{"id":"https://openalex.org/W7202279731","doi":"https://doi.org/10.1021/acsomega.6c06926","title":"Toward Precision in Biomarker Analysis: A Novel Malondialdehyde Detection Method Based on Molecularly Imprinted Polymers","display_name":"Toward Precision in Biomarker Analysis: A Novel Malondialdehyde Detection Method Based on Molecularly Imprinted Polymers","publication_year":2026,"publication_date":"2026-08-12","ids":{"openalex":"https://openalex.org/W7202279731","doi":"https://doi.org/10.1021/acsomega.6c06926","pmid":"https://pubmed.ncbi.nlm.nih.gov/42662746","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13520519"},"language":"en","primary_location":{"id":"doi:10.1021/acsomega.6c06926","doi":"https://doi.org/10.1021/acsomega.6c06926","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.6c06926","pdf_url":"https://pubs.acs.org/acsodf/article-pdf/doi/10.1021/acsomega.6c06926/66505954/acsomega.6c06926.pdf","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pubs.acs.org/acsodf/article-pdf/doi/10.1021/acsomega.6c06926/66505954/acsomega.6c06926.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5147008857","display_name":"Marise Nouhra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60770847","display_name":"Notre Dame University \u2013 Louaize","ror":"https://ror.org/030br0314","country_code":"LB","type":"education","lineage":["https://openalex.org/I60770847"]}],"countries":["LB"],"is_corresponding":false,"raw_author_name":"Marise Nouhra","raw_affiliation_strings":["Notre Dame University\u2500Louaize , , P.O. Box ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Notre Dame University\u2500Louaize , , P.O. Box ,","institution_ids":["https://openalex.org/I60770847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050416690","display_name":"Rita Maalouf","orcid":"https://orcid.org/0000-0002-9379-7906","observed_orcids":["https://orcid.org/0000-0002-9379-7906"]},"institutions":[{"id":"https://openalex.org/I60770847","display_name":"Notre Dame University \u2013 Louaize","ror":"https://ror.org/030br0314","country_code":"LB","type":"education","lineage":["https://openalex.org/I60770847"]}],"countries":["LB"],"is_corresponding":true,"raw_author_name":"Rita Maalouf","raw_affiliation_strings":["Notre Dame University\u2500Louaize , , P.O. Box ,"],"raw_orcid":"https://orcid.org/0000-0003-1327-2227","affiliations":[{"raw_affiliation_string":"Notre Dame University\u2500Louaize , , P.O. Box ,","institution_ids":["https://openalex.org/I60770847"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003031031","display_name":"Simona Sawan","orcid":"https://orcid.org/0000-0003-1327-2227","observed_orcids":["https://orcid.org/0000-0003-1327-2227"]},"institutions":[{"id":"https://openalex.org/I60770847","display_name":"Notre Dame University \u2013 Louaize","ror":"https://ror.org/030br0314","country_code":"LB","type":"education","lineage":["https://openalex.org/I60770847"]}],"countries":["LB"],"is_corresponding":false,"raw_author_name":"Simona Sawan","raw_affiliation_strings":["Notre Dame University\u2500Louaize , , P.O. Box ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Notre Dame University\u2500Louaize , , P.O. Box ,","institution_ids":["https://openalex.org/I60770847"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5050416690"],"corresponding_institution_ids":["https://openalex.org/I60770847"],"apc_list":{"value":1935,"currency":"USD","value_usd":1935},"apc_paid":{"value":1935,"currency":"USD","value_usd":1935},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"33","first_page":"50461","last_page":"50470"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10180","display_name":"Analytical chemistry methods development","score":0.012799999676644802,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11434","display_name":"Electrochemical Analysis and Applications","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1603","display_name":"Electrochemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecularly-imprinted-polymers","display_name":"molecularly imprinted polymers","score":0.9779999852180481},{"id":"https://openalex.org/keywords/electrochemical-sensor","display_name":"electrochemical sensor","score":0.8930000066757202},{"id":"https://openalex.org/keywords/oxidative-stress-biomarkers","display_name":"oxidative stress biomarkers","score":0.8180000185966492},{"id":"https://openalex.org/keywords/fe3o4-nanoparticles","display_name":"Fe3O4 