{"id":"https://openalex.org/W7202286299","doi":"https://doi.org/10.64898/2026.08.06.743332","title":"An Aging Risk-Factor Scale: Biomarkers of Renal Disease and Anemia are Primary Predictors of Three-Year Survival in Common Marmosets ( Callithrix jacchus )","display_name":"An Aging Risk-Factor Scale: Biomarkers of Renal Disease and Anemia are Primary Predictors of Three-Year Survival in Common Marmosets ( Callithrix jacchus )","publication_year":2026,"publication_date":"2026-08-12","ids":{"openalex":"https://openalex.org/W7202286299","doi":"https://doi.org/10.64898/2026.08.06.743332"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.06.743332","doi":"https://doi.org/10.64898/2026.08.06.743332","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.06.743332","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.08.06.743332","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019783593","display_name":"Juan Pablo Arroyo","orcid":"https://orcid.org/0000-0002-5992-5011","observed_orcids":["https://orcid.org/0000-0002-5992-5011","https://orcid.org/0009-0004-1113-1695"]},"institutions":[{"id":"https://openalex.org/I1289525096","display_name":"Texas Biomedical Research Institute","ror":"https://ror.org/00wbskb04","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289525096"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Juan Pablo Arroyo","raw_affiliation_strings":["Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA;"],"raw_orcid":"https://orcid.org/0009-0004-1113-1695","affiliations":[{"raw_affiliation_string":"Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA;","institution_ids":["https://openalex.org/I1289525096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000734819","display_name":"Aaryn C. Mustoe","orcid":"https://orcid.org/0000-0001-7618-8810","observed_orcids":["https://orcid.org/0000-0001-7618-8810"]},"institutions":[{"id":"https://openalex.org/I1289525096","display_name":"Texas Biomedical Research Institute","ror":"https://ror.org/00wbskb04","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289525096"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaryn C. Mustoe","raw_affiliation_strings":["Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA;","institution_ids":["https://openalex.org/I1289525096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090330032","display_name":"Kelly R. Reveles","orcid":"https://orcid.org/0000-0001-8880-4879","observed_orcids":["https://orcid.org/0000-0001-8880-4879"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly R. Reveles","raw_affiliation_strings":["College of Pharmacy, The University of Texas at Austin, Austin, Texas, USA;","Integrated Biomedical Sciences PhD Program, UT Health San Antonio, San Antonio, Texas, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, The University of Texas at Austin, Austin, Texas, USA;","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"Integrated Biomedical Sciences PhD Program, UT Health San Antonio, San Antonio, Texas, USA;","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078136293","display_name":"Kathleen M. Brasky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289525096","display_name":"Texas Biomedical Research Institute","ror":"https://ror.org/00wbskb04","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289525096"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen M. Brasky","raw_affiliation_strings":["Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA;","institution_ids":["https://openalex.org/I1289525096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138883824","display_name":"Donna Perry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289525096","display_name":"Texas Biomedical Research Institute","ror":"https://ror.org/00wbskb04","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289525096"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donna Perry","raw_affiliation_strings":["Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA;","institution_ids":["https://openalex.org/I1289525096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057170214","display_name":"Lidia Cervantes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289525096","display_name":"Texas Biomedical Research Institute","ror":"https://ror.org/00wbskb04","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289525096"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lidia Cervantes","raw_affiliation_strings":["Integrated Biomedical Sciences PhD Program, UT Health San Antonio, San Antonio, Texas, USA;","Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrated Biomedical Sciences PhD Program, UT Health San Antonio, San Antonio, Texas, USA;","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA;","institution_ids":["https://openalex.org/I1289525096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111079320","display_name":"Addaline