{"id":"https://openalex.org/W7202215882","doi":"https://doi.org/10.21203/rs.3.rs-10610675/v1","title":"A survey method using three indicators (total, regimen, and each line contribution periods) to understand the actual treatment status for patients with recurrent ovarian cancer in real-world clinical practice","display_name":"A survey method using three indicators (total, regimen, and each line contribution periods) to understand the actual treatment status for patients with recurrent ovarian cancer in real-world clinical practice","publication_year":2026,"publication_date":"2026-08-11","ids":{"openalex":"https://openalex.org/W7202215882","doi":"https://doi.org/10.21203/rs.3.rs-10610675/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-10610675/v1","doi":"https://doi.org/10.21203/rs.3.rs-10610675/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10610675/v1","pdf_url":"https://www.researchsquare.com/article/rs-10610675/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-10610675/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103238014","display_name":"Osamu Maeda","orcid":"https://orcid.org/0000-0002-8078-2537","observed_orcids":["https://orcid.org/0000-0002-8078-2537"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Osamu Maeda","raw_affiliation_strings":["Nagoya University Graduate School of Medicine Faculty of Medicine: Nagoya Daigaku Daigakuin Igakukei Kenkyuka Igakubu"],"raw_orcid":"https://orcid.org/0000-0002-8078-2537","affiliations":[{"raw_affiliation_string":"Nagoya University Graduate School of Medicine Faculty of Medicine: Nagoya Daigaku Daigakuin Igakukei Kenkyuka Igakubu","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064908158","display_name":"Masato Yoshihara","orcid":"https://orcid.org/0000-0001-5811-3137","observed_orcids":["https://orcid.org/0000-0001-5811-3137"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masato Yoshihara","raw_affiliation_strings":["Nagoya University Graduate School of Medicine Faculty of Medicine: Nagoya Daigaku Daigakuin Igakukei Kenkyuka Igakubu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nagoya University Graduate School of Medicine Faculty of Medicine: Nagoya Daigaku Daigakuin Igakukei Kenkyuka Igakubu","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025125509","display_name":"Yashiro Motooka","orcid":"https://orcid.org/0000-0002-4230-7559","observed_orcids":["https://orcid.org/0000-0002-4230-7559"]},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yashiro Motooka","raw_affiliation_strings":["Fujita Ika Daigaku"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujita Ika Daigaku","institution_ids":["https://openalex.org/I145673806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146439763","display_name":"Masafumi Ito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masafumi Ito","raw_affiliation_strings":["Nagoya University Graduate School of Medicine Faculty of Medicine: Nagoya Daigaku Daigakuin Igakukei Kenkyuka Igakubu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nagoya University Graduate School of Medicine Faculty of Medicine: Nagoya Daigaku Daigakuin Igakukei Kenkyuka Igakubu","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069533190","display_name":"Kazumasa Mogi","orcid":"https://orcid.org/0000-0002-3866-2566","observed_orcids":["https://orcid.org/0000-0002-3866-2566"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazumasa Mogi","raw_affiliation_strings":["Nagoya University Graduate School of Medicine Faculty of Medicine: Nagoya Daigaku Daigakuin Igakukei Kenkyuka Igakubu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nagoya University Graduate School of Medicine Faculty of Medicine: Nagoya Daigaku Daigakuin Igakukei Kenkyuka Igakubu","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079407472","display_name":"Akira Yokoi","orcid":"https://orcid.org/0000-0003-0789-5102","observed_orcids":["https://orcid.org/0000-0003-0789-5102","https://orcid.org/0009-0001-7869-2399"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Yokoi","raw_affiliation_strings":["Nagoya University Graduate School of Medicine Faculty of Medicine: Nagoya Daigaku Daigakuin Igakukei Kenkyuka Igakubu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nagoya University Graduate School of Medicine Faculty of Medicine: Nagoya Daigaku Daigakuin Igakukei Kenkyuka Igakubu","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064350256","display_name":"Nobuhisa Yoshikawa","orcid":"https://orcid.org/0000-0001-8662-9421","observed_orcids":["https://orcid.org/0000-0001-8662-9421"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuhisa Yoshikawa","raw_affiliation_strings":["Nagoya University Graduate School of Medicine Faculty of Medicine: