{"id":"https://openalex.org/W7202276557","doi":"https://doi.org/10.21203/rs.3.rs-10546825/v1","title":"ADGRG1 blockade drives astrocytes into the extracellular matrix to reduce glial scar size","display_name":"ADGRG1 blockade drives astrocytes into the extracellular matrix to reduce glial scar size","publication_year":2026,"publication_date":"2026-08-12","ids":{"openalex":"https://openalex.org/W7202276557","doi":"https://doi.org/10.21203/rs.3.rs-10546825/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-10546825/v1","doi":"https://doi.org/10.21203/rs.3.rs-10546825/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10546825/v1","pdf_url":"https://www.researchsquare.com/article/rs-10546825/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-10546825/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081694888","display_name":"Gentaro Ono","orcid":"https://orcid.org/0000-0002-4118-7997","observed_orcids":["https://orcid.org/0000-0002-4118-7997"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Gentaro Ono","raw_affiliation_strings":["Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020503679","display_name":"Kazu Kobayakawa","orcid":"https://orcid.org/0000-0002-7444-0661","observed_orcids":["https://orcid.org/0000-0002-7444-0661"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazu Kobayakawa","raw_affiliation_strings":["Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010897940","display_name":"Hirokazu Saiwai","orcid":"https://orcid.org/0000-0003-3114-5969","observed_orcids":["https://orcid.org/0000-0003-3114-5969"]},"institutions":[{"id":"https://openalex.org/I4210127395","display_name":"Spinal Injuries Center","ror":"https://ror.org/02g9t7f35","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210127395"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirokazu Saiwai","raw_affiliation_strings":["Spinal Injuries Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spinal Injuries Center","institution_ids":["https://openalex.org/I4210127395"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061651964","display_name":"Kazuya Yokota","orcid":"https://orcid.org/0000-0002-5930-6499","observed_orcids":["https://orcid.org/0000-0002-5930-6499","https://orcid.org/0009-0005-0928-8826"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuya Yokota","raw_affiliation_strings":["Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147032882","display_name":"Tetuya Tamaru","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetuya Tamaru","raw_affiliation_strings":["Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048078789","display_name":"Kazuhiro Hata","orcid":"https://orcid.org/0000-0003-2701-7032","observed_orcids":["https://orcid.org/0000-0003-2701-7032"]},"institutions":[{"id":"https://openalex.org/I4210127395","display_name":"Spinal Injuries Center","ror":"https://ror.org/02g9t7f35","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210127395"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiro Hata","raw_affiliation_strings":["Spinal Injuries Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spinal Injuries Center","institution_ids":["https://openalex.org/I4210127395"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013258783","display_name":"Hirotaka Iura","orcid":"https://orcid.org/0000-0002-6968-6165","observed_orcids":["https://orcid.org/0000-0002-6968-6165"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirotaka Iura","raw_affiliation_strings":["Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052564981","display_name":"Yohei Haruta","orcid":"https://orcid.org/0000-0001-6752-1394","observed_orcids":["https://orcid.org/0000-0001-6752-1394"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yohei Haruta","raw_affiliation_strings":["Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066990615","display_name":"Kazuki Kitade","orcid":"https://orcid.org/0000-0001-9983-1055","observed_orcids":["https://orcid.org/0000-0001-9983-1055"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuki Kitade","raw_affiliation_strings":["Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093630327","display_name":"Jun Kishikawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Kishikawa","raw_affiliation_strings":["Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068900459","display_name":"Kiyoshi Tarukado","orcid":"https://orcid.org/0000-0001-6033-5492","observed_orcids":["https://orcid.org/0000-0001-6033-5492"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoshi Tarukado","raw_affiliation_strings":["Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101763895","display_name":"Kenichi Kawaguchi","orcid":"https://orcid.org/0000-0003-1841-8950","observed_orcids":["https://orcid.org/0000-0003-1841-8950"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenichi