{"id":"https://openalex.org/W7202214691","doi":"https://doi.org/10.1186/s12916-026-05134-x","title":"Current and emerging strategies to enhance chemotherapeutic efficacy in pancreatic ductal adenocarcinoma","display_name":"Current and emerging strategies to enhance chemotherapeutic efficacy in pancreatic ductal adenocarcinoma","publication_year":2026,"publication_date":"2026-08-11","ids":{"openalex":"https://openalex.org/W7202214691","doi":"https://doi.org/10.1186/s12916-026-05134-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/43004418"},"language":"en","primary_location":{"id":"doi:10.1186/s12916-026-05134-x","doi":"https://doi.org/10.1186/s12916-026-05134-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12916-026-05134-x","pdf_url":null,"source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12916-026-05134-x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5153440823","display_name":"David Hackett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"David Hackett","raw_affiliation_strings":["Discipline of Surgery, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland","Trinity St. James's Cancer Institute, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Surgery, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]},{"raw_affiliation_string":"Trinity St. James's Cancer Institute, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013584181","display_name":"Laura E. Kane","orcid":"https://orcid.org/0000-0002-9107-6240","observed_orcids":["https://orcid.org/0000-0002-9107-6240"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Laura E. Kane","raw_affiliation_strings":["Discipline of Surgery, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland","Trinity St. James's Cancer Institute, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Surgery, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]},{"raw_affiliation_string":"Trinity St. James's Cancer Institute, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030283020","display_name":"Adriele Prina\u2010Mello","orcid":"https://orcid.org/0000-0002-4371-2214","observed_orcids":["https://orcid.org/0000-0002-4371-2214"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Adriele Prina-Mello","raw_affiliation_strings":["Nanomedicine Group and Laboratory for Biological Characterisation of Advanced Materials (LBCAM), Department of Clinical Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland","Trinity St. James's Cancer Institute, Trinity College Dublin, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanomedicine Group and Laboratory for Biological Characterisation of Advanced Materials (LBCAM), Department of Clinical Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]},{"raw_affiliation_string":"Trinity St. James's Cancer Institute, Trinity College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075269834","display_name":"Stephen G. Maher","orcid":"https://orcid.org/0000-0003-0126-7906","observed_orcids":["https://orcid.org/0000-0003-0126-7906"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Stephen G. Maher","raw_affiliation_strings":["Discipline of Surgery, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland. maherst@tcd.ie","Trinity St. James's Cancer Institute, Trinity College Dublin, Dublin, Ireland. maherst@tcd.ie"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Surgery, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland. maherst@tcd.ie","institution_ids":["https://openalex.org/I205274468"]},{"raw_affiliation_string":"Trinity St. James's Cancer Institute, Trinity College Dublin, Dublin, Ireland. maherst@tcd.ie","institution_ids":["https://openalex.org/I205274468"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5075269834"],"corresponding_institution_ids":["https://openalex.org/I205274468"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.6629999876022339},{"id":"https://openalex.org/keywords/chemotherapy-efficacy","display_name":"chemotherapy efficacy","score":0.7599999904632568},{"id":"https://openalex.org/keywords/chemosensitizers","display_name":"chemosensitizers","score":0.9079999923706055},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9570000171661377},{"id":"https://openalex.org/keywords/desmoplastic-stroma","display_name":"desmoplastic stroma","score":0.8650000095367432},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8500000238418579},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.9210000038146973},{"id":"https://openalex.org/keywords/mtap","display_name":"MTAP","score":0.9959999918937683},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.9990000128746033},{"id":"https://openalex.org/keywords/claudin-18-2","display_name":"claudin 