281","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210105654","https://openalex.org/I42237331"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ricardo Cortez Cardoso Penha","raw_affiliation_strings":["Genomic Epidemiology Branch, International Agency for Research on Cancer , Lyon,"],"raw_orcid":"https://orcid.org/0000-0002-2847-1993","affiliations":[{"raw_affiliation_string":"Genomic Epidemiology Branch, International Agency for Research on Cancer , Lyon,","institution_ids":["https://openalex.org/I42237331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046275543","display_name":"Shama Virani","orcid":"https://orcid.org/0000-0002-1163-432X","observed_orcids":["https://orcid.org/0000-0002-1163-432X"]},"institutions":[{"id":"https://openalex.org/I42237331","display_name":"Centre international de recherche sur le cancer","ror":"https://ror.org/00v452281","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210105654","https://openalex.org/I42237331"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Shama Virani","raw_affiliation_strings":["Genomic Epidemiology Branch, International Agency for Research on Cancer , Lyon,"],"raw_orcid":"https://orcid.org/0000-0002-1163-432X","affiliations":[{"raw_affiliation_string":"Genomic Epidemiology Branch, International Agency for Research on Cancer , Lyon,","institution_ids":["https://openalex.org/I42237331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042818118","display_name":"Jeremiah Ray Holt","orcid":"https://orcid.org/0000-0002-5201-5015","observed_orcids":["https://orcid.org/0000-0002-5201-5015"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremiah R Holt","raw_affiliation_strings":["University of Tennessee Health Science Center Department of Medicine, Division of Hematology-Oncology, , Memphis, TN,","University of Tennessee Health Science Center UTHSC Center for Cancer Research, , Memphis, TN,"],"raw_orcid":"https://orcid.org/0000-0002-5201-5015","affiliations":[{"raw_affiliation_string":"University of Tennessee Health Science Center Department of Medicine, Division of Hematology-Oncology, , Memphis, TN,","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"University of Tennessee Health Science Center UTHSC Center for Cancer Research, , Memphis, TN,","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147101084","display_name":"Xiaobei Zhao","orcid":"https://orcid.org/0000-0002-5277-0846","observed_orcids":["https://orcid.org/0000-0002-5277-0846"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaobei Zhao","raw_affiliation_strings":["University of Tennessee Health Science Center UTHSC Center for Cancer Research, , Memphis, TN,"],"raw_orcid":"https://orcid.org/0000-0002-5277-0846","affiliations":[{"raw_affiliation_string":"University of Tennessee Health Science Center UTHSC Center for Cancer Research, , Memphis, TN,","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051333258","display_name":"Paul Little","orcid":"https://orcid.org/0000-0002-9789-8501","observed_orcids":["https://orcid.org/0000-0002-9789-8501"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Little","raw_affiliation_strings":["University of Tennessee Health Science Center UTHSC Center for Cancer Research, , Memphis, TN,"],"raw_orcid":"https://orcid.org/0000-0002-9789-8501","affiliations":[{"raw_affiliation_string":"University of Tennessee Health Science Center UTHSC Center for Cancer Research, , Memphis, TN,","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063682870","display_name":"Myriam Brossard","orcid":"https://orcid.org/0000-0003-4144-3978","observed_orcids":["https://orcid.org/0000-0003-4144-3978"]},"institutions":[{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I4210130843","display_name":"Sinai Health System","ror":"https://ror.org/044790d95","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Myriam Brossard","raw_affiliation_strings":["Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health , Toronto, ON,"],"raw_orcid":"https://orcid.org/0000-0003-4144-3978","affiliations":[{"raw_affiliation_string":"Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health , Toronto, ON,","institution_ids":["https://openalex.org/I210557978","https://openalex.org/I4210130843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055784647","display_name":"Val\u00e9rie Gaborieau","orcid":"https://orcid.org/0000-0002-0210-5215","observed_orcids":["https://orcid.org/0000-0002-0210-5215"]},"institutions":[{"id":"https://openalex.org/I42237331","display_name":"Centre international de recherche sur le cancer","ror":"https://ror.org/00v452281","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210105654","https://openalex.org/I42237331"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Val\u00e9rie Gaborieau","raw_affiliation_strings":["Genomic Epidemiology Branch, International Agency for Research on Cancer , Lyon,"],"raw_orcid":"https://orcid.org/0000-0002-0210-5215","affiliations":[{"raw_affiliation_string":"Genomic Epidemiology Branch, International Agency for Research on Cancer , Lyon,","institution_ids":["https://openalex.org/I42237331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012882786","display_name":"Maja