Alvarez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289525096","display_name":"Texas Biomedical Research Institute","ror":"https://ror.org/00wbskb04","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289525096"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Addaline Alvarez","raw_affiliation_strings":["Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA;","institution_ids":["https://openalex.org/I1289525096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093279784","display_name":"Clarissa Hinojosa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289525096","display_name":"Texas Biomedical Research Institute","ror":"https://ror.org/00wbskb04","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289525096"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clarissa Hinojosa","raw_affiliation_strings":["Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA;","institution_ids":["https://openalex.org/I1289525096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010928157","display_name":"Jessica Greig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289525096","display_name":"Texas Biomedical Research Institute","ror":"https://ror.org/00wbskb04","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289525096"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Greig","raw_affiliation_strings":["Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA;","institution_ids":["https://openalex.org/I1289525096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079124579","display_name":"Alexana J. Hickmott","orcid":"https://orcid.org/0000-0002-0893-4903","observed_orcids":["https://orcid.org/0000-0002-0893-4903"]},"institutions":[{"id":"https://openalex.org/I1289525096","display_name":"Texas Biomedical Research Institute","ror":"https://ror.org/00wbskb04","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289525096"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexana J. Hickmott","raw_affiliation_strings":["Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA;","institution_ids":["https://openalex.org/I1289525096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021162304","display_name":"Benjamin J. Ridenhour","orcid":"https://orcid.org/0000-0001-8271-4629","observed_orcids":["https://orcid.org/0000-0001-8271-4629"]},"institutions":[{"id":"https://openalex.org/I155093810","display_name":"University of Idaho","ror":"https://ror.org/03hbp5t65","country_code":"US","type":"education","lineage":["https://openalex.org/I155093810"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin J. Ridenhour","raw_affiliation_strings":["Department of Mathematics and Statistical Science, University of Idaho, Moscow, Idaho, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistical Science, University of Idaho, Moscow, Idaho, USA;","institution_ids":["https://openalex.org/I155093810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146948991","display_name":"Katherine R Amato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine R. Amato","raw_affiliation_strings":["Department of Anthropology, Northwestern University, Evanston, Illinois;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anthropology, Northwestern University, Evanston, Illinois;","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114375468","display_name":"Michael L. Power","orcid":"https://orcid.org/0000-0002-6120-3528","observed_orcids":["https://orcid.org/0000-0002-6120-3528"]},"institutions":[{"id":"https://openalex.org/I4210113136","display_name":"National Zoological Park","ror":"https://ror.org/026etfb20","country_code":"US","type":"archive","lineage":["https://openalex.org/I103187081","https://openalex.org/I4210113136"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael L. Power","raw_affiliation_strings":["Center for Species Survival, Smithsonian\u2019s National Zoo and Conservation Biology Institute, Washington D.C., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Species Survival, Smithsonian\u2019s National Zoo and Conservation Biology Institute, Washington D.C., USA","institution_ids":["https://openalex.org/I4210113136"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101787724","display_name":"Corinna N. Ross","orcid":"https://orcid.org/0000-0003-0299-2069","observed_orcids":["https://orcid.org/0000-0003-0299-2069"]},"institutions":[{"id":"https://openalex.org/I1289525096","display_name":"Texas Biomedical Research Institute","ror":"https://ror.org/00wbskb04","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289525096"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corinna N. Ross","raw_affiliation_strings":["Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA;","institution_ids":["https://openalex.org/I1289525096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5019783593"],"corresponding_institution_ids":["https://openalex.org/I1289525096"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11580","display_name":"Veterinary