{"id":"https://openalex.org/W7202289000","doi":"https://doi.org/10.1093/jacamr/dlag166","title":"In vitro activities of aztreonam/nacubactam and cefepime/nacubactam against a global collection of molecularly characterized Enterobacterales isolates carrying carbapenemases: a global antimicrobial resistance surveillance study from 2021 to 2023","display_name":"In vitro activities of aztreonam/nacubactam and cefepime/nacubactam against a global collection of molecularly characterized Enterobacterales isolates carrying carbapenemases: a global antimicrobial resistance surveillance study from 2021 to 2023","publication_year":2026,"publication_date":"2026-07-02","ids":{"openalex":"https://openalex.org/W7202289000","doi":"https://doi.org/10.1093/jacamr/dlag166","pmid":"https://pubmed.ncbi.nlm.nih.gov/42592333","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13463764"},"language":"en","primary_location":{"id":"doi:10.1093/jacamr/dlag166","doi":"https://doi.org/10.1093/jacamr/dlag166","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jacamr/dlag166","pdf_url":null,"source":{"id":"https://openalex.org/S4210190703","display_name":"JAC-Antimicrobial Resistance","issn_l":"2632-1823","issn":["2632-1823"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAC-Antimicrobial Resistance","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/jacamr/dlag166","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5122816838","display_name":"Mark Estabrook","orcid":"https://orcid.org/0009-0000-3941-6589","observed_orcids":["https://orcid.org/0009-0000-3941-6589"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Estabrook","raw_affiliation_strings":["IHMA Inc. , Schaumburg, IL 60173 ,"],"raw_orcid":"https://orcid.org/0009-0000-3941-6589","affiliations":[{"raw_affiliation_string":"IHMA Inc. , Schaumburg, IL 60173 ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158770534","display_name":"Eisuke Suzuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405275510","display_name":"Meiji Seika Pharma Co., Ltd. (Japan)","ror":"https://ror.org/03qt4xn36","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405275510"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eisuke Suzuki","raw_affiliation_strings":["Meiji Seika Pharma Co., Ltd , 2-4-16, Kyobashi, Chuo-ku, Tokyo 104-8002 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Meiji Seika Pharma Co., Ltd , 2-4-16, Kyobashi, Chuo-ku, Tokyo 104-8002 ,","institution_ids":["https://openalex.org/I4405275510"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038831019","display_name":"Atsuyuki Shimizu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405275510","display_name":"Meiji Seika Pharma Co., Ltd. (Japan)","ror":"https://ror.org/03qt4xn36","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405275510"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsuyuki Shimizu","raw_affiliation_strings":["Meiji Seika Pharma Co., Ltd , 2-4-16, Kyobashi, Chuo-ku, Tokyo 104-8002 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Meiji Seika Pharma Co., Ltd , 2-4-16, Kyobashi, Chuo-ku, Tokyo 104-8002 ,","institution_ids":["https://openalex.org/I4405275510"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017657848","display_name":"Hayato Okade","orcid":"https://orcid.org/0000-0002-2570-6056","observed_orcids":["https://orcid.org/0000-0002-2570-6056"]},"institutions":[{"id":"https://openalex.org/I4405275510","display_name":"Meiji Seika Pharma Co., Ltd. (Japan)","ror":"https://ror.org/03qt4xn36","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405275510"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hayato Okade","raw_affiliation_strings":["Meiji Seika Pharma Co., Ltd , 2-4-16, Kyobashi, Chuo-ku, Tokyo 104-8002 ,"],"raw_orcid":"https://orcid.org/0000-0002-2570-6056","affiliations":[{"raw_affiliation_string":"Meiji Seika Pharma Co., Ltd , 2-4-16, Kyobashi, Chuo-ku, Tokyo 104-8002 ,","institution_ids":["https://openalex.org/I4405275510"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017657848"],"corresponding_institution_ids":["https://openalex.org/I4405275510"],"apc_list":{"value":1978,"currency":"GBP","value_usd":2609},"apc_paid":{"value":1978,"currency":"GBP","value_usd":2609},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"4","first_page":"dlag166","last_page":"dlag166"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carbapenemase-producing-enterobacterales","display_name":"carbapenemase-producing Enterobacteriaceae","score":0.9169999957084656},{"id":"https://openalex.org/keywords/carbapenem-resistance","display_name":"carbapenem