{"id":"https://openalex.org/W7202210506","doi":"https://doi.org/10.3390/ijms27198709","title":"Advances in Somatostatin Receptor-Targeting Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumors: Biological Rationale, Combination Strategies, and Clinical Perspectives","display_name":"Advances in Somatostatin Receptor-Targeting Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumors: Biological Rationale, Combination Strategies, and Clinical Perspectives","publication_year":2026,"publication_date":"2026-09-29","ids":{"openalex":"https://openalex.org/W7202210506","doi":"https://doi.org/10.3390/ijms27198709","pmid":"https://pubmed.ncbi.nlm.nih.gov/42883952","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13665047"},"language":"en","primary_location":{"id":"doi:10.3390/ijms27198709","doi":"https://doi.org/10.3390/ijms27198709","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27198709","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms27198709","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5094082616","display_name":"Hana Bakr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hana Bakr","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084635418","display_name":"Amin Al-Awar","orcid":"https://orcid.org/0000-0002-3199-2634","observed_orcids":["https://orcid.org/0000-0002-3199-2634","https://orcid.org/0000-0002-5870-5009"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amin Al-Awar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048819262","display_name":"Johan K. E. Spetz","orcid":"https://orcid.org/0000-0002-5216-9786","observed_orcids":["https://orcid.org/0000-0002-5216-9786"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johan K.E. Spetz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5216-9786","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5069898768","display_name":"Eva B. Forssell-Aronsson","orcid":"https://orcid.org/0000-0002-7558-4368","observed_orcids":["https://orcid.org/0000-0002-7558-4368"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Eva Forssell-Aronsson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7558-4368","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5069898768"],"corresponding_institution_ids":[],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.8361,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.77004522,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"27","issue":"19","first_page":"8709","last_page":"8709"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peptide-receptor-radionuclide-therapy","display_name":"peptide receptor radionuclide therapy","score":0.9559999704360962},{"id":"https://openalex.org/keywords/somatostatin-receptors","display_name":"somatostatin receptors","score":0.9039999842643738},{"id":"https://openalex.org/keywords/neuroendocrine-tumors","display_name":"neuroendocrine tumors","score":0.8840000033378601},{"id":"https://openalex.org/keywords/gastroenteropancreatic-neuroendocrine-tumors","display_name":"gastroenteropancreatic neuroendocrine tumors","score":0.9559999704360962},{"id":"https://openalex.org/keywords/177lu-dotatate","display_name":"177Lu-DOTATATE","score":0.9909999966621399},{"id":"https://openalex.org/keywords/radiolabeled-somatostatin-analogs","display_name":"radiolabeled somatostatin analogs","score":0.9240000247955322},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6679999828338623},{"id":"https://openalex.org/keywords/dna-repair-inhibitors","display_name":"DNA repair inhibitors","score":0.6679999828338623},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.8529999852180481},{"id":"https://openalex.org/keywords/dna-pk-inhibitor","display_name":"DNA-PK inhibitor","score":0.8259999752044678},{"id":"https://openalex.org/keywords/hsp90-inhibitors","display_name":"Hsp90 inhibitors","score":0.9789999723434448},{"id":"https://openalex.org/keywords/epigenetic-modifiers","display_name":"epigenetic regulators","score":0.7979999780654907},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.7929999828338623},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.6179999709129333},{"id":"https://openalex.org/keywords/personalized-dosimetry","display_name":"personalized dosimetry","score":0.8059999942779541},{"id":"https://openalex.org/keywords/mtor-inhibitors","display_name":"mTOR inhibitors","score":0.6809999942779541},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.921999990940094},{"id":"https://openalex.org/keywords/hedgehog-pathway-inhibitors","display_name":"Hedgehog