18.2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/wee1","display_name":"WEE1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8529999852180481}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9681000113487244},{"id":"https://openalex.org/C2992026798","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic ductal adenocarcinoma","level":4,"score":0.8057000041007996},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5655999779701233},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.560699999332428},{"id":"https://openalex.org/C148043351","wikidata":"https://www.wikidata.org/wiki/Q4456944","display_name":"Current (fluid)","level":2,"score":0.4932999908924103},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.3698999881744385},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.36090001463890076},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3522000014781952},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3458999991416931},{"id":"https://openalex.org/C3020076753","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic carcinoma","level":4,"score":0.32670000195503235},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2980000078678131},{"id":"https://openalex.org/C2780862961","wikidata":"https://www.wikidata.org/wiki/Q5311598","display_name":"Ductal carcinoma","level":4,"score":0.26510000228881836},{"id":"https://openalex.org/C2777148230","wikidata":"https://www.wikidata.org/wiki/Q17144959","display_name":"FOLFIRINOX","level":5,"score":0.2635999917984009}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1186/s12916-026-05134-x","doi":"https://doi.org/10.1186/s12916-026-05134-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12916-026-05134-x","pdf_url":null,"source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},{"id":"pmid:43004418","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43004418","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/s12916-026-05134-x","doi":"https://doi.org/10.1186/s12916-026-05134-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12916-026-05134-x","pdf_url":null,"source":{"id":"https://openalex.org/S135560524","display_name":"BMC Medicine","issn_l":"1741-7015","issn":["1741-7015"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6798321670","display_name":null,"funder_award_id":"MBPhD-0122","funder_id":"https://openalex.org/F4320331720","funder_display_name":"Breakthrough Cancer Research"}],"funders":[{"id":"https://openalex.org/F4320331720","display_name":"Breakthrough Cancer Research","ror":"https://ror.org/036ntj052"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":269,"referenced_works":["https://openalex.org/W1497915798","https://openalex.org/W1558905924","https://openalex.org/W1601662735","https://openalex.org/W1780086376","https://openalex.org/W1902180775","https://openalex.org/W1931508686","https://openalex.org/W1971286548","https://openalex.org/W1971298987","https://openalex.org/W1975153720","https://openalex.org/W1980980429","https://openalex.org/W1987313243","https://openalex.org/W1988230026","https://openalex.org/W1991881518","https://openalex.org/W1994177577","https://openalex.org/W1996912024","https://openalex.org/W2004956320","https://openalex.org/W2010283945","https://openalex.org/W2013543641","https://openalex.org/W2015943054","https://openalex.org/W2041903527","https://openalex.org/W2044363258","https://openalex.org/W2047956375","https://openalex.org/W2052617606","https://openalex.org/W2055091294","https://openalex.org/W2062216168","https://openalex.org/W2063117613","https://openalex.org/W2068345698","https://openalex.org/W2079067257","https://openalex.org/W2080280001","https://openalex.org/W2084319978","https://openalex.org/W2088110734","https://openalex.org/W2088812649","https://openalex.org/W2091246492","https://openalex.org/W2092083235","https://openalex.org/W2092100136","https://openalex.org/W2098360608","https://openalex.org/W2112123361","https://openalex.org/W2115658806","https://openalex.org/W2118797060","https://openalex.org/W2120426523","https://openalex.org/W2122041824","https://openalex.org/W2128339707","https://openalex.org/W2130464657","https://openalex.org/W2131441324","https://openalex.org/W2135669426","https://openalex.org/W2138582833","https://openalex.org/W2141941839","https://openalex.org/W2146996882","https://openalex.org/W2147918436","https://openalex.org/W2148660029","https://openalex.org/W2151253787","https://openalex.org/W2154790710","https://openalex.org/W2158134441","https://openalex.org/W2158734599","https://openalex.org/W2160302344","https://openalex.org/W2165480504","https://openalex.org/W2170202192","https://openalex.org/W2171972386","https://openalex.org/W2187917981","https://openalex.org/W2210453860","https://openalex.org/W2236482561","https://openalex.org/W2257573908","https://openalex.org/W2259627090","https://openalex.org/W2271971696","https://openalex.org/W2426351061","https://openalex.org/W2465801062","https://openalex.org/W2508572934","https://openalex.org/W2510391033","https://openalex.org/W2531210961","https://openalex.org/W2566110361","https://openalex.org/W2581973599","https://openalex.org/W2584038912","https://openalex.org/W2588479177","https://openalex.org/W2606436364","https://openalex.org/W2613659776","https://openalex.org/W2621755511","https://openalex.org/W2622499649","https://openalex.org/W2741958124","https://openalex.org/W2745837416","https://openalex.org/W2765354611","https://openalex.org/W2767403472","https://openalex.org/W2768082354","https://openalex.org/W2769960045","https://openalex.org/W2772923107","https://openalex.org/W2780727948","https://openalex.org/W2782767753","https://openalex.org/W2790356839","https://openalex.org/W2791129010","https://openalex.org/W2792327545","https://openalex.org/W2793938850","https://openalex.org/W2798100913","https://openalex.org/W2799575632","https://openalex.org/W2889217475","https://openalex.org/W2890167612","https://openalex.org/W2891603015","https://openalex.org/W2896652675","https://openalex.org/W2898435366","https://openalex.org/W2903623792","https://openalex.org/W2908229190","https://openalex.org/W2909729333","https://openalex.org/W2910105770","https://openalex.org/W2911125781","https://openalex.org/W2912445517","https://openalex.org/W2919944461","https://openalex.org/W2941257841","https://openalex.org/W2944085998","https://openalex.org/W2954610188","https://openalex.org/W2959096163","https://openalex.org/W2968502728","https://openalex.org/W2972545654","https://openalex.org/W2984284890","https://openalex.org/W2984359187","https://openalex.org/W2984642856","https://openalex.org/W2991084017","https://openalex.org/W2993622087","https://openalex.org/W2994278681","https://openalex.org/W3001713806","https://openalex.org/W3003020132","https://openalex.org/W3003574401","https://openalex.org/W3008190574","https://openalex.org/W3008379955","https://openalex.org/W3011562658","https://openalex.org/W3012839541","https://openalex.org/W3014882016","https://openalex.org/W3017314211","https://openalex.org/W3021137054","https://openalex.org/W3022265443","https://openalex.org/W3036393903","https://openalex.org/W3042344811","https://openalex.org/W3042953038","https://openalex.org/W3044807317","https://openalex.org/W3085590770","https://openalex.org/W3087232085","https://openalex.org/W3089277249","https://openalex.org/W3097509991","https://openalex.org/W3101939854","https://openalex.org/W3108774824","https://openalex.org/W3111723945","https://openalex.org/W3114152881","https://openalex.org/W3116290443","https://openalex.org/W3126766669","https://openalex.org/W3128733970","https://openalex.org/W3130117796","https://openalex.org/W3132199378","https://openalex.org/W3136036415","https://openalex.org/W3146983201","https://openalex.org/W3153075376","https://openalex.org/W3161692269","https://openalex.org/W3162365966","https://openalex.org/W3167955109","https://openalex.org/W3169750602","https://openalex.org/W3172916716","https://openalex.org/W3176534616","https://openalex.org/W3178275964","https://openalex.org/W3186969813","https://openalex.org/W3189374483","https://openalex.org/W3191803175","https://openalex.org/W3197559541","https://openalex.org/W3200900608","https://openalex.org/W3204487449","https://openalex.org/W3207227589","https://openalex.org/W3208047819","https://openalex.org/W3209508921","https://openalex.org/W3212307488","https://openalex.org/W4200034683","https://openalex.org/W4200299203","https://openalex.org/W4205177974","https://openalex.org/W4205355255","https://openalex.org/W4205933836","https://openalex.org/W4206432791","https://openalex.org/W4206528874","https://openalex.org/W4210426142","https://openalex.org/W4210438451","https://openalex.org/W4211253487","https://openalex.org/W4220685687","https://openalex.org/W4220878944","https://openalex.org/W4223653113","https://openalex.org/W4281623889","https://openalex.org/W4282037063","https://openalex.org/W4284886018","https://openalex.org/W4284887854","https://openalex.org/W4285386328","https://openalex.org/W4286296272","https://openalex.org/W4293109639","https://openalex.org/W4294001741","https://openalex.org/W4304144165","https://openalex.org/W4311114400","https://openalex.org/W4311292692","https://openalex.org/W4311425047","https://openalex.org/W4311672560","https://openalex.org/W4312094134","https://openalex.org/W4312186426","https://openalex.org/W4316174652","https://openalex.org/W4323572378","https://openalex.org/W4360610306","https://openalex.org/W4376133743","https://openalex.org/W4379282192","https://openalex.org/W4379984464","https://openalex.org/W4379984508","https://openalex.org/W4384339320","https://openalex.org/W4385628554","https://openalex.org/W4385830709","https://openalex.org/W4385931420","https://openalex.org/W4386030602