{"id":"https://openalex.org/W7202283389","doi":"https://doi.org/10.1212/wnl.0000000000218407","title":"Analysis of Interindividual Lesion Progression Variability in Adult Cerebral Adrenoleukodystrophy","display_name":"Analysis of Interindividual Lesion Progression Variability in Adult Cerebral Adrenoleukodystrophy","publication_year":2026,"publication_date":"2026-08-12","ids":{"openalex":"https://openalex.org/W7202283389","doi":"https://doi.org/10.1212/wnl.0000000000218407","pmid":"https://pubmed.ncbi.nlm.nih.gov/42585611"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.0000000000218407","doi":"https://doi.org/10.1212/wnl.0000000000218407","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000218407","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052167968","display_name":"Markus Ponleitner","orcid":"https://orcid.org/0000-0002-3709-1845","observed_orcids":["https://orcid.org/0000-0002-3709-1845"]},"institutions":[{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT","DE"],"is_corresponding":false,"raw_author_name":"Markus Ponleitner","raw_affiliation_strings":["Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Austria;","Department of Neurology, Leipzig University Medical Center, Germany;","Department of Neurology, Medical University of Vienna, Austria;"],"raw_orcid":"https://orcid.org/0000-0002-3709-1845","affiliations":[{"raw_affiliation_string":"Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Department of Neurology, Leipzig University Medical Center, Germany;","institution_ids":["https://openalex.org/I4210125843"]},{"raw_affiliation_string":"Department of Neurology, Medical University of Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036650555","display_name":"Julia Lier","orcid":"https://orcid.org/0000-0002-8454-9425","observed_orcids":["https://orcid.org/0000-0002-8454-9425"]},"institutions":[{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia Lier","raw_affiliation_strings":["Department of Neurology, Leipzig University Medical Center, Germany;"],"raw_orcid":"https://orcid.org/0000-0002-8454-9425","affiliations":[{"raw_affiliation_string":"Department of Neurology, Leipzig University Medical Center, Germany;","institution_ids":["https://openalex.org/I4210125843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001677651","display_name":"Luc Bracoud","orcid":"https://orcid.org/0000-0001-7175-8781","observed_orcids":["https://orcid.org/0000-0001-7175-8781"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luc Bracoud","raw_affiliation_strings":["Clario Inc., Lyon, France;"],"raw_orcid":"https://orcid.org/0000-0001-7175-8781","affiliations":[{"raw_affiliation_string":"Clario Inc., Lyon, France;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092022831","display_name":"Eda G. Kabak","orcid":"https://orcid.org/0000-0003-2434-5292","observed_orcids":["https://orcid.org/0000-0003-2434-5292"]},"institutions":[{"id":"https://openalex.org/I4210096594","display_name":"Emma Kinderziekenhuis","ror":"https://ror.org/00bmv4102","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210096594","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Eda G. Kabak","raw_affiliation_strings":["Department of Neurology and Pediatric Neurology, Emma Children's Hospital, Amsterdam UMC, Amsterdam Leukodystrophy Center, Amsterdam University Medical Center, Amsterdam, the Netherlands;"],"raw_orcid":"https://orcid.org/0000-0003-2434-5292","affiliations":[{"raw_affiliation_string":"Department of Neurology and Pediatric Neurology, Emma Children's Hospital, Amsterdam UMC, Amsterdam Leukodystrophy Center, Amsterdam University Medical Center, Amsterdam, the Netherlands;","institution_ids":["https://openalex.org/I4210096594","https://openalex.org/I4210151833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040556295","display_name":"Robert E. Thompson","orcid":"https://orcid.org/0009-0000-0507-8104","observed_orcids":["https://orcid.org/0009-0000-0507-8104"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Thompson","raw_affiliation_strings":["Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston;"],"raw_orcid":"https://orcid.org/0009-0000-0507-8104","affiliations":[{"raw_affiliation_string":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147023413","display_name":"Haley G. McLaughlin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haley G. McLaughlin","raw_affiliation_strings":["Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147035864","display_name":"Alessandro Delmonte","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alessandro Delmonte","raw_affiliation_strings":["Clario Inc., Lyon, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clario Inc., Lyon, France;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031335066","display_name":"Thomas Cajgfinger","orcid":"https://orcid.org/0009-0007-1298-1108","observed_orcids":["https://orcid.org/0009-0007-1298-1108"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Cajgfinger","raw_affiliation_strings":["Clario Inc., Lyon, France;"],"raw_orcid":"https://orcid.org/0009-0007-1298-1108","affiliations":[{"raw_affiliation_string":"Clario