{"id":"https://openalex.org/W7202201869","doi":"https://doi.org/10.1186/s12979-026-00590-8","title":"JUND-DNAJB1-p21 axis drives fibroblast senescence to recruit CD4\u207a T cells in salivary gland pathogenesis of Sj\u00f6gren\u2019s disease","display_name":"JUND-DNAJB1-p21 axis drives fibroblast senescence to recruit CD4\u207a T cells in salivary gland pathogenesis of Sj\u00f6gren\u2019s disease","publication_year":2026,"publication_date":"2026-08-11","ids":{"openalex":"https://openalex.org/W7202201869","doi":"https://doi.org/10.1186/s12979-026-00590-8"},"language":"en","primary_location":{"id":"doi:10.1186/s12979-026-00590-8","doi":"https://doi.org/10.1186/s12979-026-00590-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12979-026-00590-8","pdf_url":null,"source":{"id":"https://openalex.org/S183475463","display_name":"Immunity & Ageing","issn_l":"1742-4933","issn":["1742-4933"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity &amp; Ageing","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12979-026-00590-8","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100944291","display_name":"Yingliang Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingliang Shi","raw_affiliation_strings":["State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146522384","display_name":"Yi Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Guo","raw_affiliation_strings":["State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086641520","display_name":"H K Tu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128042","display_name":"Stomatological Hospital of Chongqing Medical University","ror":"https://ror.org/02bnr5073","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hanlin Tu","raw_affiliation_strings":["The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I4210128042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146461304","display_name":"Jiaqi Yue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaqi Yue","raw_affiliation_strings":["State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101391258","display_name":"Zhongyang Zou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongyang Zou","raw_affiliation_strings":["State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146444075","display_name":"Yuyan He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuyan He","raw_affiliation_strings":["State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146542323","display_name":"Jing Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Zhou","raw_affiliation_strings":["State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146509589","display_name":"Xiang Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122157","display_name":"Hubei Polytechnic University","ror":"https://ror.org/01z07eq06","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210122157"]},{"id":"https://openalex.org/I4210161227","display_name":"Huangshi Central Hospital","ror":"https://ror.org/05ncqj764","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161227"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang Li","raw_affiliation_strings":["Department of Stomatology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Huangshi, China","Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, Huangshi, 435000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stomatology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Huangshi, China","institution_ids":["https://openalex.org/I4210122157","https://openalex.org/I4210161227"]},{"raw_affiliation_string":"Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, Huangshi, 435000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065444939","display_name":"Sangang He","orcid":"https://orcid.org/0000-0001-8684-8878","observed_orcids":["https://orcid.org/0000-0001-8684-8878"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Sangang He","raw_affiliation_strings":["Department of Oral and Maxillofacial surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, 430079, China","State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, 430079, China","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078591256","display_name":"Guoliang Sa","orcid":"https://orcid.org/0000-0002-4069-7231","observed_orcids":["https://orcid.org/0000-0002-4069-7231"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guoliang Sa","raw_affiliation_strings":["Department of Oral and Maxillofacial surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, 430079, China","State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, 