{"id":"https://openalex.org/W7202216651","doi":"https://doi.org/10.1016/j.ajt.2026.08.002","title":"Marginal zone B cell targeting limits alloantigen availability to follicular dendritic cells and mitigates antibody-mediated rejection","display_name":"Marginal zone B cell targeting limits alloantigen availability to follicular dendritic cells and mitigates antibody-mediated rejection","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7202216651","doi":"https://doi.org/10.1016/j.ajt.2026.08.002","pmid":"https://pubmed.ncbi.nlm.nih.gov/42580442"},"language":"en","primary_location":{"id":"doi:10.1016/j.ajt.2026.08.002","doi":"https://doi.org/10.1016/j.ajt.2026.08.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajt.2026.08.002","pdf_url":null,"source":{"id":"https://openalex.org/S182625382","display_name":"American Journal of Transplantation","issn_l":"1600-6135","issn":["1600-6135","1600-6143"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.ajt.2026.08.002","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022382649","display_name":"Rodrigo Benedetti Gassen","orcid":"https://orcid.org/0000-0003-0513-1555","observed_orcids":["https://orcid.org/0000-0003-0513-1555"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rodrigo B. Gassen","raw_affiliation_strings":["Center of Transplantation Science, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":"https://orcid.org/0000-0003-0513-1555","affiliations":[{"raw_affiliation_string":"Center of Transplantation Science, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027517304","display_name":"Kaifeng Liu","orcid":"https://orcid.org/0009-0003-0157-8349","observed_orcids":["https://orcid.org/0009-0003-0157-8349"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaifeng Liu","raw_affiliation_strings":["Center of Transplantation Science, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Transplantation Science, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040128706","display_name":"Yoshikazu Ganchiku","orcid":"https://orcid.org/0000-0001-7122-3066","observed_orcids":["https://orcid.org/0000-0001-7122-3066"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoshikazu Ganchiku","raw_affiliation_strings":["Center of Transplantation Science, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":"https://orcid.org/0000-0001-7122-3066","affiliations":[{"raw_affiliation_string":"Center of Transplantation Science, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124200502","display_name":"Karina Lima","orcid":"https://orcid.org/0000-0003-2478-1182","observed_orcids":["https://orcid.org/0000-0003-2478-1182"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karina Lima","raw_affiliation_strings":["Center of Transplantation Science, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":"https://orcid.org/0000-0003-2478-1182","affiliations":[{"raw_affiliation_string":"Center of Transplantation Science, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078668547","display_name":"Ayman Al Jurdi","orcid":"https://orcid.org/0000-0002-7652-3399","observed_orcids":["https://orcid.org/0000-0002-7652-3399","https://orcid.org/0000-0002-7957-137X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayman Al Jurdi","raw_affiliation_strings":["Center of Transplantation Science, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":"https://orcid.org/0000-0002-7652-3399","affiliations":[{"raw_affiliation_string":"Center of Transplantation Science, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057297665","display_name":"Katalin Suszt\u00e1k","orcid":"https://orcid.org/0000-0002-1005-3726","observed_orcids":["https://orcid.org/0000-0002-1005-3726"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katalin Susztak","raw_affiliation_strings":["Renal Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0002-1005-3726","affiliations":[{"raw_affiliation_string":"Renal Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035930422","display_name":"Ciara N. Magee","orcid":"https://orcid.org/0000-0002-0814-4143","observed_orcids":["https://orcid.org/0000-0002-0814-4143"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ciara N. Magee","raw_affiliation_strings":["Department of Medicine, Renal Division, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Renal Division, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083488593","display_name":"Naoka Murakami","orcid":"https://orcid.org/0000-0001-8168-5811","observed_orcids":["https://orcid.org/0000-0001-8168-5811"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naoka Murakami","raw_affiliation_strings":["Department of Medicine, Renal Division, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":"https://orcid.org/0000-0001-8168-5811","affiliations":[{"raw_affiliation_string":"Department of Medicine, Renal Division, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011634251","display_name":"Ivy A. Rosales","orcid":"https://orcid.org/0000-0003-0621-3202","observed_orcids":["https://orcid.org/0000-0003-0621-3202"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivy A. Rosales","raw_affiliation_strings":["Center of Transplantation Science, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":"https://orcid.org/0000-0003-0621-3202","affiliations":[{"raw_affiliation_string":"Center