Kawaguchi","raw_affiliation_strings":["Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050905103","display_name":"Dai-jiro Konno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I916559398","display_name":"Kindai University","ror":"https://ror.org/05kt9ap64","country_code":"JP","type":"education","lineage":["https://openalex.org/I916559398"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Dai-Jiro Konno","raw_affiliation_strings":["Kindai University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kindai University","institution_ids":["https://openalex.org/I916559398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109082183","display_name":"Kinichi Nakashima","orcid":"https://orcid.org/0000-0001-5901-9628","observed_orcids":["https://orcid.org/0000-0001-5901-9628"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kinichi Nakashima","raw_affiliation_strings":["Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000264811","display_name":"Takeshi Maeda","orcid":"https://orcid.org/0000-0002-2594-1128","observed_orcids":["https://orcid.org/0000-0002-2594-1128"]},"institutions":[{"id":"https://openalex.org/I4210127395","display_name":"Spinal Injuries Center","ror":"https://ror.org/02g9t7f35","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210127395"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Maeda","raw_affiliation_strings":["Spinal Injuries Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spinal Injuries Center","institution_ids":["https://openalex.org/I4210127395"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121003321","display_name":"Seiji Okada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seiji Okada","raw_affiliation_strings":["Osaka University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osaka University","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002669324","display_name":"Yasuharu Nakashima","orcid":"https://orcid.org/0000-0002-6692-982X","observed_orcids":["https://orcid.org/0000-0002-6692-982X","https://orcid.org/0000-0002-2653-5324"]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuharu Nakashima","raw_affiliation_strings":["Kyushu University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kyushu University","institution_ids":["https://openalex.org/I135598925"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5081694888"],"corresponding_institution_ids":["https://openalex.org/I135598925"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adgrg1","display_name":"ADGRG1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/type-iii-collagen","display_name":"type III collagen","score":0.8790000081062317},{"id":"https://openalex.org/keywords/glial-scar","display_name":"glial scar","score":0.7319999933242798},{"id":"https://openalex.org/keywords/reactive-astrocytes","display_name":"reactive astrocytes","score":0.9559999704360962},{"id":"https://openalex.org/keywords/astrocyte-migration","display_name":"astrocyte migration","score":0.9179999828338623},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8009999990463257},{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":0.9380000233650208},{"id":"https://openalex.org/keywords/rhoa-signaling","display_name":"RhoA signaling","score":0.906000018119812},{"id":"https://openalex.org/keywords/corticospinal-tract-regeneration","display_name":"corticospinal tract regeneration","score":0.871999979019165},{"id":"https://openalex.org/keywords/axon-regeneration","display_name":"axon regeneration","score":0.5350000262260437},{"id":"https://openalex.org/keywords/motor-recovery","display_name":"motor recovery","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.8517000079154968},{"id":"https://openalex.org/C2777594495","wikidata":"https://www.wikidata.org/wiki/Q5569540","display_name":"Glial scar","level":4,"score":0.8201000094413757},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7376999855041504},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6118000149726868},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.536300003528595},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4887999892234802},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.4372999966144562},{"id":"https://openalex.org/C2780884517","wikidata":"https://www.wikidata.org/wiki/Q177105","display_name":"Neuroglia","level":3,"score":0.4106999933719635},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.37709999084472656},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.37220001220703125},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3546999990940094},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.34380000829696655},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.32850000262260437},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.31690001487731934},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.30079999566078186},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3001999855041504},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2939000129699707},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.28940001130104065},{"id":"https://openalex.org/C2780644872","wikidata":"https://www.wikidata.org/wiki/Q14881714","display_name":"Type