Nagoya Daigaku Daigakuin Igakukei Kenkyuka Igakubu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nagoya University Graduate School of Medicine Faculty of Medicine: Nagoya Daigaku Daigakuin Igakukei Kenkyuka Igakubu","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078859785","display_name":"Hiroaki Kajiyama","orcid":"https://orcid.org/0000-0003-0493-1825","observed_orcids":["https://orcid.org/0000-0003-0493-1825"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroaki Kajiyama","raw_affiliation_strings":["Nagoya University Graduate School of Medicine Faculty of Medicine: Nagoya Daigaku Daigakuin Igakukei Kenkyuka Igakubu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nagoya University Graduate School of Medicine Faculty of Medicine: Nagoya Daigaku Daigakuin Igakukei Kenkyuka Igakubu","institution_ids":["https://openalex.org/I60134161"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recurrent-ovarian-cancer","display_name":"recurrent ovarian cancer","score":1.0},{"id":"https://openalex.org/keywords/platinum-sensitive-recurrence","display_name":"platinum-sensitive recurrence","score":0.8320000171661377},{"id":"https://openalex.org/keywords/treatment-lines","display_name":"treatment lines","score":0.48500001430511475},{"id":"https://openalex.org/keywords/taxanes","display_name":"taxanes","score":0.5580000281333923},{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nedaplatin","display_name":"nedaplatin","score":0.953000009059906},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.8980000019073486},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.7390000224113464},{"id":"https://openalex.org/keywords/histological-subtypes","display_name":"histological subtypes","score":0.781000018119812},{"id":"https://openalex.org/keywords/high-grade-serous-carcinoma","display_name":"high-grade serous carcinoma","score":0.8450000286102295},{"id":"https://openalex.org/keywords/clear-cell-carcinoma","display_name":"clear cell carcinoma","score":0.984000027179718},{"id":"https://openalex.org/keywords/real-world-clinical-practice","display_name":"real-world clinical practice","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8726999759674072},{"id":"https://openalex.org/C2777511904","wikidata":"https://www.wikidata.org/wiki/Q425227","display_name":"Taxane","level":4,"score":0.7684999704360962},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6567999720573425},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.6491000056266785},{"id":"https://openalex.org/C2778203143","wikidata":"https://www.wikidata.org/wiki/Q6986146","display_name":"Nedaplatin","level":4,"score":0.5992000102996826},{"id":"https://openalex.org/C2781451048","wikidata":"https://www.wikidata.org/wiki/Q415588","display_name":"Carboplatin","level":4,"score":0.5734000205993652},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5694000124931335},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5619999766349792},{"id":"https://openalex.org/C150173356","wikidata":"https://www.wikidata.org/wiki/Q6144101","display_name":"Serous fluid","level":2,"score":0.4715000092983246},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.40290001034736633},{"id":"https://openalex.org/C2993493390","wikidata":"https://www.wikidata.org/wiki/Q5453208","display_name":"First line","level":2,"score":0.38679999113082886},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34689998626708984},{"id":"https://openalex.org/C3017976582","wikidata":"https://www.wikidata.org/wiki/Q179661","display_name":"First line treatment","level":3,"score":0.3411000072956085},{"id":"https://openalex.org/C3018840467","wikidata":"https://www.wikidata.org/wiki/Q179661","display_name":"Second line treatment","level":3,"score":0.3379000127315521},{"id":"https://openalex.org/C2991678472","wikidata":"https://www.wikidata.org/wiki/Q108872574","display_name":"Cancer recurrence","level":3,"score":0.3343000113964081},{"id":"https://openalex.org/C3019258254","wikidata":"https://www.wikidata.org/wiki/Q1423317","display_name":"Second line","level":3,"score":0.30809998512268066},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3001999855041504},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.288100004196167},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2870999872684479},{"id":"https://openalex.org/C2779962180","wikidata":"https://www.wikidata.org/wiki/Q7083106","display_name":"Olaparib","level":5,"score":0.27790001034736633},{"id":"https://openalex.org/C2780223747","wikidata":"https://www.wikidata.org/wiki/Q7455060","display_name":"Serous cystadenocarcinoma","level":4,"score":0.27079999446868896},{"id":"https://openalex.org/C201645570","wikidata":"https://www.wikidata.org/wiki/Q830637","display_name":"Radiation