{"id":"https://openalex.org/W7202285738","doi":"https://doi.org/10.64898/2026.08.08.26359816","title":"Association of age with clinical progression across plasma p-tau217 levels","display_name":"Association of age with clinical progression across plasma p-tau217 levels","publication_year":2026,"publication_date":"2026-08-10","ids":{"openalex":"https://openalex.org/W7202285738","doi":"https://doi.org/10.64898/2026.08.08.26359816"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.08.26359816","doi":"https://doi.org/10.64898/2026.08.08.26359816","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.08.26359816","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/10/2026.08.08.26359816.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/10/2026.08.08.26359816.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101622512","display_name":"Ruyu Shi","orcid":"https://orcid.org/0009-0004-3230-2625","observed_orcids":["https://orcid.org/0009-0004-3230-2625"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruyu Shi","raw_affiliation_strings":["Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh PA 15213, USA","Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh PA 15213, USA","institution_ids":["https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121314973","display_name":"Lamia T. Choity","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lamia T. Choity","raw_affiliation_strings":["Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh PA 15213, USA","Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh PA 15213, USA","institution_ids":["https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118956557","display_name":"Shayna T. Brodman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shayna T. Brodman","raw_affiliation_strings":["Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh PA 15213, USA","Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh PA 15213, USA","institution_ids":["https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049300645","display_name":"Xuemei Zeng","orcid":"https://orcid.org/0000-0002-6561-5079","observed_orcids":["https://orcid.org/0000-0002-6561-5079"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuemei Zeng","raw_affiliation_strings":["Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh PA 15213, USA","Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh PA 15213, USA","institution_ids":["https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023350863","display_name":"Marissa F. Farinas","orcid":"https://orcid.org/0000-0002-3889-2185","observed_orcids":["https://orcid.org/0000-0002-3889-2185"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marissa F. Farinas","raw_affiliation_strings":["Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh PA 15213, USA","Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh PA 15213, USA","institution_ids":["https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121322153","display_name":"Michel N Nafash","orcid":"https://orcid.org/0009-0005-6953-075X","observed_orcids":["https://orcid.org/0009-0005-6953-075X"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michel N. Nafash","raw_affiliation_strings":["Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh PA 15213, USA","Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":"https://orcid.org/0009-0005-6953-075X","affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh PA 15213, USA","institution_ids":["https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058476097","display_name":"Alexandra Gogola","orcid":"https://orcid.org/0000-0002-8798-1715","observed_orcids":["https://orcid.org/0000-0002-8798-1715"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra Gogola","raw_affiliation_strings":["Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","Department of Radiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Radiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068192630","display_name":"Brian J. Lopresti","orcid":"https://orcid.org/0000-0002-0595-0203","observed_orcids":["https://orcid.org/0000-0002-0595-0203"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Lopresti","raw_affiliation_strings":["Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","Department of Radiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Radiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001794663","display_name":"Dana Tudorascu","orcid":"https://orcid.org/0000-0003-4675-3692","observed_orcids":["https://orcid.org/0000-0003-4675-3692"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dana L. Tudorascu","raw_affiliation_strings":["Department of Biostatistics and Health Data Science, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA","Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Health Data