Medicine and Surgery","score":0.5654000043869019,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11580","display_name":"Veterinary Medicine and Surgery","score":0.5654000043869019,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.2728999853134155,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10838","display_name":"Animal Behavior and Welfare Studies","score":0.01810000091791153,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/marmoset","display_name":"marmoset","score":0.753000020980835},{"id":"https://openalex.org/keywords/common-marmoset","display_name":"Callithrix jacchus","score":0.9959999918937683},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8880000114440918},{"id":"https://openalex.org/keywords/kidney-failure","display_name":"renal failure","score":0.8289999961853027},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.8980000019073486},{"id":"https://openalex.org/keywords/mortality-prediction","display_name":"mortality prediction","score":0.7020000219345093},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8190000057220459},{"id":"https://openalex.org/keywords/captive-primates","display_name":"captive primates","score":0.6800000071525574},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.34700000286102295},{"id":"https://openalex.org/keywords/body-composition","display_name":"body composition","score":0.7009999752044678},{"id":"https://openalex.org/keywords/resting-energy-expenditure","display_name":"resting energy expenditure","score":0.9639999866485596},{"id":"https://openalex.org/keywords/healthspan","display_name":"healthspan","score":0.4339999854564667},{"id":"https://openalex.org/keywords/animal-models-of-aging","display_name":"animal models of aging","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8016999959945679},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.7095000147819519},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5839999914169312},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.519599974155426},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.517799973487854},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.49050000309944153},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.48489999771118164},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.4648999869823456},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.4431999921798706},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.43700000643730164},{"id":"https://openalex.org/C2777984932","wikidata":"https://www.wikidata.org/wiki/Q7336293","display_name":"Risk of mortality","level":2,"score":0.3815999925136566},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.350600004196167},{"id":"https://openalex.org/C138528620","wikidata":"https://www.wikidata.org/wiki/Q2510752","display_name":"Explained variation","level":2,"score":0.3463999927043915},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.34200000762939453},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.32749998569488525},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.31380000710487366},{"id":"https://openalex.org/C43346845","wikidata":"https://www.wikidata.org/wiki/Q8057732","display_name":"Youden's J statistic","level":3,"score":0.3027999997138977},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.29980000853538513},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.2973000109195709},{"id":"https://openalex.org/C2778063415","wikidata":"https://www.wikidata.org/wiki/Q391744","display_name":"Hemodialysis","level":2,"score":0.28769999742507935},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.2858999967575073},{"id":"https://openalex.org/C164465091","wikidata":"https://www.wikidata.org/wiki/Q7248371","display_name":"Prognostic variable","level":3,"score":0.2851000130176544},{"id":"https://openalex.org/C2779668873","wikidata":"https://www.wikidata.org/wiki/Q6693756","display_name":"Lower risk","level":3,"score":0.2849999964237213},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.2824000120162964},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.2727999985218048},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.2612999975681305}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.06.743332","doi":"https://doi.org/10.64898/2026.08.06.743332","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.06.743332","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.06.743332","doi":"https://doi.org/10.64898/2026.08.06.743332","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.06.743332","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5553123077","display_name":"Dual Beckman Coulter DxH 690T and Beckman Coulter DxH 560 AL","funder_award_id":"1s10od032443-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6590927881","display_name":"Microbiome-mediated therapies for aging and healthspan in