{"id":"https://openalex.org/W7202294353","doi":"https://doi.org/10.1172/jci207031","title":"Metabolic stress\u2013activated endothelial STING rewires the sinusoidal immune niche to promote MASLD progression","display_name":"Metabolic stress\u2013activated endothelial STING rewires the sinusoidal immune niche to promote MASLD progression","publication_year":2026,"publication_date":"2026-08-06","ids":{"openalex":"https://openalex.org/W7202294353","doi":"https://doi.org/10.1172/jci207031","pmid":"https://pubmed.ncbi.nlm.nih.gov/42585137","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13626822"},"language":"en","primary_location":{"id":"doi:10.1172/jci207031","doi":"https://doi.org/10.1172/jci207031","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci207031","pdf_url":"http://www.jci.org/articles/view/207031/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.jci.org/articles/view/207031/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019838272","display_name":"Zhibin Lin","orcid":"https://orcid.org/0000-0002-0779-0530","observed_orcids":["https://orcid.org/0000-0002-0779-0530"]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-Bin Lin","raw_affiliation_strings":["Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153201887","display_name":"Peng Zou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Zou","raw_affiliation_strings":["Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146970260","display_name":"Xian-Yi Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xian-Yi Ma","raw_affiliation_strings":["Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031499916","display_name":"Jun-Bo Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun-Bo Song","raw_affiliation_strings":["Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146963163","display_name":"Hong Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Zhang","raw_affiliation_strings":["Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101691272","display_name":"Wei Du","orcid":"https://orcid.org/0000-0001-7464-9441","observed_orcids":["https://orcid.org/0000-0001-7464-9441"]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Du","raw_affiliation_strings":["Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100955497","display_name":"W\u00e8i D\u0101n","orcid":"https://orcid.org/0000-0001-9455-9566","observed_orcids":["https://orcid.org/0000-0001-9455-9566"]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dan Wei","raw_affiliation_strings":["Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153392154","display_name":"Ping Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ping Song","raw_affiliation_strings":["Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101787690","display_name":"Xin Hong","orcid":"https://orcid.org/0000-0002-7202-6969","observed_orcids":["https://orcid.org/0000-0002-7202-6969"]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Hong","raw_affiliation_strings":["Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100442557","display_name":"Jingjing Liu","orcid":"https://orcid.org/0000-0001-9210-6950","observed_orcids":["https://orcid.org/0000-0001-9210-6950"]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing-Jing Liu","raw_affiliation_strings":["Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043013078","display_name":"Zhi-Qiang FANG","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-Qiang Fang","raw_affiliation_strings":["Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146993861","display_name":"Hao Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Xu","raw_affiliation_strings":["Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101826782","display_name":"Fei He","orcid":"https://orcid.org/0000-0001-8368-5030","observed_orcids":["https://orcid.org/0000-0001-8368-5030"]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei He","raw_affiliation_strings":["Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113530323","display_name":"Juanli Duan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan-Li Duan","raw_affiliation_strings":["Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101612753","display_name":"Dou Ke-feng","orcid":"https://orcid.org/0000-0003-3224-5072","observed_orcids":["https://orcid.org/0000-0003-3224-5072"]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke-Feng Dou","raw_affiliation_strings":["Department of Hepatobiliary Surgery , Xijing Hospital , Fourth Military Medical University , Xi'an , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery , Xijing Hospital , Fourth Military Medical University , Xi'an , China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5147024034","display_name":"Lin Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lin Wang","raw_affiliation_strings":["Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, Fourth Military Medical University, Xi\u2019an, China","institution_ids":["https://openalex.org/I9916479"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5147024034"],"corresponding_institution_ids":["https://openalex.org/I9916479"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":{"value":5200,"currency":"USD","value_usd":5200},"fwci":4.6124,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.95662706,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"136","issue":"19","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.823199987411499,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.823199987411499,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.07240000367164612,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.05719999969005585,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolic-stress","display_name":"metabolic stress","score":0.6340000033378601},{"id":"https://openalex.org/keywords/liver-sinusoidal-endothelial-cells","display_name":"liver sinusoidal endothelial cells","score":0.9509999752044678},{"id":"https://openalex.org/keywords/sting-signaling","display_name":"STING signaling","score":0.8489999771118164},{"id":"https://openalex.org/keywords/cgas-sting-pathway","display_name":"cGAS-STING pathway","score":0.8100000023841858},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9049999713897705},{"id":"https://openalex.org/keywords/bmp4","display_name":"BMP4","score":0.7789999842643738},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8420000076293945},{"id":"https://openalex.org/keywords/angiocrine-signaling","display_name":"angiocrine signaling","score":0.8330000042915344},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":0.7710000276565552},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9810000061988831},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.8690000176429749},{"id":"https://openalex.org/keywords/steatohepatitis","display_name":"steatohepatitis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/peptide-functionalized-nanoparticles","display_name":"peptide-functionalized nanoparticles","score":0.8429999947547913},{"id":"https://openalex.org/keywords/single-nucleus-transcriptomics","display_name":"single-nucleus