Science, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023066705","display_name":"Sarah  B. Berman","orcid":"https://orcid.org/0000-0002-5096-4962","observed_orcids":["https://orcid.org/0000-0002-5096-4962"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah B. Berman","raw_affiliation_strings":["Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088688660","display_name":"Robert A. Sweet","orcid":"https://orcid.org/0000-0001-9154-9709","observed_orcids":["https://orcid.org/0000-0001-9154-9709"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Sweet","raw_affiliation_strings":["Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058052951","display_name":"Victor L. Villemagne","orcid":"https://orcid.org/0000-0002-5832-9875","observed_orcids":["https://orcid.org/0000-0002-5832-9875"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor L. Villemagne","raw_affiliation_strings":["Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048994785","display_name":"Julia Kofler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia Kofler","raw_affiliation_strings":["Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019748344","display_name":"C. Elizabeth Shaaban","orcid":"https://orcid.org/0000-0002-3016-1951","observed_orcids":["https://orcid.org/0000-0002-3016-1951"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Elizabeth Shaaban","raw_affiliation_strings":["Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA","Department of Health and Community Systems, University of Pittsburgh School of Nursing, Pittsburgh, PA 15213, USA"],"raw_orcid":"https://orcid.org/0000-0002-3016-1951","affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Health and Community Systems, University of Pittsburgh School of Nursing, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021171640","display_name":"Milo\u0161 D. Ikonomovi\u0107","orcid":"https://orcid.org/0000-0002-8745-3293","observed_orcids":["https://orcid.org/0000-0002-8745-3293"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210110523","display_name":"Geriatric Research Education and Clinical Center","ror":"https://ror.org/01nh3sx96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110523","https://openalex.org/I4210133905","https://openalex.org/I4210147340"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Milos D. Ikonomovic","raw_affiliation_strings":["Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA","Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA","Geriatric Research Education and Clinical Center, VA Pittsburgh HS, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Geriatric Research Education and Clinical Center, VA Pittsburgh HS, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I4210110523"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006091170","display_name":"Tharick Ali Pascoal","orcid":"https://orcid.org/0000-0001-9057-8014","observed_orcids":["https://orcid.org/0000-0001-9057-8014"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tharick A. Pascoal","raw_affiliation_strings":["Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA","Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024995302","display_name":"Ann D. Cohen","orcid":"https://orcid.org/0000-0001-7395-9624","observed_orcids":["https://orcid.org/0000-0001-7395-9624"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann D. Cohen","raw_affiliation_strings":["Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100619838","display_name":"Oscar L. L\u00f3pez","orcid":"https://orcid.org/0000-0002-8546-8256","observed_orcids":["https://orcid.org/0000-0002-8546-8256"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oscar L. Lopez","raw_affiliation_strings":["Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053071315","display_name":"Beth Ellen Snitz","orcid":"https://orcid.org/0000-0002-9978-1374","observed_orcids":["https://orcid.org/0000-0002-9978-1374"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beth E. Snitz","raw_affiliation_strings":["Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082479521","display_name":"M. Ilyas Kamboh","orcid":"https://orcid.org/0000-0002-3453-1438","observed_orcids":["https://orcid.org/0000-0002-3453-1438"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Ilyas Kamboh","raw_affiliation_strings":["Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","Department of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Human Genetics, School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053530106","display_name":"Thomas K. Karikari","orcid":"https://orcid.org/0000-0003-1422-4358","observed_orcids":["https://orcid.org/0000-0003-1422-4358"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas K. Karikari","raw_affiliation_strings":["Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh PA 