{"id":"https://openalex.org/W7202342261","doi":"https://doi.org/10.3324/haematol.2025.300279","title":"ATRA resistance conferred by a clustered subset of hotspot PML::RARA mutations enhancing basal repression rather than precluding transactivation","display_name":"ATRA resistance conferred by a clustered subset of hotspot PML::RARA mutations enhancing basal repression rather than precluding transactivation","publication_year":2026,"publication_date":"2026-08-13","ids":{"openalex":"https://openalex.org/W7202342261","doi":"https://doi.org/10.3324/haematol.2025.300279","pmid":"https://pubmed.ncbi.nlm.nih.gov/42610425"},"language":"en","primary_location":{"id":"doi:10.3324/haematol.2025.300279","doi":"https://doi.org/10.3324/haematol.2025.300279","is_oa":true,"landing_page_url":"https://doi.org/10.3324/haematol.2025.300279","pdf_url":null,"source":{"id":"https://openalex.org/S2752781272","display_name":"Haematologica","issn_l":"0390-6078","issn":["0390-6078","1592-8721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317774","host_organization_name":"Ferrata Storti Foundation","host_organization_lineage":["https://openalex.org/P4310317774"],"host_organization_lineage_names":["Ferrata Storti Foundation"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3324/haematol.2025.300279","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5147129670","display_name":"Glauce M. Barbosa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210100279","display_name":"Centre de Biologie Structurale","ror":"https://ror.org/0189yvq06","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210100279"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Glauce M. Barbosa","raw_affiliation_strings":["Universit\u00e9 de Montpellier, Centre de Biologie Structurale (CBS), CNRS UMR5048-INSERM U1054, Montpellier"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Montpellier, Centre de Biologie Structurale (CBS), CNRS UMR5048-INSERM U1054, Montpellier","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210100279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147130975","display_name":"Hao Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]},{"id":"https://openalex.org/I4392021104","display_name":"State Key Laboratory of Medical Genomics","ror":"https://ror.org/04m0qde81","country_code":"CN","type":"facility","lineage":["https://openalex.org/I183067930","https://openalex.org/I4392021104"]},{"id":"https://openalex.org/I4403386645","display_name":"Institut de recherche Saint-Louis","ror":"https://ror.org/01wa61d03","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I4403386645"]}],"countries":["CN","FR"],"is_corresponding":false,"raw_author_name":"Hao Yuan","raw_affiliation_strings":["Universit\u00e9 Paris Cit\u00e9, Institut de Recherche Saint-Louis (IRSL), INSERM UMR1342-CNRS EMR8000, Paris, France; Sino-French Research Center for Life Sciences and Genomics, State Key Laboratory of Medical Genomics, CNRS-LIA124, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, Institut de Recherche Saint-Louis (IRSL), INSERM UMR1342-CNRS EMR8000, Paris, France; Sino-French Research Center for Life Sciences and Genomics, State Key Laboratory of Medical Genomics, CNRS-LIA124, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I183067930","https://openalex.org/I204730241","https://openalex.org/I2801556517","https://openalex.org/I4392021104","https://openalex.org/I4403386645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017715604","display_name":"Izabella Tambones","orcid":"https://orcid.org/0000-0002-4073-9227","observed_orcids":["https://orcid.org/0000-0002-4073-9227"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210100279","display_name":"Centre de Biologie Structurale","ror":"https://ror.org/0189yvq06","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210100279"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Izabella Tambones","raw_affiliation_strings":["Universit\u00e9 de Montpellier, Centre de Biologie Structurale (CBS), CNRS UMR5048-INSERM U1054, Montpellier"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Montpellier, Centre de Biologie Structurale (CBS), CNRS UMR5048-INSERM U1054, Montpellier","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210100279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005345147","display_name":"Roland H. Stote","orcid":"https://orcid.org/0000-0003-2230-7145","observed_orcids":["https://orcid.org/0000-0003-2230-7145"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210086872","display_name":"Institut de g\u00e9n\u00e9tique et de biologie mol\u00e9culaire et cellulaire","ror":"https://ror.org/0015ws592","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I4210096427","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Roland H. Stote","raw_affiliation_strings":["Universit\u00e9 de Strasbourg, IGBMC, CNRS, Inserm, UMR 7104-UMR-S 1258, F-67400 Illkirch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Strasbourg, IGBMC, CNRS, Inserm, UMR 