Inc., Lyon, France;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026101594","display_name":"Lisa Sch\u00e4fer","orcid":"https://orcid.org/0000-0002-9714-9682","observed_orcids":["https://orcid.org/0000-0002-9714-9682"]},"institutions":[{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lisa Sch\u00e4fer","raw_affiliation_strings":["Department of Neurology, Leipzig University Medical Center, Germany;"],"raw_orcid":"https://orcid.org/0000-0002-9714-9682","affiliations":[{"raw_affiliation_string":"Department of Neurology, Leipzig University Medical Center, Germany;","institution_ids":["https://openalex.org/I4210125843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000980329","display_name":"Carolin Awissus","orcid":"https://orcid.org/0009-0001-4407-5368","observed_orcids":["https://orcid.org/0009-0001-4407-5368"]},"institutions":[{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carolin Eva Awi\u00dfus","raw_affiliation_strings":["Department of Neurology, Leipzig University Medical Center, Germany;"],"raw_orcid":"https://orcid.org/0009-0001-4407-5368","affiliations":[{"raw_affiliation_string":"Department of Neurology, Leipzig University Medical Center, Germany;","institution_ids":["https://openalex.org/I4210125843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009546183","display_name":"Isabelle Weinhofer","orcid":"https://orcid.org/0000-0002-8455-2069","observed_orcids":["https://orcid.org/0000-0002-8455-2069"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Isabelle Weinhofer","raw_affiliation_strings":["Department Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Austria; and"],"raw_orcid":"https://orcid.org/0000-0002-8455-2069","affiliations":[{"raw_affiliation_string":"Department Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Austria; and","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034197878","display_name":"Paulus Stefan Rommer","orcid":"https://orcid.org/0000-0001-5209-6647","observed_orcids":["https://orcid.org/0000-0001-5209-6647"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Paulus S. Rommer","raw_affiliation_strings":["Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Austria;","Department of Neurology, Medical University of Vienna, Austria;"],"raw_orcid":"https://orcid.org/0000-0001-5209-6647","affiliations":[{"raw_affiliation_string":"Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Department of Neurology, Medical University of Vienna, Austria;","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071560474","display_name":"Johannes Berger","orcid":"https://orcid.org/0000-0003-0182-2658","observed_orcids":["https://orcid.org/0000-0003-0182-2658"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Johannes Berger","raw_affiliation_strings":["Department Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Austria; and"],"raw_orcid":"https://orcid.org/0000-0003-0182-2658","affiliations":[{"raw_affiliation_string":"Department Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Austria; and","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004439585","display_name":"Daniel J. Loes","orcid":"https://orcid.org/0000-0001-7661-3442","observed_orcids":["https://orcid.org/0000-0001-7661-3442"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel J. Loes","raw_affiliation_strings":["Suburban Radiologic Consultants Ltd., Minneapolis, MN"],"raw_orcid":"https://orcid.org/0000-0001-7661-3442","affiliations":[{"raw_affiliation_string":"Suburban Radiologic Consultants Ltd., Minneapolis, MN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036919823","display_name":"Florian Eichler","orcid":"https://orcid.org/0000-0001-6836-1089","observed_orcids":["https://orcid.org/0000-0001-6836-1089","https://orcid.org/0009-0001-2878-9758"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Florian S. Eichler","raw_affiliation_strings":["Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston;"],"raw_orcid":"https://orcid.org/0000-0001-6836-1089","affiliations":[{"raw_affiliation_string":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057253916","display_name":"Marc Engelen","orcid":"https://orcid.org/0000-0002-5346-8497","observed_orcids":["https://orcid.org/0000-0002-5346-8497"]},"institutions":[{"id":"https://openalex.org/I4210096594","display_name":"Emma Kinderziekenhuis","ror":"https://ror.org/00bmv4102","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210096594","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marc Engelen","raw_affiliation_strings":["Department of Neurology and Pediatric Neurology, Emma Children's Hospital, Amsterdam UMC, Amsterdam Leukodystrophy Center, Amsterdam University Medical Center, Amsterdam, the Netherlands;"],"raw_orcid":"https://orcid.org/0000-0002-5346-8497","affiliations":[{"raw_affiliation_string":"Department of Neurology and Pediatric Neurology, Emma Children's Hospital, Amsterdam UMC, Amsterdam Leukodystrophy Center, Amsterdam University Medical Center, Amsterdam, the Netherlands;","institution_ids":["https://openalex.org/I4210096594","https://openalex.org/I4210151833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140740868","display_name":"Wolfgang