{"id":"https://openalex.org/W7202348009","doi":"https://doi.org/10.1021/acs.jmedchem.6c01350","title":"Bifunctional Ionophores for Cuproptosis Activation: Dual Targeting of Copper and Fe\u2013S Protein Homeostasis","display_name":"Bifunctional Ionophores for Cuproptosis Activation: Dual Targeting of Copper and Fe\u2013S Protein Homeostasis","publication_year":2026,"publication_date":"2026-08-13","ids":{"openalex":"https://openalex.org/W7202348009","doi":"https://doi.org/10.1021/acs.jmedchem.6c01350","pmid":"https://pubmed.ncbi.nlm.nih.gov/42679166"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jmedchem.6c01350","doi":"https://doi.org/10.1021/acs.jmedchem.6c01350","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.6c01350","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037726112","display_name":"Liuxin Yang","orcid":"https://orcid.org/0009-0007-9696-120X","observed_orcids":["https://orcid.org/0009-0007-9696-120X"]},"institutions":[{"id":"https://openalex.org/I75900474","display_name":"Hubei University","ror":"https://ror.org/03a60m280","country_code":"CN","type":"education","lineage":["https://openalex.org/I75900474"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liuxin Yang","raw_affiliation_strings":["Hubei University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei University , , ,","institution_ids":["https://openalex.org/I75900474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147135077","display_name":"Yiyu Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]},{"id":"https://openalex.org/I75900474","display_name":"Hubei University","ror":"https://ror.org/03a60m280","country_code":"CN","type":"education","lineage":["https://openalex.org/I75900474"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiyu Cheng","raw_affiliation_strings":["Central China Normal University , , ,","Hubei University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central China Normal University , , ,","institution_ids":["https://openalex.org/I40963666"]},{"raw_affiliation_string":"Hubei University , , ,","institution_ids":["https://openalex.org/I75900474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139176996","display_name":"Si Qin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Si Qin","raw_affiliation_strings":["The Third Affiliated Hospital of Chongqing Medical University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Affiliated Hospital of Chongqing Medical University , , ,","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jun Jiang","orcid":"https://orcid.org/0000-0003-3401-792X","observed_orcids":["https://orcid.org/0000-0003-3401-792X"]},"institutions":[{"id":"https://openalex.org/I75900474","display_name":"Hubei University","ror":"https://ror.org/03a60m280","country_code":"CN","type":"education","lineage":["https://openalex.org/I75900474"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Jiang","raw_affiliation_strings":["Hubei University , , ,"],"raw_orcid":"https://orcid.org/0000-0003-3401-792X","affiliations":[{"raw_affiliation_string":"Hubei University , , ,","institution_ids":["https://openalex.org/I75900474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147129207","display_name":"Shiyi Zhong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75900474","display_name":"Hubei University","ror":"https://ror.org/03a60m280","country_code":"CN","type":"education","lineage":["https://openalex.org/I75900474"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiyi Zhong","raw_affiliation_strings":["Hubei University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei University , , ,","institution_ids":["https://openalex.org/I75900474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147110696","display_name":"Xinyue Bi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47689461","display_name":"Northeast Forestry University","ror":"https://ror.org/02yxnh564","country_code":"CN","type":"education","lineage":["https://openalex.org/I47689461"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyue Bi","raw_affiliation_strings":["Northeast Forestry University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeast Forestry University , , ,","institution_ids":["https://openalex.org/I47689461"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137025892","display_name":"Jiali Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75900474","display_name":"Hubei University","ror":"https://ror.org/03a60m280","country_code":"CN","type":"education","lineage":["https://openalex.org/I75900474"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiali Xu","raw_affiliation_strings":["Hubei University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei University , , ,","institution_ids":["https://openalex.org/I75900474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106120443","display_name":"Kai Wang","orcid":"https://orcid.org/0000-0002-3513-3511","observed_orcids":["https://orcid.org/0000-0002-3513-3511"]},"institutions":[{"id":"https://openalex.org/I75900474","display_name":"Hubei University","ror":"https://ror.org/03a60m280","country_code":"CN","type":"education","lineage":["https://openalex.org/I75900474"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Kai Wang","raw_affiliation_strings":["Hubei University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei University , , ,","institution_ids":["https://openalex.org/I75900474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067982736","display_name":"Shuang