7104-UMR-S 1258, F-67400 Illkirch","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210086872","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002895832","display_name":"Hsin-Chieh Wu","orcid":"https://orcid.org/0000-0001-8793-7821","observed_orcids":["https://orcid.org/0000-0001-8793-7821"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I187986737","display_name":"Coll\u00e8ge de France","ror":"https://ror.org/04ex24z53","country_code":"FR","type":"education","lineage":["https://openalex.org/I187986737"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210113621","display_name":"Centre Interdisciplinaire de Recherche en Biologie","ror":"https://ror.org/01mvzn566","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I187986737","https://openalex.org/I4210096427","https://openalex.org/I4210113621"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Hsin Chieh Wu","raw_affiliation_strings":["Coll\u00e8ge de France, Oncologie Cellulaire et Mol\u00e9culaire, Universit\u00e9 Paris Cit\u00e9, INSERM UMR 1050, CNRS UMR 7241, Paris"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Coll\u00e8ge de France, Oncologie Cellulaire et Mol\u00e9culaire, Universit\u00e9 Paris Cit\u00e9, INSERM UMR 1050, CNRS UMR 7241, Paris","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I187986737","https://openalex.org/I204730241","https://openalex.org/I4210113621"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073076461","display_name":"Hugues de Th\u00e9","orcid":"https://orcid.org/0000-0002-1113-4472","observed_orcids":["https://orcid.org/0000-0002-1113-4472"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I187986737","display_name":"Coll\u00e8ge de France","ror":"https://ror.org/04ex24z53","country_code":"FR","type":"education","lineage":["https://openalex.org/I187986737"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4210113621","display_name":"Centre Interdisciplinaire de Recherche en Biologie","ror":"https://ror.org/01mvzn566","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I187986737","https://openalex.org/I4210096427","https://openalex.org/I4210113621"]},{"id":"https://openalex.org/I4210144610","display_name":"H\u00f4pital Saint-Louis","ror":"https://ror.org/049am9t04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210144610"]},{"id":"https://openalex.org/I4392021104","display_name":"State Key Laboratory of Medical Genomics","ror":"https://ror.org/04m0qde81","country_code":"CN","type":"facility","lineage":["https://openalex.org/I183067930","https://openalex.org/I4392021104"]},{"id":"https://openalex.org/I4403386645","display_name":"Institut de recherche Saint-Louis","ror":"https://ror.org/01wa61d03","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I4403386645"]}],"countries":["CN","FR"],"is_corresponding":false,"raw_author_name":"Hugues De Th\u00e9","raw_affiliation_strings":["Universit\u00e9 Paris Cit\u00e9, Institut de Recherche Saint-Louis (IRSL), INSERM UMR1342-CNRS EMR8000, Paris, France; Sino-French Research Center for Life Sciences and Genomics, State Key Laboratory of Medical Genomics, CNRS-LIA124, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Coll\u00e8ge de France, Oncologie Cellulaire et Mol\u00e9culaire, Universit\u00e9 Paris Cit\u00e9, INSERM UMR 1050, CNRS UMR 7241, Paris France; Laboratoire d'h\u00e9matologie, H\u00f4pital Saint-Louis, Assistance Publique H\u00f4pitaux de Paris (AH/HP), Paris. hugues.dethe@inserm.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, Institut de Recherche Saint-Louis (IRSL), INSERM UMR1342-CNRS EMR8000, Paris, France; Sino-French Research Center for Life Sciences and Genomics, State Key Laboratory of Medical Genomics, CNRS-LIA124, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Coll\u00e8ge de France, Oncologie Cellulaire et Mol\u00e9culaire, Universit\u00e9 Paris Cit\u00e9, INSERM UMR 1050, CNRS UMR 7241, Paris France; Laboratoire d'h\u00e9matologie, H\u00f4pital Saint-Louis, Assistance Publique H\u00f4pitaux de Paris (AH/HP), Paris. hugues.dethe@inserm.fr","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I183067930","https://openalex.org/I187986737","https://openalex.org/I204730241","https://openalex.org/I4210097159","https://openalex.org/I4210113621","https://openalex.org/I4210144610","https://openalex.org/I4392021104","https://openalex.org/I4403386645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084423309","display_name":"Albane le Maire","orcid":"https://orcid.org/0000-0003-3336-2158","observed_orcids":["https://orcid.org/0000-0003-3336-2158"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210100279","display_name":"Centre de Biologie Structurale","ror":"https://ror.org/0189yvq06","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210100279"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Albane Le Maire","raw_affiliation_strings":["Universit\u00e9 de Montpellier, Centre de Biologie Structurale (CBS), CNRS UMR5048-INSERM U1054, Montpellier. albane.lemaire@cbs.cnrs.