","https://openalex.org/W4386279361","https://openalex.org/W4386528862","https://openalex.org/W4386614978","https://openalex.org/W4387007701","https://openalex.org/W4387722601","https://openalex.org/W4388662516","https://openalex.org/W4388785190","https://openalex.org/W4389238917","https://openalex.org/W4391145275","https://openalex.org/W4391319242","https://openalex.org/W4391514138","https://openalex.org/W4391659120","https://openalex.org/W4392403685","https://openalex.org/W4399795849","https://openalex.org/W4399940228","https://openalex.org/W4400272832","https://openalex.org/W4400273026","https://openalex.org/W4400416899","https://openalex.org/W4400418559","https://openalex.org/W4401630500","https://openalex.org/W4402452339","https://openalex.org/W4402560254","https://openalex.org/W4402581170","https://openalex.org/W4404313672","https://openalex.org/W4404649102","https://openalex.org/W4405051006","https://openalex.org/W4405135267","https://openalex.org/W4405421471","https://openalex.org/W4406869397","https://openalex.org/W4406869769","https://openalex.org/W4407722177","https://openalex.org/W4408152748","https://openalex.org/W4409110383","https://openalex.org/W4409691038","https://openalex.org/W4410866403","https://openalex.org/W4412041524","https://openalex.org/W4412403886","https://openalex.org/W4412538269","https://openalex.org/W4413100243","https://openalex.org/W4413147816","https://openalex.org/W4414952043","https://openalex.org/W4415673450","https://openalex.org/W4415941821","https://openalex.org/W4416444936","https://openalex.org/W4416925880","https://openalex.org/W4417245295","https://openalex.org/W7122540716","https://openalex.org/W7122580740","https://openalex.org/W7122807723","https://openalex.org/W7123452202","https://openalex.org/W7123691167","https://openalex.org/W7126050090","https://openalex.org/W7129273090","https://openalex.org/W7138944575","https://openalex.org/W7140092697","https://openalex.org/W7140812529","https://openalex.org/W7154747457","https://openalex.org/W7155551129","https://openalex.org/W7160097917","https://openalex.org/W7161020861","https://openalex.org/W7162551120","https://openalex.org/W7162952636","https://openalex.org/W7168589269","https://openalex.org/W7168652900","https://openalex.org/W7169180681"],"related_works":["https://openalex.org/W4413870350","https://openalex.org/W4411898197","https://openalex.org/W7155511760","https://openalex.org/W4412393052","https://openalex.org/W4297476727","https://openalex.org/W4281557572","https://openalex.org/W7135650409","https://openalex.org/W1963917068","https://openalex.org/W2076067964","https://openalex.org/W2041343513"],"abstract_inverted_index":{"BACKGROUND:":[0],"Pancreatic":[1,67],"cancer":[2,145],"remains":[3],"one":[4],"of":[5,13,33,92,97,114,141],"the":[6,31,34,86,89,112,138],"most":[7],"aggressive":[8],"solid":[9],"malignancies.":[10],"The":[11],"majority":[12],"patients":[14],"present":[15,127],"with":[16],"locally":[17],"advanced":[18],"or":[19],"metastatic":[20,74],"disease,":[21],"limiting":[22],"treatment":[23],"options":[24],"to":[25,60,100,110,156],"systemic":[26],"chemotherapy.":[27,115],"Conventional":[28],"chemotherapy":[29,62,142],"forms":[30],"backbone":[32],"standard-of-care":[35,51],"regimen":[36],"and":[37,53,81,124],"offers":[38],"modest":[39],"but":[40],"significant":[41],"survival":[42],"benefits.":[43],"MAIN":[44],"BODY:":[45],"This":[46],"review":[47],"discusses":[48],"currently":[49],"established":[50],"regimens":[52],"cutting":[54],"edge":[55],"clinical":[56,90,148],"trials":[57],"which":[58,126],"aim":[59,109],"enhance":[61,111],"efficacy":[63,113,153],"in":[64,143],"pancreatic":[65,144],"cancer.":[66],"cancer's":[68],"distinct":[69],"pathological":[70],"features-including":[71],"its":[72,152],"high":[73],"potential,":[75],"inherent":[76],"chemoresistance,":[77],"dense":[78],"desmoplastic":[79],"stroma,":[80],"profoundly":[82],"immunosuppressive":[83],"tumour":[84],"microenvironment-underscore":[85],"rationale":[87],"for":[88,130,160],"development":[91],"chemosensitizing":[93],"agents.":[94],"As":[95],"mechanisms":[96],"chemoresistance":[98],"continue":[99],"be":[101],"uncovered,":[102],"new":[103],"therapeutic":[104],"avenues":[105],"are":[106,134,154],"emerging":[107],"that":[108,150],"Emerging":[116],"targets":[117],"including":[118],"KRAS,":[119],"MTAP,":[120],"EGFR,":[121],"Claudin":[122],"18.2,":[123],"WEE1,":[125],"unique":[128],"vulnerabilities":[129],"rational":[131],"combination":[132],"therapies,":[133],"discussed.":[135],"CONCLUSION:":[136],"Given":[137],"central":[139],"role":[140],"treatment,":[146],"ongoing":[147],"strategies":[149],"improve":[151],"essential":[155],"achieving":[157],"better":[158],"outcomes":[159],"patients.":[161]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-08-12T00:00:00"}