K\u00f6hler","orcid":"https://orcid.org/0000-0002-6058-9545","observed_orcids":["https://orcid.org/0000-0002-6058-9545"]},"institutions":[{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang K\u00f6hler","raw_affiliation_strings":["Department of Neurology, Leipzig University Medical Center, Germany;"],"raw_orcid":"https://orcid.org/0000-0002-6058-9545","affiliations":[{"raw_affiliation_string":"Department of Neurology, Leipzig University Medical Center, Germany;","institution_ids":["https://openalex.org/I4210125843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034758715","display_name":"Caroline Gertrud Bergner","orcid":"https://orcid.org/0000-0002-0327-1389","observed_orcids":["https://orcid.org/0000-0002-0327-1389"]},"institutions":[{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Caroline G. Bergner","raw_affiliation_strings":["Department of Neurology, Leipzig University Medical Center, Germany;"],"raw_orcid":"https://orcid.org/0000-0002-0327-1389","affiliations":[{"raw_affiliation_string":"Department of Neurology, Leipzig University Medical Center, Germany;","institution_ids":["https://openalex.org/I4210125843"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.58644764,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"107","issue":"5","first_page":"e218407","last_page":"e218407"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.6553000211715698,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.6553000211715698,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.25589999556541443,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.015200000256299973,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebral-adrenoleukodystrophy","display_name":"cerebral adrenoleukodystrophy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/x-linked-adrenoleukodystrophy","display_name":"X-linked adrenoleukodystrophy","score":0.9900000095367432},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.9319999814033508},{"id":"https://openalex.org/keywords/natural-history-disease","display_name":"natural history (disease)","score":0.5820000171661377},{"id":"https://openalex.org/keywords/mri-lesion-volume","display_name":"MRI lesion volume","score":0.5339999794960022},{"id":"https://openalex.org/keywords/gadolinium-enhancement","display_name":"gadolinium enhancement","score":0.9319999814033508},{"id":"https://openalex.org/keywords/neurofilament-light-chain","display_name":"neurofilament light chain","score":0.902999997138977},{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-transplantation","display_name":"hematopoietic stem cell transplantation","score":0.9110000133514404},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.30799999833106995}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7534000277519226},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.7120000123977661},{"id":"https://openalex.org/C2777150068","wikidata":"https://www.wikidata.org/wiki/Q366964","display_name":"Adrenoleukodystrophy","level":4,"score":0.579200029373169},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.5333999991416931},{"id":"https://openalex.org/C2992477034","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Clinical neurology","level":2,"score":0.3723999857902527},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.3359000086784363},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.26809999346733093},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.26010000705718994},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.2401999980211258},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2240000069141388}],"mesh":[{"descriptor_ui":"D000326","descriptor_name":"Adrenoleukodystrophy","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000326","descriptor_name":"Adrenoleukodystrophy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1212/wnl.0000000000218407","doi":"https://doi.org/10.1212/wnl.0000000000218407","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.0000000000218407","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},{"id":"pmid:42585611","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42585611","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/b3cabfc9-cb44-4473-8262-dfae304fa864","doi":null,"is_oa":false,"landing_page_url":"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=105047160762&origin=inward","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ponleitner, M, Lier, J, Bracoud, L, Kabak, E G, Thompson, R, McLaughlin, H G, Delmonte, A, Cajgfinger, T, Sch\u00e4fer, L, Awi\u00dfus, C E, Weinhofer, I, Rommer, P S, Berger, J, Loes, D J, Eichler, F S, Engelen, M, K\u00f6hler, W & Bergner, C G 2026, 'Analysis of Interindividual Lesion Progression Variability in Adult Cerebral Adrenoleukodystrophy', Neurology, vol. 107, no. 5, e218407. https://doi.org/10.1212/WNL.0000000000218407","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G9000919685","display_name":"Training Grant in