{"id":"https://openalex.org/W7202112154","doi":"https://doi.org/10.64898/2026.08.04.737285","title":"MicroRNA correlates of resilience to Alzheimer\u2019s disease identify candidate therapeutic targets for neuroprotection","display_name":"MicroRNA correlates of resilience to Alzheimer\u2019s disease identify candidate therapeutic targets for neuroprotection","publication_year":2026,"publication_date":"2026-08-10","ids":{"openalex":"https://openalex.org/W7202112154","doi":"https://doi.org/10.64898/2026.08.04.737285","pmid":"https://pubmed.ncbi.nlm.nih.gov/42845305","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13640498"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.04.737285","doi":"https://doi.org/10.64898/2026.08.04.737285","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.04.737285","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/10/2026.08.04.737285.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/10/2026.08.04.737285.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082256578","display_name":"Pourya Naderi Yeganeh","orcid":"https://orcid.org/0000-0002-4693-8331","observed_orcids":["https://orcid.org/0000-0002-4693-8331"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pourya Naderi","raw_affiliation_strings":["Department of Pathology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, United States","Harvard Medical School Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, United States","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028694657","display_name":"Latika Matai","orcid":"https://orcid.org/0000-0003-4104-6809","observed_orcids":["https://orcid.org/0000-0003-4104-6809"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Latika Matai","raw_affiliation_strings":["Department of Pathology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, United States","Harvard Medical School Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, United States","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082152779","display_name":"Quadri Adewale","orcid":"https://orcid.org/0000-0001-5090-6140","observed_orcids":["https://orcid.org/0000-0001-5090-6140"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Quadri Adewale","raw_affiliation_strings":["Department of Pathology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, United States","Harvard Medical School Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, United States","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037136517","display_name":"Isabel Castanho","orcid":"https://orcid.org/0000-0003-1413-626X","observed_orcids":["https://orcid.org/0000-0003-1413-626X"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isabel Castanho","raw_affiliation_strings":["Department of Pathology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, United States","Harvard Medical School Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, United States","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146385002","display_name":"Alice Rodrigues","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alice Rodrigues","raw_affiliation_strings":["Department of Pathology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, United States","Harvard Medical School Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, United States","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069526376","display_name":"Maria Mavrikaki","orcid":"https://orcid.org/0000-0002-8646-5022","observed_orcids":["https://orcid.org/0000-0002-8646-5022"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Mavrikaki","raw_affiliation_strings":["Department of Pathology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, United States","Harvard Medical School Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, United States","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042613823","display_name":"Ioannis S. Vlachos","orcid":"https://orcid.org/0000-0002-8849-808X","observed_orcids":["https://orcid.org/0000-0002-8849-808X"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ioannis S. Vlachos","raw_affiliation_strings":["Broad Institute of MIT and Harvard, Cambridge, MA, United States","Department of Pathology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, United States","Harvard Medical School Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Broad Institute of MIT and Harvard, Cambridge, MA, United States","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Department of Pathology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, United States","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013989133","display_name":"Frank John