15213, USA","Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA","Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA"],"raw_orcid":"https://orcid.org/0000-0003-1422-4358","affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Research Center, University of Pittsburgh, Pittsburgh PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Biofluid Biomarker Laboratory, Western Psychiatric Hospital, University of Pittsburgh Medical Center, Pittsburgh PA 15213, USA","institution_ids":["https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5053530106"],"corresponding_institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasma-p-tau217","display_name":"plasma p-tau217","score":0.9229999780654907},{"id":"https://openalex.org/keywords/tau-biomarkers","display_name":"tau biomarkers","score":0.5870000123977661},{"id":"https://openalex.org/keywords/chronological-age","display_name":"chronological age","score":0.8330000042915344},{"id":"https://openalex.org/keywords/clinical-progression","display_name":"clinical progression","score":0.7390000224113464},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.765999972820282},{"id":"https://openalex.org/keywords/clinical-dementia-rating","display_name":"Clinical Dementia Rating","score":0.824999988079071},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.6010000109672546},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8100000023841858},{"id":"https://openalex.org/keywords/age-stratified-risk","display_name":"age-stratified risk","score":0.718999981880188},{"id":"https://openalex.org/keywords/amyloid-pet","display_name":"amyloid PET","score":0.7170000076293945},{"id":"https://openalex.org/keywords/trial-enrichment","display_name":"trial enrichment","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7404999732971191},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6442999839782715},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6193000078201294},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5562000274658203},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.4339999854564667},{"id":"https://openalex.org/C2780906993","wikidata":"https://www.wikidata.org/wiki/Q5133756","display_name":"Clinical Dementia Rating","level":4,"score":0.38260000944137573},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37880000472068787},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.37779998779296875},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.351500004529953},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.3497999906539917},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.34290000796318054},{"id":"https://openalex.org/C3017575891","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma levels","level":2,"score":0.326200008392334},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.31700000166893005},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.30799999833106995},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.30059999227523804},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.295199990272522},{"id":"https://openalex.org/C2986834420","wikidata":"https://www.wikidata.org/wiki/Q5932254","display_name":"Age groups","level":2,"score":0.29409998655319214},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.2903999984264374},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.28600001335144043},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.28369998931884766},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.28130000829696655},{"id":"https://openalex.org/C2779668873","wikidata":"https://www.wikidata.org/wiki/Q6693756","display_name":"Lower risk","level":3,"score":0.27950000762939453},{"id":"https://openalex.org/C48718317","wikidata":"https://www.wikidata.org/wiki/Q4691855","display_name":"Age adjustment","level":3,"score":0.27070000767707825},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.2689000070095062},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.2678999900817871},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.26440000534057617},{"id":"https://openalex.org/C2779504383","wikidata":"https://www.wikidata.org/wiki/Q41482","display_name":"Autopsy","level":2,"score":0.2581000030040741},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.2558000087738037},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.25049999356269836}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.08.26359816","doi":"https://doi.org/10.64898/2026.08.08.26359816","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.08.26359816","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/10/2026.08.08.26359816.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.08.26359816","doi":"https://doi.org/10.64898/2026.08.08.26359816","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.08.26359816","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/10/2026.08.08.26359816.