resistance","score":0.8619999885559082},{"id":"https://openalex.org/keywords/new-delhi-metallo-beta-lactamase","display_name":"New Delhi metallo-beta-lactamase","score":0.8539999723434448},{"id":"https://openalex.org/keywords/klebsiella-pneumoniae-carbapenemase","display_name":"KPC","score":0.6970000267028809},{"id":"https://openalex.org/keywords/oxa-48-like","display_name":"OXA-48-like","score":0.9200000166893005},{"id":"https://openalex.org/keywords/beta-lactamase-inhibitors","display_name":"beta-lactamase inhibitors","score":0.7799999713897705},{"id":"https://openalex.org/keywords/avibactam","display_name":"avibactam","score":0.6949999928474426},{"id":"https://openalex.org/keywords/cefiderocol","display_name":"cefiderocol","score":0.9739999771118164},{"id":"https://openalex.org/keywords/antimicrobial-susceptibility","display_name":"antimicrobial susceptibility","score":0.6660000085830688},{"id":"https://openalex.org/keywords/nanopore-sequencing","display_name":"nanopore sequencing","score":0.6420000195503235},{"id":"https://openalex.org/keywords/antimicrobial-resistance-surveillance","display_name":"antimicrobial resistance surveillance","score":0.6460000276565552},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8999999761581421},{"id":"https://openalex.org/keywords/klebsiella","display_name":"Klebsiella","score":0.9330000281333923}],"concepts":[{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.6934999823570251},{"id":"https://openalex.org/C2780416669","wikidata":"https://www.wikidata.org/wiki/Q418546","display_name":"Aztreonam","level":5,"score":0.6446999907493591},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6237999796867371},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6154999732971191},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.5910000205039978},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.43880000710487366},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.4187000095844269},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.4108000099658966},{"id":"https://openalex.org/C64778159","wikidata":"https://www.wikidata.org/wiki/Q271021","display_name":"Cephalosporin","level":3,"score":0.4018999934196472},{"id":"https://openalex.org/C2778910516","wikidata":"https://www.wikidata.org/wiki/Q380136","display_name":"Enterobacteriaceae","level":4,"score":0.37610000371932983},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3370000123977661},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.3312999904155731},{"id":"https://openalex.org/C2910948552","wikidata":"https://www.wikidata.org/wiki/Q380136","display_name":"Enterobacteriaceae Infections","level":5,"score":0.28769999742507935},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.27959999442100525},{"id":"https://openalex.org/C2779259085","wikidata":"https://www.wikidata.org/wiki/Q418946","display_name":"Colistin","level":3,"score":0.27469998598098755},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.26829999685287476},{"id":"https://openalex.org/C2778983983","wikidata":"https://www.wikidata.org/wiki/Q134281","display_name":"Enterobacter","level":4,"score":0.2506999969482422}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/jacamr/dlag166","doi":"https://doi.org/10.1093/jacamr/dlag166","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jacamr/dlag166","pdf_url":null,"source":{"id":"https://openalex.org/S4210190703","display_name":"JAC-Antimicrobial Resistance","issn_l":"2632-1823","issn":["2632-1823"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAC-Antimicrobial Resistance","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13463764","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13463764/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13463764/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAC Antimicrob Resist","raw_type":"Text"},{"id":"pmid:42592333","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42592333","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAC-antimicrobial resistance","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/jacamr/dlag166","doi":"https://doi.org/10.1093/jacamr/dlag166","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jacamr/dlag166","pdf_url":null,"source":{"id":"https://openalex.org/S4210190703","display_name":"JAC-Antimicrobial Resistance","issn_l":"2632-1823","issn":["2632-1823"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JAC-Antimicrobial Resistance","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2404959719","display_name":"\u65b0\u898f\u8fc5\u901f\u907a\u4f1d\u5b50\u8a3a\u65ad\u6cd5\u306a\u3089\u3073\u306b\u975e\u81e8\u5e8aPK/PD\u7406\u8ad6\u3092\u6d3b\u7528\u3057\u305f\u65b0\u898f\u03b2-\u30e9\u30af\u30bf\u30de\u30fc\u30bc\u963b\u5bb3\u5264(OP0595)\u306e\u5358\u5473\u88fd\u5264\u306e\u7814\u7a76\u958b\u767a","funder_award_id":"18pc0101028h0001","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"}],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320322415","display_name":"Meiji Seika Pharma","ror":"https://ror.org/027tjex48"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7202289000.pdf","grobid_xml":"https://content.openalex.org/works/W7202289000.