Slack","orcid":"https://orcid.org/0000-0001-8263-0409","observed_orcids":["https://orcid.org/0000-0001-8263-0409"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Frank J. Slack","raw_affiliation_strings":["Department of Pathology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, United States","Harvard Medical School Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, United States","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5122919736","display_name":"Winston Hide","orcid":"https://orcid.org/0000-0002-8621-3271","observed_orcids":["https://orcid.org/0000-0002-8621-3271"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Winston Hide","raw_affiliation_strings":["Department of Pathology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, United States","Harvard Medical School Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, United States","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School Initiative for RNA Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5013989133","https://openalex.org/A5122919736"],"corresponding_institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.649399995803833,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.649399995803833,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.30469998717308044,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.024800000712275505,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9580000042915344},{"id":"https://openalex.org/keywords/resilience","display_name":"resilience","score":0.44200000166893005},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.9179999828338623},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9419999718666077},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.7200000286102295},{"id":"https://openalex.org/keywords/dorsolateral-prefrontal-cortex","display_name":"dorsolateral prefrontal cortex","score":0.9660000205039978},{"id":"https://openalex.org/keywords/mir-362-3p","display_name":"miR-362-3p","score":0.9139999747276306},{"id":"https://openalex.org/keywords/mir-433-3p","display_name":"miR-433-3p","score":0.9520000219345093},{"id":"https://openalex.org/keywords/mir-132-3p","display_name":"miR-132-3p","score":0.968999981880188},{"id":"https://openalex.org/keywords/mir-129-5p","display_name":"miR-129-5p","score":0.9829999804496765},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8080000281333923},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7250000238418579},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.6430000066757202},{"id":"https://openalex.org/keywords/rho-gtpases","display_name":"Rho GTPases","score":0.9580000042915344},{"id":"https://openalex.org/keywords/neurotransmitter-receptors","display_name":"neurotransmitter receptors","score":0.9120000004768372},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.7059999704360962},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7490000128746033},{"id":"https://openalex.org/keywords/postmortem-brain","display_name":"postmortem brain","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7506999969482422},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6804999709129333},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.6733999848365784},{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.6525999903678894},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6496000289916992},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.630299985408783},{"id":"https://openalex.org/C60365752","wikidata":"https://www.wikidata.org/wiki/Q5156306","display_name":"Competing endogenous RNA","level":5,"score":0.38920000195503235},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3700000047683716},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.3662000000476837},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.3449999988079071},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.32100000977516174},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3158999979496002},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3052000105381012},{"id":"https://openalex.org/C2779867133","wikidata":"https://www.wikidata.org/wiki/Q21111297","display_name":"Dicer","level":5,"score":0.3034000098705292},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.273499995470047},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2671999931335449},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.25540000200271606},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.25429999828338623}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.08.04.737285","doi":"https://doi.org/10.64898/2026.08.04.737285","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.04.737285","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/10/2026.08.04.737285.