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Montpellier, Centre de Biologie Structurale (CBS), CNRS UMR5048-INSERM U1054, Montpellier. albane.lemaire@cbs.cnrs.fr","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210100279"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037890718","display_name":"Marie\u2010Claude Geoffroy","orcid":"https://orcid.org/0000-0001-8298-467X","observed_orcids":["https://orcid.org/0000-0001-8298-467X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I187986737","display_name":"Coll\u00e8ge de France","ror":"https://ror.org/04ex24z53","country_code":"FR","type":"education","lineage":["https://openalex.org/I187986737"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210113621","display_name":"Centre Interdisciplinaire de Recherche en Biologie","ror":"https://ror.org/01mvzn566","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I187986737","https://openalex.org/I4210096427","https://openalex.org/I4210113621"]},{"id":"https://openalex.org/I4403386645","display_name":"Institut de recherche Saint-Louis","ror":"https://ror.org/01wa61d03","country_code":"FR","type":"facility","lineage":["https://openalex.org/I204730241","https://openalex.org/I4403386645"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie-Claude Geoffroy","raw_affiliation_strings":["Universit\u00e9 Paris Cit\u00e9, Institut de Recherche Saint-Louis (IRSL), INSERM UMR1342-CNRS EMR8000, Paris, France; Coll\u00e8ge de France, Oncologie Cellulaire et Mol\u00e9culaire, Universit\u00e9 Paris Cit\u00e9, INSERM UMR 1050, CNRS UMR 7241, Paris. marie-claude.geoffroy@inserm.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris Cit\u00e9, Institut de Recherche Saint-Louis (IRSL), INSERM UMR1342-CNRS EMR8000, Paris, France; Coll\u00e8ge de France, Oncologie Cellulaire et Mol\u00e9culaire, Universit\u00e9 Paris Cit\u00e9, INSERM UMR 1050, CNRS UMR 7241, Paris. marie-claude.geoffroy@inserm.fr","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I187986737","https://openalex.org/I204730241","https://openalex.org/I4210113621","https://openalex.org/I4403386645"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":15,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2000,"currency":"EUR","value_usd":2157},"apc_paid":{"value":2000,"currency":"EUR","value_usd":2157},"fwci":1.4605,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.85888371,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-promyelocytic-leukemia","display_name":"acute promyelocytic leukemia","score":0.8820000290870667},{"id":"https://openalex.org/keywords/pml-rara-fusion","display_name":"PML-RARA fusion","score":0.9269999861717224},{"id":"https://openalex.org/keywords/all-trans-retinoic-acid-resistance","display_name":"all-trans retinoic acid resistance","score":0.9359999895095825},{"id":"https://openalex.org/keywords/clustered-mutations","display_name":"clustered mutations","score":0.7590000033378601},{"id":"https://openalex.org/keywords/mutation-hotspots","display_name":"mutational hotspots","score":0.6740000247955322},{"id":"https://openalex.org/keywords/ncor","display_name":"NCoR","score":0.7509999871253967},{"id":"https://openalex.org/keywords/smrt","display_name":"SMRT","score":0.9869999885559082},{"id":"https://openalex.org/keywords/corepressors","display_name":"corepressors","score":0.7509999871253967},{"id":"https://openalex.org/keywords/gain-of-function-mutations","display_name":"gain-of-function mutations","score":0.7039999961853027},{"id":"https://openalex.org/keywords/arsenic-trioxide","display_name":"arsenic trioxide","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.7289999723434448},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.7174999713897705},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.694100022315979},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6557999849319458},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5554999709129333},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5199000239372253},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.47940000891685486},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.47769999504089355},{"id":"https://openalex.org/C2779963572","wikidata":"https://www.wikidata.org/wiki/Q29417","display_name":"Tretinoin","level":4,"score":0.4731000065803528},{"id":"https://openalex.org/C2776601000","wikidata":"https://www.wikidata.org/wiki/Q612108","display_name":"Acute promyelocytic leukemia","level":4,"score":0.44999998807907104},{"id":"https://openalex.org/C120197328","wikidata":"https://www.wikidata.org/wiki/Q2838685","display_name":"Retinoic acid