marmosets","funder_award_id":"R01AG065546","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000878543","display_name":"The Southwest National Primate Research Center","funder_award_id":"P51OD011133","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1552991827","https://openalex.org/W1974990308","https://openalex.org/W2080051246","https://openalex.org/W2084460488","https://openalex.org/W2098124630","https://openalex.org/W2105092978","https://openalex.org/W2129155846","https://openalex.org/W2129524037","https://openalex.org/W2142655569","https://openalex.org/W2147561227","https://openalex.org/W2159914115","https://openalex.org/W2161866663","https://openalex.org/W2169978819","https://openalex.org/W2206789629","https://openalex.org/W2337955410","https://openalex.org/W2884699563","https://openalex.org/W2885738092","https://openalex.org/W2898108730","https://openalex.org/W2901403904","https://openalex.org/W2901626951","https://openalex.org/W2913448723","https://openalex.org/W3161209579","https://openalex.org/W4232325624","https://openalex.org/W4293386428","https://openalex.org/W4311664034","https://openalex.org/W4313531093","https://openalex.org/W4378189628","https://openalex.org/W4390196897","https://openalex.org/W4393411387","https://openalex.org/W4399043167","https://openalex.org/W4399803162","https://openalex.org/W4400036990","https://openalex.org/W4400770129","https://openalex.org/W4403609944","https://openalex.org/W4404685978","https://openalex.org/W4409256941","https://openalex.org/W4412708082","https://openalex.org/W4413360820","https://openalex.org/W4416422339","https://openalex.org/W6912470868"],"related_works":["https://openalex.org/W7096125632","https://openalex.org/W1973752217","https://openalex.org/W2906021190","https://openalex.org/W2161866663","https://openalex.org/W2984219517","https://openalex.org/W2912377971","https://openalex.org/W2913448723","https://openalex.org/W4402972077","https://openalex.org/W2065821717","https://openalex.org/W7095589392"],"abstract_inverted_index":{"Abstract":[0],"Valid":[1],"animal":[2],"models":[3],"are":[4],"needed":[5],"to":[6,81,89,166],"evaluate":[7],"how":[8],"age-related":[9,38],"changes":[10,39],"in":[11,27,67,100,110,140,180,206,240],"kidney":[12],"function":[13],"influence":[14],"healthspan.":[15],"Aging":[16],"marmosets":[17,71],"frequently":[18],"develop":[19,90],"renal":[20,236],"insufficiency":[21],"with":[22,170,198,215],"anemia":[23,239],"and":[24,30,42,59,69,88,91,116,133,144,168,182,208,229,238],"exhibit":[25],"reductions":[26],"body":[28,53],"mass":[29],"metabolic":[31],"rate.":[32],"However,":[33],"it":[34],"remains":[35],"unclear":[36],"which":[37,43],"predict":[40],"survival":[41,66,151,181,214],"thresholds":[44,137],"indicate":[45],"increased":[46,187],"mortality":[47,98,188,227],"risk.":[48],"We":[49],"prospectively":[50],"evaluated":[51,148],"age,":[52],"composition,":[54],"resting":[55],"energy":[56],"expenditure,":[57],"hematology,":[58],"blood":[60],"chemistry":[61],"as":[62,222],"predictors":[63,139],"of":[64,77,178,234],"3-year":[65,213],"female":[68],"male":[70],"(n":[72],"=":[73,123],"66),":[74],"2\u201316":[75],"years":[76],"age.":[78],"Objectives":[79],"were":[80,147,157],"identify":[82],"prognostic":[83],"markers,":[84],"define":[85],"high-risk":[86,136,210],"thresholds,":[87],"test":[92],"a":[93,160,203,223],"composite":[94,161],"risk-factor":[95],"scale":[96,162,174,221],"for":[97,119,138,226],"screening":[99,224],"captivity.":[101],"A":[102],"10-variable":[103],"model":[104],"showed":[105],"the":[106,141,220,231],"best":[107],"predictive":[108],"performance":[109],"multivariable":[111,142],"Cox":[112,171],"proportional":[113],"hazards":[114],"modeling,":[115],"was":[117],"retained":[118],"further":[120],"analysis":[121],"(concordance":[122],"0.881,":[124],"p":[125,194],"<":[126,195],"0.001).":[127,196],"ROC":[128],"curves":[129],"using":[130],"Youden\u2019s":[131],"Index":[132],"AUC":[134],"identified":[135],"model,":[143],"threshold-defined":[145],"categories":[146],"by":[149],"Kaplan\u2013Meier":[150],"analysis.":[152],"The":[153,173],"10":[154,167],"binary":[155],"risk-factors":[156],"combined":[158],"into":[159],"scored":[163],"from":[164],"0":[165],"tested":[169],"regression.":[172],"explained":[175],"approximately":[176],"42%":[177],"variance":[179],"each":[183],"additional":[184],"risk":[185,189,200,228],"factor":[186],"1.75-fold":[190],"(95%":[191],"CI:":[192],"1.43\u20132.14,":[193],"Marmosets":[197],"\u22657":[199],"factors":[201],"exhibited":[202],"19-month":[204],"reduction":[205],"survival,":[207],"this":[209],"threshold":[211],"predicted":[212],"89.4%":[216],"accuracy.":[217],"Results":[218],"support":[219],"tool":[225],"highlight":[230],"high":[232],"prevalence":[233],"age-associated":[235],"disease":[237],"marmosets.":[241]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2026-08-13T00:00:00"}