transcriptomics","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7200999855995178},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.680400013923645},{"id":"https://openalex.org/C2779300339","wikidata":"https://www.wikidata.org/wiki/Q7617409","display_name":"Sting","level":2,"score":0.6252999901771545},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5105999708175659},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4943999946117401},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4643999934196472},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.41510000824928284},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.41449999809265137},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4068000018596649},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.39340001344680786},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.3666999936103821},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3666999936103821},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.36579999327659607},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3538999855518341},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.34049999713897705},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.33230000734329224},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.3276999890804291},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.32679998874664307},{"id":"https://openalex.org/C2776246508","wikidata":"https://www.wikidata.org/wiki/Q5376428","display_name":"Endothelial activation","level":3,"score":0.3239000141620636},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.3190000057220459},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.29760000109672546},{"id":"https://openalex.org/C2779559532","wikidata":"https://www.wikidata.org/wiki/Q1076369","display_name":"Cytokine storm","level":5,"score":0.29179999232292175},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.2791000008583069},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.27320000529289246},{"id":"https://openalex.org/C11988809","wikidata":"https://www.wikidata.org/wiki/Q412889","display_name":"Interleukin 6","level":3,"score":0.2718000113964081},{"id":"https://openalex.org/C2910341952","wikidata":"https://www.wikidata.org/wiki/Q570425","display_name":"Leukocyte Trafficking","level":4,"score":0.25}],"mesh":[{"descriptor_ui":"D000099196","descriptor_name":"cGAS-STING Signaling Pathway","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099197","descriptor_name":"STING Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055415","descriptor_name":"Bone Morphogenetic Protein 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055415","descriptor_name":"Bone Morphogenetic Protein 4","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci207031","doi":"https://doi.org/10.1172/jci207031","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci207031","pdf_url":"http://www.jci.org/articles/view/207031/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmid:42585137","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42585137","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13626822","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13626822/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1172/jci207031","doi":"https://doi.org/10.1172/jci207031","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci207031","pdf_url":"http://www.jci.org/articles/view/207031/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2052129206","display_name":null,"funder_award_id":"2025M774458","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G4536945813","display_name":null,"funder_award_id":"92468202","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G497093035","display_name":null,"funder_award_id":"2021YFA1100502","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G623323265","display_name":null,"funder_award_id":"82325007","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6267168057","display_name":null,"funder_award_id":"82371793","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7006522009","display_name":null,"funder_award_id":"82400667","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8858850961","display_name":null,"funder_award_id":"82421002","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320324530","display_name":"Fourth Military Medical University","ror":"https://ror.org/00ms48f15"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7202294353.pdf","grobid_xml":"https://content.openalex.org/works/W7202294353.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4408745542","https://openalex.org/W4407089868","https://openalex.org/W4413329944","https://openalex.org/W7213402231","https://openalex.org/W7221602558","https://openalex.org/W7124283908","https://openalex.org/W7140288017","https://openalex.org/W7212400549","https://openalex.org/W4407101248","https://openalex.org/W7222888032"],"abstract_inverted_index":{"Liver":[0],"sinusoidal":[1,103],"endothelial":[2,63,126,161],"cells":[3],"(LSECs)":[4],"regulate":[5],"nutrient":[6],"flux":[7],"and":[8,76,179],"immune":[9,26,168,177],"surveillance":[10],"within":[11],"the":[12,85,93,101,154],"hepatic":[13,120,149],"niche,":[14,105],"yet":[15],"how":[16],"they":[17],"function":[18],"as":[19,163],"metabolic":[20,29,69,121,173],"stress":[21,174],"sensors":[22],"that":[23,59,170],"instruct":[24],"adaptive":[25,176],"remodeling":[27,178],"during":[28],"dysfunction-associated":[30],"steatotic":[31],"liver":[32],"disease":[33],"(MASLD)":[34],"remains":[35],"unclear.":[36],"Here,":[37],"single-nucleus":[38],"transcriptomics":[39],"of":[40,46,50,92,98,139],"human":[41,124],"MASLD":[42],"revealed":[43],"stage-dependent":[44],"activation":[45,64,83],"cyclic":[47],"GMP-AMP":[48],"synthase/stimulator":[49],"interferon":[51],"genes":[52],"(cGAS/STING)":[53],"signaling":[54],"in":[55,60,78],"LSEC":[56],"comparable":[57],"with":[58,62,131],"macrophages,":[61],"showing":[65],"greater":[66],"responsiveness":[67],"to":[68,143,175],"stress.":[70],"Endothelium-specific":[71],"STING":[72,82,127,141,162],"deletion":[73],"attenuated":[74],"steatohepatitis":[75],"fibrosis":[77],"mice.":[79],"Mechanistically,":[80],"LSEC-intrinsic":[81],"reprogrammed":[84],"angiocrine":[86],"landscape":[87],"through":[88],"NF-\u03baB-mediated":[89],"transcriptional":[90],"repression":[91],"endothelium-derived":[94],"factor":[95],"BMP4.":[96],"Loss":[97],"BMP4":[99,132],"disrupted":[100],"tolerance-supporting":[102],"immunometabolic":[104,150],"skewing":[106],"CD4+":[107],"T":[108],"cell":[109],"differentiation":[110],"toward":[111],"pathogenic":[112],"Th17":[113],"states":[114],"while":[115],"destabilizing":[116],"Treg,":[117],"collectively":[118],"exacerbating":[119],"failure.":[122],"In":[123],"MASLD,":[125],"activity":[128],"inversely":[129],"correlated":[130],"expression":[133],"at":[134,152],"single-cell":[135],"resolution.":[136],"Targeted":[137],"delivery":[138],"a":[140,164],"inhibitor":[142],"LSECs":[144],"using":[145],"peptide-functionalized":[146],"nanoparticles":[147],"restored":[148],"balance":[151],"one-tenth":[153],"systemic":[155],"dose.":[156],"Together,":[157],"these":[158],"findings":[159],"establish":[160],"metabolically":[165],"responsive":[166],"vascular":[167],"checkpoint":[169],"links":[171],"chronic":[172],"fibrotic":[180],"progression.":[181]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-08-13T00:00:00"}