Milojevic","orcid":"https://orcid.org/0000-0002-8248-8884","observed_orcids":["https://orcid.org/0000-0002-8248-8884"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]},{"id":"https://openalex.org/I4210160921","display_name":"Centre of Excellence for Health, Immunity and Infections","ror":"https://ror.org/05p017741","country_code":"DK","type":"other","lineage":["https://openalex.org/I4210160921"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Maja Milojevic","raw_affiliation_strings":["Rigshospitalet, Copenhagen University Hospital Department of Infectious Diseases and Centre of Excellence for Health, Immunity and Infections, , Copenhagen,"],"raw_orcid":"https://orcid.org/0000-0002-8248-8884","affiliations":[{"raw_affiliation_string":"Rigshospitalet, Copenhagen University Hospital Department of Infectious Diseases and Centre of Excellence for Health, Immunity and Infections, , Copenhagen,","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210160921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085895715","display_name":"Laura Torrens","orcid":"https://orcid.org/0000-0002-3309-6200","observed_orcids":["https://orcid.org/0000-0002-3309-6200"]},"institutions":[{"id":"https://openalex.org/I42237331","display_name":"Centre international de recherche sur le cancer","ror":"https://ror.org/00v452281","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210105654","https://openalex.org/I42237331"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laura Torrens","raw_affiliation_strings":["Genomic Epidemiology Branch, International Agency for Research on Cancer , Lyon,"],"raw_orcid":"https://orcid.org/0000-0002-3309-6200","affiliations":[{"raw_affiliation_string":"Genomic Epidemiology Branch, International Agency for Research on Cancer , Lyon,","institution_ids":["https://openalex.org/I42237331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001328738","display_name":"Hanla A. Park","orcid":"https://orcid.org/0000-0001-8055-3729","observed_orcids":["https://orcid.org/0000-0001-8055-3729"]},"institutions":[{"id":"https://openalex.org/I42237331","display_name":"Centre international de recherche sur le cancer","ror":"https://ror.org/00v452281","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210105654","https://openalex.org/I42237331"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Hanla A Park","raw_affiliation_strings":["Genomic Epidemiology Branch, International Agency for Research on Cancer , Lyon,"],"raw_orcid":"https://orcid.org/0000-0001-8055-3729","affiliations":[{"raw_affiliation_string":"Genomic Epidemiology Branch, International Agency for Research on Cancer , Lyon,","institution_ids":["https://openalex.org/I42237331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056103429","display_name":"Tom Dudding","orcid":"https://orcid.org/0000-0003-3756-040X","observed_orcids":["https://orcid.org/0000-0003-3756-040X"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tom Dudding","raw_affiliation_strings":["Bristol Dental School, University of Bristol , Bristol,"],"raw_orcid":"https://orcid.org/0000-0003-3756-040X","affiliations":[{"raw_affiliation_string":"Bristol Dental School, University of Bristol , Bristol,","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001660012","display_name":"Wendell Gray Yarbrough","orcid":"https://orcid.org/0000-0003-0855-6444","observed_orcids":["https://orcid.org/0000-0003-0855-6444"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendell G Yarbrough","raw_affiliation_strings":["Department of Otolaryngology/Head and Neck Surgery, UNC School of Medicine, University of North Carolina , Chapel Hill, NC,"],"raw_orcid":"https://orcid.org/0000-0003-0855-6444","affiliations":[{"raw_affiliation_string":"Department of Otolaryngology/Head and Neck Surgery, UNC School of Medicine, University of North Carolina , Chapel Hill, NC,","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017447294","display_name":"Miranda Pring","orcid":"https://orcid.org/0000-0003-4658-5772","observed_orcids":["https://orcid.org/0000-0003-4658-5772"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miranda Pring","raw_affiliation_strings":["Department of Otolaryngology/Head and Neck Surgery, UNC School of Medicine, University of North Carolina , Chapel Hill, NC,"],"raw_orcid":"https://orcid.org/0000-0003-4658-5772","affiliations":[{"raw_affiliation_string":"Department of Otolaryngology/Head and Neck Surgery, UNC School of Medicine, University of North Carolina , Chapel Hill, NC,","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086084361","display_name":"Vonn Walter","orcid":"https://orcid.org/0000-0001-6114-6714","observed_orcids":["https://orcid.org/0000-0001-6114-6714"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vonn Walter","raw_affiliation_strings":["Department of Public Health Sciences, Penn State College of Medicine , Hershey, PA,"],"raw_orcid":"https://orcid.org/0000-0001-6114-6714","affiliations":[{"raw_affiliation_string":"Department of Public Health Sciences, Penn State College of Medicine , Hershey, PA,","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063842271","display_name":"Scott Victor Bratman","orcid":"https://orcid.org/0000-0001-8610-4908","observed_orcids":["https://orcid.org/0000-0001-8610-4908"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Scott V Bratman","raw_affiliation_strings":["Radiation Medicine