430079, China","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China","institution_ids":["https://openalex.org/I37461747"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5065444939","https://openalex.org/A5078591256"],"corresponding_institution_ids":["https://openalex.org/I37461747"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.54421513,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-sjogren-syndrome","display_name":"primary Sj\u00f6gren's syndrome","score":0.9890000224113464},{"id":"https://openalex.org/keywords/fibroblast-senescence","display_name":"fibroblast senescence","score":0.9810000061988831},{"id":"https://openalex.org/keywords/dnajb1","display_name":"DNAJB1","score":0.8289999961853027},{"id":"https://openalex.org/keywords/jund","display_name":"JunD","score":0.9649999737739563},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cd4-t-cell-recruitment","display_name":"CD4+ T cell recruitment","score":0.875},{"id":"https://openalex.org/keywords/salivary-glands","display_name":"salivary glands","score":0.6600000262260437},{"id":"https://openalex.org/keywords/senolytics","display_name":"senolytics","score":0.7720000147819519},{"id":"https://openalex.org/keywords/dasatinib","display_name":"dasatinib","score":0.9380000233650208},{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":1.0},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9750000238418579},{"id":"https://openalex.org/keywords/autoimmune-inflammation","display_name":"autoimmune inflammation","score":0.5479999780654907},{"id":"https://openalex.org/keywords/salivary-flow","display_name":"salivary flow","score":0.6179999709129333},{"id":"https://openalex.org/keywords/lymphocytic-infiltration","display_name":"lymphocyte infiltration","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.7452999949455261},{"id":"https://openalex.org/C2778937882","wikidata":"https://www.wikidata.org/wiki/Q134938","display_name":"Salivary gland","level":2,"score":0.6789000034332275},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.6668000221252441},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5932000279426575},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5060999989509583},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4722999930381775},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4593999981880188},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44020000100135803},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4350999891757965},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4083999991416931},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3635999858379364},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3382999897003174},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.3296000063419342},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3224000036716461},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.3172000050544739},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3127000033855438},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.31040000915527344},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.30959999561309814},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.30559998750686646},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.2989000082015991},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.29600000381469727},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28949999809265137},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2865000069141388},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.27810001373291016},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27630001306533813},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.274399995803833},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.2671000063419342},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.26100000739097595},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.26089999079704285},{"id":"https://openalex.org/C11988809","wikidata":"https://www.wikidata.org/wiki/Q412889","display_name":"Interleukin 6","level":3,"score":0.25679999589920044},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.2565000057220459},{"id":"https://openalex.org/C6045943","wikidata":"https://www.wikidata.org/wiki/Q21014462","display_name":"Immortalised cell line","level":3,"score":0.2500999867916107}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s12979-026-00590-8","doi":"https://doi.org/10.1186/s12979-026-00590-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12979-026-00590-8","pdf_url":null,"source":{"id":"https://openalex.org/S183475463","display_name":"Immunity & Ageing","issn_l":"1742-4933","issn":["1742-4933"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity &amp; Ageing","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s12979-026-00590-8","doi":"https://doi.org/10.1186/s12979-026-00590-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12979-026-00590-8","pdf_url":null,"source":{"id":"https://openalex.org/S183475463","display_name":"Immunity & Ageing","issn_l":"1742-4933","issn":["1742-4933"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunity &amp; Ageing","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1913314107","display_name":null,"funder_award_id":"82571069","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8044158939","display_name":null,"funder_award_id":"2024AFB563","funder_id":"https://openalex.org/F4320322186","funder_display_name":"Natural Science Foundation of Hubei Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322186","display_name":"Natural Science Foundation of Hubei Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4399482058","https://openalex.org/W4415729550","https://openalex.org/W7164734799","https://openalex.org/W4392780133","https://openalex.org/W3183638965","https://openalex.org/W3012083974","https://openalex.org/W7140211210","https://openalex.org/W6892122778","https://openalex.org/W7000449983","https://openalex.org/W7169792410"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Advanced":[2],"age":[3],"is":[4],"a":[5,15,128,141,164,191,205,275],"recognized":[6],"risk":[7],"factor":[8],"for":[9,17,279],"primary":[10,93],"Sj\u00f6gren\u2019s":[11],"disease":[12],"(pSjD),":[13],"suggesting":[14],"role":[16,39],"aging-related":[18],"mechanisms":[19,55],"in":[20,63,170,179,201,220,233,266],"its":[21,60],"pathogenesis.":[22],"However,":[23],"whether":[24],"cellular":[25],"senescence":[26,58,67,225,262],"directly":[27],"drives":[28],"autoimmune":[29,264],"inflammation":[30],"and":[31,59,78,86,115,145,151,161,186,200,226,263],"glandular":[32,244,281],"dysfunction":[33],"remains":[34],"unclear.":[35],"Furthermore,":[36,232],"the":[37,44,54,123,138,238,243,248,256],"specific":[38],"of":[40,69,140,157,167,176,194,270],"senescent":[41,168,177,271],"fibroblasts":[42,96,169],"within":[43],"pSjD":[45,171],"microenvironment":[46],"has":[47],"not":[48],"been":[49],"defined.":[50],"This":[51],"study":[52],"investigates":[53],"underlying":[56,124],"fibroblast":[57,195,209,261],"therapeutic":[61,277],"potential":[62,276],"pSjD.":[64,267],"Methods":[65],"The":[66],"landscape":[68],"salivary":[70,94,148,172,188],"glands":[71],"was":[72,134,219],"assessed":[73],"by":[74],"immunohistochemistry,":[75],"multiplex":[76],"immunofluorescence,":[77],"single-cell":[79],"RNA":[80],"sequencing,":[81],"coupled":[82],"with":[83,100,223],"computational":[84,198],"trajectory":[85],"gene":[87],"regulatory":[88],"network":[89],"inference.":[90],"In":[91,126],"vitro,":[92],"gland":[95],"(SGFs)":[97],"were":[98,119],"treated":[99],"interferon-gamma":[101],"(IFN-\u03b3).":[102],"Senescence-associated":[103],"\u03b2-galactosidase":[104],"staining,":[105],"reactive":[106],"oxygen":[107],"species":[108],"detection,":[109],"siRNA":[110],"knockdown,":[111],"co-immunoprecipitation,":[112],"dual-luciferase":[113],"reporter,":[114],"transwell":[116],"migration":[117],"assays":[118],"conducted":[120],"to":[121,136,260],"elucidate":[122],"mechanisms.":[125],"vivo,":[127],"non-obese":[129],"diabetic":[130],"(NOD)":[131],"mouse":[132],"model":[133],"utilized":[135],"evaluate":[137],"efficacy":[139],"senolytic":[142,239],"combination":[143],"(dasatinib":[144],"quercetin)":[146],"on":[147],"flow":[149],"rates":[150],"lymphocytic":[152,184],"infiltration.":[153],"Results":[154],"Integrative":[155],"analysis":[156],"human":[158],"clinical":[159],"samples":[160],"scRNA-seq":[162],"revealed":[163],"significant":[165],"accumulation":[166],"glands.":[173],"Pharmacological":[174],"clearance":[175,269],"cells":[178,272],"NOD":[180],"mice":[181],"significantly":[182],"attenuated":[183],"infiltration":[185],"restored":[187],"function,":[189],"supporting":[190],"pathogenic":[192],"contribution":[193],"senescence.":[196],"Subsequent":[197],"trajectories":[199],"vitro":[202],"validations":[203],"identified":[204],"senescence-enriched":[206],"DNAJB1":[207,214],"high":[208],"subpopulation.":[210],"Mechanistically,":[211],"IFN-\u03b3":[212],"upregulated":[213],"transcription":[215],"via":[216],"JUND,":[217],"which":[218],"turn":[221],"associated":[222],"p21-mediated":[224],"enhanced":[227],"CD4\u207a":[228],"T":[229],"cell":[230],"recruitment.":[231],"vivo":[234],"evaluations":[235],"confirmed":[236],"that":[237,255],"intervention":[240],"effectively":[241],"suppressed":[242],"JUND-DNAJB1-p21":[245,257],"axis,":[246],"corroborating":[247],"mechanistic":[249],"findings.":[250],"Conclusions":[251],"These":[252],"findings":[253],"indicate":[254],"axis":[258],"contributes":[259],"pathogenesis":[265],"Senolytic":[268],"may":[273],"represent":[274],"strategy":[278],"mitigating":[280],"dysfunction.":[282]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-12T00:00:00"}