treatment planning","level":3,"score":0.2621999979019165},{"id":"https://openalex.org/C2986587452","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical analysis","level":2,"score":0.2515999972820282}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-10610675/v1","doi":"https://doi.org/10.21203/rs.3.rs-10610675/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10610675/v1","pdf_url":"https://www.researchsquare.com/article/rs-10610675/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-10610675/v1","doi":"https://doi.org/10.21203/rs.3.rs-10610675/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10610675/v1","pdf_url":"https://www.researchsquare.com/article/rs-10610675/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7202215882.pdf","grobid_xml":"https://content.openalex.org/works/W7202215882.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1543697093","https://openalex.org/W2019607817","https://openalex.org/W2044421413","https://openalex.org/W2044779350","https://openalex.org/W2079537409","https://openalex.org/W2107457010","https://openalex.org/W2133506440","https://openalex.org/W2134947875","https://openalex.org/W2138035969","https://openalex.org/W2151050516","https://openalex.org/W2158553214","https://openalex.org/W2160466424","https://openalex.org/W2168453180","https://openalex.org/W2170928115","https://openalex.org/W2560862072","https://openalex.org/W2605456582","https://openalex.org/W2737389832","https://openalex.org/W2985168992","https://openalex.org/W3016364201"],"related_works":["https://openalex.org/W2226735525","https://openalex.org/W4406379085","https://openalex.org/W2081671373","https://openalex.org/W2326304879","https://openalex.org/W3027288224","https://openalex.org/W3186780355","https://openalex.org/W2122624385","https://openalex.org/W2067383190","https://openalex.org/W2322979802","https://openalex.org/W2333045456"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"There":[2],"is":[3],"no":[4],"indicator":[5],"to":[6,39,114,128,146,221],"evaluate":[7,22],"the":[8,61,112,126,154,159,210,226],"\u201cusefulness\u201d":[9,211],"of":[10,60,117,131,148,212],"anticancer":[11,56],"treatment":[12],"for":[13,236,243],"recurrent":[14,43],"ovarian":[15,44],"cancer":[16,45],"in":[17,99,111,125,216],"clinical":[18,217],"practice.":[19],"Methods":[20],"To":[21],"\u201cusefulness,\u201d":[23],"we":[24],"propose":[25],"three":[26,166,208],"indicators:":[27],"\u201ctotal,\u201d":[28],"\u201cregimen,\u201d":[29],"and":[30,53,105,178,228],"\u201ceach":[31,229],"line":[32,93,230],"contribution":[33,72,90,94,161,183,200,231],"periods.\u201d":[34,91],"These":[35],"indicators":[36],"were":[37,47,75,107,140],"applied":[38],"183":[40],"patients":[41,62,100,134,170,188],"with":[42,63,69,84,101,135,171,189],"who":[46],"classified":[48],"as":[49,150],"platinum-sensitive":[50,64,102,172],"or":[51,214],"platinum-resistant":[52,85,136,190],"had":[54,87,180,196],"received":[55,66],"treatment.":[57,132,152],"Results":[58],"Many":[59],"recurrence":[65,86,173,191],"platinum-based":[67,138],"drugs":[68],"long":[70],"\u201cregimen":[71,89,160,182,199],"periods,\u201d":[73],"which":[74],"further":[76],"prolonged":[77],"by":[78],"adding":[79],"molecularly":[80],"targeted":[81],"drugs.":[82],"Patients":[83],"shorter":[88],"\u201cEach":[92],"period\u201d":[95,162,184,201],"follow-up":[96],"revealed":[97],"that":[98,147],"recurrence,":[103,137],"taxane":[104],"carboplatin":[106],"administered":[108,122,141],"more":[109,123],"frequently":[110,124],"first":[113],"third":[115],"lines":[116,130],"treatment,":[118],"whereas":[119],"nedaplatin":[120],"was":[121,163,219],"fourth":[127],"sixth":[129],"In":[133,169,187],"agents":[139],"at":[142],"a":[143,197],"frequency":[144],"comparable":[145],"non-platinum":[149,203],"first-line":[151],"Because":[153],"histological":[155,167],"type":[156],"affected":[157],"prognosis,":[158],"examined":[164],"using":[165,246],"types.":[168],"clear":[174],"cell":[175],"carcinoma,":[176,194],"taxane+carboplatin+bevacizumab":[177],"gemcitabine":[179],"longer":[181,198],"than":[185,202],"taxane+carboplatin.":[186],"high-grade":[192],"serous":[193],"taxane+carboplatin":[195],"agents.":[204],"Conclusion":[205],"Using":[206],"these":[207],"indicators,":[209],"regimens":[213],"treatments":[215],"practice":[218],"able":[220],"be":[222],"evaluated":[223],"wonderfully.":[224],"However,":[225],"\u201cregimen\u201d":[227],"periods\u201d":[232],"are":[233,241],"not":[234],"suitable":[235],"statistical":[237],"analysis;":[238],"thus,":[239],"they":[240],"used":[242],"visual":[244],"judgment":[245],"box-and-whisker":[247],"plots.":[248]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-12T00:00:00"}