Program, Princess Margaret Cancer Centre, University of Toronto , Toronto, ON,"],"raw_orcid":"https://orcid.org/0000-0001-8610-4908","affiliations":[{"raw_affiliation_string":"Radiation Medicine Program, Princess Margaret Cancer Centre, University of Toronto , Toronto, ON,","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030844189","display_name":"Wolfgang Ahrens","orcid":"https://orcid.org/0000-0003-3777-570X","observed_orcids":["https://orcid.org/0000-0003-3777-570X"]},"institutions":[{"id":"https://openalex.org/I4210113759","display_name":"Leibniz Institute for Prevention Research and Epidemiology - BIPS","ror":"https://ror.org/02c22vc57","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210113759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang Ahrens","raw_affiliation_strings":["Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology-BIPS , Bremen,"],"raw_orcid":"https://orcid.org/0000-0003-3777-570X","affiliations":[{"raw_affiliation_string":"Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology-BIPS , Bremen,","institution_ids":["https://openalex.org/I4210113759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108685323","display_name":"Laia Alemany","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107147","display_name":"Institut Catal\u00e0 d'Oncologia","ror":"https://ror.org/01j1eb875","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210107147"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Laia Alemany","raw_affiliation_strings":["Catalan Institute of Oncology, L'hospitalet de Llobregat Unit of Molecular Epidemiology and Genetics, Cancer Epidemiology Research Program, , L\u2019Hospitalet, Barcelona,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Catalan Institute of Oncology, L'hospitalet de Llobregat Unit of Molecular Epidemiology and Genetics, Cancer Epidemiology Research Program, , L\u2019Hospitalet, Barcelona,","institution_ids":["https://openalex.org/I4210107147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057127488","display_name":"Cristina Canova","orcid":"https://orcid.org/0000-0001-7027-7935","observed_orcids":["https://orcid.org/0000-0001-7027-7935"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cristina Canova","raw_affiliation_strings":["Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padova Unit of Biostatistics, Epidemiology and Public Health, , Padova,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padova Unit of Biostatistics, Epidemiology and Public Health, , Padova,","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048523520","display_name":"David Ian Conway","orcid":"https://orcid.org/0000-0001-7762-4063","observed_orcids":["https://orcid.org/0000-0001-7762-4063"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David I Conway","raw_affiliation_strings":["School of Medicine, Dentistry & Nursing, University of Glasgow, Glasgow,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Dentistry & Nursing, University of Glasgow, Glasgow,","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071615775","display_name":"Claire Mary Healy","orcid":"https://orcid.org/0000-0003-0583-6360","observed_orcids":["https://orcid.org/0000-0003-0583-6360"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]},{"id":"https://openalex.org/I4210142514","display_name":"Dublin Dental University Hospital","ror":"https://ror.org/03v4j0e89","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210142514"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Claire M Healy","raw_affiliation_strings":["School of Dental Science, Dublin Dental University Hospital, Trinity College Dublin , Dublin,"],"raw_orcid":"https://orcid.org/0000-0003-0583-6360","affiliations":[{"raw_affiliation_string":"School of Dental Science, Dublin Dental University Hospital, Trinity College Dublin , Dublin,","institution_ids":["https://openalex.org/I205274468","https://openalex.org/I4210142514"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033421883","display_name":"Ivana Holc\u00e1tov\u00e1","orcid":"https://orcid.org/0000-0002-1366-0337","observed_orcids":["https://orcid.org/0000-0002-1366-0337"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210097985","display_name":"University Hospital in Motol","ror":"https://ror.org/0125yxn03","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210097985","https://openalex.org/I4405269046"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Ivana Holcatova","raw_affiliation_strings":["Department of Oncology, University Hospital Motol and Second Faculty of Medicine, Charles University , Prague,","Institute of Hygiene and Epidemiology, First Faculty of Medicine, Charles University , Prague,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, University Hospital Motol and Second Faculty of Medicine, Charles University , Prague,","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210097985"]},{"raw_affiliation_string":"Institute of Hygiene and Epidemiology, First Faculty of Medicine, Charles University , Prague,","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051046598","display_name":"Lu\u00eds Felipe Ribeiro Pinto","orcid":"https://orcid.org/0000-0001-5509-1008","observed_orcids":["https://orcid.org/0000-0001-5509-1008"]},"institutions":[{"id":"https://openalex.org/I4210142683","display_name":"Instituto