pathway inhibitors","score":0.8619999885559082},{"id":"https://openalex.org/keywords/nampt-inhibitors","display_name":"NAMPT inhibitors","score":0.9480000138282776},{"id":"https://openalex.org/keywords/p53-stabilization","display_name":"p53 stabilization","score":0.9929999709129333}],"concepts":[{"id":"https://openalex.org/C80115893","wikidata":"https://www.wikidata.org/wiki/Q2067077","display_name":"Somatostatin receptor","level":3,"score":0.8210999965667725},{"id":"https://openalex.org/C2779066768","wikidata":"https://www.wikidata.org/wiki/Q1981276","display_name":"Neuroendocrine tumors","level":2,"score":0.6776000261306763},{"id":"https://openalex.org/C2779371878","wikidata":"https://www.wikidata.org/wiki/Q3896970","display_name":"Pasireotide","level":5,"score":0.6420999765396118},{"id":"https://openalex.org/C2993559085","wikidata":"https://www.wikidata.org/wiki/Q2126444","display_name":"Radionuclide therapy","level":2,"score":0.6179999709129333},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6171000003814697},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6164000034332275},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5586000084877014},{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.5066999793052673},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.47870001196861267},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4343999922275543},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.3889999985694885},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.37869998812675476},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3774999976158142},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.358599990606308},{"id":"https://openalex.org/C3017732841","wikidata":"https://www.wikidata.org/wiki/Q25098597","display_name":"Peptide receptor","level":3,"score":0.3375999927520752},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3231000006198883},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3231000006198883},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3176000118255615},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3131999969482422},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.30649998784065247},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.3027999997138977},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.30140000581741333},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29589998722076416},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.28949999809265137},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.28929999470710754},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.2849000096321106},{"id":"https://openalex.org/C2781025020","wikidata":"https://www.wikidata.org/wiki/Q419935","display_name":"Octreotide","level":3,"score":0.2824999988079071},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.2687000036239624}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011868","descriptor_name":"Radioisotopes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015282","descriptor_name":"Octreotide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D015282","descriptor_name":"Octreotide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017481","descriptor_name":"Receptors, Somatostatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018358","descriptor_name":"Neuroendocrine Tumors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018358","descriptor_name":"Neuroendocrine Tumors","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms27198709","doi":"https://doi.org/10.3390/ijms27198709","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27198709","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"doi:10.20944/preprints202608.0689.v1","doi":"https://doi.org/10.20944/preprints202608.0689.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202608.0689.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13665047","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13665047/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13665047/pdf/ijms-27-08709.