{"id":"https://openalex.org/W7202284036","doi":"https://doi.org/10.5281/zenodo.21902030","title":"Multi-Target Neuroprotective Potential of Achyranthes aspera and Abutilon indicum: A Systematic Review of Preclinical Evidence and a Rationale for Combination Research","display_name":"Multi-Target Neuroprotective Potential of Achyranthes aspera and Abutilon indicum: A Systematic Review of Preclinical Evidence and a Rationale for Combination Research","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7202284036","doi":"https://doi.org/10.5281/zenodo.21902030"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.21902030","doi":"https://doi.org/10.5281/zenodo.21902030","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.21902030","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.21902030","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070973912","display_name":"Sanjukta Roy","orcid":"https://orcid.org/0000-0001-9781-3240","observed_orcids":["https://orcid.org/0000-0001-9781-3240","https://orcid.org/0009-0007-0264-3877"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sanjukta Roy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135175425","display_name":"Baisnabdas Pathak","orcid":"https://orcid.org/0009-0002-7417-7397","observed_orcids":["https://orcid.org/0009-0002-7417-7397"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Baisnabdas Pathak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147054436","display_name":"Krishnendu Ray","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krishnendu Ray","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147005322","display_name":"Shaheen Parveen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shaheen Parveen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023829790","display_name":"Souparna Kabiraj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Souparna Kabiraj","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5159898324","display_name":"Rakesh Das","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rakesh Das","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/achyranthes-aspera","display_name":"Achyranthes aspera","score":1.0},{"id":"https://openalex.org/keywords/abutilon-indicum","display_name":"Abutilon indicum","score":1.0},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9490000009536743},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.7630000114440918},{"id":"https://openalex.org/keywords/plant-extracts","display_name":"plant extracts","score":0.6380000114440918},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.47999998927116394},{"id":"https://openalex.org/keywords/chronic-stress","display_name":"chronic stress","score":0.5569999814033508},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.8159999847412109},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.9089999794960022},{"id":"https://openalex.org/keywords/seizures","display_name":"seizures","score":0.8370000123977661},{"id":"https://openalex.org/keywords/acetylcholinesterase","display_name":"acetylcholinesterase","score":0.8519999980926514},{"id":"https://openalex.org/keywords/aluminum-chloride-induced-neurotoxicity","display_name":"aluminum chloride-induced neurotoxicity","score":0.8339999914169312},{"id":"https://openalex.org/keywords/pentylenetetrazole","display_name":"pentylenetetrazole","score":0.8529999852180481},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.41499999165534973},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.824999988079071},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9620000123977661},{"id":"https://openalex.org/keywords/gabaergic-mechanisms","display_name":"GABAergic mechanisms","score":0.6140000224113464},{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":0.6620000004768372},{"id":"https://openalex.org/keywords/free-radical-scavenging-activity","display_name":"free radical scavenging","score":0.8600000143051147},{"id":"https://openalex.org/keywords/isobologram-analysis","display_name":"isobolographic analysis","score":0.7039999961853027},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"traditional medicine","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C2776573487","wikidata":"https://www.wikidata.org/wiki/Q3286822","display_name":"Achyranthes aspera","level":3,"score":0.7439000010490417},{"id":"https://openalex.org/C25876315","wikidata":"https://www.wikidata.org/wiki/Q15197465","display_name":"Neurochemical","level":2,"score":0.6396999955177307},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6365000009536743},{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.6299999952316284},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5755000114440918},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5647000074386597},{"id":"https://openalex.org/C2777765862","wikidata":"https://www.wikidata.org/wiki/Q62903","display_name":"Anxiolytic","level":3,"score":0.5482000112533569},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.49219998717308044},{"id":"https://openalex.org/C136569192","wikidata":"https://www.wikidata.org/wiki/Q4880745","display_name":"Behavioural despair test","level":4,"score":0.3336000144481659},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.3158000111579895},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.305400013923645},{"id":"https://openalex.org/C2779158651","wikidata":"https://www.wikidata.org/wiki/Q188840","display_name":"Medicinal