Nacional de C\u00e2ncer - INCA","ror":"https://ror.org/055n68305","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210142683"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luis Felipe Ribeiro Pinto","raw_affiliation_strings":["Instituto Nacional de C\u00e2ncer\u2014INCA, Programa de Carcinog\u00eanese Molecular , Rio de Janeiro,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Nacional de C\u00e2ncer\u2014INCA, Programa de Carcinog\u00eanese Molecular , Rio de Janeiro,","institution_ids":["https://openalex.org/I4210142683"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090934538","display_name":"Mar\u00eda Paula Curado","orcid":"https://orcid.org/0000-0001-8172-2483","observed_orcids":["https://orcid.org/0000-0001-8172-2483"]},"institutions":[{"id":"https://openalex.org/I3019035496","display_name":"AC Camargo Hospital","ror":"https://ror.org/03025ga79","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I3019035496"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Paula Curado","raw_affiliation_strings":["Epidemiology and Statistics Group, Research Center, A. C. Camargo Cancer Center , S\u00e3o Paulo,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epidemiology and Statistics Group, Research Center, A. C. Camargo Cancer Center , S\u00e3o Paulo,","institution_ids":["https://openalex.org/I3019035496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008686431","display_name":"Sandra Ventorin von Zeidler","orcid":"https://orcid.org/0000-0002-8897-5747","observed_orcids":["https://orcid.org/0000-0002-8897-5747"]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Sandra Ventorin von Zeidler","raw_affiliation_strings":["Pathology Department, Federal University of Esp\u00edrito Santo , Vit\u00f3ria,"],"raw_orcid":"https://orcid.org/0000-0002-8897-5747","affiliations":[{"raw_affiliation_string":"Pathology Department, Federal University of Esp\u00edrito Santo , Vit\u00f3ria,","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119813961","display_name":"Jose Carlos de Oliviera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112957","display_name":"Hospital Ara\u00fajo Jorge","ror":"https://ror.org/022d66a71","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210112957"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jose Carlos de Oliveira","raw_affiliation_strings":["Associa\u00e7\u00e3o de Combate ao C\u00e2ncer em Goi\u00e1s, Ara\u00fajo Jorge Cancer Hospital , Goiania,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associa\u00e7\u00e3o de Combate ao C\u00e2ncer em Goi\u00e1s, Ara\u00fajo Jorge Cancer Hospital , Goiania,","institution_ids":["https://openalex.org/I4210112957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051657479","display_name":"Jos\u00e9 Roberto Vasconcelos de Podest\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Roberto Vasconcelos de Podest\u00e1","raw_affiliation_strings":["Associa\u00e7\u00e3o Feminina de Educa\u00e7\u00e3o e Combate ao C\u00e2ncer\u2014Hospital Santa Rita de C\u00e1ssia , Vit\u00f3ria,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associa\u00e7\u00e3o Feminina de Educa\u00e7\u00e3o e Combate ao C\u00e2ncer\u2014Hospital Santa Rita de C\u00e1ssia , Vit\u00f3ria,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027677885","display_name":"Marta Vilensky","orcid":"https://orcid.org/0000-0003-0990-4092","observed_orcids":["https://orcid.org/0000-0003-0990-4092"]},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Marta Vilensky","raw_affiliation_strings":["Instituto de Oncologia Angel H Roffo, Universidad de Buenos Aires , Buenos Aires,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Oncologia Angel H Roffo, Universidad de Buenos Aires , Buenos Aires,","institution_ids":["https://openalex.org/I24354313"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074382099","display_name":"Areti Lagiou","orcid":"https://orcid.org/0000-0002-6687-358X","observed_orcids":["https://orcid.org/0000-0002-6687-358X"]},"institutions":[{"id":"https://openalex.org/I4210094138","display_name":"University of West Attica","ror":"https://ror.org/00r2r5k05","country_code":"GR","type":"education","lineage":["https://openalex.org/I4210094138"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Areti Lagiou","raw_affiliation_strings":["Department of Public and Community Health, School of Public Health, University of West Attica , Athens,"],"raw_orcid":"https://orcid.org/0000-0002-6687-358X","affiliations":[{"raw_affiliation_string":"Department of Public and Community Health, School of Public Health, University of West Attica , Athens,","institution_ids":["https://openalex.org/I4210094138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053915331","display_name":"Gary John Macfarlane","orcid":"https://orcid.org/0000-0003-2322-3314","observed_orcids":["https://orcid.org/0000-0003-2322-3314"]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gary J Macfarlane","raw_affiliation_strings":["Epidemiology Group, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen , Aberdeen,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epidemiology Group, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen , Aberdeen,","institution_ids":["https://openalex.org/I195460627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090745215","display_name":"Jerry