{"id":"https://openalex.org/W7202149486","doi":"https://doi.org/10.1111/trf.70373","title":"Relevance of circulating IgG levels as a marker of health in plasma donors","display_name":"Relevance of circulating IgG levels as a marker of health in plasma donors","publication_year":2026,"publication_date":"2026-08-10","ids":{"openalex":"https://openalex.org/W7202149486","doi":"https://doi.org/10.1111/trf.70373","pmid":"https://pubmed.ncbi.nlm.nih.gov/42574244"},"language":"en","primary_location":{"id":"doi:10.1111/trf.70373","doi":"https://doi.org/10.1111/trf.70373","is_oa":false,"landing_page_url":"https://doi.org/10.1111/trf.70373","pdf_url":null,"source":{"id":"https://openalex.org/S186746772","display_name":"Transfusion","issn_l":"0041-1132","issn":["0041-1132","0372-1248","1537-2995","1878-2000"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059707080","display_name":"Audrey Laforce\u2010Lavoie","orcid":"https://orcid.org/0009-0005-0256-0639","observed_orcids":["https://orcid.org/0009-0005-0256-0639"]},"institutions":[{"id":"https://openalex.org/I1328242539","display_name":"H\u00e9ma-Qu\u00e9bec","ror":"https://ror.org/008jvv944","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I1328242539","https://openalex.org/I2801902503","https://openalex.org/I4210139015"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Audrey Laforce\u2010Lavoie","raw_affiliation_strings":["Medical Affairs and Innovation H\u00e9ma\u2010Qu\u00e9bec  Quebec City Quebec Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Affairs and Innovation H\u00e9ma\u2010Qu\u00e9bec  Quebec City Quebec Canada","institution_ids":["https://openalex.org/I1328242539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048487527","display_name":"Jessyka Desch\u00eanes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1328242539","display_name":"H\u00e9ma-Qu\u00e9bec","ror":"https://ror.org/008jvv944","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I1328242539","https://openalex.org/I2801902503","https://openalex.org/I4210139015"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jessyka Desch\u00eanes","raw_affiliation_strings":["Medical Affairs and Innovation H\u00e9ma\u2010Qu\u00e9bec  Montreal Quebec Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Affairs and Innovation H\u00e9ma\u2010Qu\u00e9bec  Montreal Quebec Canada","institution_ids":["https://openalex.org/I1328242539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028915593","display_name":"Marc Cloutier","orcid":"https://orcid.org/0000-0002-0598-8754","observed_orcids":["https://orcid.org/0000-0002-0598-8754"]},"institutions":[{"id":"https://openalex.org/I1328242539","display_name":"H\u00e9ma-Qu\u00e9bec","ror":"https://ror.org/008jvv944","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I1328242539","https://openalex.org/I2801902503","https://openalex.org/I4210139015"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Marc Cloutier","raw_affiliation_strings":["Medical Affairs and Innovation H\u00e9ma\u2010Qu\u00e9bec  Quebec City Quebec Canada"],"raw_orcid":"https://orcid.org/0000-0002-0598-8754","affiliations":[{"raw_affiliation_string":"Medical Affairs and Innovation H\u00e9ma\u2010Qu\u00e9bec  Quebec City Quebec Canada","institution_ids":["https://openalex.org/I1328242539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087006402","display_name":"Antoine Lewin","orcid":"https://orcid.org/0000-0003-1748-4198","observed_orcids":["https://orcid.org/0000-0003-1748-4198"]},"institutions":[{"id":"https://openalex.org/I1328242539","display_name":"H\u00e9ma-Qu\u00e9bec","ror":"https://ror.org/008jvv944","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I1328242539","https://openalex.org/I2801902503","https://openalex.org/I4210139015"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Antoine Lewin","raw_affiliation_strings":["Medical Affairs and Innovation H\u00e9ma\u2010Qu\u00e9bec  Montreal Quebec Canada"],"raw_orcid":"https://orcid.org/0000-0003-1748-4198","affiliations":[{"raw_affiliation_string":"Medical Affairs and Innovation H\u00e9ma\u2010Qu\u00e9bec  Montreal Quebec Canada","institution_ids":["https://openalex.org/I1328242539"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057947476","display_name":"Ren\u00e9e