nanoparticles","score":0.9890000224113464},{"id":"https://openalex.org/keywords/boron-doped-diamond-electrode","display_name":"boron-doped diamond electrode","score":1.0},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.6700000166893005},{"id":"https://openalex.org/keywords/artificial-serum","display_name":"artificial serum","score":0.4569999873638153},{"id":"https://openalex.org/keywords/differential-pulse-voltammetry","display_name":"differential pulse voltammetry","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C162602672","wikidata":"https://www.wikidata.org/wiki/Q2695129","display_name":"Molecularly imprinted polymer","level":4,"score":0.7731000185012817},{"id":"https://openalex.org/C2779525745","wikidata":"https://www.wikidata.org/wiki/Q5275361","display_name":"Differential pulse voltammetry","level":5,"score":0.7621999979019165},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.7110999822616577},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6534000039100647},{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.6503999829292297},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.6269000172615051},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5981000065803528},{"id":"https://openalex.org/C2777869211","wikidata":"https://www.wikidata.org/wiki/Q1147647","display_name":"Cyclic voltammetry","level":4,"score":0.508899986743927},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4993000030517578},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4099000096321106},{"id":"https://openalex.org/C188095982","wikidata":"https://www.wikidata.org/wiki/Q5357970","display_name":"Electrochemical gas sensor","level":4,"score":0.40549999475479126},{"id":"https://openalex.org/C2779603750","wikidata":"https://www.wikidata.org/wiki/Q904093","display_name":"Voltammetry","level":4,"score":0.3986999988555908},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.39309999346733093},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.35010001063346863},{"id":"https://openalex.org/C2780420688","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Immunoassay","level":3,"score":0.3463999927043915},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.34630000591278076},{"id":"https://openalex.org/C2778636629","wikidata":"https://www.wikidata.org/wiki/Q422649","display_name":"Biopolymer","level":3,"score":0.325300008058548},{"id":"https://openalex.org/C118792377","wikidata":"https://www.wikidata.org/wiki/Q108584245","display_name":"Selectivity","level":3,"score":0.3176000118255615},{"id":"https://openalex.org/C2988629283","wikidata":"https://www.wikidata.org/wiki/Q44337","display_name":"Complex matrix","level":2,"score":0.3167000114917755},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.30070000886917114},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.25690001249313354}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1021/acsomega.6c06926","doi":"https://doi.org/10.1021/acsomega.6c06926","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.6c06926","pdf_url":"https://pubs.acs.org/acsodf/article-pdf/doi/10.1021/acsomega.6c06926/66505954/acsomega.6c06926.pdf","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},{"id":"pmid:42662746","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42662746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS omega","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13520519","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13520519/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:2c214f1c02b4486f9ca688ad4c790e5e","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/2c214f1c02b4486f9ca688ad4c790e5e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Omega, Vol 11, Iss 33, Pp 50461-50470 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1021/acsomega.6c06926","doi":"https://doi.org/10.1021/acsomega.6c06926","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.6c06926","pdf_url":"https://pubs.acs.org/acsodf/article-pdf/doi/10.1021/acsomega.6c06926/66505954/acsomega.6c06926.pdf","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310638","display_name":"McGill University","ror":"https://ror.org/01pxwe438"},{"id":"https://openalex.org/F4320313968","display_name":"Notre Dame University-Louaize","ror":"https://ror.org/030br0314"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7202279731.pdf","grobid_xml":"https://content.openalex.org/works/W7202279731.