{"id":"https://openalex.org/W7202346699","doi":"https://doi.org/10.64898/2026.08.12.744421","title":"Sequence-dependent binding modes of INO80 control +1 nucleosome positioning","display_name":"Sequence-dependent binding modes of INO80 control +1 nucleosome positioning","publication_year":2026,"publication_date":"2026-08-13","ids":{"openalex":"https://openalex.org/W7202346699","doi":"https://doi.org/10.64898/2026.08.12.744421","pmid":"https://pubmed.ncbi.nlm.nih.gov/42845601","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13640735"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.12.744421","doi":"https://doi.org/10.64898/2026.08.12.744421","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.12.744421","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/13/2026.08.12.744421.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/13/2026.08.12.744421.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114479210","display_name":"Mariia Likhodeeva","orcid":"https://orcid.org/0009-0005-1369-718X","observed_orcids":["https://orcid.org/0009-0005-1369-718X"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mariia Likhodeeva","raw_affiliation_strings":["Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"],"raw_orcid":"https://orcid.org/0009-0005-1369-718X","affiliations":[{"raw_affiliation_string":"Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113196756","display_name":"Annika Brem","orcid":"https://orcid.org/0009-0002-6273-9997","observed_orcids":["https://orcid.org/0009-0002-6273-9997"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Annika Brem","raw_affiliation_strings":["Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"],"raw_orcid":"https://orcid.org/0009-0002-6273-9997","affiliations":[{"raw_affiliation_string":"Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140185885","display_name":"Alberto L\u00f3pez-Francos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alberto L\u00f3pez-Francos L\u00f3pez-Romero","raw_affiliation_strings":["Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027651611","display_name":"Drin Shabani","orcid":"https://orcid.org/0000-0002-6326-1051","observed_orcids":["https://orcid.org/0000-0002-6326-1051"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Drin Shabani","raw_affiliation_strings":["Biomedical Center, Division of Molecular Biology, Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Martinsried, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Center, Division of Molecular Biology, Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Martinsried, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140213384","display_name":"Franziska D\u00e4rr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Franziska D\u00e4rr","raw_affiliation_strings":["Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027011966","display_name":"Dirk Kostrewa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dirk Kostrewa","raw_affiliation_strings":["Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049334425","display_name":"Katja Lammens","orcid":"https://orcid.org/0000-0002-4438-1381","observed_orcids":["https://orcid.org/0000-0002-4438-1381"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katja Lammens","raw_affiliation_strings":["Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059612621","display_name":"Manuela Moldt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Manuela Moldt","raw_affiliation_strings":["Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064759813","display_name":"Olga Fettscher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Olga Fettscher","raw_affiliation_strings":["Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021255846","display_name":"Blaine Bartholomew","orcid":"https://orcid.org/0000-0003-4014-9750","observed_orcids":["https://orcid.org/0000-0003-4014-9750"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Blaine Bartholomew","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, United States","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074285928","display_name":"Philipp Korber","orcid":"https://orcid.org/0000-0001-7526-6549","observed_orcids":["https://orcid.org/0000-0001-7526-6549"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Philipp Korber","raw_affiliation_strings":["Biomedical Center, Division of Molecular Biology, Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Martinsried, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7526-6549","affiliations":[{"raw_affiliation_string":"Biomedical Center, Division of Molecular Biology, Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Martinsried, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063163809","display_name":"Karl\u2010Peter Hopfner","orcid":"https://orcid.org/0000-0002-4528-8357","observed_orcids":["https://orcid.org/0000-0002-4528-8357"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Karl-Peter Hopfner","raw_affiliation_strings":["Cluster for Nucleic Acid Sciences and Technologies, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany","Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany"],"raw_orcid":"https://orcid.org/0000-0002-4528-8357","affiliations":[{"raw_affiliation_string":"Cluster for Nucleic Acid Sciences and