Bazin","orcid":"https://orcid.org/0000-0001-9594-2532","observed_orcids":["https://orcid.org/0000-0001-9594-2532"]},"institutions":[{"id":"https://openalex.org/I1328242539","display_name":"H\u00e9ma-Qu\u00e9bec","ror":"https://ror.org/008jvv944","country_code":"CA","type":"nonprofit","lineage":["https://openalex.org/I1328242539","https://openalex.org/I2801902503","https://openalex.org/I4210139015"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ren\u00e9e Bazin","raw_affiliation_strings":["Medical Affairs and Innovation H\u00e9ma\u2010Qu\u00e9bec  Quebec City Quebec Canada"],"raw_orcid":"https://orcid.org/0000-0001-9594-2532","affiliations":[{"raw_affiliation_string":"Medical Affairs and Innovation H\u00e9ma\u2010Qu\u00e9bec  Quebec City Quebec Canada","institution_ids":["https://openalex.org/I1328242539"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1328242539"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"66","issue":"11","first_page":"2195","last_page":"2203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12735","display_name":"Blood donation and transfusion practices","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12735","display_name":"Blood donation and transfusion practices","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasma-donation","display_name":"plasma donation","score":0.640999972820282},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7590000033378601},{"id":"https://openalex.org/keywords/covid-19-antibodies","display_name":"COVID-19 antibodies","score":0.7319999933242798},{"id":"https://openalex.org/keywords/antibody-avidity","display_name":"antibody avidity","score":0.7400000095367432},{"id":"https://openalex.org/keywords/donor-health","display_name":"donor health","score":0.5059999823570251},{"id":"https://openalex.org/keywords/self-reported-health-problems","display_name":"self-reported health problems","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6891999840736389},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6654000282287598},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5651999711990356},{"id":"https://openalex.org/C2775933685","wikidata":"https://www.wikidata.org/wiki/Q1124860","display_name":"Donation","level":2,"score":0.5562999844551086},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.5166000127792358},{"id":"https://openalex.org/C179223381","wikidata":"https://www.wikidata.org/wiki/Q419425","display_name":"Avidity","level":3,"score":0.5073000192642212},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.4442000091075897},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.43959999084472656},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.4390999972820282},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.374099999666214},{"id":"https://openalex.org/C3019514911","wikidata":"https://www.wikidata.org/wiki/Q48928650","display_name":"Donor specific antibodies","level":4,"score":0.3409999907016754},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3052000105381012}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000086663","descriptor_name":"COVID-19 Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000086663","descriptor_name":"COVID-19 Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000094345","descriptor_name":"Blood Donation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001782","descriptor_name":"Blood Donors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/trf.70373","doi":"https://doi.org/10.1111/trf.70373","is_oa":false,"landing_page_url":"https://doi.org/10.1111/trf.70373","pdf_url":null,"source":{"id":"https://openalex.org/S186746772","display_name":"Transfusion","issn_l":"0041-1132","issn":["0041-1132","0372-1248","1537-2995","1878-2000"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"journal-article"},{"id":"pmid:42574244","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42574244","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1967851910","https://openalex.org/W1969732692","https://openalex.org/W1984164519","https://openalex.org/W2017823556","https://openalex.org/W2047205279","https://openalex.org/W2062547293","https://openalex.org/W2071843728","https://openalex.org/W2090663297","https://openalex.org/W2156829523","https://openalex.org/W2420978498","https://openalex.org/W2521741241","https://openalex.org/W2606693839