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W2003577423","https://openalex.org/W2025639892","https://openalex.org/W2031771006","https://openalex.org/W2046538895","https://openalex.org/W2058013384","https://openalex.org/W2110125079","https://openalex.org/W2891530043","https://openalex.org/W2898975378","https://openalex.org/W2963826541","https://openalex.org/W3022803082","https://openalex.org/W3023435249","https://openalex.org/W3036791602","https://openalex.org/W3039077710","https://openalex.org/W3126423108","https://openalex.org/W3178155291","https://openalex.org/W3199640160","https://openalex.org/W3208072621","https://openalex.org/W3216044194","https://openalex.org/W4220860535","https://openalex.org/W4229082342","https://openalex.org/W4292566967","https://openalex.org/W4292721241","https://openalex.org/W4296250144","https://openalex.org/W4308336337","https://openalex.org/W4321478664","https://openalex.org/W4366813998","https://openalex.org/W4385707176","https://openalex.org/W4386177890","https://openalex.org/W4387562825","https://openalex.org/W4387741623","https://openalex.org/W4390747767","https://openalex.org/W4390821352","https://openalex.org/W4393138720","https://openalex.org/W4396768690","https://openalex.org/W4402537360","https://openalex.org/W4402578468","https://openalex.org/W4403458402","https://openalex.org/W4404724262","https://openalex.org/W4411709171","https://openalex.org/W4414077790","https://openalex.org/W7131667568"],"related_works":["https://openalex.org/W4220860535","https://openalex.org/W4321478664","https://openalex.org/W4312071212","https://openalex.org/W2977026226","https://openalex.org/W4411302139","https://openalex.org/W1966174426","https://openalex.org/W2898975378","https://openalex.org/W4416187034","https://openalex.org/W3083556092","https://openalex.org/W2929714354"],"abstract_inverted_index":{"Abstract":[0],"Malondialdehyde":[1],"(MDA)":[2],"is":[3],"a":[4,11,38,49,59,106,113,169],"critical":[5],"biomarker":[6,177],"of":[7,37,117,135],"oxidative":[8,21,175],"stress,":[9],"playing":[10],"significant":[12],"role":[13],"in":[14,132,144],"diagnosing":[15],"and":[16,28,35,79,94,112,128,147,171,179],"monitoring":[17],"conditions":[18,89],"associated":[19],"with":[20,55],"damage,":[22],"including":[23],"cardiovascular":[24],"diseases,":[25],"neurodegenerative":[26],"disorders,":[27],"cancer.":[29],"This":[30],"study":[31],"reports":[32],"the":[33,99,133],"synthesis":[34],"application":[36],"molecularly":[39],"imprinted":[40],"polymer":[41],"(MIP)-based":[42],"electrochemical":[43],"sensor":[44,85,100,157],"for":[45,84,174],"MDA":[46,131,162],"detection":[47,108,115,178],"using":[48],"dual":[50],"biopolymer":[51],"chitosan/\u03ba-carrageenan":[52],"matrix":[53],"integrated":[54],"Fe3O4":[56,97],"nanoparticles":[57],"on":[58],"boron-doped":[60],"diamond":[61],"(BDD)":[62],"electrode.":[63],"Differential":[64],"pulse":[65],"voltammetry":[66,81],"(DPV)":[67],"was":[68,141],"employed":[69],"to":[70],"evaluate":[71],"analyte":[72],"recognition,":[73],"while":[74],"FTIR,":[75],"DLS,":[76],"SEM,":[77],"EIS,":[78],"cyclic":[80],"were":[82],"used":[83],"characterization.":[86],"Under":[87],"optimized":[88],"(75%":[90],"chitosan,":[91],"25%":[92],"\u03ba-carrageenan,":[93],"10":[95],"mg":[96],"nanoparticles),":[98],"exhibited":[101],"high":[102],"sensitivity":[103],"(687.35":[104],"\u03bcA/\u03bcM),":[105],"low":[107],"limit":[109],"(0.005":[110],"\u03bcM),":[111],"linear":[114],"range":[116],"0.026\u20130.26":[118],"\u03bcM.":[119],"The":[120,155],"developed":[121],"platform":[122],"also":[123],"demonstrated":[124],"good":[125],"reproducibility,":[126],"repeatability,":[127],"selectivity":[129],"toward":[130],"presence":[134],"common":[136],"interfering":[137],"compounds.":[138],"Analytical":[139],"performance":[140],"further":[142],"validated":[143],"spiked":[145],"water":[146],"artificial":[148],"serum":[149],"samples,":[150],"showing":[151],"satisfactory":[152],"recovery":[153],"values.":[154],"proposed":[156],"outperformed":[158],"several":[159],"previously":[160],"reported":[161],"sensing":[163],"platforms,":[164],"highlighting":[165],"its":[166],"potential":[167],"as":[168],"sensitive":[170],"reliable":[172],"tool":[173],"stress":[176],"future":[180],"clinical":[181],"applications.":[182]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-08-13T00:00:00"}