{"id":"https://openalex.org/W7202214932","doi":"https://doi.org/10.1080/14712598.2026.2718366","title":"Persistent subretinal fluid in neovascular AMD: clinical significance and implications for treatment","display_name":"Persistent subretinal fluid in neovascular AMD: clinical significance and implications for treatment","publication_year":2026,"publication_date":"2026-08-03","ids":{"openalex":"https://openalex.org/W7202214932","doi":"https://doi.org/10.1080/14712598.2026.2718366","pmid":"https://pubmed.ncbi.nlm.nih.gov/42579523"},"language":"en","primary_location":{"id":"doi:10.1080/14712598.2026.2718366","doi":"https://doi.org/10.1080/14712598.2026.2718366","is_oa":false,"landing_page_url":"https://doi.org/10.1080/14712598.2026.2718366","pdf_url":null,"source":{"id":"https://openalex.org/S57380513","display_name":"Expert Opinion on Biological Therapy","issn_l":"1471-2598","issn":["1471-2598","1744-7682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Biological Therapy","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5121898249","display_name":"Jae Hui Kim","orcid":"https://orcid.org/0000-0001-8121-6353","observed_orcids":["https://orcid.org/0000-0001-8121-6353"]},"institutions":[{"id":"https://openalex.org/I4210117632","display_name":"Kim's Eye Hospital","ror":"https://ror.org/02nh1np55","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210117632"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jae Hui Kim","raw_affiliation_strings":["Kim\u2019s Eye Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kim\u2019s Eye Hospital","institution_ids":["https://openalex.org/I4210117632"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5121898249"],"corresponding_institution_ids":["https://openalex.org/I4210117632"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"8","first_page":"755","last_page":"761"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neovascular-age-related-macular-degeneration","display_name":"neovascular age-related macular degeneration","score":0.9679999947547913},{"id":"https://openalex.org/keywords/subretinal-fluid","display_name":"subretinal fluid","score":0.9800000190734863},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.8410000205039978},{"id":"https://openalex.org/keywords/intraretinal-fluid","display_name":"intraretinal fluid","score":0.7929999828338623},{"id":"https://openalex.org/keywords/macular-atrophy","display_name":"macular atrophy","score":0.9010000228881836},{"id":"https://openalex.org/keywords/visual-acuity-outcomes","display_name":"visual acuity outcomes","score":0.9229999780654907},{"id":"https://openalex.org/keywords/undertreatment","display_name":"undertreatment","score":0.9269999861717224}],"concepts":[{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.7416999936103821},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7383000254631042},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.3944999873638153},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.390500009059906},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3662000000476837},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.33320000767707825},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3001999855041504},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2937999963760376},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.29100000858306885},{"id":"https://openalex.org/C2780248432","wikidata":"https://www.wikidata.org/wiki/Q1434206","display_name":"Fluorescein angiography","level":3,"score":0.2849999964237213},{"id":"https://openalex.org/C2778024200","wikidata":"https://www.wikidata.org/wiki/Q2346242","display_name":"Retinal pigment epithelium","level":3,"score":0.2628999948501587},{"id":"https://openalex.org/C2778313320","wikidata":"https://www.wikidata.org/wiki/Q550455","display_name":"Retinopathy","level":3,"score":0.2572999894618988},{"id":"https://openalex.org/C2776148792","wikidata":"https://www.wikidata.org/wiki/Q3041498","display_name":"Eye disease","level":2,"score":0.25040000677108765}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D014792","descriptor_name":"Visual Acuity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020256","descriptor_name":"Choroidal Neovascularization","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D020256","descriptor_name":"Choroidal Neovascularization","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D057135","descriptor_name":"Wet Macular Degeneration","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D057135","descriptor_name":"Wet Macular Degeneration","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D058471","descriptor_name":"Subretinal