plants","level":2,"score":0.2994999885559082},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.2888999879360199},{"id":"https://openalex.org/C2779145073","wikidata":"https://www.wikidata.org/wiki/Q58396","display_name":"Imipramine","level":3,"score":0.25999999046325684},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2556000053882599}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.5281/zenodo.21902030","doi":"https://doi.org/10.5281/zenodo.21902030","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.21902030","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.5281/zenodo.21902031","doi":"https://doi.org/10.5281/zenodo.21902031","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.21902031","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.5281/zenodo.21932380","doi":"https://doi.org/10.5281/zenodo.21932380","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.21932380","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.5281/zenodo.21902030","doi":"https://doi.org/10.5281/zenodo.21902030","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.21902030","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4282934385","https://openalex.org/W4409308378","https://openalex.org/W2026824049","https://openalex.org/W1992283564","https://openalex.org/W4396557673","https://openalex.org/W3109337040","https://openalex.org/W1890315628","https://openalex.org/W2974848602","https://openalex.org/W7163904675","https://openalex.org/W2596966252"],"abstract_inverted_index":{"Background.":[0],"Neurodegenerative":[1],"and":[2,31,44,71,84,106,158,172,180,203,212,217,233,235,256,269,292,297],"neuro-behavioural":[3],"disorders":[4],"progress":[5],"through":[6],"several":[7],"injury":[8],"routes":[9],"at":[10,175],"once,":[11],"which":[12],"is":[13,186,190,194,280,307,312],"one":[14,62],"reason":[15],"single-target":[16],"drugs":[17],"have":[18,50,57],"performed":[19],"poorly":[20],"in":[21,36,155,170,207,241,287],"latephase":[22],"trials.":[23],"Plant":[24],"extracts":[25,302],"act":[26],"on":[27,247],"many":[28],"targets":[29],"simultaneously,":[30],"two":[32,261],"species":[33,225,262],"used":[34],"widely":[35],"Indian":[37],"traditional":[38],"practice,":[39],"Achyranthes":[40],"aspera":[41,149],"Linn.":[42],"(Amaranthaceae)":[43],"Abutilon":[45],"indicum":[46,193],"(L.)":[47],"Sweet":[48],"(Malvaceae),":[49],"each":[51],"accumulated":[52],"separate":[53],"neuropharmacological":[54],"literatures":[55],"that":[56,185],"never":[58],"been":[59],"read":[60],"against":[61,111],"another.":[63],"Objective.":[64],"To":[65],"collate":[66],"the":[67,145,151],"preclinical":[68],"neurobehavioural,":[69],"neurochemical":[70,127],"phytochemical":[72,137],"evidence":[73,311],"for":[74,139],"both":[75,236],"species,":[76],"to":[77,85,93,130,177,221,299],"test":[78],"whether":[79],"their":[80],"reported":[81,120,244],"mechanisms":[82,245],"overlap,":[83],"specify":[86],"what":[87],"a":[88,121,126,135,181,293],"combination":[89],"study":[90,271],"would":[91],"need":[92],"demonstrate.":[94],"Methods.":[95],"A":[96,277],"structured":[97],"search":[98],"of":[99,103,161],"PubMed,":[100],"Scopus,":[101],"Web":[102],"Science,":[104],"ScienceDirect":[105],"Google":[107],"Scholar":[108],"was":[109],"screened":[110],"PRISMA":[112],"2020":[113],"guidance.":[114],"Studies":[115],"were":[116],"eligible":[117],"if":[118],"they":[119],"central":[122],"nervous":[123],"system":[124],"outcome,":[125,133],"marker":[128],"relevant":[129],"such":[131],"an":[132,288],"or":[134],"quantified":[136],"profile":[138],"either":[140],"species.":[141],"Twenty-seven":[142],"sources":[143],"met":[144],"criteria.":[146],"Results.":[147],"A.":[148,192],"has":[150,272],"deeper":[152],"record:":[153],"protection":[154],"cerebral":[156],"ischaemia":[157],"reperfusion,":[159],"reversal":[160],"chronic":[162],"stress":[163],"induced":[164],"depressive":[165],"behaviour":[166],"with":[167,283],"parallel":[168],"falls":[169],"TNF-\u03b1":[171],"IL-6,":[173],"anxiolysis":[174],"100":[176,222],"600":[178],"mg/kg,":[179],"seizure":[182],"threshold":[183,295],"effect":[184],"lost":[187],"when":[188],"flumazenil":[189],"co-administered.":[191],"thinner":[195],"but":[196],"not":[197],"empty:":[198],"it":[199],"lowers":[200],"brain":[201],"acetylcholinesterase":[202],"shortens":[204],"transfer":[205],"latency":[206],"aluminium":[208,289],"chloride":[209,290],"treated":[210],"rats,":[211],"shows":[213],"dose":[214],"dependent":[215],"anxiolytic":[216],"antidepressant":[218],"activity":[219],"up":[220],"mg/kg.":[223],"Both":[224],"carry":[226],"phenolic":[227],"acids,":[228],"flavonoids,":[229],"triterpenes,":[230],"phytosterols,":[231],"saponins":[232],"alkaloids,":[234],"show":[237],"consistent":[238],"radical":[239],"scavenging":[240],"vitro.":[242],"Their":[243],"converge":[246],"four":[248],"nodes:":[249],"redox":[250],"rescue,":[251],"cytokine":[252],"suppression,":[253],"cholinergic":[254],"support":[255],"GABAergic":[257],"tone.":[258],"Conclusion.":[259],"The":[260],"are":[263],"mechanistically":[264],"complementary":[265],"rather":[266],"than":[267],"redundant,":[268],"no":[270],"yet":[273],"tested":[274],"them":[275],"together.":[276],"staged":[278],"programme":[279],"proposed,":[281],"beginning":[282],"fixedratio":[284],"isobolographic":[285],"screening":[286],"model":[291],"pentylenetetrazole":[294],"model,":[296],"continuing":[298],"chemically":[300],"standardised":[301],"before":[303],"any":[304],"clinical":[305],"claim":[306],"made.":[308],"All":[309],"current":[310],"preclinical.":[313]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-08-13T00:00:00"}