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:42883952","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42883952","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms27198709","doi":"https://doi.org/10.3390/ijms27198709","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27198709","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1969289855","display_name":null,"funder_award_id":"232975","funder_id":"https://openalex.org/F4320321491","funder_display_name":"Cancerfonden"},{"id":"https://openalex.org/G4647091481","display_name":null,"funder_award_id":"2021-02636","funder_id":"https://openalex.org/F4320321491","funder_display_name":"Cancerfonden"},{"id":"https://openalex.org/G6694590956","display_name":"Molecular radionuclide therapy (MRNT) of neuroendocrine tumours and breast cancer: Novel treatment strategies","funder_award_id":"2021-02636","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"}],"funders":[{"id":"https://openalex.org/F4320311291","display_name":"Kungl. Vetenskaps- och Vitterhets-Samh\u00e4llet i G\u00f6teborg","ror":"https://ror.org/035mcxx74"},{"id":"https://openalex.org/F4320321491","display_name":"Cancerfonden","ror":"https://ror.org/0527jb766"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320323416","display_name":"Sahlgrenska Universitetssjukhuset","ror":"https://ror.org/04vgqjj36"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7202210506.pdf","grobid_xml":"https://content.openalex.org/works/W7202210506.grobid-xml"},"referenced_works_count":259,"referenced_works":["https://openalex.org/W587945571","https://openalex.org/W1508955841","https://openalex.org/W1525734370","https://openalex.org/W1686539570","https://openalex.org/W1845264055","https://openalex.org/W1892562842","https://openalex.org/W1900790478","https://openalex.org/W1965239527","https://openalex.org/W1965292383","https://openalex.org/W1966675362","https://openalex.org/W1967665878","https://openalex.org/W1969170786","https://openalex.org/W1971493425","https://openalex.org/W1972443124","https://openalex.org/W1980444527","https://openalex.org/W1985153805","https://openalex.org/W1988986189","https://openalex.org/W1993365120","https://openalex.org/W1994266647","https://openalex.org/W2000749364","https://openalex.org/W2002989784","https://openalex.org/W2003806136","https://openalex.org/W2006830353","https://openalex.org/W2012883094","https://openalex.org/W2016356824","https://openalex.org/W2017550948","https://openalex.org/W2018913523","https://openalex.org/W2026143081","https://openalex.org/W2027676394","https://openalex.org/W2028793063","https://openalex.org/W2029425304","https://openalex.org/W2030082720","https://openalex.org/W2034427801","https://openalex.org/W2037890961","https://openalex.org/W2038629978","https://openalex.org/W2042767677","https://openalex.org/W2045153367","https://openalex.org/W2045927962","https://openalex.org/W2049693836","https://openalex.org/W2050083847","https://openalex.org/W2050861850","https://openalex.org/W2061019285","https://openalex.org/W2064609355","https://openalex.org/W2073692301","https://openalex.org/W2074061487","https://openalex.org/W2080163983","https://openalex.org/W2080232093","https://openalex.org/W2080667014","https://openalex.org/W2080916065","https://openalex.org/W2088344186","https://openalex.org/W2091303227","https://openalex.org/W2093693472","https://openalex.org/W2094377580","https://openalex.org/W2099478219","https://openalex.org/W2100945326","https://openalex.org/W2102617530","https://openalex.org/W2111117263","https://openalex.org/W2111689182","https://openalex.org/W2117247812","https://openalex.org/W2119501407","https://openalex.org/W2119700304","https://openalex.org/W2119777818","https://openalex.org/W2119921005","https://openalex.org/W2123433901","https://openalex.org/W2123715993","https://openalex.org/W2125398839","https://openalex.org/W2128544796","https://openalex.org/W2128596214","https://openalex.org/W2134152344","https://openalex.org/W2135593703","https://openalex.org/W2136146667","https://openalex.org/W2146320180","https://openalex.org/W2152185113","https://openalex.org/W2154745425","https://openalex.org/W2155775593","https://openalex.org/W2156731811","https://openalex.org/W2173300126","https://openalex.org/W2178639867","https://openalex.org/W2178853365","https://openalex.org/W2179237675","https://openalex.org/W2238041893","https://openalex.org/W2264682687","https://openalex.org/W2327663281","https://openalex.org/W2343978366","https://openalex.org/W2400120669","https://openalex.org/W2411559315","https://openalex.org/W2490739915","https://openalex.org/W2514976083","https://openalex.org/W2525884013","https://openalex.org/W2528183884","https://openalex.org/