of Transplantation Science, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003943728","display_name":"Thiago J. Borges","orcid":"https://orcid.org/0000-0002-6554-0169","observed_orcids":["https://orcid.org/0000-0002-6554-0169"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thiago J. Borges","raw_affiliation_strings":["Center of Transplantation Science, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA"],"raw_orcid":"https://orcid.org/0000-0002-6554-0169","affiliations":[{"raw_affiliation_string":"Center of Transplantation Science, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083826351","display_name":"Leonardo V. Riella","orcid":"https://orcid.org/0000-0002-7636-3196","observed_orcids":["https://orcid.org/0000-0002-7636-3196"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leonardo V. Riella","raw_affiliation_strings":["Center of Transplantation Science, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA; Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: lriella@mgh.harvard.edu"],"raw_orcid":"https://orcid.org/0000-0002-7636-3196","affiliations":[{"raw_affiliation_string":"Center of Transplantation Science, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA; Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: lriella@mgh.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5083826351"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":4300,"currency":"USD","value_usd":4300},"apc_paid":{"value":4300,"currency":"USD","value_usd":4300},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.60736732,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.5770999789237976,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.5770999789237976,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.2678000032901764,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.1340000033378601,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/marginal-zone-b-cells","display_name":"marginal zone B cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/antibody-mediated-rejection","display_name":"antibody-mediated rejection","score":0.8539999723434448},{"id":"https://openalex.org/keywords/chronic-rejection","display_name":"chronic rejection","score":0.7419999837875366},{"id":"https://openalex.org/keywords/notch2","display_name":"Notch2","score":0.781000018119812},{"id":"https://openalex.org/keywords/follicular-dendritic-cells","display_name":"follicular dendritic cells","score":0.9020000100135803},{"id":"https://openalex.org/keywords/alloantigen","display_name":"alloantigen","score":0.6899999976158142},{"id":"https://openalex.org/keywords/donor-specific-antibodies","display_name":"donor-specific antibodies","score":0.8059999942779541},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.7239999771118164},{"id":"https://openalex.org/keywords/heart-transplantation","display_name":"heart transplantation","score":0.777999997138977},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":1.0},{"id":"https://openalex.org/keywords/hla-a2-transgenic-mice","display_name":"HLA-A2 transgenic mice","score":0.8679999709129333},{"id":"https://openalex.org/keywords/germinal-center","display_name":"germinal center","score":0.8320000171661377},{"id":"https://openalex.org/keywords/plasma-cells","display_name":"plasma cells","score":0.7940000295639038},{"id":"https://openalex.org/keywords/c4d-deposition","display_name":"C4d deposition","score":0.8730000257492065}],"concepts":[{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.6858999729156494},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6852999925613403},{"id":"https://openalex.org/C2779921676","wikidata":"https://www.wikidata.org/wiki/Q6760434","display_name":"Marginal zone","level":4,"score":0.5548999905586243},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.512499988079071},{"id":"https://openalex.org/C3753494","wikidata":"https://www.wikidata.org/wiki/Q2631550","display_name":"Follicular dendritic cells","level":5,"score":0.4765999913215637},{"id":"https://openalex.org/C187785154","wikidata":"https://www.wikidata.org/wiki/Q5464664","display_name":"Follicular phase","level":2,"score":0.42559999227523804},{"id":"https://openalex.org/C3019230761","wikidata":"https://www.wikidata.org/wiki/Q1765748","display_name":"Graft rejection","level":3,"score":0.39399999380111694},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.38679999113082886},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38280001282691956},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.35760000348091125},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.34209999442100525},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2881999909877777},{"id":"https://openalex.org/C30278631","wikidata":"https://www.wikidata.org/wiki/Q281721","display_name":"Chimera (genetics)","level":3,"score":0.27469998598098755},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2736000120639801},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.27309998869895935},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.26589998602867126},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.26080000400543213}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ajt.2026.08.002","doi":"https://doi.org/10.1016/j.ajt.2026.08.