Qiu","orcid":"https://orcid.org/0000-0003-2537-4829","observed_orcids":["https://orcid.org/0000-0003-2537-4829"]},"institutions":[{"id":"https://openalex.org/I47689461","display_name":"Northeast Forestry University","ror":"https://ror.org/02yxnh564","country_code":"CN","type":"education","lineage":["https://openalex.org/I47689461"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shuang Qiu","raw_affiliation_strings":["Northeast Forestry University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeast Forestry University , , ,","institution_ids":["https://openalex.org/I47689461"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100331100","display_name":"Xiang Li","orcid":"https://orcid.org/0000-0003-0356-4066","observed_orcids":["https://orcid.org/0000-0003-0356-4066"]},"institutions":[{"id":"https://openalex.org/I75900474","display_name":"Hubei University","ror":"https://ror.org/03a60m280","country_code":"CN","type":"education","lineage":["https://openalex.org/I75900474"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiang Li","raw_affiliation_strings":["Hubei University , , ,"],"raw_orcid":"https://orcid.org/0000-0003-0356-4066","affiliations":[{"raw_affiliation_string":"Hubei University , , ,","institution_ids":["https://openalex.org/I75900474"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5067982736","https://openalex.org/A5100331100","https://openalex.org/A5106120443"],"corresponding_institution_ids":["https://openalex.org/I47689461","https://openalex.org/I75900474"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"69","issue":"16","first_page":"19877","last_page":"19890"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.27250000834465027,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.27250000834465027,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.13930000364780426,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.06620000302791595,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cuproptosis","display_name":"cuproptosis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/copper-ionophores","display_name":"copper ionophores","score":0.8119999766349792},{"id":"https://openalex.org/keywords/iron-sulfur-proteins","display_name":"iron-sulfur proteins","score":0.8669999837875366},{"id":"https://openalex.org/keywords/8-hydroxyquinoline","display_name":"8-hydroxyquinoline","score":0.8999999761581421},{"id":"https://openalex.org/keywords/elesclomol","display_name":"elesclomol","score":0.8309999704360962},{"id":"https://openalex.org/keywords/copper-toxicity","display_name":"copper toxicity","score":0.5889999866485596},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.7200000286102295},{"id":"https://openalex.org/keywords/iron-homeostasis","display_name":"iron homeostasis","score":0.7770000100135803},{"id":"https://openalex.org/keywords/dna-replication","display_name":"DNA replication","score":0.5299999713897705},{"id":"https://openalex.org/keywords/respiration","display_name":"respiration","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9373999834060669},{"id":"https://openalex.org/C544778455","wikidata":"https://www.wikidata.org/wiki/Q753","display_name":"Copper","level":2,"score":0.7552000284194946},{"id":"https://openalex.org/C2780443040","wikidata":"https://www.wikidata.org/wiki/Q3737863","display_name":"Bifunctional","level":3,"score":0.7103000283241272},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.48969998955726624},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.45719999074935913},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.4262000024318695},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.421999990940094},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.41609999537467957},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.39730000495910645},{"id":"https://openalex.org/C17165728","wikidata":"https://www.wikidata.org/wiki/Q423350","display_name":"Metalloprotein","level":3,"score":0.36910000443458557},{"id":"https://openalex.org/C2779585090","wikidata":"https://www.wikidata.org/wiki/Q3457762","display_name":"Resilience (materials science)","level":2,"score":0.3425000011920929},{"id":"https://openalex.org/C181312439","wikidata":"https://www.wikidata.org/wiki/Q909712","display_name":"Copper protein","level":3,"score":0.3353999853134155},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.3183000087738037},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.2996000051498413},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.298799991607666},{"id":"https://openalex.org/C20719415","wikidata":"https://www.wikidata.org/wiki/Q416896","display_name":"Metallothionein","level":3,"score":0.28700000047683716},{"id":"https://openalex.org/C2779014961","wikidata":"https://www.wikidata.org/wiki/Q415168","display_name":"Ionophore","level":3,"score":0.2831999957561493},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.26980000734329224},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.2667999863624573},{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.2531999945640564}],"mesh":[{"descriptor_ui":"D000099217","descriptor_name":"Cuproptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007476","descriptor_name":"Ionophores","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D007476","descriptor_name":"Ionophores","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007476","descriptor_name":"Ionophores","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007476","descriptor_name":"Ionophores","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007506","descriptor_name":"Iron-Sulfur Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jmedchem.6c01350","doi":"https://doi.org/10.1021/acs.jmedchem.6c01350","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.6c01350","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:42679166","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42679166","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2941361703","display_name":null,"funder_award_id":"2024AFB207","funder_id":"https://openalex.org/F4320322186","funder_display_name":"Natural