{"id":"https://openalex.org/W7202362970","doi":"https://doi.org/10.67440/ahj.v21i5s.1448","title":"Clinical Utility Of Serum Uric Acid For Screening, Risk Stratification, And Prediction Of Metabolic Syndrome In Adults: A Systematic Review","display_name":"Clinical Utility Of Serum Uric Acid For Screening, Risk Stratification, And Prediction Of Metabolic Syndrome In Adults: A Systematic Review","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7202362970","doi":"https://doi.org/10.67440/ahj.v21i5s.1448"},"language":"en","primary_location":{"id":"doi:10.67440/ahj.v21i5s.1448","doi":"https://doi.org/10.67440/ahj.v21i5s.1448","is_oa":true,"landing_page_url":"https://doi.org/10.67440/ahj.v21i5s.1448","pdf_url":"https://adolescenciaesaude.com/index.php/aes/article/download/1448/1175","source":{"id":"https://openalex.org/S4306500736","display_name":"Adolescencia e Saude","issn_l":"1679-9941","issn":["1679-9941","2177-5281"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adolesc\u00eancia e Sa\u00fade","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://adolescenciaesaude.com/index.php/aes/article/download/1448/1175","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064431188","display_name":"Prerna Singh","orcid":"https://orcid.org/0000-0002-8429-5701","observed_orcids":["https://orcid.org/0000-0002-8429-5701"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Prerna Singh","raw_affiliation_strings":["Associate Professor, Department of Biochemistry , Andaman and Nicobar Islands Institute of Medical sciences (ANIIMS) , Sri Vijaya Puram , A & N Islands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor, Department of Biochemistry , Andaman and Nicobar Islands Institute of Medical sciences (ANIIMS) , Sri Vijaya Puram , A & N Islands","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5064431188"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"5s","first_page":"673","last_page":"681"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serum-uric-acid","display_name":"serum uric acid","score":1.0},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cardiometabolic-risk","display_name":"cardiometabolic risk","score":0.7350000143051147},{"id":"https://openalex.org/keywords/metabolic-syndrome-screening","display_name":"metabolic syndrome screening","score":0.6779999732971191},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.9649999737739563},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.890999972820282},{"id":"https://openalex.org/keywords/triglyceride-glucose-index","display_name":"triglyceride-glucose index","score":0.9789999723434448},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9769999980926514},{"id":"https://openalex.org/keywords/prediabetes","display_name":"prediabetes","score":0.8159999847412109},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.6200000047683716},{"id":"https://openalex.org/keywords/urate-lowering-therapy","display_name":"urate-lowering therapy","score":0.9020000100135803},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8500000238418579},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.7651000022888184},{"id":"https://openalex.org/C2779668308","wikidata":"https://www.wikidata.org/wiki/Q2087205","display_name":"Prediabetes","level":4,"score":0.6549999713897705},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6000000238418579},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5170000195503235},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5138999819755554},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.5033000111579895},{"id":"https://openalex.org/C2779721657","wikidata":"https://www.wikidata.org/wiki/Q49970","display_name":"Hyperuricemia","level":3,"score":0.48899999260902405},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.45730000734329224},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4544999897480011},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4032999873161316},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.39259999990463257},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.3840000033378601},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.3596999943256378},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.35089999437332153},{"id":"https://openalex.org/C2780402116","wikidata":"https://www.wikidata.org/wiki/Q133087","display_name":"Gout","level":2,"score":0.33379998803138733},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3319000005722046},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.3197999894618988},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.29919999837875366},{"id":"https://openalex.org/C2778136018","wikidata":"https://www.wikidata.org/wiki/Q10350689","display_name":"Predictive power","level":2,"score":0.29260000586509705},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.29089999198913574},{"id":"https://openalex.org/C3018380654","wikidata":"https://www.wikidata.org/wiki/Q5572348","display_name":"Fasting glucose","level":4,"score":0.2888999879360199},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.28040000796318054},{"id":"https://openalex.org/C3020132585","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic accuracy","level":2,"score":0.27379998564720154},{"id":"https://openalex.org/C2779668873","wikidata":"https://www.wikidata.org/wiki/Q6693756","display_name":"Lower