Polesel","orcid":"https://orcid.org/0000-0001-9381-1520","observed_orcids":["https://orcid.org/0000-0001-9381-1520"]},"institutions":[{"id":"https://openalex.org/I4210128630","display_name":"Centro di Riferimento Oncologico","ror":"https://ror.org/03ks1vk59","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210128630","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Jerry Polesel","raw_affiliation_strings":["Unit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS , Aviano,"],"raw_orcid":"https://orcid.org/0000-0001-9381-1520","affiliations":[{"raw_affiliation_string":"Unit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS , Aviano,","institution_ids":["https://openalex.org/I4210128630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023976598","display_name":"Lorenzo Richiardi","orcid":"https://orcid.org/0000-0003-0316-9402","observed_orcids":["https://orcid.org/0000-0003-0316-9402"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lorenzo Richiardi","raw_affiliation_strings":["Department of Medical Sciences, University of Turin , Turin,"],"raw_orcid":"https://orcid.org/0000-0003-0316-9402","affiliations":[{"raw_affiliation_string":"Department of Medical Sciences, University of Turin , Turin,","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049247909","display_name":"Max Robinson","orcid":"https://orcid.org/0000-0003-4491-6865","observed_orcids":["https://orcid.org/0000-0003-4491-6865"]},"institutions":[{"id":"https://openalex.org/I2801663869","display_name":"Newcastle upon Tyne Hospitals NHS Foundation Trust","ror":"https://ror.org/05p40t847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Max Robinson","raw_affiliation_strings":["Cellular Pathology, The Newcastle upon Tyne Hospitals NHS Foundation Trust , Newcastle upon Tyne,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Pathology, The Newcastle upon Tyne Hospitals NHS Foundation Trust , Newcastle upon Tyne,","institution_ids":["https://openalex.org/I2801663869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065864395","display_name":"Ariana Znaor","orcid":"https://orcid.org/0000-0002-5849-4782","observed_orcids":["https://orcid.org/0000-0002-5849-4782"]},"institutions":[{"id":"https://openalex.org/I42237331","display_name":"Centre international de recherche sur le cancer","ror":"https://ror.org/00v452281","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210105654","https://openalex.org/I42237331"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ariana Znaor","raw_affiliation_strings":["Cancer Surveillance Branch, International Agency for Research on Cancer , Lyon,"],"raw_orcid":"https://orcid.org/0000-0002-5849-4782","affiliations":[{"raw_affiliation_string":"Cancer Surveillance Branch, International Agency for Research on Cancer , Lyon,","institution_ids":["https://openalex.org/I42237331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087212234","display_name":"Jose P. Zevallos","orcid":"https://orcid.org/0009-0003-2442-6014","observed_orcids":["https://orcid.org/0009-0003-2442-6014"]},"institutions":[{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose Zevallos","raw_affiliation_strings":["Department of Otolaryngology, University of Pittsburgh Medical Center , Pittsburgh, PA,"],"raw_orcid":"https://orcid.org/0009-0003-2442-6014","affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, University of Pittsburgh Medical Center , Pittsburgh, PA,","institution_ids":["https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129850993","display_name":"Sandra Perdomo","orcid":"https://orcid.org/0000-0001-7740-8141","observed_orcids":["https://orcid.org/0000-0001-7740-8141"]},"institutions":[{"id":"https://openalex.org/I42237331","display_name":"Centre international de recherche sur le cancer","ror":"https://ror.org/00v452281","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210105654","https://openalex.org/I42237331"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sandra Perdomo","raw_affiliation_strings":["Genomic Epidemiology Branch, International Agency for Research on Cancer , Lyon,"],"raw_orcid":"https://orcid.org/0000-0001-7740-8141","affiliations":[{"raw_affiliation_string":"Genomic Epidemiology Branch, International Agency for Research on Cancer , Lyon,","institution_ids":["https://openalex.org/I42237331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001258652","display_name":"Paul Brennan","orcid":"https://orcid.org/0000-0002-0518-8714","observed_orcids":["https://orcid.org/0000-0002-0518-8714","https://orcid.org/0000-0003-1128-6254","https://orcid.org/0000-0001-8368-1478","https://orcid.org/0000-0002-7977-6818","https://orcid.org/0000-0002-8950-7646"]},"institutions":[{"id":"https://openalex.org/I42237331","display_name":"Centre international de recherche sur le cancer","ror":"https://ror.org/00v452281","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210105654","https://openalex.org/I42237331"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Paul Brennan","raw_affiliation_strings":["Genomic Epidemiology Branch, International Agency for Research on Cancer , Lyon,"],"raw_orcid":"https://orcid.org/0000-0002-0518-8714","affiliations":[{"raw_affiliation_string":"Genomic Epidemiology Branch, International