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13640498","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13640498/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13640498/pdf/nihpp-2026.08.04.737285v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmid:42845305","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42845305","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.64898/2026.08.04.737285","doi":"https://doi.org/10.64898/2026.08.04.737285","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.04.737285","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/10/2026.08.04.737285.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000876689","display_name":"Non-coding RNAs in resilience to Alzheimer\u2019s Disease","funder_award_id":"R01AG082093","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000917648","display_name":"Molecular mechanisms of aging and accelerated aging in the human brain","funder_award_id":"R01AG079799","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7202112154.pdf","grobid_xml":"https://content.openalex.org/works/W7202112154.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1548995643","https://openalex.org/W1958284284","https://openalex.org/W1978991736","https://openalex.org/W1980794267","https://openalex.org/W1987824810","https://openalex.org/W2005202312","https://openalex.org/W2010457001","https://openalex.org/W2022945065","https://openalex.org/W2077327925","https://openalex.org/W2084062482","https://openalex.org/W2096128947","https://openalex.org/W2102819831","https://openalex.org/W2105336002","https://openalex.org/W2120522615","https://openalex.org/W2132073780","https://openalex.org/W2146512944","https://openalex.org/W2406250479","https://openalex.org/W2480455979","https://openalex.org/W2499115595","https://openalex.org/W2562423557","https://openalex.org/W2575149017","https://openalex.org/W2605681290","https://openalex.org/W2768955389","https://openalex.org/W2788972437","https://openalex.org/W2804633924","https://openalex.org/W2805386160","https://openalex.org/W2890460868","https://openalex.org/W2899178822","https://openalex.org/W2949187527","https://openalex.org/W2950886245","https://openalex.org/W2951194531","https://openalex.org/W2951557451","https://openalex.org/W2976163884","https://openalex.org/W2977865573","https://openalex.org/W2993255485","https://openalex.org/W3001537463","https://openalex.org/W3015940544","https://openalex.org/W3040771723","https://openalex.org/W3043048574","https://openalex.org/W3081150912","https://openalex.org/W3084891346","https://openalex.org/W3108982385","https://openalex.org/W3139466802","https://openalex.org/W3165570809","https://openalex.org/W3192802547","https://openalex.org/W4210318312","https://openalex.org/W4220661917","https://openalex.org/W4293536424","https://openalex.org/W4321178754","https://openalex.org/W4379878477","https://openalex.org/W4385330114","https://openalex.org/W4387142593","https://openalex.org/W4388869747","https://openalex.org/W4388870409","https://openalex.org/W4389978715","https://openalex.org/W4390726801","https://openalex.org/W4391383852","https://openalex.org/W4391609257","https://openalex.org/W4392563235","https://openalex.org/W4399517645","https://openalex.org/W4400089962","https://openalex.org/W4401211160","https://openalex.org/W4402400766","https://openalex.org/W4402490171","https://openalex.org/W4402549066","https://openalex.org/W4402673314","https://openalex.org/W4404756588","https://openalex.org/W4405205675","https://openalex.org/W4407987368","https://openalex.org/W4409210034","https://openalex.org/W4411236091","https://openalex.org/W4414702452","https://openalex.org/W4415479502"],"related_works":["https://openalex.org/W4407987368","https://openalex.org/W4406050981","https://openalex.org/W4390199644","https://openalex.org/W4409227016","https://openalex.org/W2951557451","https://openalex.org/W2147495042","https://openalex.org/W2789606268","https://openalex.org/W4392563235","https://openalex.org/W4293536424","https://openalex.org/W3003668627"],"abstract_inverted_index":{"Abstract":[0],"Many":[1],"aged":[2],"individuals":[3],"accumulate":[4],"advanced":[5],"Alzheimer\u2019s":[6,294],"disease":[7,295,343],"(AD)":[8],"neuropathology":[9],"without":[10],"cognitive":[11,199,249,297,308,365],"decline,":[12,200,250,298],"signifying":[13],"potent":[14],"endogenous":[15,29,274,301],"resilience":[16,19,37,66,121,177,279,292,334],"mechanisms.":[17],"Mimicking":[18],"to":[20,193,269,280,293,300,322,350,357,368],"AD":[21,60,149,175,183,219,247,379],"may":[22,305,384],"offer":[23],"new":[24,132,270],"therapeutic":[25,403