Fluid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/14712598.2026.2718366","doi":"https://doi.org/10.1080/14712598.2026.2718366","is_oa":false,"landing_page_url":"https://doi.org/10.1080/14712598.2026.2718366","pdf_url":null,"source":{"id":"https://openalex.org/S57380513","display_name":"Expert Opinion on Biological Therapy","issn_l":"1471-2598","issn":["1471-2598","1744-7682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Biological Therapy","raw_type":"journal-article"},{"id":"pmid:42579523","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42579523","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on biological therapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1503735881","https://openalex.org/W1965018345","https://openalex.org/W1970699493","https://openalex.org/W2042321005","https://openalex.org/W2074575505","https://openalex.org/W2225799082","https://openalex.org/W2304396421","https://openalex.org/W2314609576","https://openalex.org/W2316418129","https://openalex.org/W2545082692","https://openalex.org/W2760008043","https://openalex.org/W2936430874","https://openalex.org/W2947786487","https://openalex.org/W2965769306","https://openalex.org/W3005977701","https://openalex.org/W3072257851","https://openalex.org/W3110049172","https://openalex.org/W3112680852","https://openalex.org/W3119176982","https://openalex.org/W3136819071","https://openalex.org/W3164006669","https://openalex.org/W3165655898","https://openalex.org/W3171367200","https://openalex.org/W3184911352","https://openalex.org/W3192403893","https://openalex.org/W4214582981","https://openalex.org/W4220870450","https://openalex.org/W4296026521","https://openalex.org/W4311952305","https://openalex.org/W4361205342","https://openalex.org/W4392845150","https://openalex.org/W4404844020","https://openalex.org/W4406606492","https://openalex.org/W7163060083"],"related_works":["https://openalex.org/W4409382801","https://openalex.org/W4407126864","https://openalex.org/W3192403893","https://openalex.org/W3025468081","https://openalex.org/W4403673180","https://openalex.org/W3146417451","https://openalex.org/W3112680852","https://openalex.org/W4392845150","https://openalex.org/W3165655898","https://openalex.org/W4213417871"],"abstract_inverted_index":{"INTRODUCTION:":[0],"In":[1,36],"neovascular":[2],"age-related":[3],"macular":[4,117,139],"degeneration":[5],"(AMD),":[6],"complete":[7],"resolution":[8],"of":[9,19,60,87,110,134,145,187],"retinal":[10],"fluid":[11,29,188],"has":[12,150],"traditionally":[13],"been":[14,153],"regarded":[15],"as":[16],"the":[17,39,61,97,108,131,171],"hallmark":[18],"successful":[20],"treatment,":[21],"yet":[22,152],"accumulating":[23],"evidence":[24,41,120],"suggests":[25],"that":[26],"residual":[27,111],"subretinal":[28],"(SRF)":[30],"may":[31,178],"not":[32,151],"be":[33,179],"uniformly":[34],"harmful.":[35],"this":[37],"report,":[38],"cumulative":[40],"supporting":[42],"and":[43,76,95,103,116,130,156,170,190],"qualifying":[44],"an":[45],"'SRF-tolerating'":[46],"treatment":[47],"approach":[48,177],"is":[49,160],"summarized.":[50],"AREAS":[51],"COVERED:":[52],"Relevant":[53],"articles":[54],"were":[55],"identified":[56],"through":[57],"a":[58,104],"search":[59],"PubMed/MEDLINE":[62],"database":[63],"until":[64],"April":[65],"2026,":[66],"using":[67],"terms":[68],"including":[69],"'subretinal":[70],"fluid,'":[71,73],"'intraretinal":[72],"'neovascular":[74],"AMD,'":[75],"'anti-vascular":[77],"endothelial":[78],"growth":[79],"factor.'":[80],"The":[81,143],"report":[82],"discusses":[83],"post":[84],"hoc":[85],"analyses":[86],"major":[88],"clinical":[89,158],"trials":[90],"(CATT,":[91],"VIEW,":[92],"HARBOR,":[93],"ARIES,":[94],"In-Eye),":[96],"randomized":[98],"FLUID":[99],"study,":[100],"real-world":[101],"cohorts,":[102],"recent":[105],"meta-analysis,":[106],"covering":[107],"association":[109],"SRF":[112,126,135,147],"with":[113,127],"visual":[114,191],"acuity":[115,192],"atrophy,":[118],"contrasting":[119],"linking":[121],"large-volume,":[122],"fluctuating,":[123],"or":[124],"prolonged":[125],"poorer":[128],"outcomes,":[129],"distinct":[132],"behavior":[133],"in":[136,181],"type":[137],"3":[138],"neovascularization.":[140],"EXPERT":[141],"OPINION:":[142],"impact":[144],"persistent":[146],"on":[148,164],"outcomes":[149],"fully":[154],"established,":[155],"its":[157,165],"significance":[159],"likely":[161],"to":[162,195],"depend":[163],"volume,":[166],"location,":[167],"stability,":[168],"duration,":[169],"underlying":[172],"lesion":[173],"subtype.":[174],"An":[175],"SRF-tolerating":[176],"considered":[180],"selected":[182],"patients,":[183],"but":[184],"strict":[185],"monitoring":[186],"status":[189],"are":[193],"required":[194],"prevent":[196],"undertreatment.":[197]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-08-12T00:00:00"}