Agency for Research on Cancer , Lyon,","institution_ids":["https://openalex.org/I42237331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053712654","display_name":"Rayjean J. Hung","orcid":"https://orcid.org/0000-0002-4486-7496","observed_orcids":["https://orcid.org/0000-0002-4486-7496"]},"institutions":[{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I4210130843","display_name":"Sinai Health System","ror":"https://ror.org/044790d95","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Rayjean J Hung","raw_affiliation_strings":["Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health , Toronto, ON,"],"raw_orcid":"https://orcid.org/0000-0002-4486-7496","affiliations":[{"raw_affiliation_string":"Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health , Toronto, ON,","institution_ids":["https://openalex.org/I210557978","https://openalex.org/I4210130843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080937699","display_name":"Tim Waterboer","orcid":"https://orcid.org/0000-0002-0616-6963","observed_orcids":["https://orcid.org/0000-0002-0616-6963"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tim Waterboer","raw_affiliation_strings":["Infections and Cancer Epidemiology, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) , Heidelberg,"],"raw_orcid":"https://orcid.org/0000-0002-0616-6963","affiliations":[{"raw_affiliation_string":"Infections and Cancer Epidemiology, German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) , Heidelberg,","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147117545","display_name":"Geoffrey Liu","orcid":"https://orcid.org/0000-0002-2603-7296","observed_orcids":["https://orcid.org/0000-0002-2603-7296"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Geoffrey Liu","raw_affiliation_strings":["University of Toronto and Princess Margaret Cancer Centre Department of Epidemiology, Dalla Lana School of Public Health, , Toronto, ON,"],"raw_orcid":"https://orcid.org/0000-0002-2603-7296","affiliations":[{"raw_affiliation_string":"University of Toronto and Princess Margaret Cancer Centre Department of Epidemiology, Dalla Lana School of Public Health, , Toronto, ON,","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034598130","display_name":"Andrew F. Olshan","orcid":"https://orcid.org/0000-0001-9115-5128","observed_orcids":["https://orcid.org/0000-0001-9115-5128"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew F Olshan","raw_affiliation_strings":["Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina , Chapel Hill,"],"raw_orcid":"https://orcid.org/0000-0001-9115-5128","affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina , Chapel Hill,","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088224394","display_name":"Brenda B. Diergaarde","orcid":"https://orcid.org/0000-0002-3578-6547","observed_orcids":["https://orcid.org/0000-0002-3578-6547"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brenda Diergaarde","raw_affiliation_strings":["Department of Human Genetics, School of Public Health, University of Pittsburgh and UPMC Hillman Cancer Center , Pittsburgh, PA,"],"raw_orcid":"https://orcid.org/0000-0002-3578-6547","affiliations":[{"raw_affiliation_string":"Department of Human Genetics, School of Public Health, University of Pittsburgh and UPMC Hillman Cancer Center , Pittsburgh, PA,","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121051253","display_name":"D Neil Hayes","orcid":"https://orcid.org/0000-0001-6203-7771","observed_orcids":["https://orcid.org/0000-0001-6203-7771"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Neil Hayes","raw_affiliation_strings":["University of Tennessee Health Science Center UTHSC Center for Cancer Research, , Memphis, TN,"],"raw_orcid":"https://orcid.org/0000-0001-6203-7771","affiliations":[{"raw_affiliation_string":"University of Tennessee Health Science Center UTHSC Center for Cancer Research, , Memphis, TN,","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089473534","display_name":"James McKay","orcid":"https://orcid.org/0000-0002-1787-3874","observed_orcids":["https://orcid.org/0000-0002-1787-3874"]},"institutions":[{"id":"https://openalex.org/I42237331","display_name":"Centre international de recherche sur le cancer","ror":"https://ror.org/00v452281","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210105654","https://openalex.org/I42237331"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"James D McKay","raw_affiliation_strings":["Genomic Epidemiology Branch, International Agency for Research on Cancer , Lyon,"],"raw_orcid":"https://orcid.org/0000-0002-1787-3874","affiliations":[{"raw_affiliation_string":"Genomic Epidemiology Branch, International Agency for Research on Cancer , Lyon,","institution_ids":["https://openalex.org/I42237331"]}]}],"institutions":[],"countries_distinct_count":13,"institutions_distinct_count":34,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5436,"currency":"USD","value_usd":5436},"apc_paid":{"value":5436,"currency":"USD","value_usd":5436},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.58720096,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-cancer","display_name":"oral cancer","score":0.7379999756813049},{"id":"https://openalex.org/keywords/oropharyngeal-cancer","display_name":"oropharyngeal