","https://openalex.org/W3014975517","https://openalex.org/W3090015418","https://openalex.org/W3161550204","https://openalex.org/W3187927291","https://openalex.org/W3203477922","https://openalex.org/W3217057953","https://openalex.org/W4220878948","https://openalex.org/W4223978901","https://openalex.org/W4224864065","https://openalex.org/W4224929773","https://openalex.org/W4294653738","https://openalex.org/W4317355031","https://openalex.org/W4318767306","https://openalex.org/W4321639038","https://openalex.org/W4366351322","https://openalex.org/W4386151155","https://openalex.org/W4386152623","https://openalex.org/W4386252300","https://openalex.org/W4387472201","https://openalex.org/W4388831385","https://openalex.org/W4388982443","https://openalex.org/W4401735153","https://openalex.org/W4406932837","https://openalex.org/W4410064897","https://openalex.org/W4413257538","https://openalex.org/W4413791427","https://openalex.org/W7113899107","https://openalex.org/W7163187590"],"related_works":["https://openalex.org/W4406932837","https://openalex.org/W4223978901","https://openalex.org/W3209005400","https://openalex.org/W93127600","https://openalex.org/W4224864065","https://openalex.org/W6960355992","https://openalex.org/W4413453550","https://openalex.org/W3134171257","https://openalex.org/W3080786786","https://openalex.org/W3185169550"],"abstract_inverted_index":{"BACKGROUND:":[0],"Frequent":[1],"plasma":[2,75,120,127,141,216],"donation":[3,76,121,204],"is":[4],"associated":[5,72,200,220],"with":[6,73,96,201,221],"reduced":[7],"circulating":[8],"IgG":[9,27,40,70,100,147,168,179,196,212,238],"levels,":[10],"prompting":[11],"many":[12],"jurisdictions":[13],"to":[14,58,103,119,131,203],"apply":[15],"IgG-based":[16],"deferral":[17],"thresholds":[18],"as":[19,41],"a":[20,42,160],"precautionary":[21],"donor-safety":[22],"measure.":[23],"However,":[24],"whether":[25],"low":[26,97],"in":[28,82,93,124,139,153,187,214,240],"healthy":[29,215],"individuals":[30],"reflects":[31],"clinically":[32],"meaningful":[33],"immunosuppression":[34],"remains":[35],"unclear.":[36],"This":[37],"study":[38],"evaluated":[39,92],"marker":[43],"for":[44],"donor":[45,224,241],"health":[46,61,135,208,229],"by":[47],"integrating":[48],"immunological,":[49],"behavioral":[50],"and":[51,60,85,110,114,243],"self-reported":[52,207,228],"outcomes,":[53],"including":[54],"vaccine":[55],"responses,":[56],"return":[57,202],"donation,":[59],"problems.":[62,209,230],"STUDY":[63],"DESIGN":[64],"AND":[65],"METHODS:":[66],"The":[67],"kinetics":[68],"of":[69,178,236],"decline":[71],"frequent":[74],"were":[77,91,137,184,198,218],"analyzed":[78,138],"over":[79,143,247],"18":[80],"months":[81],"49":[83],"first-time":[84,126,154],"50":[86],"repeat":[87,94],"donors.":[88],"Vaccine":[89],"responses":[90],"donors":[95,128,142,155,172,217],"or":[98,205,226],"high":[99],"using":[101],"ELISA":[102],"measure":[104],"SARS-CoV-2":[105],"Spike":[106],"receptor-binding":[107],"domain":[108],"antibodies":[109],"avidity":[111],"after":[112,174,194],"primary":[113,175],"booster":[115],"COVID-19":[116],"vaccination.":[117],"Return":[118],"was":[122,192],"examined":[123],"3897":[125],"followed":[129],"up":[130],"22":[132],"months.":[133],"Self-reported":[134],"problems":[136],"5347":[140],"10":[144],"years.":[145],"RESULTS:":[146],"levels":[148,183,197,213],"declined":[149],"during":[150],"early":[151],"donations":[152],"but":[156],"stabilized":[157],"thereafter,":[158],"suggesting":[159],"new":[161],"homeostatic":[162],"set":[163],"point":[164],"rather":[165],"than":[166],"progressive":[167],"depletion.":[169],"All":[170],"vaccinated":[171],"seroconverted":[173],"vaccination":[176],"regardless":[177],"level.":[180],"Although":[181],"antibody":[182],"slightly":[185],"lower":[186],"low-IgG":[188],"donors,":[189],"affinity":[190],"maturation":[191],"comparable":[193],"boosting.":[195],"not":[199,219],"increased":[206,227],"DISCUSSION:":[210],"Low":[211],"impaired":[222],"immunity,":[223],"retention,":[225],"These":[231],"findings":[232],"support":[233],"cautious":[234],"interpretation":[235],"isolated":[237],"values":[239],"management":[242],"favor":[244],"longitudinal":[245],"monitoring":[246],"fixed":[248],"thresholds.":[249]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-08-11T00:00:00"}