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajt.2026.08.002","pdf_url":null,"source":{"id":"https://openalex.org/S182625382","display_name":"American Journal of Transplantation","issn_l":"1600-6135","issn":["1600-6135","1600-6143"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Transplantation","raw_type":"journal-article"},{"id":"pmid:42580442","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42580442","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.ajt.2026.08.002","doi":"https://doi.org/10.1016/j.ajt.2026.08.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajt.2026.08.002","pdf_url":null,"source":{"id":"https://openalex.org/S182625382","display_name":"American Journal of Transplantation","issn_l":"1600-6135","issn":["1600-6135","1600-6143"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Transplantation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2982121942","display_name":"The Harvard Clinical and Translational Science Center","funder_award_id":"UL1TR002541","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6958116478","display_name":"Role of Siglec-E in Regulating Alloimmunity","funder_award_id":"R01AI143887","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320308349","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1526178344","https://openalex.org/W1853957385","https://openalex.org/W1975952961","https://openalex.org/W1995863606","https://openalex.org/W2008471218","https://openalex.org/W2026610457","https://openalex.org/W2031026925","https://openalex.org/W2041572974","https://openalex.org/W2070031764","https://openalex.org/W2097105111","https://openalex.org/W2098471087","https://openalex.org/W2101827867","https://openalex.org/W2108013658","https://openalex.org/W2109968192","https://openalex.org/W2112622667","https://openalex.org/W2113337076","https://openalex.org/W2122632662","https://openalex.org/W2123475341","https://openalex.org/W2128623893","https://openalex.org/W2137063023","https://openalex.org/W2139995217","https://openalex.org/W2144359292","https://openalex.org/W2152340623","https://openalex.org/W2167403404","https://openalex.org/W2418683916","https://openalex.org/W2762775515","https://openalex.org/W2780418218","https://openalex.org/W2892130773","https://openalex.org/W2912728620","https://openalex.org/W2989707275","https://openalex.org/W3025072713","https://openalex.org/W3132206600","https://openalex.org/W3197544410","https://openalex.org/W4221068559","https://openalex.org/W4280517249","https://openalex.org/W4283211433","https://openalex.org/W4391881060","https://openalex.org/W4402546917","https://openalex.org/W4405834716"],"related_works":["https://openalex.org/W4404167388","https://openalex.org/W4402546917","https://openalex.org/W2058994602","https://openalex.org/W1975484438","https://openalex.org/W4393092079","https://openalex.org/W2913418621","https://openalex.org/W2093326107","https://openalex.org/W1963632319","https://openalex.org/W2026019839","https://openalex.org/W2775303696"],"abstract_inverted_index":{"Chronic":[0],"antibody-mediated":[1,67],"rejection":[2,57,68],"is":[3],"a":[4,26,162],"leading":[5,133],"cause":[6],"of":[7,65,80,122,155],"allograft":[8],"loss,":[9],"with":[10],"limited":[11],"therapies":[12],"that":[13,43,76],"effectively":[14],"target":[15,22,89],"humoral":[16,97],"immunity.":[17],"Current":[18],"immunosuppressive":[19],"regimens":[20],"primarily":[21],"T":[23],"cells,":[24,92,105,107,132],"leaving":[25],"critical":[27],"gap":[28],"in":[29,51,101],"strategies":[30],"to":[31,87,129,134],"suppress":[32],"antibody-driven":[33],"rejection.":[34],"Marginal":[35],"zone":[36],"(MZ)":[37],"B":[38,91,104,124,150],"cells":[39,42,125,151],"are":[40],"innate-like":[41],"can":[44],"rapidly":[45],"generate":[46],"antibodies,":[47,109],"but":[48],"their":[49],"role":[50],"donor-specific":[52,108],"antibody":[53,86],"generation":[54],"and":[55,73,110,117,141,158],"chronic":[56,66],"remains":[58],"unclear.":[59],"We":[60],"developed":[61],"novel":[62],"murine":[63],"models":[64],"using":[69],"HLA-A2":[70],"transgenic":[71],"heart":[72],"kidney":[74],"transplants":[75],"recapitulate":[77],"clinical":[78],"features":[79],"human":[81],"disease.":[82],"Using":[83],"an":[84],"anti-Notch2":[85],"selectively":[88],"MZ":[90,123,149],"we":[93],"observed":[94],"reduced":[95],"antigen-specific":[96],"responses,":[98],"including":[99],"decreases":[100],"germinal":[102,143],"center":[103,144],"plasma":[106],"C4d":[111],"deposition,":[112],"alongside":[113],"improved":[114],"graft":[115],"structure":[116],"function.":[118],"Mechanistically,":[119],"the":[120],"reduction":[121],"disrupted":[126],"antigen":[127],"shuttling":[128],"follicular":[130,136],"dendritic":[131,137],"decreased":[135],"cell-associated":[138],"alloantigen":[139],"clusters":[140],"impaired":[142],"reactions.":[145],"These":[146],"findings":[147],"establish":[148],"as":[152,161],"key":[153],"drivers":[154],"alloantibody":[156],"formation":[157],"highlight":[159],"Notch2":[160],"promising":[163],"therapeutic":[164],"target.":[165]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-08-12T00:00:00"}