W2562712448","https://openalex.org/W2566496356","https://openalex.org/W2573369749","https://openalex.org/W2575947145","https://openalex.org/W2589112207","https://openalex.org/W2593666155","https://openalex.org/W2607151521","https://openalex.org/W2732346161","https://openalex.org/W2736228003","https://openalex.org/W2744586752","https://openalex.org/W2753761135","https://openalex.org/W2766623255","https://openalex.org/W2770861412","https://openalex.org/W2773668357","https://openalex.org/W2782614284","https://openalex.org/W2786723185","https://openalex.org/W2789923927","https://openalex.org/W2790846744","https://openalex.org/W2793878036","https://openalex.org/W2795287337","https://openalex.org/W2796636484","https://openalex.org/W2809957686","https://openalex.org/W2884314425","https://openalex.org/W2887096445","https://openalex.org/W2888881214","https://openalex.org/W2902100905","https://openalex.org/W2902656640","https://openalex.org/W2904469815","https://openalex.org/W2910557751","https://openalex.org/W2912381977","https://openalex.org/W2912853437","https://openalex.org/W2915601865","https://openalex.org/W2933425479","https://openalex.org/W2940207815","https://openalex.org/W2944006666","https://openalex.org/W2945556306","https://openalex.org/W2947625409","https://openalex.org/W2951468414","https://openalex.org/W2962109721","https://openalex.org/W2971865138","https://openalex.org/W2973418041","https://openalex.org/W2980748519","https://openalex.org/W2983430850","https://openalex.org/W2984721232","https://openalex.org/W2995876751","https://openalex.org/W2995898384","https://openalex.org/W2998620817","https://openalex.org/W3007008362","https://openalex.org/W3009711324","https://openalex.org/W3013074566","https://openalex.org/W3014813838","https://openalex.org/W3016240204","https://openalex.org/W3022486080","https://openalex.org/W3025274926","https://openalex.org/W3028700108","https://openalex.org/W3036666213","https://openalex.org/W3039984371","https://openalex.org/W3040054525","https://openalex.org/W3048653545","https://openalex.org/W3049583962","https://openalex.org/W3080226707","https://openalex.org/W3087682866","https://openalex.org/W3103404395","https://openalex.org/W3120206025","https://openalex.org/W3132615335","https://openalex.org/W3133553083","https://openalex.org/W3151991663","https://openalex.org/W3153955088","https://openalex.org/W3157076486","https://openalex.org/W3157209351","https://openalex.org/W3163719982","https://openalex.org/W3164095051","https://openalex.org/W3164594267","https://openalex.org/W3168590102","https://openalex.org/W3169169220","https://openalex.org/W3172453970","https://openalex.org/W3194219904","https://openalex.org/W3195671824","https://openalex.org/W3198176993","https://openalex.org/W3203242711","https://openalex.org/W3204460422","https://openalex.org/W3214097436","https://openalex.org/W4205127029","https://openalex.org/W4205249282","https://openalex.org/W4205908401","https://openalex.org/W4206395168","https://openalex.org/W4206552444","https://openalex.org/W4213456659","https://openalex.org/W4224951983","https://openalex.org/W4225155342","https://openalex.org/W4280566091","https://openalex.org/W4285597274","https://openalex.org/W4302022854","https://openalex.org/W4307284894","https://openalex.org/W4308648845","https://openalex.org/W4309722772","https://openalex.org/W4310525084","https://openalex.org/W4313578759","https://openalex.org/W4315643170","https://openalex.org/W4362633408","https://openalex.org/W4362677780","https://openalex.org/W4365446410","https://openalex.org/W4379384853","https://openalex.org/W4381486995","https://openalex.org/W4384038598","https://openalex.org/W4384818879","https://openalex.org/W4385212580","https://openalex.org/W4386200638","https://openalex.org/W4386263943","https://openalex.org/W4386387886","https://openalex.org/W4387563326","https://openalex.org/W4387940634","https://openalex.org/W4388006650","https://openalex.org/W4388622752","https://openalex.org/W4390484371","https://openalex.org/W4391691867","https://openalex.org/W4393253290","https://openalex.org/W4395464137","https://openalex.org/W4397043065","https://openalex.org/W4398228967","https://openalex.org/W4399143463","https://openalex.org/W4399369977","https://openalex.org/W4400582179","https://openalex.org/W4400788760","https://openalex.org/W4401476321","https://openalex.org/W4401528179","https://openalex.org/W4402581225","