,425],"opportunities":[26],"by":[27],"emulating":[28],"neuroprotection,":[30],"but":[31,62],"the":[32,80,104,311,326,331,370,393,399],"molecular":[33,337],"pathways":[34,194,383],"that":[35,46,195,266,276,304,333,381],"underpin":[36],"remain":[38],"largely":[39],"unknown.":[40],"MicroRNAs":[41],"(miRNAs)\u2014small":[42],"noncoding":[43],"RNA":[44,94],"molecules":[45],"post-transcriptionally":[47],"regulate":[48],"gene":[49],"expression\u2014influence":[50],"neuronal":[51,140,242],"and":[52,59,75,92,100,108,110,129,131,142,158,160,178,187,209,230,243,251,364,390,398,416],"glial":[53,244],"processes":[54],"associated":[55,197],"with":[56,123,198,223,291],"development,":[57],"aging,":[58],"neurodegeneration":[61],"their":[63,76],"role":[64],"in":[65,79,120,174,182,218,378,388,413],"has":[67],"not":[68],"been":[69],"characterized.":[70],"We":[71,88,213],"investigated":[72],"resilience-associated":[73,133,191],"miRNAs":[74,116,155,192,240],"targeted":[77],"programs":[78,245,265,303],"dorsolateral":[81],"prefrontal":[82],"cortex":[83],"of":[84,239,246,262,361,372,395],"post-mortem":[85],"human":[86],"brains.":[87],"analyzed":[89],"matched":[90],"miRNA":[91,146,163,166,312,346,376],"messenger":[93],"(mRNA)":[95],"expression":[96],"across":[97,148,241],"resilient,":[98],"AD,":[99,124],"control":[101],"subjects":[102,220],"from":[103],"Religious":[105],"Order":[106],"Study":[107],"Memory":[109],"Aging":[111],"Project":[112],"(ROSMAP)":[113],"cohort.":[114],"Nine":[115,284],"were":[117,196],"differentially":[118],"expressed":[119],"compared":[122],"including":[125,139,201,226],"previously":[126],"unreported":[127],"miR-362-3p":[128,222],"miR-433-3p":[130],"roles":[134],"for":[135,221,260,401,423],"known":[136],"AD-related":[137],"miRNAs,":[138],"miR-132-3p":[141],"miR-129-5p.":[143],"By":[144],"analyzing":[145],"activity":[147],"progression,":[150],"we":[151],"found":[152],"additional":[153],"cognitive-associated":[154],"(e.g.,":[156,354],"miR-335-5p":[157],"miR-19b)":[159],"one":[161,355],"plaque-restricted":[162],"(miR-199a-5p).":[164],"Sex-specific":[165,375],"dysregulation":[167,377],"was":[168],"observed:":[169],"miR-7-5p":[170],"showed":[171],"male-specific":[172],"upregulation":[173],"versus":[176],"suggested":[179],"sex-specific":[180,252],"differences":[181,321],"patients.":[184],"Integrated":[185],"co-expression":[186],"target-enrichment":[188],"analyses":[189,397],"linked":[190,356],"transforming":[202],"growth":[203],"factor":[204,229],"\u03b2,":[205],"Rho":[206],"guanosine":[207],"triphosphatases,":[208],"neurotransmitter":[210],"receptor":[211,232],"regulation.":[212,253],"also":[214],"report":[215],"restricted":[216],"co-activity":[217],"inflammatory":[224],"pathways,":[225],"tumor":[227],"necrosis":[228],"Toll-like":[231],"signaling.":[233],"These":[234],"results":[235],"demonstrate":[236],"systematic":[237],"involvement":[238],"resilience,":[248],"Our":[254],"study":[255],"provides":[256],"an":[257],"important":[258],"resource":[259],"discovery":[261],"actionable":[263],"regulatory":[264,302,410],"could":[267],"lead":[268],"therapies,":[271],"based":[272],"on":[273],"molecules,":[275],"emulate":[277],"natural":[278],"AD.":[281],"Key":[282],"points":[283],"distinct":[285],"cortical":[286],"microRNA":[287],"(miRNA)":[288],"signatures":[289,347],"correlate":[290],"(AD)-related":[296],"pointing":[299],"help":[306],"preserve":[307],"function.":[309],"At":[310],"level,":[313],"resilient":[314],"brains":[315],"show":[316],"minimal":[317],"or":[318],"no":[319],"detectable":[320],"healthy":[323],"individuals,":[324],"despite":[325],"profound":[327],"pathological":[328],"differences,":[329],"supporting":[330],"idea":[332],"reflects":[335],"preserved":[336],"homeostasis":[338],"rather":[339],"than":[340],"a":[341,351,421],"separate":[342],"state.":[344],"Some":[345],"are":[348],"specific":[349],"certain":[352],"pathology":[353,363],"amyloid-\u03b2":[358],"plaques":[359],"independently":[360],"tau":[362],"decline),":[366],"helping":[367],"disentangle":[369],"regulation":[371],"these":[373],"processes.":[374],"suggests":[380],"resilience-linked":[382,424],"be":[385],"regulated":[386],"differently":[387],"males":[389],"females,":[391],"reinforcing":[392],"value":[394],"sex-stratified":[396],"potential":[400],"differential":[402],"strategies.":[404],"Integrative":[405],"miRNA\u2013pathway":[406],"analysis":[407],"highlights":[408],"candidate":[409],"networks":[411],"involved":[412],"inflammation,":[414],"matrisome,":[415],"cellular":[417],"stress":[418],"responses,":[419],"providing":[420],"framework":[422],"targets.":[426]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-11T00:00:00"}