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1058046096","display_name":null,"funder_award_id":"AG066468","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1265288601","display_name":"Genetic Architecture of Alzheimer\u2019s disease Proteinopathies","funder_award_id":"R01AG064877","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2001687549","display_name":null,"funder_award_id":"AG-14449","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2112592252","display_name":"The role of astrogliosis in aging and the pathological and clinical progression of Alzheimer's Disease","funder_award_id":"P01AG025204","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2442294994","display_name":null,"funder_award_id":"AG023651","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2624723405","display_name":"Deep Resequencing of Candidate Gene Regions in Late-onset Alzheimer's Disease","funder_award_id":"R01AG041718","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3388111761","display_name":"Myosteatosis, Cognition and Blood Biomarkers of Alzheimer's Disease in Persons of African Ancestry","funder_award_id":"RF1AG077474","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3711302076","display_name":"Neurobiology of Mild Cognitive Impairment in the Elderly","funder_award_id":"P01AG014449","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3880778400","display_name":null,"funder_award_id":"AG025516","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G47404827","display_name":"Search for the Alzheimers Genes","funder_award_id":"R01AG030653","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5989133034","display_name":null,"funder_award_id":"P30 AG066468","funder_id":"https://openalex.org/F4320310174","funder_display_name":"University of Pittsburgh"},{"id":"https://openalex.org/G707218699","display_name":null,"funder_award_id":"AG025204","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000860967","display_name":"Alzheimer Diagnosis in older Adults with Chronic Conditions ADACC Network","funder_award_id":"U24AG082930","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000868267","display_name":"Examining the Persistence of Neurocognitive Benefits of Exercise","funder_award_id":"R01AG083156","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000878413","display_name":"Mild Cognitive Impairment: A Prospective Community Study","funder_award_id":"R37AG023651","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000878717","display_name":"Alzheimer Disease Research Center","funder_award_id":"P30AG066468","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000880959","display_name":"Longitudinal multicenter head-to-head harmonization of tau PET tracers","funder_award_id":"R01AG073267","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000895716","display_name":"Head-to-head comparisons of high-performance plasma phospho-tau epitopes for the detection of Alzheimer's disease","funder_award_id":"R01AG075336","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000905013","display_name":"Plasma brain-derived tau: a novel Alzheimer\u2019s disease-type neurodegeneration biomarker with potential to complete the AT(N) scheme in blood","funder_award_id":"R01AG083874","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000912957","display_name":"Brain CHEC-AC (Brain and Cognitive Health Equity Campaign for Allegheny County)","funder_award_id":"U01NS141777","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000917915","display_name":"Analytical characterization and validation of blood-biomarkers for monitoring TBI evolution","funder_award_id":"U01NS131740","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000918860","display_name":"Predictors of Altered CNS Structure, Function, and Connectomics in the Elderly using a Health Disparities Framework","funder_award_id":"R01AG072641","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000919303","display_name":"Roles of Gray Matter Brain Aging and Small Vessel Disease in AD Pathophysiology","funder_award_id":"R01AG025516","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320310174","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7202285738.pdf","grobid_xml":"https://content.openalex.org/works/W7202285738.