Technologies, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5063163809"],"corresponding_institution_ids":["https://openalex.org/I8204097"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.025200000032782555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ino80-complex","display_name":"INO80 complex","score":0.9620000123977661},{"id":"https://openalex.org/keywords/nucleosome-positioning","display_name":"nucleosome positioning","score":0.9819999933242798},{"id":"https://openalex.org/keywords/nucleosome-depleted-regions","display_name":"nucleosome-depleted regions","score":0.8090000152587891},{"id":"https://openalex.org/keywords/promoter-chromatin","display_name":"promoter chromatin","score":0.734000027179718},{"id":"https://openalex.org/keywords/nucleosome-sliding","display_name":"nucleosome sliding","score":0.5540000200271606},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8650000095367432}],"concepts":[{"id":"https://openalex.org/C84772758","wikidata":"https://www.wikidata.org/wiki/Q271794","display_name":"Nucleosome","level":4,"score":0.9223999977111816},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.8367999792098999},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6025999784469604},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5153999924659729},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47099998593330383},{"id":"https://openalex.org/C193646685","wikidata":"https://www.wikidata.org/wiki/Q1826830","display_name":"Linker DNA","level":5,"score":0.4675999879837036},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4357999861240387},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.4101000130176544},{"id":"https://openalex.org/C164974683","wikidata":"https://www.wikidata.org/wiki/Q1044051","display_name":"Chromatosome","level":5,"score":0.38339999318122864},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.37869998812675476},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.3605000078678131},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3508000075817108},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.3368000090122223},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3276999890804291},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.32600000500679016},{"id":"https://openalex.org/C176619506","wikidata":"https://www.wikidata.org/wiki/Q5065899","display_name":"ChIP-sequencing","level":5,"score":0.32359999418258667},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.320499986410141},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.31310001015663147},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2994999885559082},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.29249998927116394},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.27059999108314514},{"id":"https://openalex.org/C38976095","wikidata":"https://www.wikidata.org/wiki/Q752641","display_name":"Asymmetry","level":2,"score":0.26089999079704285},{"id":"https://openalex.org/C191961535","wikidata":"https://www.wikidata.org/wiki/Q2360205","display_name":"A-DNA","level":3,"score":0.2517000138759613}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.08.12.744421","doi":"https://doi.org/10.64898/2026.08.12.744421","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.12.744421","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/13/2026.08.12.744421.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13640735","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13640735/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13640735/pdf/nihpp-2026.08.12.744421v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmid:42845601","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42845601","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.64898/2026.08.12.744421","doi":"https://doi.org/10.64898/2026.08.12.744421","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.12.744421","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/13/2026.08.12.744421.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1633438099","display_name":null,"funder_award_id":"EXC 3113/1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3277054144","display_name":"SFB 1361: Regulation von DNAReparatur und Genomstabilit\u00e4t","funder_award_id":"393547839","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3670392329","display_name":null,"funder_award_id":"SFB1064","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G446975772","display_name":null,"funder_award_id":"HO 2489/9-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6255583909","display_name":null,"funder_award_id":"EXC 3113/1-533767322","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6407871267","display_name":null,"funder_award_id":"533767322","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G764059879","display_name":null,"funder_award_id":"SFB 1361","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320327553","display_name":"International Max Planck Research School for Advanced Methods in Process and Systems Engineering","ror":"https://ror.org/04hazks31"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7202346699.pdf","grobid_xml":"https://content.openalex.org/works/W7202346699.