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W2067286784","https://openalex.org/W2116744776","https://openalex.org/W2136653513","https://openalex.org/W2530661320","https://openalex.org/W2905985918","https://openalex.org/W2963257790","https://openalex.org/W2991573081","https://openalex.org/W3026777707","https://openalex.org/W3214569295","https://openalex.org/W4313544502","https://openalex.org/W4323349552","https://openalex.org/W4366351459","https://openalex.org/W4386084606","https://openalex.org/W4392240955","https://openalex.org/W4394688170","https://openalex.org/W4403923650","https://openalex.org/W4407626428","https://openalex.org/W4410944246","https://openalex.org/W7160420274"],"related_works":["https://openalex.org/W7160420274","https://openalex.org/W7163553798","https://openalex.org/W4389029753","https://openalex.org/W3140082236","https://openalex.org/W2259669282","https://openalex.org/W4405260646","https://openalex.org/W7116851937","https://openalex.org/W4353093978","https://openalex.org/W4405823200","https://openalex.org/W7172441762"],"abstract_inverted_index":{"Abstract":[0],"Objectives":[1],"Nacubactam":[2],"is":[3,14,234],"a":[4,50],"novel":[5],"diazabicyclooctane":[6],"\u03b2-lactamase":[7],"inhibitor":[8],"with":[9,18,206,230],"activity":[10,196],"against":[11,34,116,138,158,169,197],"PBP2":[12],"that":[13,199,210],"in":[15,23,56,144,148,194,232],"clinical":[16],"development":[17],"aztreonam":[19],"or":[20,106,128],"cefepime.":[21],"The":[22,224],"vitro":[24,195],"activities":[25,178],"of":[26,49,104,118,151,160,226],"aztreonam/nacubactam,":[27],"cefepime/nacubactam":[28,135,166,191],"and":[29,59,95,165,176,184,190,202,236],"comparator":[30],"agents":[31],"were":[32,45,72,89,99,146,179],"determined":[33],"carbapenemase-producing":[35,87],"Enterobacterales,":[36],"collected":[37,46],"globally":[38],"from":[39,53],"2021":[40],"to":[41,77],"2023.":[42],"Methods":[43],"Isolates":[44],"as":[47],"part":[48],"surveillance":[51],"study":[52],"24":[54],"countries":[55],"Asia,":[57],"Europe":[58],"North":[60],"America.":[61],"Susceptibility":[62],"testing":[63],"was":[64,114,136,156,167],"by":[65,74,101,221],"CLSI":[66],"broth":[67],"microdilution.":[68],"Meropenem-non-susceptible":[69],"Enterobacterales":[70,198],"isolates":[71,84,88,98],"sequenced":[73],"nanopore":[75],"technology":[76],"identify":[78],"resistance":[79,208],"mechanisms.":[80],"Of":[81],"12":[82],"613":[83],"collected,":[85],"630":[86],"detected.":[90],"Results":[91],"All":[92],"KPC-producing":[93],"(158)":[94],"OXA-48-like\u2013producing":[96],"(142)":[97],"inhibited":[100],"\u22644/4":[102,112,163],"mg/L":[103,108,113,164],"aztreonam/nacubactam":[105],"\u22648/8":[107,141,172],"cefepime/nacubactam.":[109],"Aztreonam/nacubactam":[110,155,189],"at":[111,140,162,171],"active":[115,137,157,168],"98.7%":[117],"the":[119,212],"307":[120],"NDM-producing":[121],"isolates,":[122],"more":[123],"than":[124],"aztreonam/avibactam":[125,175],"(95.1%":[126],"susceptible)":[127],"cefiderocol":[129,177],"[85.7%":[130],"susceptible":[131],"(CLSI":[132],"breakpoints)],":[133],"while":[134,174],"94.1%":[139],"mg/L.":[142],"Insertions":[143],"PBP3":[145,233],"present":[147],"39/47":[149],"(83%)":[150],"NDM-positive":[152,227],"Escherichia":[153],"coli.":[154],"97.4%":[159],"these":[161],"100%":[170],"mg/L,":[173],"relatively":[180],"poor":[181],"[69.2%":[182],"aztreonam/avibactam-susceptible":[183],"46.2%":[185],"cefiderocol-susceptible":[186],"(CLSI)].":[187],"Conclusions":[188],"demonstrated":[192],"potent":[193],"carried":[200],"serine-carbapenemases":[201],"MBLs,":[203],"including":[204],"those":[205],"chromosomal":[207],"mechanisms":[209],"compromise":[211],"current":[213],"best-in-class":[214],"\u03b2-lactam":[215],"antibiotics":[216],"for":[217],"treating":[218],"infections":[219],"caused":[220],"MBL-positive":[222],"organisms.":[223],"percentage":[225],"E.":[228],"coli":[229],"insertions":[231],"alarming":[235],"warrants":[237],"continued":[238],"surveillance.":[239]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-08-13T00:00:00"}