Science Foundation of Hubei Province"},{"id":"https://openalex.org/G7156868448","display_name":null,"funder_award_id":"2025DJB027","funder_id":"https://openalex.org/F4320336744","funder_display_name":"Science and Technology Program of Hubei Province"},{"id":"https://openalex.org/G7346756130","display_name":null,"funder_award_id":"2024M750377","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320322186","display_name":"Natural Science Foundation of Hubei Province","ror":null},{"id":"https://openalex.org/F4320336744","display_name":"Science and Technology Program of Hubei Province","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1759262393","https://openalex.org/W1965942744","https://openalex.org/W1967185435","https://openalex.org/W1973915107","https://openalex.org/W1994050027","https://openalex.org/W2018368831","https://openalex.org/W2020933572","https://openalex.org/W2027830530","https://openalex.org/W2034410412","https://openalex.org/W2042468380","https://openalex.org/W2052916872","https://openalex.org/W2070083014","https://openalex.org/W2070989718","https://openalex.org/W2081544621","https://openalex.org/W2130458932","https://openalex.org/W2145845104","https://openalex.org/W2165348267","https://openalex.org/W2172511820","https://openalex.org/W2396101252","https://openalex.org/W2493609747","https://openalex.org/W2534849842","https://openalex.org/W2551149511","https://openalex.org/W2621623631","https://openalex.org/W2677338014","https://openalex.org/W2679434689","https://openalex.org/W2760270739","https://openalex.org/W2897289019","https://openalex.org/W2899807611","https://openalex.org/W2990290007","https://openalex.org/W2999631926","https://openalex.org/W3043934334","https://openalex.org/W3087112711","https://openalex.org/W3091475389","https://openalex.org/W3209140465","https://openalex.org/W3212006797","https://openalex.org/W3215712841","https://openalex.org/W4205402375","https://openalex.org/W4221115671","https://openalex.org/W4293105362","https://openalex.org/W4308988730","https://openalex.org/W4310364335","https://openalex.org/W4317566656","https://openalex.org/W4318173875","https://openalex.org/W4320040166","https://openalex.org/W4384154746","https://openalex.org/W4386064950","https://openalex.org/W4387040921","https://openalex.org/W4390972061","https://openalex.org/W4399303082","https://openalex.org/W4400250324","https://openalex.org/W4401341384","https://openalex.org/W4404568055","https://openalex.org/W4407778408","https://openalex.org/W4408121471","https://openalex.org/W4408402895","https://openalex.org/W4410826589","https://openalex.org/W4411065167","https://openalex.org/W4414958361","https://openalex.org/W4415970831","https://openalex.org/W7162471653"],"related_works":["https://openalex.org/W4379614969","https://openalex.org/W4308988730","https://openalex.org/W4411650032","https://openalex.org/W4288914072","https://openalex.org/W4408896994","https://openalex.org/W4414958361","https://openalex.org/W7162471653","https://openalex.org/W7131643367","https://openalex.org/W4400381299","https://openalex.org/W7148807497"],"abstract_inverted_index":{"Cellular":[0],"resilience":[1,23],"to":[2,20,58,83],"therapy":[3],"often":[4],"arises":[5],"from":[6],"adaptive":[7],"mechanisms":[8],"that":[9,84,130],"safeguard":[10],"iron-sulfur":[11],"(Fe-S)":[12],"proteins.":[13],"Here,":[14],"we":[15,48],"present":[16],"a":[17,36,42,54,120,138],"rational":[18],"strategy":[19,141],"overcome":[21],"such":[22],"by":[24,41],"integrating":[25],"two":[26],"synergistic":[27,121],"vulnerabilities,":[28],"copper":[29,67,73,88,109,132],"toxicity":[30],"and":[31,63,70,105,116,133],"Fe-S":[32,96,134],"cluster":[33],"homeostasis,":[34,104,136],"into":[35,74],"single":[37],"molecular":[38],"scaffold.":[39],"Inspired":[40],"bacterial":[43],"sulfur":[44],"mobilization":[45],"(SUF)":[46],"inhibitor,":[47],"hybridized":[49],"its":[50],"core":[51],"structure":[52],"with":[53,77],"copper-transporting":[55],"8-hydroxyquinoline":[56],"moiety":[57],"generate":[59],"HDQ,":[60],"HDQ-S,":[61],"HDQ-Ph,":[62],"HDQ-Me.":[64],"They":[65],"coordinate":[66],"via":[68],"hydroxyquinoline":[69],"efficiently":[71],"transport":[72],"cancer":[75],"cells,":[76],"HDQ-Me":[78],"achieving":[79],"an":[80],"efficacy":[81],"comparable":[82],"of":[85],"the":[86],"clinical":[87],"ionophore":[89],"elesclomol":[90],"(ES).":[91],"Strikingly,":[92],"HDQ":[93],"alone":[94],"suppresses":[95],"proteins":[97],"across":[98],"multiple":[99],"functions,":[100],"including":[101],"respiration,":[102],"iron":[103],"DNA":[106,114],"replication.":[107],"HDQ-mediated":[108],"loading":[110],"triggers":[111],"cuproptosis":[112],"hallmarks,":[113],"damage,":[115],"ATP":[117],"collapse,":[118],"generating":[119],"lethality.":[122],"This":[123],"work":[124],"establishes":[125],"HDQs":[126],"as":[127],"bifunctional":[128],"tools":[129],"cotarget":[131],"protein":[135],"validating":[137],"convergent":[139],"therapeutic":[140],"against":[142],"resilient":[143],"cells.":[144]},"counts_by_year":[],"updated_date":"2026-10-25T09:29:13.331239","created_date":"2026-08-14T00:00:00"}