cancer","score":1.0},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/ccnd1-amplification","display_name":"CCND1 amplification","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tobacco-use","display_name":"tobacco use","score":0.4350000023841858},{"id":"https://openalex.org/keywords/alcohol-consumption","display_name":"alcohol consumption","score":0.9399999976158142},{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.9340000152587891},{"id":"https://openalex.org/keywords/apobec-mutational-signature","display_name":"APOBEC mutational signature","score":0.7580000162124634},{"id":"https://openalex.org/keywords/fgfr3-mutation","display_name":"FGFR3 mutation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/fat1-mutations","display_name":"FAT1 mutations","score":0.703000009059906},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.657800018787384},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5547000169754028},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5440000295639038},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5085999965667725},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46230000257492065},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.45089998841285706},{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.4052000045776367},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38190001249313354},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3815000057220459},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.3813999891281128},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38100001215934753},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.36039999127388},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.3531999886035919},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3398999869823456},{"id":"https://openalex.org/C2994532551","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"Human papillomavirus","level":2,"score":0.3287999927997589},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.3100000023841858},{"id":"https://openalex.org/C2986629439","wikidata":"https://www.wikidata.org/wiki/Q9635","display_name":"Oral cavity","level":2,"score":0.29820001125335693},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2883000075817108},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.2865000069141388},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.2831000089645386},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26350000500679016},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.262800008058548},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.25949999690055847},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.25540000200271606}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1093/jnci/djag267","doi":"https://doi.org/10.1093/jnci/djag267","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jnci/djag267","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI: Journal of the National Cancer Institute","raw_type":"journal-article"},{"id":"pmid:42593222","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42593222","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Cancer Institute","raw_type":"Journal Article"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire/6af00fb5-8d6f-42b8-9f7c-ba57ce7cc8e8","doi":null,"is_oa":true,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/6af00fb5-8d6f-42b8-9f7c-ba57ce7cc8e8","pdf_url":null,"source":{"id":"https://openalex.org/S4306400895","display_name":"Bristol Research (University of Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I36234482","host_organization_name":"University of Bristol","host_organization_lineage":["https://openalex.org/I36234482"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:eprints.gla.ac.uk:392744","doi":null,"is_oa":true,"landing_page_url":"https://eprints.gla.ac.uk/view/journal_volume/Journal_of_the_National_Cancer_Institute.html>,","pdf_url":"https://eprints.gla.ac.uk/392744/1/392744.pdf","source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/I4405259220","host_organization_name":"Institut Agama Islam Negeri Langsa","host_organization_lineage":["https://openalex.org/I4405259220"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Articles"},{"id":"pmh:oai:www.research.unipd.it:11577/3609921","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11577/3609921","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/jnci/djag267","doi":"https://doi.org/10.1093/jnci/djag267","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jnci/djag267","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI: Journal of the National Cancer Institute","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1175322707","display_name":"Germline risk of oral and oropharyngeal cancers across diverse populations","funder_award_id":"R03DE030257","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G1276524703","display_name":null,"funder_award_id":"RP-PG-0707-10034","funder_id":"https://openalex.org/F4320335255","funder_display_name":"Programme Grants for Applied Research"},{"id":"https://openalex.org/G2642749895","display_name":null,"funder_award_id":"C18281/A19169","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G4444790347","display_name":null,"funder_award_id":"P30CA047904","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4595286600","display_name":"Gene