I collagen","level":2,"score":0.28780001401901245},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2874000072479248},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.2870999872684479},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.26899999380111694},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.26809999346733093},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2578999996185303}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-10546825/v1","doi":"https://doi.org/10.21203/rs.3.rs-10546825/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10546825/v1","pdf_url":"https://www.researchsquare.com/article/rs-10546825/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-10546825/v1","doi":"https://doi.org/10.21203/rs.3.rs-10546825/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10546825/v1","pdf_url":"https://www.researchsquare.com/article/rs-10546825/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1877333600","display_name":"Elucidation of the mechanism of low back pain associated with adolescent idiopathic scoliosis","funder_award_id":"18K16665","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2554661191","display_name":"Development of a therapeutic approach using spinal cord organoid transplantation for chronic spinal cord injury","funder_award_id":"22K09426","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3354309503","display_name":null,"funder_award_id":"JP23H03031","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4104208476","display_name":"\u810a\u9ac4\u306e\u5e7c\u82e5\u5316\u306b\u3088\u308b\u810a\u9ac4\u640d\u50b7\u306e\u65b0\u898f\u6cbb\u7642\u6cd5\u958b\u767a","funder_award_id":"23K27722","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5138033086","display_name":"\u30b0\u30ea\u30a2\u7622\u75d5\u5f62\u6210\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u5305\u62ec\u7684\u7406\u89e3","funder_award_id":"JPMJFR220P","funder_id":"https://openalex.org/F4320334789","funder_display_name":"Japan Science and Technology Agency"},{"id":"https://openalex.org/G5183518465","display_name":null,"funder_award_id":"JPMJFR220P","funder_id":"https://openalex.org/F4320327211","funder_display_name":"General Insurance Association of Japan"},{"id":"https://openalex.org/G5447123244","display_name":"Molecular biological mechanism underlying improvement of functional recovery after the exercise therapy combined with the electrical stimulation of injured spinal cord","funder_award_id":"19K18515","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7192415987","display_name":"Development of therapeutic methods by controlling migration of glial cells and inflammatory cells in injured spinal cord","funder_award_id":"22K19587","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320327211","display_name":"General Insurance Association of Japan","ror":"https://ror.org/01zq5k385"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320334789","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7202276557.pdf","grobid_xml":"https://content.openalex.org/works/W7202276557.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1969444386","https://openalex.org/W1981030744","https://openalex.org/W1983080072","https://openalex.org/W1987874420","https://openalex.org/W2003073028","https://openalex.org/W2047585900","https://openalex.org/W2079944307","https://openalex.org/W2083047610","https://openalex.org/W2084566588","https://openalex.org/W2096230518","https://openalex.org/W2101363175","https://openalex.org/W2101667799","https://openalex.org/W2104968232","https://openalex.org/W2135145627","https://openalex.org/W2150633163","https://openalex.org/W2153814037","https://openalex.org/W2154072118","https://openalex.org/W2159319913","https://openalex.org/W2165287397","https://openalex.org/W2335534790","https://openalex.org/W2472354124","https://openalex.org/W2522147339","https://openalex.org/W2572710398","https://openalex.org/W2658281240","https://openalex.org/W2757347014","https://openalex.org/W2800392236","https://openalex.org/W2805257681","https://openalex.org/W2886051951","https://openalex.org/W2899595236","https://openalex.org/W2920816178","https://openalex.org