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W1971491328","https://openalex.org/W1974595249","https://openalex.org/W1986623751","https://openalex.org/W1988997227","https://openalex.org/W1994333151","https://openalex.org/W2016597274","https://openalex.org/W2035903214","https://openalex.org/W2044946046","https://openalex.org/W2062669590","https://openalex.org/W2069328568","https://openalex.org/W2069520341","https://openalex.org/W2092604981","https://openalex.org/W2107258457","https://openalex.org/W2114803986","https://openalex.org/W2115219137","https://openalex.org/W2117219508","https://openalex.org/W2124026197","https://openalex.org/W2136144150","https://openalex.org/W2149683434","https://openalex.org/W2153123861","https://openalex.org/W2267558770","https://openalex.org/W2530956344","https://openalex.org/W2532816831","https://openalex.org/W2587625522","https://openalex.org/W2587703700","https://openalex.org/W2593511418","https://openalex.org/W2614855056","https://openalex.org/W2728385286","https://openalex.org/W2734356283","https://openalex.org/W2785352108","https://openalex.org/W2793402357","https://openalex.org/W2796205786","https://openalex.org/W2797631238","https://openalex.org/W2797904108","https://openalex.org/W2801376357","https://openalex.org/W2831181062","https://openalex.org/W2888742489","https://openalex.org/W2945328347","https://openalex.org/W2949509585","https://openalex.org/W2966463765","https://openalex.org/W2973457155","https://openalex.org/W2995291039","https://openalex.org/W3083406432","https://openalex.org/W3087615343","https://openalex.org/W3093101538","https://openalex.org/W3108495343","https://openalex.org/W3110747960","https://openalex.org/W3113121586","https://openalex.org/W3128450527","https://openalex.org/W3135803532","https://openalex.org/W3164493072","https://openalex.org/W3165873230","https://openalex.org/W3203309436","https://openalex.org/W4213132174","https://openalex.org/W4281697297","https://openalex.org/W4292756147","https://openalex.org/W4302425393","https://openalex.org/W4311583450","https://openalex.org/W4362608393","https://openalex.org/W4372285994","https://openalex.org/W4376126459","https://openalex.org/W4382520283","https://openalex.org/W4382520324","https://openalex.org/W4386954582","https://openalex.org/W4388977940","https://openalex.org/W4389553781","https://openalex.org/W4403029465","https://openalex.org/W4403952768","https://openalex.org/W4404105421","https://openalex.org/W4405721429","https://openalex.org/W4412490639","https://openalex.org/W4416738946","https://openalex.org/W7128603322","https://openalex.org/W7135176058","https://openalex.org/W7214716574"],"related_works":["https://openalex.org/W4416738946","https://openalex.org/W3165873230","https://openalex.org/W7047383277","https://openalex.org/W4388021268","https://openalex.org/W2797904108","https://openalex.org/W7214716574","https://openalex.org/W7203541351","https://openalex.org/W7096809538","https://openalex.org/W7214039448","https://openalex.org/W1980689264"],"abstract_inverted_index":{"Cellular":[0],"self-organisation":[1,186],"counteracts":[2],"entropy":[3],"at":[4,32],"the":[5,12,49,65,75,87,91,111,121,128,139,147,168,175],"expenditure":[6],"of":[7,11,15,39,44,52,90,106,153,187],"energy.":[8],"In":[9,101],"case":[10],"first":[13],"level":[14],"nuclear":[16],"DNA":[17,83,155,181],"organisation,":[18],"this":[19,133],"relates":[20],"to":[21,184],"regular":[22],"nucleosome":[23,89,165],"arrays":[24],"and":[25,97,103],"interspaced":[26],"nucleosome-depleted":[27],"regions":[28],"(NDRs),":[29],"for":[30],"example":[31],"promoters":[33],"or":[34],"replication":[35],"origins.":[36],"The":[37],"organisation":[38],"nucleosomes":[40,109],"as":[41],"building":[42],"blocks":[43],"chromatin":[45,54,78,189],"is":[46],"orchestrated":[47],"by":[48,190],"collective":[50],"activities":[51],"ATP-dependent":[53,185],"remodellers.":[55],"Yet,":[56],"how":[57,180],"remodellers":[58],"achieve":[59],"positional":[60],"specificity,":[61],"in":[62],"particular":[63],"regarding":[64],"promoter-proximal":[66],"+1":[67,88,129],"nucleosomes,":[68],"remains":[69],"unclear.":[70],"Here,":[71],"we":[72,114],"show":[73],"that":[74],"S.":[76],"cerevisiae":[77],"remodeller":[79],"INO80":[80,107,123,131],"unexpectedly":[81],"distinguishes":[82],"sequence":[84,156,162],"asymmetry":[85],"within":[86],"SWH1":[92],"gene":[93,148],"through":[94],"distinct":[95],"inhibited":[96,117],"active":[98],"nucleosome-binding":[99],"modes.":[100],"structural":[102],"biochemical":[104],"analyses":[105],"on":[108,127],"with":[110,159],"endogenous":[112],"sequence,":[113],"identified":[115],"an":[116],"binding":[118,135],"mode":[119,136,144],"where":[120],"entire":[122],"remodelling":[124],"unit":[125],"flipped":[126],"nucleosome.":[130],"adopted":[132],"remodelling-incompetent":[134],"when":[137,145],"facing":[138,146],"promoter,":[140],"but":[141],"a":[142],"remodelling-competent":[143],"body.":[149],"This":[150],"directional":[151],"read-out":[152],"intra-nucleosomal":[154],"asymmetry,":[157],"together":[158],"extranucleosomal":[160],"NDR":[161,169],"features,":[163],"prevented":[164],"sliding":[166],"into":[167],"while":[170],"permitting":[171],"array":[172],"formation":[173],"over":[174],"gene.":[176],"Our":[177],"work":[178],"shows":[179],"features":[182],"contribute":[183],"promoter":[188],"INO80.":[191]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-08-14T00:00:00"}