Genetics","funder_award_id":"T32GM007748","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1901129140","https://openalex.org/W1951724000","https://openalex.org/W1973343526","https://openalex.org/W1979693503","https://openalex.org/W2005093647","https://openalex.org/W2071713047","https://openalex.org/W2076153637","https://openalex.org/W2089560150","https://openalex.org/W2105468919","https://openalex.org/W2111220794","https://openalex.org/W2151567647","https://openalex.org/W2560085362","https://openalex.org/W2599975163","https://openalex.org/W2767376202","https://openalex.org/W2781581970","https://openalex.org/W2883193826","https://openalex.org/W2889223700","https://openalex.org/W2893932486","https://openalex.org/W2912727107","https://openalex.org/W2916744594","https://openalex.org/W2935904135","https://openalex.org/W2945182189","https://openalex.org/W2968446587","https://openalex.org/W3007056503","https://openalex.org/W3028617995","https://openalex.org/W3089787525","https://openalex.org/W3097248280","https://openalex.org/W3139473065","https://openalex.org/W3154609564","https://openalex.org/W3168152314","https://openalex.org/W3185163408","https://openalex.org/W3197748192","https://openalex.org/W4297989795","https://openalex.org/W4317488869","https://openalex.org/W4386509330","https://openalex.org/W4391276960","https://openalex.org/W4399327360","https://openalex.org/W4410638221","https://openalex.org/W4410709088","https://openalex.org/W4415675948"],"related_works":["https://openalex.org/W2935904135","https://openalex.org/W2105468919","https://openalex.org/W4389464645","https://openalex.org/W2151567647","https://openalex.org/W2048923486","https://openalex.org/W3197748192","https://openalex.org/W2107363872","https://openalex.org/W2040981313","https://openalex.org/W1540835210","https://openalex.org/W2415471905"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"OBJECTIVES:":[2],"Cerebral":[3],"adrenoleukodystrophy":[4,13],"(cALD),":[5],"the":[6,23,51,76,164,253],"most":[7],"severe":[8],"clinical":[9,48,249],"phenotype":[10],"of":[11,22,53,79,140,190,234],"X-linked":[12],"(X-ALD),":[14],"is":[15],"characterized":[16],"by":[17,158],"rapidly":[18],"progressive,":[19],"inflammatory":[20],"destruction":[21],"cerebral":[24],"white":[25],"matter.":[26],"In":[27,98,197],"adult":[28,93,106,207],"patients,":[29],"therapeutic":[30],"options":[31],"are":[32],"limited":[33],"to":[34],"hematopoietic":[35],"stem":[36],"cell":[37],"transplantation,":[38],"which":[39],"carries":[40],"substantial":[41],"treatment-related":[42],"risks,":[43],"necessitating":[44],"careful":[45],"and":[46,65,117,121,161,175,227,247],"individualized":[47],"decision-making.":[49],"Monitoring":[50],"progression":[52,127],"characteristic":[54],"MRI":[55,81,133,167],"changes":[56,82],"provides":[57],"a":[58,136,151],"promising":[59],"approach,":[60],"both":[61],"for":[62,66,243],"guiding":[63],"treatment":[64,241],"serving":[67],"as":[68,187,231],"an":[69,215],"outcome":[70],"measure":[71],"in":[72,87,92,114,206,252],"interventional":[73],"trials.":[74],"Although":[75],"natural":[77],"history":[78],"these":[80],"has":[83],"been":[84],"well":[85],"described":[86],"childhood":[88],"cALD,":[89,208],"analogous":[90],"data":[91],"patients":[94],"remain":[95],"scarce.":[96],"METHODS:":[97],"this":[99,198],"multicenter":[100,200],"retrospective":[101,201],"cohort":[102],"study,":[103],"we":[104,209],"screened":[105],"men":[107],"with":[108,163,218,245],"confirmed":[109],"X-ALD":[110],"at":[111,129],"leukodystrophy":[112],"centers":[113],"Leipzig,":[115],"Amsterdam,":[116],"Boston":[118],"between":[119],"2000":[120],"2025.":[122],"Inclusion":[123],"criteria":[124],"required":[125],"lesion":[126,146,173,191,204,212,223,235],"on":[128,203],"least":[130],"2":[131],"high-quality":[132],"scans":[134],"during":[135],"minimal":[137],"untreated":[138],"follow-up":[139],"3":[141],"months.":[142],"Volumes":[143],"calculated":[144],"from":[145],"masks":[147],"were":[148,185],"segmented":[149],"using":[150],"3D":[152],"U-Net":[153],"convolutional":[154],"neural":[155],"network":[156],"followed":[157],"manual":[159],"correction":[160],"compared":[162],"disease-specific":[165],"semiquantitative":[166],"Loes":[168],"score.":[169],"Gadolinium":[170],"enhancement,":[171,226],"primary":[172],"location,":[174,224],"serum":[176],"neurofilament":[177],"light":[178],"chain":[179],"(sNfL)":[180],"levels,":[181],"alongside":[182],"demographic":[183],"data,":[184],"evaluated":[186],"potential":[188,232],"predictors":[189,233],"progression.":[192,236],"RESULTS:":[193],"=":[194],"0.488).":[195],"DISCUSSION:":[196],"comprehensive":[199],"study":[202],"evolution":[205],"demonstrate":[210],"that":[211],"growth":[213],"follows":[214],"exponential":[216],"trajectory,":[217],"considerable":[219],"interindividual":[220],"variability.":[221],"Primary":[222],"contrast":[225],"NfL":[228],"levels":[229],"emerge":[230],"This":[237],"might":[238],"support":[239],"personalized":[240],"strategies":[242],"adults":[244],"cALD":[246],"guide":[248],"trial":[250],"design":[251],"future.":[254]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-13T00:00:00"}