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1965616054","https://openalex.org/W1978501871","https://openalex.org/W1991952617","https://openalex.org/W1998088268","https://openalex.org/W2032980606","https://openalex.org/W2125591528","https://openalex.org/W2132842417","https://openalex.org/W2139190800","https://openalex.org/W2146729934","https://openalex.org/W2167720733","https://openalex.org/W2612089042","https://openalex.org/W2612655633","https://openalex.org/W2798054687","https://openalex.org/W2802347155","https://openalex.org/W2888048543","https://openalex.org/W2912263089","https://openalex.org/W2921245766","https://openalex.org/W2972368830","https://openalex.org/W3022830722","https://openalex.org/W3028560350","https://openalex.org/W3045997188","https://openalex.org/W3093731000","https://openalex.org/W3102160053","https://openalex.org/W3105808417","https://openalex.org/W3126187484","https://openalex.org/W3128184462","https://openalex.org/W3207525094","https://openalex.org/W4251308908","https://openalex.org/W4308210073","https://openalex.org/W4380577692","https://openalex.org/W4391022868","https://openalex.org/W4391101037","https://openalex.org/W4396932174","https://openalex.org/W4399571087","https://openalex.org/W4400833630","https://openalex.org/W4402520104","https://openalex.org/W4402652739","https://openalex.org/W4403203217","https://openalex.org/W4403258600","https://openalex.org/W4406924087","https://openalex.org/W4409279344","https://openalex.org/W4409980681","https://openalex.org/W4412470623","https://openalex.org/W4412691481","https://openalex.org/W7125489596","https://openalex.org/W7139930026","https://openalex.org/W7151420147","https://openalex.org/W7152541314","https://openalex.org/W7160995809"],"related_works":["https://openalex.org/W7117298116","https://openalex.org/W7128500870","https://openalex.org/W7170091741","https://openalex.org/W4411053500","https://openalex.org/W4407987713","https://openalex.org/W7168397271","https://openalex.org/W7117239022","https://openalex.org/W7116863462","https://openalex.org/W7119534733","https://openalex.org/W7119493209"],"abstract_inverted_index":{"STRUCTURED":[0],"ABSTRACT":[1],"BACKGROUND":[2],"Chronological":[3],"age":[4,129,158,210,234],"and":[5,68,82,87,94,109,185,211,236,253],"plasma":[6,110,191,216,224,248],"p\u2370tau217":[7],"each":[8],"predicts":[9],"cognitive":[10],"decline,":[11],"but":[12,170],"whether":[13],"their":[14,25,114],"prognostic":[15,105],"associations":[16,27,115],"interact":[17],"is":[18],"unclear.":[19],"In":[20],"this":[21],"study,":[22],"we":[23],"examined":[24],"joint":[26],"in":[28,56,71,85,113,144,152],"a":[29],"memory-clinic":[30],"cohort.":[31],"METHODS":[32],"We":[33],"included":[34,65],"3,741":[35],"participants":[36,199],"from":[37],"the":[38,126,131,135,145,153,238],"Pittsburgh":[39],"ADRC,":[40],"with":[41,116,130,161],"up":[42],"to":[43],"28":[44],"years":[45,203],"of":[46,74,246],"follow-up":[47],"(3.0":[48],"[IQR":[49],"2.0-6.0]).":[50],"The":[51],"primary":[52],"outcome":[53],"was":[54,80,139,159],"increase":[55],"Clinical":[57],"Dementia":[58],"Rating":[59],"global":[60],"score":[61],"(CDR-GS).":[62],"Secondary":[63],"outcomes":[64],"clinical-stage":[66],"progression":[67,118,163,213],"longitudinal":[69],"change":[70],"CDR":[72],"Sum":[73],"Boxes.":[75],"Plasma":[76],"p-tau217":[77,111,155,192,217,225,229,249],"cut-off":[78],"value":[79],"derived":[81],"externally":[83],"validated":[84],"amyloid-beta-PET":[86],"autopsy":[88],"sub-cohorts,":[89],"respectively.":[90,189],"Cox":[91],"proportional":[92],"hazards":[93],"linear":[95],"mixed-effects":[96],"models":[97],"tested":[98],"age-by-p-tau217":[99],"interactions":[100],"while":[101],"repeated":[102],"cross-validation":[103],"evaluated":[104],"performance.":[106],"RESULTS":[107],"Age":[108,219],"interacted":[112],"CDR-GS":[117],"(\u03c7(1)":[119],"2":[120],"=23.94;":[121],"p=9.81\u00d710":[122],"-7":[123],").":[124],"Comparing":[125],"oldest":[127],"displayed":[128],"youngest":[132],"reference":[133],"age,":[134],"adjusted":[136,179],"hazard":[137],"ratio":[138],"4.80":[140],"(95%":[141,149],"CI":[142,150,168,176],"2.74-8.27)":[143],"lowest":[146],"vs.":[147],"1.05":[148],"0.69-1.47)":[151],"highest":[154],"quartile.":[156],"Older":[157],"associated":[160],"clinical":[162,212],"at":[164,172,222],"low-p-tau217":[165],"(HR=1.97;":[166],"95%":[167,175],"1.58-2.45)":[169],"not":[171],"high-p-tau217":[173],"(HR=1.10;":[174],"0.95-1.26)":[177],"concentrations;":[178],"5-year":[180,194],"risk":[181,221,232],"differences":[182],"were":[183],"19.3":[184],"3.3":[186],"percentage":[187],"points,":[188],"Adding":[190],"improved":[193],"discrimination":[195],"most":[196],"accurately":[197],"among":[198],"younger":[200],"than":[201],"60":[202],"(AUC":[204],"0.66-0.81).":[205],"DISCUSSION":[206],"Prognostic":[207],"association":[208],"between":[209],"varies":[214],"by":[215],"concentration.":[218],"stratifies":[220],"low":[223],"levels,":[226],"whereas":[227],"elevated":[228],"identifies":[230],"higher":[231],"across":[233],"groups":[235],"attenuates":[237],"age-related":[239],"gradient.":[240],"These":[241],"findings":[242],"support":[243],"further":[244],"evaluation":[245],"age-contextualized":[247],"interpretation":[250],"for":[251],"prognosis":[252],"trial":[254],"enrichment.":[255]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-08-13T00:00:00"}