{"id":"https://openalex.org/W7202288569","doi":"https://doi.org/10.5281/zenodo.21907194","title":"Differential Effects of Commercial Quercetin Product Extracts on Metabolic and Calcium Activity in Primary Neurons Under Hypoxic Conditions","display_name":"Differential Effects of Commercial Quercetin Product Extracts on Metabolic and Calcium Activity in Primary Neurons Under Hypoxic Conditions","publication_year":2026,"publication_date":"2026-08-12","ids":{"openalex":"https://openalex.org/W7202288569","doi":"https://doi.org/10.5281/zenodo.21907194"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.21907194","doi":"https://doi.org/10.5281/zenodo.21907194","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.21907194","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"volume":null,"type":"dataset","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.21907194","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038440661","display_name":"Ne\u015fe Ay\u015fit","orcid":"https://orcid.org/0000-0002-4243-9092","observed_orcids":["https://orcid.org/0000-0002-4243-9092"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ay\u015fit, Ne\u015fe","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4243-9092","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086366944","display_name":"Sevginur Bostan","orcid":"https://orcid.org/0000-0003-0753-6150","observed_orcids":["https://orcid.org/0000-0003-0753-6150"]},"institutions":[{"id":"https://openalex.org/I3125470973","display_name":"Istanbul Medipol University","ror":"https://ror.org/037jwzz50","country_code":"TR","type":"education","lineage":["https://openalex.org/I3125470973"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"BOSTAN, SEVGINUR","raw_affiliation_strings":["Istanbul Medipol University"],"raw_orcid":"https://orcid.org/0000-0003-0753-6150","affiliations":[{"raw_affiliation_string":"Istanbul Medipol University","institution_ids":["https://openalex.org/I3125470973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040432297","display_name":"\u00dcmit Can Erim","orcid":"https://orcid.org/0000-0002-4121-588X","observed_orcids":["https://orcid.org/0000-0002-4121-588X"]},"institutions":[{"id":"https://openalex.org/I3125470973","display_name":"Istanbul Medipol University","ror":"https://ror.org/037jwzz50","country_code":"TR","type":"education","lineage":["https://openalex.org/I3125470973"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"ER\u0130M, \u00dcM\u0130T CAN","raw_affiliation_strings":["Istanbul Medipol University"],"raw_orcid":"https://orcid.org/0000-0002-4121-588X","affiliations":[{"raw_affiliation_string":"Istanbul Medipol University","institution_ids":["https://openalex.org/I3125470973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079364946","display_name":"\u00c7a\u011fr\u0131 \u00c7akici","orcid":"https://orcid.org/0000-0002-8662-5284","observed_orcids":["https://orcid.org/0000-0002-8662-5284"]},"institutions":[{"id":"https://openalex.org/I3125470973","display_name":"Istanbul Medipol University","ror":"https://ror.org/037jwzz50","country_code":"TR","type":"education","lineage":["https://openalex.org/I3125470973"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["TR","US"],"is_corresponding":false,"raw_author_name":"Cakici, Cagri","raw_affiliation_strings":["Massachusetts General Hospital","Istanbul Medipol University/School of Medicine"],"raw_orcid":"https://orcid.org/0000-0002-8662-5284","affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Istanbul Medipol University/School of Medicine","institution_ids":["https://openalex.org/I3125470973"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020448205","display_name":"F. Kemal Bayat","orcid":"https://orcid.org/0000-0002-9129-6841","observed_orcids":["https://orcid.org/0000-0002-9129-6841"]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Bayat, F. Kemal","raw_affiliation_strings":["Marmara University"],"raw_orcid":"https://orcid.org/0000-0002-9129-6841","affiliations":[{"raw_affiliation_string":"Marmara University","institution_ids":["https://openalex.org/I74897591"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.35499998927116394,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.35499998927116394,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.2953999936580658,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neurological Disorders and Treatments","score":0.24400000274181366,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8479999899864197},{"id":"https://openalex.org/keywords/neuronal-metabolic-activity","display_name":"neuronal