receptor","level":4,"score":0.44850000739097595},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4345000088214874},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4205000102519989},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4072999954223633},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.38109999895095825},{"id":"https://openalex.org/C121587040","wikidata":"https://www.wikidata.org/wiki/Q898769","display_name":"Homeobox","level":4,"score":0.35839998722076416},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.33660000562667847},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.3271999955177307},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31049999594688416},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.3070000112056732},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3019999861717224},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.2953999936580658},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.2696000039577484},{"id":"https://openalex.org/C75563809","wikidata":"https://www.wikidata.org/wiki/Q2656896","display_name":"Missense mutation","level":4,"score":0.26600000262260437},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.26170000433921814}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3324/haematol.2025.300279","doi":"https://doi.org/10.3324/haematol.2025.300279","is_oa":true,"landing_page_url":"https://doi.org/10.3324/haematol.2025.300279","pdf_url":null,"source":{"id":"https://openalex.org/S2752781272","display_name":"Haematologica","issn_l":"0390-6078","issn":["0390-6078","1592-8721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317774","host_organization_name":"Ferrata Storti Foundation","host_organization_lineage":["https://openalex.org/P4310317774"],"host_organization_lineage_names":["Ferrata Storti Foundation"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"journal-article"},{"id":"pmid:42610425","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42610425","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05775581v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-05775581","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Haematologica, 2026, &#x27E8;10.3324/haematol.2025.300279&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:1843714437b1400296b836058b7ead84","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/1843714437b1400296b836058b7ead84","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Haematologica, Vol 999, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3324/haematol.2025.300279","doi":"https://doi.org/10.3324/haematol.2025.300279","is_oa":true,"landing_page_url":"https://doi.org/10.3324/haematol.2025.300279","pdf_url":null,"source":{"id":"https://openalex.org/S2752781272","display_name":"Haematologica","issn_l":"0390-6078","issn":["0390-6078","1592-8721"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317774","host_organization_name":"Ferrata Storti Foundation","host_organization_lineage":["https://openalex.org/P4310317774"],"host_organization_lineage_names":["Ferrata Storti Foundation"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2894652054","https://openalex.org/W2398984789","https://openalex.org/W7036167097","https://openalex.org/W2173789978","https://openalex.org/W2000877431","https://openalex.org/W2256936668","https://openalex.org/W2077872976","https://openalex.org/W2574020092","https://openalex.org/W2093481931","https://openalex.org/W2518743105"],"abstract_inverted_index":{"Most":[0,60],"acute":[1],"promyelocytic":[2],"leukemia":[3],"(APL),":[4],"driven":[5],"by":[6],"the":[7,115],"PML::RARA":[8,40],"fusion,":[9],"are":[10,94],"now":[11],"cured":[12],"with":[13,27,34,51,97,100,104],"targeted":[14],"therapies":[15],"combining":[16],"all-trans":[17],"retinoic":[18,123],"acid":[19,124],"(ATRA)":[20],"and":[21,87],"arsenic":[22],"trioxide.":[23],"Some":[24],"patients":[25],"treated":[26],"earlier":[28],"ATRA/chemotherapy":[29],"regimen":[30],"developed":[31],"resistance":[32],"associated":[33,50,96],"mutations":[35,49,93],"that":[36],"most":[37],"often":[38],"preclude":[39],"ATRA-binding.":[41],"Here,":[42],"we":[43],"characterized":[44],"a":[45,69],"subset":[46],"of":[47,117,121],"clustered":[48],"ATRA-resistance,":[52],"but":[53,67],"not":[54,75],"predicted":[55],"to":[56,108],"affect":[57],"ATRA":[58],"binding.":[59],"mutants":[61],"indeed":[62],"retained":[63],"full":[64],"ligand":[65],"responsiveness,":[66],"displayed":[68],"basal":[70],"super-repressive":[71],"phenotype":[72],"which":[73],"did":[74],"result":[76],"from":[77],"an":[78],"increased":[79],"affinity":[80],"for":[81],"known":[82],"corepressors":[83],"such":[84],"as":[85],"NCoR":[86],"SMRT.":[88],"Our":[89],"findings":[90],"suggest":[91],"these":[92,112],"gain-of-function":[95],"enhanced":[98],"interactions":[99],"unidentified":[101],"RARA":[102],"partners":[103],"repressive":[105],"ability.":[106],"Similar":[107],"ATRA-resistant":[109],"PLZF::RARA":[110],"variants,":[111],"observations":[113],"stress":[114],"role":[116],"persistent":[118],"transcriptional":[119],"repression":[120],"some":[122],"target":[125],"genes":[126],"in":[127],"acquired":[128],"ATRA-resistance.":[129]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-08-14T00:00:00"}