risk","level":3,"score":0.27070000767707825},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.2639999985694885},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.2535000145435333}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.67440/ahj.v21i5s.1448","doi":"https://doi.org/10.67440/ahj.v21i5s.1448","is_oa":true,"landing_page_url":"https://doi.org/10.67440/ahj.v21i5s.1448","pdf_url":"https://adolescenciaesaude.com/index.php/aes/article/download/1448/1175","source":{"id":"https://openalex.org/S4306500736","display_name":"Adolescencia e Saude","issn_l":"1679-9941","issn":["1679-9941","2177-5281"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adolesc\u00eancia e Sa\u00fade","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.67440/ahj.v21i5s.1448","doi":"https://doi.org/10.67440/ahj.v21i5s.1448","is_oa":true,"landing_page_url":"https://doi.org/10.67440/ahj.v21i5s.1448","pdf_url":"https://adolescenciaesaude.com/index.php/aes/article/download/1448/1175","source":{"id":"https://openalex.org/S4306500736","display_name":"Adolescencia e Saude","issn_l":"1679-9941","issn":["1679-9941","2177-5281"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adolesc\u00eancia e Sa\u00fade","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7202362970.pdf","grobid_xml":"https://content.openalex.org/works/W7202362970.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2166199572","https://openalex.org/W1812462603","https://openalex.org/W2883864818","https://openalex.org/W4240713875","https://openalex.org/W2598646691","https://openalex.org/W2178802513","https://openalex.org/W3138171347","https://openalex.org/W3113801173","https://openalex.org/W4406062772","https://openalex.org/W2092628576"],"abstract_inverted_index":{"Background:":[0],"Serum":[1],"uric":[2],"acid":[3],"(SUA)":[4],"has":[5],"evolved":[6],"from":[7,57,78,84],"a":[8,14,19,235],"simple":[9],"marker":[10],"of":[11,22,32,130,145,159,226,249,253,273,290],"gout":[12],"to":[13,95,284],"central":[15],"metabolic":[16,40,202,295],"mediator":[17],"and":[18,38,72,91,101,107,111,118,133,151,172,188,221,238,247,256,266],"robust":[20,178],"predictor":[21],"cardiometabolic":[23],"risk.":[24],"This":[25],"systematic":[26],"review":[27],"assesses":[28],"the":[29,97,138,184,224,243,263,286],"clinical":[30],"utility":[31],"SUA":[33,100,122,160,196,216,233],"for":[34,201,242],"screening,":[35,183,244],"risk":[36,129,193,245],"stratification,":[37,194,246],"predicting":[39],"syndrome":[41],"(MetS)":[42],"in":[43,149,154,163,168,293],"adults.":[44],"Methods:":[45],"A":[46,208],"comprehensive":[47],"analysis":[48],"was":[49,93,123,161,212],"conducted":[50],"on":[51],"primary":[52],"research":[53,277],"articles,":[54],"including":[55,82],"data":[56],"large-scale":[58,280],"national":[59],"surveys":[60],"(e.g.,":[61,68],"KNHANES,":[62],"NHANES),":[63],"prospective":[64],"longitudinal":[65],"cohort":[66],"studies":[67],"CHIEF,":[69],"Troms\u00f8":[70],"Study),":[71],"community-based":[73],"cross-sectional":[74],"investigations.":[75],"The":[76,156,251],"evidence":[77,231],"diverse":[79],"global":[80],"populations,":[81],"cohorts":[83],"Taiwan,":[85],"China,":[86],"Korea,":[87],"South":[88],"Asia,":[89],"Brazil,":[90],"Europe,":[92],"synthesized":[94],"evaluate":[96],"association":[98],"between":[99],"MetS,":[102],"identify":[103],"optimal":[104,143],"screening":[105],"thresholds,":[106],"assess":[108],"its":[109,173],"predictive":[110,135,174],"prognostic":[112],"value":[113],"across":[114],"different":[115],"age":[116],"groups":[117],"sexes.":[119],"Results:":[120],"Elevated":[121],"consistently":[124],"associated":[125],"with":[126,142,215,258],"an":[127],"increased":[128],"incident":[131],"MetS":[132],"remained":[134],"even":[136],"within":[137],"upper":[139],"normal":[140],"range,":[141],"thresholds":[144,255],"approximately":[146],"4.9":[147],"mg/dL":[148,153],"women":[150,164],"6.3":[152],"men.":[155],"diagnostic":[157,199],"performance":[158],"greater":[162],"(AUC":[165,170],"\u22480.77)":[166],"than":[167],"men":[169],"\u22480.66),":[171],"power":[175],"is":[176],"most":[177],"during":[179,219],"young":[180],"adulthood.":[181],"Beyond":[182],"triglyceride-glucose":[185],"(TyG)":[186],"index":[187,265],"SUA/creatinine":[189,267],"ratio":[190,268],"enhanced":[191],"cardiovascular":[192],"while":[195],"demonstrated":[197],"high":[198],"accuracy":[200],"dysfunction-associated":[203],"steatotic":[204],"liver":[205],"disease":[206],"(MASLD).":[207],"distinct":[209],"\"diabetes":[210],"paradox\"":[211],"also":[213],"observed,":[214],"levels":[217],"peaking":[218],"prediabetes":[220],"declining":[222],"after":[223],"onset":[225],"overt":[227],"diabetes.":[228],"Conclusion:":[229],"Current":[230],"supports":[232],"as":[234,262],"simple,":[236],"inexpensive,":[237],"clinically":[239],"useful":[240],"biomarker":[241],"prediction":[248],"MetS.":[250],"application":[252],"sex-specific":[254],"integration":[257],"complementary":[259],"biomarkers":[260],"such":[261],"TyG":[264],"may":[269],"improve":[270],"early":[271],"identification":[272],"high-risk":[274],"individuals.":[275],"Future":[276],"must":[278],"prioritise":[279],"randomized":[281],"controlled":[282],"trials":[283],"establish":[285],"definitive":[287],"therapeutic":[288],"role":[289],"urate-lowering":[291],"therapies":[292],"managing":[294],"disease.":[296]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-08-14T00:00:00"}