https://openalex.org/W4404548396","https://openalex.org/W4404572903","https://openalex.org/W4406174977","https://openalex.org/W4407936910","https://openalex.org/W4408020669","https://openalex.org/W4408574024","https://openalex.org/W4409052290","https://openalex.org/W4409161738","https://openalex.org/W4409329938","https://openalex.org/W4409760896","https://openalex.org/W4410613452","https://openalex.org/W4410723214","https://openalex.org/W4410761422","https://openalex.org/W4413004589","https://openalex.org/W4413106589","https://openalex.org/W4415388563","https://openalex.org/W4415614678","https://openalex.org/W4416206393","https://openalex.org/W4416237396","https://openalex.org/W4416452427","https://openalex.org/W4417246278","https://openalex.org/W7119514559","https://openalex.org/W7124424037","https://openalex.org/W7125827663","https://openalex.org/W7126022412","https://openalex.org/W7128704039","https://openalex.org/W7128916404","https://openalex.org/W7131252367","https://openalex.org/W7131669961","https://openalex.org/W7134975865","https://openalex.org/W7140658527","https://openalex.org/W7160716623","https://openalex.org/W7161721373","https://openalex.org/W7163016445","https://openalex.org/W7163580059","https://openalex.org/W7163653455","https://openalex.org/W7164928353","https://openalex.org/W7167016756","https://openalex.org/W7167257429","https://openalex.org/W7169654524","https://openalex.org/W7171500043","https://openalex.org/W7213225119"],"related_works":["https://openalex.org/W7128916404","https://openalex.org/W3132567480","https://openalex.org/W2795287337","https://openalex.org/W2911101562","https://openalex.org/W4310040010","https://openalex.org/W2120609864","https://openalex.org/W828941302","https://openalex.org/W4408318917","https://openalex.org/W4313701340","https://openalex.org/W3198024920"],"abstract_inverted_index":{"Gastroenteropancreatic":[0],"(GEP)":[1],"neuroendocrine":[2],"tumors":[3],"(NETs)":[4],"are":[5,73],"the":[6],"most":[7],"common":[8],"subtype":[9],"of":[10,80,110,160],"NETs,":[11,43],"and":[12,28,46,59,63,83,102,115,121,127,130,152,167,175],"their":[13],"incidence":[14],"continues":[15],"to":[16,66,172],"increase":[17],"worldwide.":[18],"Many":[19],"NETs":[20],"express":[21],"somatostatin":[22,32,97],"receptors":[23],"(SSTRs),":[24],"enabling":[25],"molecular":[26],"imaging":[27],"treatment":[29,39],"with":[30,57,180],"radiolabeled":[31],"analogs":[33],"(SSTAs).":[34],"[177Lu]Lu-DOTATATE":[35,58],"is":[36,170],"an":[37],"established":[38],"for":[40,178],"advanced":[41],"SSTR-positive":[42],"but":[44],"complete":[45],"durable":[47],"responses":[48],"remain":[49,155],"uncommon.":[50],"This":[51],"review":[52],"summarizes":[53],"current":[54],"clinical":[55,139],"experience":[56],"emerging":[60],"SSTR-targeting":[61],"radiopharmaceuticals":[62],"examines":[64],"strategies":[65,107],"improve":[67,176],"PRRT":[68,174],"efficacy.":[69],"Two":[70],"complementary":[71],"approaches":[72],"emphasized:":[74],"increasing":[75],"tumor":[76,119],"uptake":[77],"through":[78,87],"modulation":[79],"SSTR":[81,89],"expression":[82],"enhancing":[84],"radiation":[85,95],"response":[86],"radiosensitization.":[88],"upregulation":[90],"has":[91],"been":[92],"investigated":[93],"using":[94],"priming,":[96],"analog":[98],"pretreatment,":[99],"epigenetic":[100,153],"modifiers,":[101],"selected":[103],"pharmacological":[104],"agents.":[105],"Radiosensitization":[106],"include":[108],"inhibition":[109],"DNA":[111],"repair,":[112],"cellular":[113],"stress-response":[114],"oncogenic":[116],"signaling":[117],"pathways,":[118],"metabolism,":[120],"immune":[122],"checkpoint":[123],"signaling.":[124],"PARP,":[125],"DNA-PK,":[126],"HSP90":[128],"inhibitors":[129],"chemotherapy-based":[131],"combinations":[132,169],"have":[133],"shown":[134],"particularly":[135],"strong":[136],"preclinical":[137],"or":[138],"evidence,":[140],"whereas":[141],"mTOR":[142],"inhibitors,":[143,146,148,151],"tyrosine":[144],"kinase":[145],"Hedgehog":[147],"immunotherapy,":[149],"NAMPT":[150],"modifiers":[154],"under":[156],"investigation.":[157],"Ongoing":[158],"development":[159],"novel":[161],"radiopharmaceuticals,":[162],"personalized":[163],"dosimetry,":[164],"retreatment":[165],"strategies,":[166],"rational":[168],"expected":[171],"refine":[173],"outcomes":[177],"patients":[179],"NETs.":[181]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-08-12T00:00:00"}