metabolic activity","score":0.628000020980835},{"id":"https://openalex.org/keywords/intracellular-calcium-activity","display_name":"intracellular calcium activity","score":0.9070000052452087},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cortical-neurons","display_name":"cortical neurons","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.8597999811172485},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7091000080108643},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6589999794960022},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5766000151634216},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.46320000290870667},{"id":"https://openalex.org/C3019921246","wikidata":"https://www.wikidata.org/wiki/Q104853310","display_name":"Differential effects","level":2,"score":0.387800008058548},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3815999925136566},{"id":"https://openalex.org/C2776032975","wikidata":"https://www.wikidata.org/wiki/Q5018833","display_name":"Calcium imaging","level":3,"score":0.37549999356269836},{"id":"https://openalex.org/C2993927895","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolic activity","level":2,"score":0.36980000138282776},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.3587000072002411},{"id":"https://openalex.org/C90673727","wikidata":"https://www.wikidata.org/wiki/Q901718","display_name":"Product (mathematics)","level":2,"score":0.34380000829696655},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3400999903678894},{"id":"https://openalex.org/C2777977315","wikidata":"https://www.wikidata.org/wiki/Q7243056","display_name":"Primary (astronomy)","level":2,"score":0.33730000257492065},{"id":"https://openalex.org/C2993744773","wikidata":"https://www.wikidata.org/wiki/Q2945973","display_name":"Neuronal damage","level":3,"score":0.3156999945640564},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.31200000643730164},{"id":"https://openalex.org/C196235758","wikidata":"https://www.wikidata.org/wiki/Q3333419","display_name":"Primary metabolite","level":3,"score":0.28130000829696655}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.21907194","doi":"https://doi.org/10.5281/zenodo.21907194","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.21907194","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.5281/zenodo.21907195","doi":"https://doi.org/10.5281/zenodo.21907195","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.21907195","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.5281/zenodo.21907194","doi":"https://doi.org/10.5281/zenodo.21907194","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.21907194","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3003089913","https://openalex.org/W3105459008","https://openalex.org/W2594479506","https://openalex.org/W7129694943","https://openalex.org/W7128496806","https://openalex.org/W2787588910","https://openalex.org/W2587642362","https://openalex.org/W2975716664","https://openalex.org/W2418721484","https://openalex.org/W3092354250"],"abstract_inverted_index":{"This":[0],"dataset":[1,29],"contains":[2],"the":[3,7,81,96,100,104],"experimental":[4,62],"data":[5,34,39],"supporting":[6],"manuscript":[8],"entitled":[9],"\u201cDifferential":[10],"Effects":[11],"of":[12,86],"Commercial":[13],"Quercetin":[14],"Product":[15],"Extracts":[16],"on":[17],"Metabolic":[18],"and":[19,35,44,68,84],"Calcium":[20,74],"Activity":[21],"in":[22,103],"Primary":[23],"Neurons":[24],"Under":[25],"Hypoxic":[26],"Conditions.\u201d":[27],"The":[28],"includes":[30],"MTT-derived":[31],"metabolic":[32],"activity":[33,75],"GCaMP6s-based":[36],"calcium":[37,87],"imaging":[38],"obtained":[40],"from":[41],"primary":[42],"hippocampal":[43],"cortical":[45],"neuronal":[46],"cultures":[47],"exposed":[48],"to":[49,94,99],"commercial":[50],"quercetin":[51,58,64,69],"product":[52],"extracts":[53],"(F1\u2013F7)":[54],"or":[55],"analytical-grade":[56],"pure":[57],"(F8)":[59],"under":[60,80],"two":[61],"paradigms:":[63],"pretreatment":[65],"before":[66],"hypoxia":[67],"administration":[70],"following":[71],"hypoxic":[72],"exposure.":[73],"is":[76,92],"represented":[77],"by":[78],"area":[79],"curve":[82],"(AUC)":[83],"number":[85],"events.":[88],"A":[89],"traceability":[90],"report":[91],"included":[93],"link":[95],"available":[97],"datasets":[98],"corresponding":[101],"figures":[102],"manuscript.":[105]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2026-08-13T00:00:00"}