{"id":"https://openalex.org/W7202181769","doi":"https://doi.org/10.3390/metabo16100736","title":"Lipid Metabolic Reprogramming in Thyroid Cancer: Systemic Biomarkers, Tumor Dependencies and Therapeutic Resistance","display_name":"Lipid Metabolic Reprogramming in Thyroid Cancer: Systemic Biomarkers, Tumor Dependencies and Therapeutic Resistance","publication_year":2026,"publication_date":"2026-09-30","ids":{"openalex":"https://openalex.org/W7202181769","doi":"https://doi.org/10.3390/metabo16100736","pmid":"https://pubmed.ncbi.nlm.nih.gov/42941212","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13707171"},"language":"en","primary_location":{"id":"doi:10.3390/metabo16100736","doi":"https://doi.org/10.3390/metabo16100736","is_oa":true,"landing_page_url":"https://doi.org/10.3390/metabo16100736","pdf_url":null,"source":{"id":"https://openalex.org/S2764402194","display_name":"Metabolites","issn_l":"2218-1989","issn":["2218-1989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/metabo16100736","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5121945403","display_name":"Li Zhou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Zhou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082160522","display_name":"Yiqing Mi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yiqing Mi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146564992","display_name":"Linlin Mao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Linlin Mao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146453712","display_name":"Jingjing Shi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jingjing Shi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146469848","display_name":"Yu Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157891297","display_name":"Gang Pan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gang Pan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5157913759","display_name":"You Peng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"You Peng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5157913759"],"corresponding_institution_ids":[],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.30284553,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"10","first_page":"736","last_page":"736"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipid-metabolic-reprogramming","display_name":"lipid metabolism reprogramming","score":0.9079999923706055},{"id":"https://openalex.org/keywords/thyroid-cancer","display_name":"thyroid cancer","score":1.0},{"id":"https://openalex.org/keywords/papillary-thyroid-carcinoma","display_name":"papillary thyroid carcinoma","score":0.8450000286102295},{"id":"https://openalex.org/keywords/anaplastic-thyroid-carcinoma","display_name":"anaplastic thyroid carcinoma","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cholesterol-synthesis","display_name":"cholesterol biosynthesis","score":0.5479999780654907},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.8339999914169312},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.8220000267028809},{"id":"https://openalex.org/keywords/srebf1","display_name":"SREBF1","score":0.7049999833106995},{"id":"https://openalex.org/keywords/stearoyl-coa-desaturase-1","display_name":"stearoyl-CoA desaturase 1","score":0.8740000128746033},{"id":"https://openalex.org/keywords/fatty-acid-synthase","display_name":"fatty acid synthase","score":0.6710000038146973},{"id":"https://openalex.org/keywords/membrane-remodeling","display_name":"membrane remodeling","score":0.5440000295639038},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.6110000014305115},{"id":"https://openalex.org/keywords/recurrence-risk-stratification","display_name":"recurrence risk stratification","score":0.7960000038146973},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.703000009059906},{"id":"https://openalex.org/keywords/radioiodine-resistance","display_name":"radioiodine resistance","score":0.9240000247955322}],"concepts":[{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.6628999710083008},{"id":"https://openalex.org/C2778111914","wikidata":"https://www.wikidata.org/wiki/Q7116159","display_name":"Oxysterol","level":3,"score":0.6577000021934509},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4666000008583069},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.43479999899864197},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.4334999918937683},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39969998598098755},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.3995000123977661},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3817000091075897},{"id":"https://openalex.org/C141359234","wikidata":"https://www.wikidata.org/wiki/Q2734301","display_name":"Lipogenesis","level":3,"score":0.3682999908924103},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3560999929904938},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.353300005197525},{"id":"https://openalex.org/C25095133","wikidata":"https://www.wikidata.org/wiki/Q573950","display_name":"Lipid droplet","level":2,"score":0.337799996137619},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.33059999346733093},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3305000066757202},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32690000534057617},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3215000033378601},{"id":"https://openalex.org/C2777704780","wikidata":"https://www.wikidata.org/wiki/Q21115210","display_name":"ABCA1","level":4,"score":0.32010000944137573},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3091999888420105},{"id":"https://openalex.org/C7251936","wikidata":"https://www.wikidata.org/wiki/Q7201525","display_name":"Plant lipid transfer proteins","level":3,"score":0.2937000095844269},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.2922999858856201},{"id":"https://openalex.org/C39567582","wikidata":"https://www.wikidata.org/wiki/Q415624","display_name":"Perilipin","level":4,"score":0.29170000553131104},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.29109999537467957},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2879999876022339},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2847999930381775},{"id":"https://openalex.org/C180899940","wikidata":"https://www.wikidata.org/wiki/Q117982","display_name":"Lipid signaling","level":3,"score":0.2816999852657318},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.2581999897956848},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.2524000108242035}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/metabo16100736","doi":"https://doi.org/10.3390/metabo16100736","is_oa":true,"landing_page_url":"https://doi.org/10.3390/metabo16100736","pdf_url":null,"source":{"id":"https://openalex.org/S2764402194","display_name":"Metabolites","issn_l":"2218-1989","issn":["2218-1989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"journal-article"},{"id":"doi:10.20944/preprints202608.0708.v1","doi":"https://doi.org/10.20944/preprints202608.0708.