Environment Interaction in Head and Neck Cancer","funder_award_id":"R01CA090731","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6001157897","display_name":"The role of germline and somatic DNA mutations in oral and oropharyngeal cancers","funder_award_id":"R01DE025712","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G614487154","display_name":"Evidence based health care for major congenital and acquired problems of the head and neck","funder_award_id":"RP-PG-0707-10034","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G633032242","display_name":null,"funder_award_id":"QLK1-2001-00182","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6966134840","display_name":null,"funder_award_id":"P30 CA047904","funder_id":"https://openalex.org/F4320310174","funder_display_name":"University of Pittsburgh"},{"id":"https://openalex.org/G8247575195","display_name":null,"funder_award_id":"10034","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G9000895320","display_name":"Head and Neck Cancer SPORE","funder_award_id":"P50CA097190","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000897317","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA047904","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309746","display_name":"Compagnia di San Paolo","ror":"https://ror.org/00d1b1c41"},{"id":"https://openalex.org/F4320310174","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320323682","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Esp\u00edrito Santo","ror":"https://ror.org/03cen2c33"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334576","display_name":"Canadian Cancer Society Research Institute","ror":"https://ror.org/017343w90"},{"id":"https://openalex.org/F4320335255","display_name":"Programme Grants for Applied Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7202363081.pdf","grobid_xml":"https://content.openalex.org/works/W7202363081.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2397329148","https://openalex.org/W6983600290","https://openalex.org/W2891490308","https://openalex.org/W2792929591","https://openalex.org/W2285984680","https://openalex.org/W1964779047","https://openalex.org/W4413738181","https://openalex.org/W2897576789","https://openalex.org/W3133565951","https://openalex.org/W2936320755"],"abstract_inverted_index":{"Tobacco,":[0],"alcohol,":[1],"and":[2,14,49,65,77,123,143,188,194,219,222,235],"human":[3],"papillomavirus":[4],"(HPV)":[5],"are":[6],"major":[7],"risk":[8,231],"factors":[9],"for":[10,192],"oral":[11],"cavity":[12],"(OC)":[13],"oropharyngeal":[15],"(OPC)":[16],"cancers,":[17],"yet":[18],"their":[19,51],"specific":[20],"contributions":[21],"to":[22,120,173,183,189,198],"the":[23,87,139,146,164],"tumor":[24],"molecular":[25,225],"landscape":[26],"remain":[27],"incompletely":[28],"understood.":[29],"We":[30],"analyzed":[31],"somatic":[32,215],"alterations":[33,56,216],"in":[34,70,92,100,106,127,138,155,233],"1,086":[35],"tumors":[36,122,168,199],"(606":[37],"OC,":[38,159],"480":[39],"OPC,":[40],"including":[41],"287":[42],"HPV(+)OPC)":[43],"profiled":[44],"with":[45,53,95],"a":[46,71,224],"1,109-gene":[47],"panel":[48],"evaluated":[50],"associations":[52],"exposures.":[54],"PIK3CA":[55],"were":[57,79,108,117,124,180],"widespread":[58],"but":[59],"context-specific:":[60],"HPV(+)OPC":[61],"featured":[62],"APOBEC-driven":[63],"mutations":[64,69,196],"co-occurrence":[66],"of":[67,73,112,161,163,167,214],"FGFR3":[68],"subset":[72],"cases,":[74],"while":[75],"HPV(-)OPC":[76],"OC":[78,107],"marked":[80],"by":[81,217],"3q26/28":[82],"(PIK3CA/TP63/SOX2)":[83],"amplifications.":[84],"TP53":[85,103],"was":[86,136,153],"most":[88,125],"frequently":[89],"mutated":[90],"gene":[91],"HPV(-)":[93,121],"tumors,":[94],"strong":[96],"enrichment":[97,191],"among":[98],"smokers":[99],"HPV(-)OPC,":[101],"whereas":[102],"mutation":[104],"frequencies":[105],"consistently":[109],"high":[110],"regardless":[111],"smoking":[113],"status.":[114],"CCND1":[115,150],"amplifications":[116],"largely":[118],"restricted":[119],"frequent":[126],"individuals":[128],"reporting":[129],"combined":[130,134],"tobacco/alcohol":[131],"use.":[132],"This":[133],"effect":[135],"replicated":[137],"TCGA":[140],"OC-OPC":[141],"cohort":[142],"mirrored":[144],"at":[145],"transcriptomic":[147],"level,":[148],"where":[149],"mRNA":[151],"expression":[152],"highest":[154],"dual":[156],"users.":[157],"Within":[158],"characterization":[160],"one":[162],"largest":[165],"cohorts":[166],"from":[169,185,200],"never":[170],"smoker-never":[171],"drinkers":[172,203],"date":[174],"(N":[175,204],"=":[176,205],"100)":[177],"showed":[178],"they":[179],"more":[181],"likely":[182],"be":[184],"female":[186],"patients":[187],"exhibit":[190],"FAT1":[193],"CASP8":[195],"compared":[197],"ever":[201],"smoker-ever":[202],"353).":[206],"Together,":[207],"these":[208],"findings":[209],"define":[210],"distinct,":[211],"exposure-driven":[212],"patterns":[213],"subsite":[218],"HPV":[220],"status,":[221],"provide":[223],"framework":[226],"that":[227],"may":[228],"inform":[229],"etiologic-based":[230],"stratification":[232],"head":[234],"neck":[236],"cancer.":[237]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-14T00:00:00"}