/W2924294387","https://openalex.org/W3018541302","https://openalex.org/W3032487381","https://openalex.org/W3049429323","https://openalex.org/W3086014455","https://openalex.org/W3161590961","https://openalex.org/W3198002666","https://openalex.org/W3207790306","https://openalex.org/W4280596398","https://openalex.org/W4281493182","https://openalex.org/W4284885575","https://openalex.org/W4388524259","https://openalex.org/W4389670555","https://openalex.org/W4390064086","https://openalex.org/W4390110986","https://openalex.org/W4399830205","https://openalex.org/W4399893493","https://openalex.org/W4401057359"],"related_works":["https://openalex.org/W7116668848","https://openalex.org/W2658281240","https://openalex.org/W7208123634","https://openalex.org/W2101667799","https://openalex.org/W2777513196","https://openalex.org/W1572273948","https://openalex.org/W2121860798","https://openalex.org/W2077493495","https://openalex.org/W2208934017","https://openalex.org/W2138895240"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"After":[2],"wide":[3],"range":[4],"of":[5,23,106,244,288,306],"traumatic":[6],"damage":[7],"to":[8,199,225],"the":[9,16,21,24,31,37,43,59,71,87,117,128,203,233,253,286,289,304,307],"spinal":[10,108],"cord,":[11],"reactive":[12,32,165],"astrocytes":[13,33,51,133,166,201,251,284],"migrate":[14],"toward":[15],"lesion":[17],"but":[18,89],"stop":[19,52,67],"at":[20,53,202,285],"edge":[22,287],"fibrotic":[25,72,204,290],"extracellular":[26],"matrix":[27],"(ECM)":[28],"core.":[29],"There,":[30],"accumulate":[34],"and":[35,102,141,144,179,192,217,229,246,268,292],"form":[36],"glial":[38,261,308],"scar":[39,93,309],"border":[40,55],"that":[41,65,120,159],"prevents":[42],"regenerating":[44],"axons":[45],"from":[46,70,295],"passing":[47],"through.":[48],"Why":[49],"these":[50],"this":[54,66],"rather":[56],"than":[57],"entering":[58,296],"ECM":[60,291],"remains":[61],"unknown.":[62,96],"We":[63,98,125,154],"reasoned":[64],"signal":[68],"comes":[69],"ECM.":[73],"Among":[74,163],"its":[75],"components,":[76],"we":[77,114],"focused":[78],"on":[79],"type":[80,122,172,209,226,254,312],"III":[81,123,173,210,227,255,281,313],"collagen,":[82,174],"which":[83],"is":[84,95],"abundant":[85],"in":[86,92,131,134,137,145,276],"core":[88],"whose":[90],"role":[91],"formation":[94],"Methods":[97],"analyzed":[99],"single-nucleus":[100],"RNA-sequencing":[101],"spatial":[103],"transcriptomic":[104],"datasets":[105],"mouse":[107],"cords.":[109],"Using":[110],"cell-cell":[111],"interaction":[112,170],"analysis,":[113],"searched":[115],"for":[116,322],"astrocyte":[118,157,219],"receptor":[119,183],"binds":[121],"collagen.":[124],"then":[126],"tested":[127],"candidate":[129],"pathway":[130],"primary":[132],"vitro":[135,207],",":[136,178,208,240],"vivo":[138,239],"using":[139],"pharmacological":[140,242],"genetic":[142],"inhibition,":[143],"human":[146],"induced":[147],"pluripotent":[148],"stem":[149],"cell":[150],"(hiPSC)-derived":[151],"astrocytes.":[152,278],"Results":[153],"found":[155],"six":[156],"subclusters":[158],"changed":[160],"over":[161],"time.":[162],"them,":[164],"showed":[167],"a":[168,318],"strong":[169],"between":[171],"encoded":[175],"by":[176,232],"Col3a1":[177,186],"adhesion":[180],"G":[181],"protein-coupled":[182],"G1":[184],"(ADGRG1).":[185],"-expressing":[187],"vascular":[188],"leptomeningeal":[189],"cells":[190,195],"(VLMCs)":[191],"arachnoid":[193],"barrier":[194],"(ABCs)":[196],"sat":[197],"next":[198],"ADGRG1-expressing":[200],"border.":[205,310],"In":[206,238],"collagen":[211,228,282],"activated":[212],"RhoA-GTP":[213],"loading":[214],"through":[215,299],"ADGRG1":[216,234,245],"suppressed":[218],"migration.":[220],"This":[221,258,302],"effect":[222],"was":[223,230],"specific":[224],"reversed":[231],"antagonist":[235],"Dihydromunduletone":[236],"(DHM).":[237],"both":[241],"inhibition":[243],"astrocyte-specific":[247],"Adgrg1":[248],"knockdown":[249],"let":[250],"enter":[252],"collagen-rich":[256],"matrix.":[257],"produced":[259],"smaller":[260],"scars,":[262],"enhanced":[263],"corticospinal":[264],"tract":[265],"(CST)":[266],"regeneration,":[267],"improved":[269],"motor":[270],"recovery.":[271],"The":[272,311],"same":[273],"response":[274],"occurred":[275],"hiPSC-derived":[277],"Conclusions":[279],"Type":[280],"keeps":[283],"stops":[293],"them":[294],"it,":[297],"acting":[298],"ADGRG1\u2013RhoA":[300],"signaling.":[301],"sets":[303],"position":[305],"collagen\u2013ADGRG1":[314],"axis":[315],"may":[316],"be":[317],"new":[319],"therapeutic":[320],"target":[321],"controlling":[323],"maladaptive":[324],"scarring":[325],"after":[326],"CNS":[327],"injury.":[328]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-08-13T00:00:00"}