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202608.0708.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:42941212","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42941212","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13707171","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13707171/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:42f897d23d19466b91adc49dd1a38dbe","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/42f897d23d19466b91adc49dd1a38dbe","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Metabolites, Vol 16, Iss 10, p 736 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/metabo16100736","doi":"https://doi.org/10.3390/metabo16100736","is_oa":true,"landing_page_url":"https://doi.org/10.3390/metabo16100736","pdf_url":null,"source":{"id":"https://openalex.org/S2764402194","display_name":"Metabolites","issn_l":"2218-1989","issn":["2218-1989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000842012","display_name":null,"funder_award_id":"LGF22H070008","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"}],"funders":[{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1997435180","https://openalex.org/W2241586700","https://openalex.org/W2485687482","https://openalex.org/W2554070381","https://openalex.org/W2793231138","https://openalex.org/W2957741945","https://openalex.org/W3094369981","https://openalex.org/W3175522385","https://openalex.org/W3199960211","https://openalex.org/W4200284105","https://openalex.org/W4225979405","https://openalex.org/W4283575440","https://openalex.org/W4309076300","https://openalex.org/W4316467955","https://openalex.org/W4387702714","https://openalex.org/W4390029745","https://openalex.org/W4391685069","https://openalex.org/W4392560088","https://openalex.org/W4394753932","https://openalex.org/W4397038812","https://openalex.org/W4399799099","https://openalex.org/W4399814739","https://openalex.org/W4400238767","https://openalex.org/W4401701273","https://openalex.org/W4401809181","https://openalex.org/W4407697787","https://openalex.org/W4408008509","https://openalex.org/W4409252816","https://openalex.org/W4410313607","https://openalex.org/W4410477741","https://openalex.org/W4411568881","https://openalex.org/W4412612658","https://openalex.org/W4416296563","https://openalex.org/W4416664932","https://openalex.org/W4416839740","https://openalex.org/W4417336339","https://openalex.org/W7116730681","https://openalex.org/W7128484258","https://openalex.org/W7135021048","https://openalex.org/W7139927768","https://openalex.org/W7162261088"],"related_works":["https://openalex.org/W4410313607","https://openalex.org/W7161604074","https://openalex.org/W4400238767","https://openalex.org/W4200284105","https://openalex.org/W3197005643","https://openalex.org/W4413862268","https://openalex.org/W7148302448","https://openalex.org/W4408326838","https://openalex.org/W4401612440","https://openalex.org/W7161001721"],"abstract_inverted_index":{"Lipid":[0,149],"metabolic":[1],"reprogramming":[2],"is":[3,134],"increasingly":[4],"implicated":[5],"in":[6,94],"thyroid":[7,82,107],"cancer":[8],"progression":[9],"and":[10,64,67,76,85,91,99,105,116,128,138,158,179,186],"treatment":[11,146,159],"resistance":[12,123],"alongside":[13],"circulating":[14,55],"lipid":[15,22,31,35,56,72,78,168],"associations":[16],"are":[17,147],"often":[18],"conflated":[19],"with":[20],"tumor":[21,180],"dependency.":[23],"A":[24],"clinically":[25],"useful":[26],"synthesis":[27,110],"must":[28],"distinguish":[29],"systemic":[30],"markers":[32],"from":[33],"intratumoral":[34],"flux":[36],"before":[37],"integrating":[38],"them":[39],"into":[40],"mechanistic":[41,86,137],"or":[42,170],"therapeutic":[43],"models.":[44],"This":[45],"critical":[46],"narrative":[47],"review":[48],"integrates":[49],"evidence":[50,133],"across":[51],"three":[52],"connected":[53],"layers:":[54],"markers;":[57],"tumor-intrinsic":[58],"uptake,":[59],"oxidation,":[60],"synthesis,":[61],"desaturation,":[62],"cholesterol":[63,109],"oxysterol":[65],"pathways;":[66],"immune-spatial":[68],"niches":[69],"involving":[70],"macrophage":[71],"handling,":[73],"APOE-associated":[74],"polarization":[75],"ferroptosis-related":[77],"peroxidation.":[79],"In":[80,103],"papillary":[81],"carcinoma,":[83],"multi-omics":[84],"studies":[87],"implicate":[88],"LPL-FATP2-CPT1A,":[89],"PC-AKT/mTOR-SREBP1c-FASN":[90],"METTL16/YTHDC2/SCD1":[92],"programs":[93],"membrane":[95],"remodeling,":[96],"invasion-related":[97],"behavior":[98],"recurrence":[100],"risk":[101],"stratification.":[102],"aggressive":[104],"anaplastic":[106],"cancer,":[108],"signaling,":[111],"fatty":[112],"acid":[113],"oxidation":[114],"adaptation":[115],"SREBF1/SCD1-linked":[117],"ferroptosis":[118],"defense":[119],"may":[120],"contribute":[121],"to":[122,124],"radioiodine,":[125],"radiotherapy,":[126],"chemotherapy":[127],"BRAF/MEK":[129],"inhibition.":[130],"The":[131],"current":[132],"strongest":[135],"for":[136,155],"biomarker":[139],"hypotheses;":[140],"thyroid-cancer-specific":[141],"prospective":[142,188],"trials":[143],"of":[144],"lipid-directed":[145],"lacking.":[148],"metabolism":[150],"therefore":[151],"provides":[152],"a":[153],"framework":[154],"molecular":[156],"stratification":[157],"sensitization,":[160],"but":[161],"it":[162],"does":[163],"not":[164],"currently":[165],"justify":[166],"nonspecific":[167],"lowering":[169],"routine":[171],"lipid-targeted":[172],"therapy.":[173],"Translation":[174],"will":[175],"require":[176],"paired":[177],"blood":[178],"lipidomics,":[181],"spatial":[182],"profiling,":[183],"functional":[184],"perturbation":[185],"biomarker-defined":[187],"studies.":[189]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2026-08-12T00:00:00"}
